The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes

2001 ◽  
Vol 114 (2) ◽  
pp. 257-267 ◽  
Author(s):  
A. Abrieu ◽  
M. Doree ◽  
D. Fisher
Keyword(s):  
Cell Cycle ◽  
Map Kinase ◽  
Cell Cycle Progression ◽  
Mitotic Cell ◽  
Model Systems ◽  
Cyclin B ◽  
Cdc2 Kinase ◽  
Meiotic Chromosomes ◽  
Map Kinase Cascade ◽  
Kinase Cascade

Throughout oocyte maturation, and subsequently during the first mitotic cell cycle, the MAP kinase cascade and cyclin-B-Cdc2 kinase are associated with the control of cell cycle progression. Many roles have been directly or indirectly attributed to MAP kinase and its influence on cyclin-B-Cdc2 kinase in different model systems; yet a principle theme does not emerge from the published literature, some of which is apparently contradictory. Interplay between these two kinases affects the major events of meiotic maturation throughout the animal kingdom, including the suppression of DNA replication, the segregation of meiotic chromosomes, and the prevention of parthenogenetic activation. Central to many of these events appears to be the control by MAP kinase of cyclin translation and degradation.

scholarly journals Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

Cell ◽  
1996 ◽  
Vol 87 (3) ◽  
pp. 519-529 ◽  
Author(s):  
Nathalie Lamarche ◽  
Nicolas Tapon ◽  
Lisa Stowers ◽  
Peter D Burbelo ◽  
Pontus Aspenström ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Map Kinase ◽  
Cell Cycle Progression ◽  
Actin Polymerization ◽  
Cycle Progression ◽  
Map Kinase Cascade ◽  
Kinase Cascade

MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells

1999 ◽  
Vol 277 (4) ◽  
pp. C652-C664 ◽  
Author(s):  
Nathalie Rivard ◽  
Marie-Josée Boucher ◽  
Claude Asselin ◽  
Gilles L’Allemain
Keyword(s):  
Cell Cycle ◽  
Epithelial Cells ◽  
Map Kinase ◽  
Transcriptional Activity ◽  
Cell Types ◽  
S Phase ◽  
Protein Levels ◽  
Map Kinase Cascade ◽  
Kinase Cascade ◽  
Phase Entry

The present report delineates the critical pathway in the G1 phase involved in downregulation of p27Kip1, a cyclin-dependent kinase inhibitor, which plays a pivotal role in controlling entry into the S phase of the cell cycle. In resting CCL39 fibroblasts and IEC-6 intestinal epithelial cells, protein levels of p27Kip1 were elevated but dramatically decreased on serum stimulation, along with hyperphosphorylation of pRb and increased CDK2 activity. In both cell types, expression of ras resulted in an increase of basal and serum-stimulated E2F-dependent transcriptional activity and a reduction in p27Kip1 protein levels as well. The role of the mitogen-activated protein (MAP) kinase cascade in p27Kip1 reduction and S phase reentry was reinforced by the blockades of serum-induced E2F-dependent transcriptional activity and p27Kip1 downregulation with the MKK-1/2 inhibitor PD-98059. In both cell lines, downregulation of p27Kip1 was associated with a repression of its synthesis, an event mediated by the p42/p44 MAP kinase pathway. Using an antisense approach, we demonstrated that p27Kip1 may control cell cycle exit in both cell types. These data indicate that activation of the MAP kinase cascade is required for S phase entry and p27Kip1 downregulation in fibroblasts and epithelial cells.

scholarly journals The Raf/MAP Kinase Cascade in Cell Cycle Regulation and Differentiation in Drosophila.

1996 ◽  
Vol 21 (5) ◽  
pp. 437-444 ◽  
Author(s):  
Yasuyoshi Nishida ◽  
Yoshihiro H. Inoue ◽  
Leo Tsuda ◽  
Takashi Adachi-Yamada ◽  
Young-Mi Lim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Map Kinase ◽  
Cell Cycle Regulation ◽  
Map Kinase Cascade ◽  
Kinase Cascade ◽  
Cycle Regulation

scholarly journals Cyclic AMP-Mediated Inhibition of Cell Growth Requires the Small G Protein Rap1

2001 ◽  
Vol 21 (11) ◽  
pp. 3671-3683 ◽  
Author(s):  
John M. Schmitt ◽  
Philip J. S. Stork
Keyword(s):  
Cyclic Amp ◽  
Map Kinase ◽  
G Protein ◽  
Cell Cycle Progression ◽  
3T3 Cells ◽  
Small G Protein ◽  
Map Kinase Cascade ◽  
Kinase Cascade ◽  
Nih 3T3 ◽  
Nih 3T3 Cells

ABSTRACT In many normal and transformed cell types, the intracellular second messenger cyclic AMP (cAMP) blocks the effects of growth factors and serum on mitogenesis, proliferation, and cell cycle progression. cAMP exerts these growth-inhibitory effects via inhibition of the mitogen-activated protein (MAP) kinase cascade. Here, using Hek293 and NIH 3T3 cells, we show that cAMP's inhibition of the MAP kinase cascade is mediated by the small G protein Rap1. Activation of Rap1 by cAMP induces the association of Rap1 with Raf-1 and limits Ras-dependent activation of ERK. In NIH 3T3 cells, Rap1 is required not only for cAMP's inhibition of ERK activation but for inhibition of cell proliferation and mitogenesis as well.

scholarly journals Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells

Oncogene ◽  
1998 ◽  
Vol 16 (21) ◽  
pp. 2803-2813 ◽  
Author(s):  
Rodney J Fiddes ◽  
Peter W Janes ◽  
Susan P Sivertsen ◽  
Robert L Sutherland ◽  
Elizabeth A Musgrove ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cell Cycle Progression ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cycle Progression ◽  
Map Kinase Cascade ◽  
Kinase Cascade

scholarly journals Mating in Saccharomyces cerevisiae: The Role of the Pheromone Signal Transduction Pathway in the Chemotropic Response to Pheromone

Genetics ◽  
1997 ◽  
Vol 147 (1) ◽  
pp. 19-32 ◽  
Author(s):  
Kathrin Schrick ◽  
Barbara Garvik ◽  
Leland H Hartwell
Keyword(s):  
Signal Transduction ◽  
Map Kinase ◽  
Transcriptional Activation ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Wild Type ◽  
Mating Partner ◽  
Map Kinase Cascade ◽  
Kinase Cascade ◽  
Wild Type Control

Abstract The mating process in yeast has two distinct aspects. One is the induction and activation of proteins required for cell fusion in response to a pheromone signal; the other is chemotropism, i.e., detection of a pheromone gradient and construction of a fusion site available to the signaling cell. To determine whether components of the signal transduction pathway necessary for transcriptional activation also play a role in chemotropism, we examined strains with null mutations in components of the signal transduction pathway for diploid formation, prezygote formation and the chemotropic process of mating partner discrimination when transcription was induced downstream of the mutation. Cells mutant for components of the mitogen-activated protein (MAP) kinase cascade (ste5, ste20, ste11, ste7 or fus3 kss1) formed diploids at a frequency 1% that of the wild-type control, but formed prezygotes as efficiently as the wild-type control and showed good mating partner discrimination, suggesting that the MAP kinase cascade is not essential for chemotropism. In contrast, cells mutant for the receptor (ste2) or the β or γ subunit (ste4 and stel8) of the G protein were extremely defective in both diploid and prezygote formation and discriminated poorly between signaling and nonsignaling mating partners, implying that these components are important for chemotropism.

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