The Angiotensin-Converting Enzyme I/D Polymorphism and Exercise-Induced Changes in Physical Function among Caucasian Older Adults

2014 ◽  
Vol 46 ◽  
pp. 598
Author(s):  
Thomas W. Buford ◽  
Fang-Chi Hsu ◽  
Tina E. Brinkley ◽  
Christy S. Carter ◽  
Timothy S. Church ◽  
...  
Keyword(s):  
Older Adults ◽  
Angiotensin Converting Enzyme ◽  
Physical Function ◽  
Converting Enzyme ◽  
Exercise Induced ◽  
Induced Changes ◽  
Enzyme I

scholarly journals The Ability of Exercise to Mitigate Caloric Restriction-Induced Bone Loss in Older Adults: A Structured Review of RCTs and Narrative Review of Exercise-Induced Changes in Bone Biomarkers

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1250
Author(s):  
Sarah J. Wherry ◽  
Ryan M. Miller ◽  
Sarah H. Jeong ◽  
Kristen M. Beavers
Keyword(s):  
Older Adults ◽  
Bone Loss ◽  
Caloric Restriction ◽  
Controlled Trial ◽  
Areal Bone Mineral Density ◽  
Bone Biomarkers ◽  
Mineral Density ◽  
Increased Risk ◽  
Exercise Induced ◽  
Induced Changes

Despite the adverse metabolic and functional consequences of obesity, caloric restriction- (CR) induced weight loss is often contra-indicated in older adults with obesity due to the accompanying loss of areal bone mineral density (aBMD) and subsequent increased risk of fracture. Several studies show a positive effect of exercise on aBMD among weight-stable older adults; however, data on the ability of exercise to mitigate bone loss secondary to CR are surprisingly equivocal. The purpose of this review is to provide a focused update of the randomized controlled trial literature assessing the efficacy of exercise as a countermeasure to CR-induced bone loss among older adults. Secondarily, we present data demonstrating the occurrence of exercise-induced changes in bone biomarkers, offering insight into why exercise is not more effective than observed in mitigating CR-induced bone loss.

scholarly journals Angiotensin-converting enzyme: I. New strategies for assay

1980 ◽  
Vol 35 ◽  
pp. 165-169 ◽  
Author(s):  
James W. Ryan ◽  
Alfred Chung ◽  
Una S. Ryan
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Enzyme I ◽  
New Strategies

Pulmonary angiotensin-converting enzyme substrate hydrolysis during exercise

1992 ◽  
Vol 72 (5) ◽  
pp. 1868-1886 ◽  
Author(s):  
J. Dupuis ◽  
C. A. Goresky ◽  
J. W. Ryan ◽  
J. L. Rouleau ◽  
G. G. Bach
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Surface Area ◽  
Blood Volume ◽  
Extravascular Lung Water ◽  
Central Blood Volume ◽  
Converting Enzyme ◽  
Lung Water ◽  
Vascular Surface ◽  
Enzyme Substrate ◽  
Exercise Induced

We examined exercise-induced changes in indicator-dilution estimates of the angiotensin-converting enzyme first-order kinetic parameter, the ratio of a normalized maximal enzymatic conversion rate to the Michaelis constant (Amax/Km), which, under stable enzymatic conditions, will vary with the pulmonary vascular surface area accessible to vascular substrate, the extravascular lung water (an index of the proportion of lung tissue perfused), and the central blood volume (from pulmonary trunk to aorta). Experiments were performed in 10 mongrel dogs at rest and through two increasing levels of treadmill exercise, with the use of two vascular space tracers (labeled erythrocytes and albumin), a water space tracer ([1,8–14C]-octanediol), and a vascular endothelium surface area marker, benzoyl-Phe-Gly-Pro ([3H]BPGP), which is a pharmacologically inactive angiotensin-converting enzyme substrate. The exercise-induced increase in cardiac output was accompanied by a linear increase in central blood volume, and dilutional extravascular lung water rapidly increased to an asymptotic proportion close to 100% of postmortem vascular lung water. There was an average 55% [3H]BPGP hydrolysis, which did not vary with flow, and the computed Amax/Km increased linearly with exercise. We conclude that exercise results in complete lung tissue recruitment and increases the pulmonary vascular surface area available for BPGP hydrolysis linearly with flow, so that pulmonary vascular recruitment continues after full tissue recruitment.

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