Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in multiple sclerosis

2011 ◽  
Vol 26 (8) ◽  
pp. 319-325 ◽  
Author(s):  
A Thapar ◽  
T Lane ◽  
R Nicholas ◽  
T Friede ◽  
M Ellis ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Selection Criteria ◽  
Venous Insufficiency ◽  
Substantial Variation ◽  
Demographic Differences ◽  
Cross Sectional ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
Cross Sectional Studies ◽  
Strength Of Association

Objective The sonographic findings of chronic cerebrospinal venous insufficiency (CCSVI) are used by some as selection criteria for venography. We performed a systematic review to establish the prevalence and strength of association between sonographic CCSVI and multiple sclerosis (MS). Method Two reviewers searched PubMed and EMBASE from 1948 to date using the keywords ‘chronic cerebrospinal venous insufficiency’ according to PRISMA guidelines. Results Four cross-sectional studies met the criteria for inclusion. The prevalence of CCSVI ranged from 7% to 100% in MS patients and from 2% to 36% in healthy controls. Diagnostic odds ratios for MS varied between 2 and 26, 499 ( I 2 = 94%). Sensitivities of CCSVI for MS varied between 7% and 100% ( I 2 = 98%). Specificities varied between 64% and 100% ( I 2 = 95%). Conclusion There is substantial variation in the strength of association between CCSVI and MS beyond that explained by demographic differences or sonographer training. Reliable evidence on which to base decisions requires sonographic consensus and assessment of the reproducibility of individual criteria between trained sonographers.

scholarly journals Risk factors associated with premature myocardial infarction: a systematic review protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e023647
Author(s):  
Sagar B Dugani ◽  
Ana Patricia Ayala Melendez ◽  
Roger Reka ◽  
Yousif M Hydoub ◽  
Shannon N McCafferty ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Systematic Review ◽  
Selection Criteria ◽  
Case Control ◽  
Cross Sectional ◽  
Factors Associated ◽  
Primary Screening ◽  
Premature Myocardial Infarction ◽  
Cross Sectional Studies

IntroductionPremature myocardial infarction (MI) generally refers to MI in men ≤55 years or women ≤65 years. Premature MI is a major contributor to cardiovascular disease (CVD), which claimed 17.6 million lives globally in 2016. Reducing premature MI and CVD is a key priority for all nations; however, there is sparse synthesis of information on risk factors associated with premature MI. To address this knowledge gap, we are conducting a systematic review to describe the association between risk factors (demographics, lifestyle factors and biomarkers) and premature MI.Methods and analysisThe following databases were searched from inception to June 2018: CENTRAL, CINAHL, Clinical Trials, EMBASE and MEDLINE. We will include original research articles (case–control, cohort and cross-sectional studies) that report a quantitative relationship between at least one risk factor and premature MI. Two investigators will use predetermined selection criteria and independently screen articles based on title and abstract (primary screening). Articles that meet selection criteria will undergo full-text screening based on criteria used for primary screening (secondary screening). Data will be extracted using predetermined data extraction forms. The Newcastle-Ottawa Scale for case–control and cohort studies will be used to evaluate the risk of bias and will be adapted for cross-sectional studies. Whenever feasible, data will be summarised into a random-effects meta-analysis.Ethics and disseminationTo our knowledge, this will be the first study to synthesise results on the relationship between risk factors and premature MI. These findings will inform healthcare providers on factors associated with risk of premature MI and potentially improve primary prevention efforts by guiding development of interventions. These findings will be summarised and presented at conferences and through publication in a peer-reviewed journal.PROSPERO registration numberCRD42018076862.

Chronic cerebrospinal venous insufficiency is not more prevalent in patients with mild multiple sclerosis: a sonographer-blinded, case-control ultrasound study

2012 ◽  
Vol 19 (6) ◽  
pp. 749-756 ◽  
Author(s):  
Brian Chambers ◽  
Jayne Chambers ◽  
Heather Cameron ◽  
Richard Macdonell
Keyword(s):  
Multiple Sclerosis ◽  
Venous Insufficiency ◽  
Clinical Status ◽  
Duplex Ultrasound ◽  
Case Control ◽  
Cross Sectional ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
Ultrasound Study ◽  
The Difference ◽  
Definition Of

Objectives: We designed a prospective case-control study of patients with clinically isolated syndrome (CIS) and Relapsing–Remitting Multiple Sclerosis (RRMS) with an Expanded Disability Status Score (EDSS) of ≤2, compared with age-and-sex-matched healthy controls, to test the hypothesis that chronic cerebrospinal venous insufficiency (CCSVI) is more prevalent in patients with CIS or mild MS. Methods: All subjects were examined using a Siemens Antares duplex ultrasound machine. The internal jugular, vertebral and intracranial veins were studied in subjects in both supine and sitting postures. The sonographer was blind to the subject’s clinical status. Measures included the criteria proposed by Zamboni and volume flow. Presence of CCSVI was defined as ≥2 Zamboni criteria. Results: Seventy patient-control pairs were recruited, with 11 males and 59 females in each group. Only one subject, a control, satisfied the Zamboni definition of CCSVI; however, 19 patients and 13 controls had abnormalities as defined by Zamboni, the difference largely caused by a higher prevalence in patients of internal jugular vein (IJV) stenosis, defined as a cross-sectional area ≤0.3cm2. This difference disappeared with a more rigorous stenosis definition. Further analysis revealed there was IJV valve variation in seven patients and one control. Conclusions: Our findings indicate that CCSVI, as defined by the Zamboni ultrasound criteria, is not present in CIS and mild RRMS (EDSS ≤2), providing further evidence that CCSVI does not have a causal role in MS; however, we found an apparent increase in IJV variation in patients with CIS or mild MS that would warrant further investigation.

scholarly journals The strength of association between psychological factors and clinical outcome in tendinopathy: A systematic review

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242568
Author(s):  
Carl Stubbs ◽  
Sean Mc Auliffe ◽  
Adrian Mallows ◽  
Kieran O’sullivan ◽  
Terence Haines ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Outcome ◽  
Prospective Studies ◽  
Psychological Factors ◽  
Risk Of Bias ◽  
Cross Sectional ◽  
Observational Design ◽  
Cross Sectional Studies ◽  
Strength Of Association

Objective Tendinopathy is often a disabling, and persistent musculoskeletal disorder. Psychological factors appear to play a role in the perpetuation of symptoms and influence recovery in musculoskeletal pain. To date, the impact of psychological factors on clinical outcome in tendinopathy remains unclear. Therefore, the purpose of this systematic review was to investigate the strength of association between psychological factors and clinical outcome in tendinopathy. Methods A systematic review of the literature and qualitative synthesis of published trials was conducted. Electronic searches of ovid MEDLINE, ovid EMBASE, PsychINFO, CINAHL and Cochrane Library was undertaken from their inception to June 2020. Eligibility criteria included RCT’s and studies of observational design incorporating measurements of psychological factors and pain, disability and physical functional outcomes in people with tendinopathy. Risk of Bias was assessed by two authors using a modified version of the Newcastle Ottawa Scale. High or low certainty evidence was examined using the GRADE criteria. Results Ten studies of observational design (6-cross sectional and 4 prospective studies), involving a sample of 719 participants with tendinopathy were included. Risk of bias for the included studies ranged from 12/21 to 21/21. Cross-sectional studies of low to very low level of certainty evidence revealed significant weak to moderate strength of association (r = 0.24 to 0.53) between psychological factors and clinical outcomes. Prospective baseline data of very low certainty evidence showed weak strength of association between psychological factors and clinical outcome. However, prospective studies were inconsistent in showing a predictive relationship between baseline psychological factors on long-term outcome. Cross sectional studies report similar strengths of association between psychological factors and clinical outcomes in tendinopathy to those found in other musculoskeletal conditions. Conclusion The overall body of the evidence after applying the GRADE criteria was low to very low certainty evidence, due to risk of bias, imprecision and indirectness found across included studies. Future, high quality longitudinal cohort studies are required to investigate the predictive value of baseline psychological factors on long-term clinical outcome.

A Systematic Review of the Association between Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis (P05.126)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P05.126-P05.126
Author(s):  
J. Burton ◽  
A. Laupacis ◽  
E. Lillie ◽  
A. Dueck ◽  
S. Straus ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Venous Insufficiency ◽  
Chronic Cerebrospinal Venous Insufficiency

scholarly journals Knowledge of blood donation and associated factors in Ethiopia: a systematic review and meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e044343
Author(s):  
Addisu Getie ◽  
Adam Wondmieneh ◽  
Melaku Bimerew ◽  
Getnet Gedefaw ◽  
Asmamaw Demis
Keyword(s):  
Systematic Review ◽  
Associated Factors ◽  
Blood Donation ◽  
Meta Analysis ◽  
Educational Status ◽  
Sensitivity Analyses ◽  
Cross Sectional ◽  
Level Of Knowledge ◽  
Cross Sectional Studies ◽  
Study Participants

ObjectiveTo assess the level of knowledge about blood donation and associated factors in Ethiopia.DesignSystematic review and meta-analysis.MethodsBoth published and unpublished cross-sectional studies on the level of knowledge about blood donation in Ethiopia were included. Articles from different databases such as PubMed/MEDLINE, HINARI, EMBASE, Scopus, Google Scholar and African Journals Online were searched. Cochrane I2 statistics were used to check for heterogeneity. Subgroup and sensitivity analyses of evidence of heterogeneity were carried out. Egger’s test with funnel plot was conducted to investigate publication bias.ResultTwenty cross-sectional studies with a total of 8338 study participants (4712 men and 3626 women) were included. The overall nationwide level of knowledge about blood donation was 56.57% (95% CI 50.30 to 62.84). Being in secondary school and above (adjusted OR=3.12; 95% CI 2.34 to 4.16) and being male (adjusted OR=1.81; 95% CI 1.44 to 2.28) were the factors associated with level of knowledge about blood donation.ConclusionMore than half of the study participants were knowledgeable about blood donation. Sex and educational status were the factors significantly associated with level of knowledge about blood donation in Ethiopia. Therefore, there is a need for education and dissemination of information about blood donation among the general population to build adequate knowledge and maintain regular blood supply.

scholarly journals Chronic cerebrospinal venous insufficiency in multiple sclerosis: a highly prevalent age-dependent phenomenon

BMC Neurology ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Roberta Lanzillo ◽  
Marcello Mancini ◽  
Raffaele Liuzzi ◽  
Orlando Di Donato ◽  
Elena Salvatore ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Venous Insufficiency ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
Age Dependent
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