Bioabsorbable polymers: Materials technology and surgical applications

1998 ◽  
Vol 212 (2) ◽  
pp. 101-111 ◽  
Author(s):  
P TÖrmälä ◽  
T Pohjonen ◽  
P Rokkanen
Keyword(s):  
Connective Tissue ◽  
Musculoskeletal System ◽  
Tissue Damage ◽  
Bone Fractures ◽  
Bioabsorbable Implants ◽  
Polymeric Implants ◽  
Small Implants

Biostable and bioabsorbable biomaterials are used to manufacture implants for supporting, replacement, augmentation and guiding of growth of tissues. Bioabsorbable implants are a better choice for applications where only the temporary presence of the implant is needed. Because of bioabsorption of such implants, there is no need for a removal operation after healing of the tissue and the risks of implant related, long-term complications are eliminated or strongly reduced. Reinforcing of bioabsorbable materials is necessary in order to develop strong and safe, small implants for fixation of bone fractures and connective tissue damage. Self-reinforced bioabsorbable polymeric implants have been used so far extensively in the treatment of traumas of the musculoskeletal system.

Occupational Incidence of Employees of Enterprises State Corporation "Rosatom"

2017 ◽  
Vol 62 (1) ◽  
pp. 38-43
Author(s):  
Немков ◽  
A. Nemkov ◽  
Афонин ◽  
S. Afonin ◽  
Антоненков ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Musculoskeletal System ◽  
Occupational Diseases ◽  
Adhesive Capsulitis ◽  
Morbidity Rate ◽  
Malignant Neoplasms ◽  
Vibration Disease ◽  
Leading Position ◽  
State Corporation

Purpose: To analyze the incidence of occupational diseases of employees of factories and organizations in State Corporation «Rosatom». Material and methods: The study was conducted with the use of primary documents, containing information about the diseases and working conditions in the workplace. The calculation of this indicator is based on the standard and original software. Results: In 2014 leading position among professional pathologies adhesive capsulitis of the shoulder (26.1 %), a number enthesopathies (13.4 %), lateral and medial epicondylitis (4.2 % and 0.8 %, respectively) occupy. Pathologies associated with decrease in hearing (9.2 %). Cancers of the respiratory system, as well as malignant neoplasms unspecified localization (5.9 %). In the structure of occupational diseases employees from 50 to 59 years (36.9 %) is dominated; the lowest level of occupational diseases in the group under 39 years (5.9 %). 68.9 % of employees , registered in 2014, were over the age of 50. For the 2010–2014 long-term dynamics of occupational diseases shows its growth from 1.6 cases per 10,000 employees (2010) to 4.5 cases per 10,000 employees (2014). The negative long-term dynamics (2010–2014) observed for occupational diseases of the musculoskeletal system and connective tissue (from 0.1 to 2.57 cases per 10,000 employees), vibration disease (from 0.7 to 0.9 cases per 10,000 employees), malignant neoplasms (from 0.2 to 4.2 cases per 100,000 employees). Conclusion: During 2010–2014 there was an increase of the incidence, mainly due to professional pathology of the musculoskeletal system and connective tissue, cases of vibration disease and malignant neoplasms. The highest morbidity rate of professional diseases was observed in workers of Priargunsky Industrial Mining and Chemical Union.Analysis of the data showed that the greatest number of diseases was revealed at persons in the age range 50–59 years old.

Detection and residence time of bisphosphonates in bone of horses

2021 ◽  
Vol 34 (1) ◽  
pp. 23-27
Author(s):  
Heather K. Knych ◽  
Jennifer Janes ◽  
Laura Kennedy ◽  
Daniel S. McKemie ◽  
Rick M. Arthur ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Residence Time ◽  
Bone Fractures ◽  
Limited Information ◽  
Long Term Effects ◽  
Normal Bone ◽  
Postmortem Blood ◽  
Affect Bone Healing ◽  
Postmortem Sample

Bisphosphonates are potent anti-resorptive agents that have the potential to adversely affect bone healing in equine athletes, and normal bone adaption in young racehorses. A concern exists that bisphosphonate inhibition of normal bone metabolism could lead to increased bone fractures during high-intensity exercise. We found only a single report describing concentrations of tiludronate in the bone of horses, and no studies describing clodronate. Knowledge of the residence time in bone could allow for a better understanding of the long-term effects of these compounds. Our objectives were to develop a method for detection of bisphosphonates in bone and add to the limited information available regarding the disposition of these drugs in the bone of horses. Two horses received clodronate and 2 tiludronate disodium. Postmortem collection of bones and teeth occurred either 4 or 30 d post drug administration. Additionally, postmortem blood, synovial fluid, aqueous humor, and bone samples from racehorses with various histories of bisphosphonate administration were collected, and concentrations determined using the developed LC-MS/MS method. Bisphosphonates were detected in bones and teeth tested at 4 and 30 d. In a postmortem sample, clodronate was detected in bone from a horse with reported administration 18 mo prior; clodronate was not detected in other sample types collected from this horse. Bisphosphonates reside in bone for extended periods of time, which could lead to potential long-term effects, increasing the potential for bone fractures in young and/or athletic horses.

Continuous Mesothelial Injury and Regeneration during long Term Peritoneal Dialysis

1987 ◽  
Vol 7 (3) ◽  
pp. 148-156 ◽  
Author(s):  
Lazaro Gotloib ◽  
Abshalom Shostack ◽  
Phina Bar-Sella ◽  
Ricardo Cohen
Keyword(s):  
Peritoneal Dialysis ◽  
Connective Tissue ◽  
Peritoneal Fluid ◽  
Mesothelial Cell ◽  
Mesothelial Cells

This study reconstructs the whole sequence of mesothelial injury and regeneration in patients on longterm peritoneal dialysis. Our observations indicate that peritoneal dialysis induces a process of continuous mesothelial injury and regeneration. New mesothelial cells seem to originate from wandering mesothelial cells of the peritoneal fluid, as well as from mesothelial cell precursors localized in the sub-mesothelial connective tissue.

Cell and Tissue Damage after Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects after a Single and Fractional Doses

2014 ◽  
Vol 200 (3-4) ◽  
pp. 240-252 ◽  
Author(s):  
Kahori Kinoshita ◽  
Hisako Ishimine ◽  
Kenshiro Shiraishi ◽  
Harunosuke Kato ◽  
Kentaro Doi ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Tissue Damage ◽  
Long Term Effects ◽  
Skin Exposure ◽  
Short And Long Term
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