scholarly journals Oxidative Stress and Acute-Phase Response Status During Treatment in Premature Calves with Respiratory Distress Syndrome

2021 ◽  
Vol 72 (3) ◽  
pp. 3249
Author(s):  
M OK ◽  
R YILDIZ ◽  
B TRAŞ ◽  
P COSKUN ◽  
A AKAR
Keyword(s):  
Oxidative Stress ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Acute Phase ◽  
Ipratropium Bromide ◽  
Distress Syndrome ◽  
Venous Blood ◽  
Lipid Peroxide ◽  
Amyloid A ◽  
Group 2

This study aimed to determine lipid peroxide (LPO), antioxidant capacity (AOC), and acute-phase protein changes before and after different nebulization treatments in premature calves with respiratory distress syndrome (RDS). Thirty-six premature calves were divided into equal number of 6 groups. Group 1 was labelled as negative control and received standard treatment. Group 2 was labelled as positive control; Groups 3, 4, 5, and 6 were labelled as trial groups. These groups received nebulizer treatment. Nebulizer drug combinations were as follows: Group 2 (fluticasone), Group 3 (formoterol + fluticasone), Group 4 (ipratropium bromide + fluticasone), Group 5 (fluticasone + furosemide) and Group 6 (formoterol + ipratropium bromide + furosemide + fluticasone). Venous blood was taken from all calves before (0 hour) and after treatment (24th, 48th, 72nd hour). It was concluded that total LPO levels gradually decreased while AOC levels increased during treatment but there was no difference in the serum amyloid A (SAA) and fibrinogen levels within groups. In conclusion, supportive and nebulizer treatments to improve function of lungs were demonstrated to alleviate oxidative stress. However, in order to reveal the effects of local nebulizer applications on oxidative stress, further studies are required to investigate oxidation parameters in the bronchoalveolar fluid.

scholarly journals Oxygen Dissociation Curve in the Adult Respiratory Distress Syndrome

1992 ◽  
Vol 20 (4) ◽  
pp. 456-459 ◽  
Author(s):  
W-N Huang ◽  
J. F. Cade ◽  
M. C. F. Pain
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Adult Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Intensive Therapy ◽  
Venous Blood ◽  
Mean Value ◽  
Serum Phosphate Level ◽  
Dissociation Curve ◽  
Term Outcome

The oxygen tension for half saturation (P50) was determined for venous blood in thirteen patients with the adult respiratory distress syndrome undergoing intensive therapy. The mean value for P50 was found to be significantly lower than the value found in ten normal control subjects (22.9 mmHg and 26.7 mmHg respectively; t = 3.03, P < 0.01). The extent of reduction in P50 was not related to serum phosphate level nor was it a predictor of short-term outcome. It is unlikely that the slight left-shifted oxygen-haemoglobin dissociation curve contributes in a major way to an oxygen delivery deficiency and its cause is unexplained.

scholarly journals A novel approach to study oxidative stress in neonatal respiratory distress syndrome

BBA Clinical ◽  
2015 ◽  
Vol 3 ◽  
pp. 65-69 ◽  
Author(s):  
Reena Negi ◽  
Deepti Pande ◽  
Kanchan Karki ◽  
Ashok Kumar ◽  
Ranjana S. Khanna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Neonatal Respiratory Distress Syndrome ◽  
Novel Approach ◽  
Neonatal Respiratory Distress

scholarly journals Arterio-venous differences in glutamate concentration predict clinical outcomes in acute respiratory distress syndrome

2021 ◽  
Author(s):  
Fan Zhan ◽  
Haipeng Cheng ◽  
Min Shao ◽  
Yujia Qiu ◽  
Xingwen Bao ◽  
...  
Keyword(s):  
Amino Acids ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
High Performance ◽  
Distress Syndrome ◽  
Venous Blood ◽  
Biological Marker ◽  
Serum Samples ◽  
Icu Admission

Abstract Background We aimed to explore whether the arterio-venous (A-V) differences in amino acids are useful for diagnosing and predicting acute respiratory distress syndrome (ARDS) outcomes, thereby guiding clinical therapy. The enrolled subjects included 36 adult patients with ARDS admitted in the intensive care unit (ICU) and 38 age- and sex-matched controls. Patients with ARDS were further divided into mild, moderate, and severe categories, and into survivor and non-survivor subgroups. Serum samples from the radial artery and jugular vein were collected on the first day following ICU admission, and the serum concentrations of 15 amino acids from the arterial and venous blood were measured by high performance liquid chromatography (HPLC) on the LC-10DVP system. Results We found that the arteriovenous (A-V) differences in glutamate (Glu) concentration in patients with ARDS were significantly greater than those in controls. Although no significant A-V differences were found in other amino acids between controls and patients with ARDS, surprisingly, survivors showed greater A-V differences in Glu concentration than non-survivors. Particularly, non-survivors who died within 2 weeks following ICU admission showed significantly less A-V differences in Glu concentration compared to those of survivors. Conclusions A-V differences in Glu concentration may be a biological marker for ARDS, with a significant association with mortality.

scholarly journals Serum heme oxygenase-1 measurement is useful for evaluating disease activity and outcomes in patients with acute respiratory distress syndrome and acute exacerbation of interstitial lung disease

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ryo Nagasawa ◽  
Yu Hara ◽  
Kota Murohashi ◽  
Ayako Aoki ◽  
Nobuaki Kobayashi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Respiratory Distress Syndrome ◽  
Interstitial Lung Disease ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Lung Disease ◽  
Acute Exacerbation ◽  
Heme Oxygenase ◽  
Distress Syndrome ◽  
Heme Oxygenase 1

Abstract Background Oxidative stress plays an important role in acute lung injury, which is associated with the development and progression of acute respiratory failure. Here, we investigated whether the degree of oxidative stress as indicated by serum heme oxygenase-1 (HO-1) is clinically useful for predicting prognosis among the patients with acute respiratory distress syndrome (ARDS) and acute exacerbation of interstitial lung disease (AE-ILD). Methods Serum HO-1 levels of newly diagnosed or untreated ARDS and AE-ILD patients were measured at diagnosis. Relationships between serum HO-1 and other clinical parameters and 1 and 3-month mortality were evaluated. Results Fifty-five patients including 22 of ARDS and 33 of AE-ILD were assessed. Serum HO-1 level at diagnosis was significantly higher in ARDS patients than AE-ILD patients (87.8 ± 60.0 ng/mL vs. 52.5 ± 36.3 ng/mL, P <  0.001). Serum HO-1 correlated with serum total bilirubin (R = 0.454, P <  0.001) and serum LDH (R = 0.500, P <  0.001). In both patients with ARDS and AE-ILDs, serum HO-1 level tended to decrease from diagnosis to 2 weeks after diagnosis, however, did not normalized. Composite parameters including serum HO-1, age, sex, and partial pressure of oxygen in arterial blood/fraction of inspired oxygen (P/F) ratio for prediction of 3-month mortality showed a higher AUC (ARDS: 0.925, AE-ILDs: 0.892) than did AUCs of a single predictor or combination of two or three predictors. Conclusion Oxidative stress assessed by serum HO-1 is persistently high among enrolled patients for 2 weeks after diagnosis. Also, serum HO-1 levels at the diagnosis combined with age, sex, and P/F ratio could be clinically useful for predicting 3-month mortality in both ARDS and AE-ILD patients.

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