Design of a stability-detecting device for dental implants

2005 ◽  
Vol 219 (3) ◽  
pp. 203-211 ◽  
Author(s):  
H-M Huang ◽  
K-Y Cheng ◽  
C-F Chen ◽  
K-L Ou ◽  
C-T Lin ◽  
...  
Keyword(s):  
Animal Models ◽  
Dental Implant ◽  
Bone Healing ◽  
Test Apparatus ◽  
Implant Stability ◽  
Left Tibia ◽  
Vibrational Signals ◽  
Acoustic Receiver ◽  
Rf Values

Resonance frequency (RF) analysis technology was used to design a dental implant stability detector. The device uses a miniature-sized electromagnetic triggering rod to elicit vibration in a dental implant. Vibrational signals were recorded via an acoustic receiver. To assess the in vivo performance of the test apparatus, animal models were used. Implants were placed in the left tibia of 12 rabbits using a conventional surgical procedure. Standard 3.2 mm × 8 mm implants were placed in each test tibia with pre-tapping cavities of 3.2 mm and 3.7 mm diameters to simulate either a ‘well-fitting’ or a ‘loosely fitting’ situation. The RF values of the test implants were detected by the newly developed device which was directly mounted on the healing abutments of the implants. The results showed that the RF values of the implants under well-fitting conditions significantly increased (p<0.01) 3 weeks after surgery and reached a plateau at around 6-7 weeks. Meanwhile implants with higher initial RF values had shorter healing times and higher final RF values at the plateau. Based on these findings, it was concluded that the idea of using the current designed device for detecting the degree of bone healing during the osseointegration process seems feasible.

scholarly journals Rabbits as Animal Models in Contemporary Implant Biomaterial Research

2011 ◽  
Vol 2 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Himanshu Arora ◽  
Anil Nafria ◽  
Anup Kanase
Keyword(s):  
Animal Models ◽  
Dental Implants ◽  
Dental Implant ◽  
Mechanical Stability ◽  
In Vitro Studies ◽  
Clinical Use ◽  
Essential Step ◽  
Rigorous Testing

ABSTRACT Development of an optimal interface between bone and orthopedic or dental implants has taken place for many years. In order to determine whether a newly developed implant material conforms to the requirements of biocompatibility, mechanical stability and safety, it must undergo rigorous testing both in vitro and in vivo. Results from in vitro studies can be difficult to extrapolate to the in vivo situation. For this reason the use of animal models is often an essential step in the testing of orthopedic and dental implants prior to clinical use in humans. This review discusses the reasons, the importance, and the research carried out in rabbits in our quest to develop a dental implant ideally suited for human bone.

scholarly journals Bone Healing Evaluation Following Different Osteotomic Techniques in Animal Models: A Suitable Method for Clinical Insights

2020 ◽  
Vol 10 (20) ◽  
pp. 7165
Author(s):  
Alexandre Anesi ◽  
Mattia Di Bartolomeo ◽  
Arrigo Pellacani ◽  
Marzia Ferretti ◽  
Francesco Cavani ◽  
...  
Keyword(s):  
Elevated Temperature ◽  
Animal Models ◽  
Bone Healing ◽  
Ex Vivo ◽  
Trauma Surgery ◽  
Mechanical Damage ◽  
Bone Drilling ◽  
Animal Bone ◽  
Piezoelectric Devices

Osteotomy is a common step in oncological, reconstructive, and trauma surgery. Drilling and elevated temperature during osteotomy produce thermal osteonecrosis. Heat and associated mechanical damage during osteotomy can impair bone healing, with consequent failure of fracture fixation or dental implants. Several ex vivo studies on animal bone were recently focused on heating production during osteotomy with conventional drill and piezoelectric devices, particularly in endosseous dental implant sites. The current literature on bone drilling and osteotomic surface analysis is here reviewed and the dynamics of bone healing after osteotomy with traditional and piezoelectric devices are discussed. Moreover, the methodologies involved in the experimental osteotomy and clinical studies are compared, focusing on ex vivo and in vivo findings.

scholarly journals Animal Models Used in Testing the Biocompatibility of the Dental Implant – A Review

2020 ◽  
Vol 77 (2) ◽  
pp. 1
Author(s):  
Diana Larisa ANCUŢA ◽  
Cristin COMAN ◽  
Diana Mihaela ALEXANDRU ◽  
Maria CRIVINEANU
Keyword(s):  
Animal Models ◽  
Dental Implant ◽  
Animal Species ◽  
Bone Structure ◽  
In Vitro Tests ◽  
Accurate Data ◽  
Sufficient Data

In order to investigate the interaction between the bone and the dental implant, in vivo testsare performed in accordance with the biocompatibility requirements. As in vitro tests do not provide sufficient data on the quality of the implants, the animal models are used because they allow a complete assessment of all the factors involved in the osseointegration process.The aim of the paper is to provide data on the bone structure of animal species involved in dental research, highlighting the complexity of bone structure and osseointegration depending on the species. At the same time, the importance of selecting animal models is emphasized, in order to obtain the most accurate data for the development of dental implants and their use in humans. Following the research, essential data were obtained that helped to synthesize the bone characteristics of animals such as rats, rabbits, pigs, sheep or goats and relate them to the human bone skeleton. These data are useful in choosing an animal model when testing a new dental implant.

Transplantation of Adipose-derived Cells for Periodontal Regeneration: A Systematic Review

2019 ◽  
Vol 14 (6) ◽  
pp. 504-518 ◽  
Author(s):  
Dilcele Silva Moreira Dziedzic ◽  
Bassam Felipe Mogharbel ◽  
Priscila Elias Ferreira ◽  
Ana Carolina Irioda ◽  
Katherine Athayde Teixeira de Carvalho
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Platelet Rich Plasma ◽  
Periodontal Regeneration ◽  
In Vitro Studies ◽  
In Vivo Studies ◽  
Cell Sources ◽  
Study Designs

This systematic review evaluated the transplantation of cells derived from adipose tissue for applications in dentistry. SCOPUS, PUBMED and LILACS databases were searched for in vitro studies and pre-clinical animal model studies using the keywords “ADIPOSE”, “CELLS”, and “PERIODONTAL”, with the Boolean operator “AND”. A total of 160 titles and abstracts were identified, and 29 publications met the inclusion criteria, 14 in vitro and 15 in vivo studies. In vitro studies demonstrated that adipose- derived cells stimulate neovascularization, have osteogenic and odontogenic potential; besides adhesion, proliferation and differentiation on probable cell carriers. Preclinical studies described improvement of bone and periodontal healing with the association of adipose-derived cells and the carrier materials tested: Platelet Rich Plasma, Fibrin, Collagen and Synthetic polymer. There is evidence from the current in vitro and in vivo data indicating that adipose-derived cells may contribute to bone and periodontal regeneration. The small quantity of studies and the large variation on study designs, from animal models, cell sources and defect morphology, did not favor a meta-analysis. Additional studies need to be conducted to investigate the regeneration variability and the mechanisms of cell participation in the processes. An overview of animal models, cell sources, and scaffolds, as well as new perspectives are provided for future bone and periodontal regeneration study designs.

scholarly journals Heme Oxygenase-1 Deficiency and Oxidative Stress: A Review of 9 Independent Human Cases and Animal Models

2021 ◽  
Vol 22 (4) ◽  
pp. 1514 ◽  
Author(s):  
Akihiro Yachie
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Heme Oxygenase ◽  
Inflammatory Diseases ◽  
Cell Types ◽  
Pharmacological Intervention ◽  
Heme Oxygenase 1 ◽  
Inflammatory Reactions

Since Yachie et al. reported the first description of human heme oxygenase (HO)-1 deficiency more than 20 years ago, few additional human cases have been reported in the literature. A detailed analysis of the first human case of HO-1 deficiency revealed that HO-1 is involved in the protection of multiple tissues and organs from oxidative stress and excessive inflammatory reactions, through the release of multiple molecules with anti-oxidative stress and anti-inflammatory functions. HO-1 production is induced in vivo within selected cell types, including renal tubular epithelium, hepatic Kupffer cells, vascular endothelium, and monocytes/macrophages, suggesting that HO-1 plays critical roles in these cells. In vivo and in vitro studies have indicated that impaired HO-1 production results in progressive monocyte dysfunction, unregulated macrophage activation and endothelial cell dysfunction, leading to catastrophic systemic inflammatory response syndrome. Data from reported human cases of HO-1 deficiency and numerous studies using animal models suggest that HO-1 plays critical roles in various clinical settings involving excessive oxidative stress and inflammation. In this regard, therapy to induce HO-1 production by pharmacological intervention represents a promising novel strategy to control inflammatory diseases.

scholarly journals Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitro

2021 ◽  
Vol 6 (12) ◽  
pp. 4568-4579
Author(s):  
Xiaoyu Huang ◽  
Yang Ge ◽  
Bina Yang ◽  
Qi Han ◽  
Wen Zhou ◽  
...  
Keyword(s):  
Dental Implant

scholarly journals Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models

mAbs ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1954136
Author(s):  
Sujatha Kumar ◽  
Srimoyee Ghosh ◽  
Geeta Sharma ◽  
Zebin Wang ◽  
Marilyn R. Kehry ◽  
...  
Keyword(s):  
Animal Models ◽  
Immune Function ◽  
Cellular Assays ◽  
In Vivo Animal Models
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