Magnetic resonance imaging using a clinical whole body system: an introduction to a useful technique in small animal experiments

1992 ◽  
Vol 26 (3) ◽  
pp. 222-227 ◽  
Author(s):  
R. F. E. Wolf ◽  
K. H. Lam ◽  
E. L. Mooyaart ◽  
R. P. Bleichrodt ◽  
P. Nieuwenhuis ◽  
...  

A clinical whole body magnetic resonance imaging (MRI) system with high resolution coils was used to obtain non-invasive images of the living rat. The results demonstrate the feasibility of the set-up and the advantages of this new imaging technique: detailed information, no extra costs, longitudinal studies without killing animals and simple anaesthesia. It is concluded that in small animal experimentation, this use of high resolution coils in whole body magnetic resonance systems may be particularly helpful in establishing effects of experimental procedures. Whenever non-invasive visualization is required, especially in longitudinal animal studies, e.g. biomaterial research or tumour investigation, this use of MRI will offer challenging possibilities.

2021 ◽  
Author(s):  
Kilian Maria Arthur Mueller ◽  
Geoffrey Topping ◽  
Sebastian Patrick Schwaminger ◽  
Younzhe Zou ◽  
Diana Marcela Rojas-González ◽  
...  

Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in...


Author(s):  
N.D. Scollan ◽  
L.J. Caston ◽  
Z. Liu ◽  
A.K. Zubair ◽  
S. Leeson ◽  
...  

In studies of animal growth it is often necessary to assess whole body composition or organ size prior to and during the course of a particular treatment. Nuclear Magnetic Resonance (NMR) offers the possibility to achieve these measurements on the same animal and in a non-invasive fashion. The use of NMR in attaining body images, referred to as Magnetic Resonance Imaging (MRI), has developed as the imaging method of choice for humans, due to its excellent soft tissue contrast and use of nonionizing radiation. The use of NMR in animal studies has been limited, which is probably related to the availability of suitable facilities and the cost of using them. However, several research groups have applied it to determining fat and water content of tissue samples and intact animals (Mitchell et al., 1991; Scollan et al., 1993). The aim of this study was to evaluate the use of MRI to determine the size (volume) and shape of the Pectoralis muscle (Pectoralis major and minor) in broiler chickens, non-invasively and in vivo.


2002 ◽  
Vol 282 (3) ◽  
pp. R890-R899 ◽  
Author(s):  
Haiying Tang ◽  
Joseph R. Vasselli ◽  
Ed X. Wu ◽  
Carol N. Boozer ◽  
Dympna Gallagher

Magnetic resonance imaging (MRI) has the ability to discriminate between various soft tissues in vivo. Whole body, specific organ, total adipose tissue (TAT), intra-abdominal adipose tissue (IAAT), and skeletal muscle (SM) weights determined by MRI were compared with weights determined by dissection and chemical analysis in two studies with male Sprague-Dawley rats. A 4.2-T MRI machine acquired high-resolution, in vivo, longitudinal whole body images of rats as they developed obesity or aged. Weights of the whole body and specific tissues were determined using computer image analysis software, including semiautomatic segmentation algorithms for volume calculations. High correlations were found for body weight ( r = 0.98), TAT ( r = 0.99), and IAAT ( r = 0.98) between MRI and dissection and chemical analyses. MRI estimated the weight of the brain, kidneys, and spleen with high accuracy ( r > 0.9), but overestimated IAAT, SM, and liver volumes. No differences were detected in organ weights using MRI and dissection measurements. Longitudinal MRI measurements made during the development of obesity and aging accurately represented changes in organ and tissue mass.


2017 ◽  
Vol 83 (3) ◽  
pp. 638-644 ◽  
Author(s):  
Jonathan P Dyke ◽  
Amanda C Garfinkel ◽  
Alan M Groves ◽  
Arzu Kovanlikaya

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