On the role of small peptides in the regulation of RNA synthesis in Tetrahymena pyriformis
Keyword(s):
Tetrahymena cells secrete a factor which inhibits RNA synthesis in vivo and in vitro. The factor is a relatively small peptide with a molecular weight between 300 and 1500 Daltons. Other, non-specific peptides in the broth medium or added to a chemically defined medium have a stimulatory effect on RNA synthesis in vivo and such peptides also stimulate the in vitro synthesis of RNA in a r-chromatin preparation. On the basis of these results we conclude that such extracellular small peptides compete with a specific factor which is part of the intracellular regulatory mechanism controlling the rate of RNA synthesis. The consequence of such competition is a high overproduction of ribosomal RNA in cells inoculated on peptide-rich broth media.
1976 ◽
Vol 70
(3)
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pp. 573-580
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Keyword(s):
1992 ◽
Vol 84
(2)
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pp. 236-242
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Keyword(s):
1970 ◽
Vol 52
(2)
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pp. 281-300
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1980 ◽
Vol 607
(2)
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pp. 295-303
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