scholarly journals The antioxidant effect of Michauxia campanuloides on rat ovaries

2021 ◽  
Vol 72 (3) ◽  
pp. 3163
Author(s):  
S KURT ◽  
RH KOCA ◽  
MM HÜRKUL ◽  
U SEKER ◽  
A KÖROĞLU
Keyword(s):  
Antioxidant Activity ◽  
Granulosa Cells ◽  
Proliferating Cell Nuclear Antigen ◽  
Antioxidant Effect ◽  
Nuclear Antigen ◽  
Antral Follicles ◽  
Positive Effects ◽  
Total Antioxidant ◽  
Proliferating Cell ◽  
Follicular Dynamics

This study investigated how Michauxia campanuloides affects the Proliferating Cell Nuclear Antigen (PCNA) expression in granulosa cells, the ovarian histomorphology and serum total antioxidant capacity (TAC) in rats. Rats were divided into control (C), treatment 1 (T 1) and treatment 2 (T 2) groups. The rats in the T 1 and T 2 groups received aqueous extract of M. campanuloides at doses of 20 mg/kg/day and 40 mg/kg/day orally for 21 days, respectively. Serum TAC levels, follicles counts including primordial, primary, preantral, antral and atretic follicles, and PCNA expression in granulosa cells were evaluated. Numbers of preantral follicles increased in T 1 and T 2 groups compared to C group (P < 0.05). TAC and numbers of preantral and antral follicles increased in T 2 group compared to T 1 and C groups (P < 0.05). PCNA expression in granulosa cells was increased in T 2 group compared to T 1 and C groups (P < 0.01). In conclusion, treatment with M. campanuloides had positive effects on antioxidant activity, follicular dynamics, and PCNA expression of granulosa cell in rats.

Proliferative activity of follicles and serum steroid concentration in Scotophilus heathi (vespertilionid bat) during periods of delayed ovulation

2000 ◽  
Vol 78 (8) ◽  
pp. 1301-1308 ◽  
Author(s):  
A Krishna ◽  
S Abhilasha
Keyword(s):  
Granulosa Cells ◽  
Follicular Development ◽  
Nuclear Antigen ◽  
High Concentration ◽  
Antral Follicles ◽  
Recruitment And Selection ◽  
Ovulatory Follicles ◽  
Two Peaks ◽  
Second Wave ◽  
Proliferating Cell

Follicular kinetics were studied using immunocytochemical localization of proliferating cell nuclear antigen (PCNA) and changes in circulating steroid concentrations to investigate the cause of prolonged survival of Graafian follicles and delayed ovulation in the vespertilionid bat Scotophilus heathi. PCNA immunoreactivity was limited to the granulosa cells and varied with stage of follicular development and reproductive phase. Two waves of follicular growth appear to be initiated in October and February. The first wave resulted in the appearance of some late antral follicles in November. These antral follicles grew slowly and differed from typical mammalian Graafian follicles, as the cells of their cumulus oophoricus were large and hypertrophied. The second wave of follicular development resulted in fresh recruitment and selection of dominant follicles in February. The steroid-hormone profile showed an unusually high concentration of circulating androstenedione from October to December. The estradiol concentration showed two peaks coinciding with two peaks of PCNA immunoreactivity. The results show that the unusually high androstenedione concentration might be responsible for the development of non-ovulatory Graafian follicles with hypertrophied granulosa cells, which survive for a prolonged period. The decline in androstenedione concentration allows the development of ovulatory follicles in S. heathi.

scholarly journals Proliferating cell nuclear antigen antibody testing – getting them all

Pathology ◽  
2021 ◽  
Vol 53 ◽  
pp. S47
Author(s):  
Christine Bundell ◽  
Mathew Krummenacher ◽  
Elina Tan ◽  
Paul Sjollema ◽  
Nick Acquarola ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Antibody Testing ◽  
Antigen Antibody ◽  
Proliferating Cell
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