Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

Prostate cancer (CaP) is one of the leading causes of death in men worldwide. Much attention has been given on its prevention and treatment strategies, including targeting the regulation of 5-alpha-Reductase (5αR) enzyme activity, aimed to limit the progression of CaP by inhibiting the conversion of potent androgen dihydrotestosterone from testosterone that is thought to play a role in pathogenesis of CaP, by using the 5-alpha-Reductase inhibitors (5αRis) such as finasteride and dutasteride. However, 5αRis are reported to exhibit numerous adverse side effects, for instance erectile dysfunction, ejaculatory dysfunction and loss of libido. This has led to a surge of interest on plant-derived alternatives that might offer favourable side effects and less toxic profiles. Phytochemicals from plants are shown to exhibit numerous medicinal properties in various studies targeting many major illnesses including CaP. Therefore, in this review, we aim to discuss the use of phytochemicals namely phytosterols, polyphenols and fatty acids, found in various plants with proven anti-CaP properties, as an alternative herbal CaP medicines as well as to outline their inhibitory activities on 5αRs isozymes based on their structural similarities with current 5αRis as part of CaP treatment approaches.

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Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

F1000Research ◽

10.12688/f1000research.51066.2 ◽

2021 ◽

Vol 10 ◽

pp. 221

Author(s):

Aziemah Azizi ◽

Nuramalina H Mumin ◽

Naeem Shafqat

Keyword(s):

Prostate Cancer ◽

Side Effects ◽

Reductase Activity ◽

Treatment Strategies ◽

Prostate Cancer Treatment ◽

Reductase Inhibitors ◽

Ejaculatory Dysfunction ◽

Medicinal Properties ◽

Loss Of Libido ◽

5 Alpha Reductase Inhibitors

Prostate cancer (CaP) is one of the leading causes of death in men worldwide. Much attention has been given on its prevention and treatment strategies, including targeting the regulation of 5-alpha-Reductase (5αR) enzyme activity, aimed to limit the progression of CaP by inhibiting the conversion of potent androgen dihydrotestosterone from testosterone that is thought to play a role in pathogenesis of CaP, by using the 5-alpha-Reductase inhibitors (5αRis) such as finasteride and dutasteride. However, 5αRis are reported to exhibit numerous adverse side effects, for instance erectile dysfunction, ejaculatory dysfunction and loss of libido. This has led to a surge of interests on plant-derived alternatives that might offer favourable side effects and less toxic profiles. Phytochemicals from plants are shown to exhibit numerous medicinal properties in various studies targeting many major illnesses including CaP. Therefore, in this review, we aim to discuss on the use of phytochemicals namely phytosterols, polyphenols and fatty acids, found in various plants with proven anti-CaP properties, as an alternative herbal CaP medicines as well as to outline their inhibitory activities on 5αRs isozymes based on their structural similarities with current 5αRis as part of CaP treatment approaches.

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Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

F1000Research ◽

10.12688/f1000research.51066.1 ◽

2021 ◽

Vol 10 ◽

pp. 221

Author(s):

Aziemah Azizi ◽

Nuramalina H Mumin ◽

Naeem Shafqat

Keyword(s):

Prostate Cancer ◽

Side Effects ◽

Reductase Activity ◽

Treatment Strategies ◽

Prostate Cancer Treatment ◽

Reductase Inhibitors ◽

Ejaculatory Dysfunction ◽

Medicinal Properties ◽

Loss Of Libido ◽

5 Alpha Reductase Inhibitors

Prostate cancer (CaP) is one of the leading causes of death in men worldwide. Much attention has been given on its prevention and treatment strategies, including targeting the regulation of 5-alpha-Reductase (5αR) enzyme activity, aimed to limit the progression of CaP by inhibiting the conversion of potent androgen dihydrotestosterone from testosterone that is thought to play a role in pathogenesis of CaP, by using the 5-alpha-Reductase inhibitors (5αRis) such as finasteride and dutasteride. However, 5αRis are reported to exhibit numerous adverse side effects, for instance erectile dysfunction, ejaculatory dysfunction and loss of libido. This has led to a surge of interests on plant-derived alternatives that might offer favourable side effects and less toxic profiles. Phytochemicals from plants are shown to exhibit numerous medicinal properties in various studies targeting many major illnesses including CaP. Therefore, in this review, we aim to discuss on the use of phytochemicals namely phytosterols, polyphenols and fatty acids, found in various plants with proven anti-CaP properties, as an alternative herbal CaP medicines as well as to outline their inhibitory activities on 5αRs isozymes based on their structural similarities with current 5αRis as part of CaP treatment approaches.

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Cardiovascular risk in men with prostate cancer

ESC CardioMed ◽

10.1093/med/9780198784906.003.0294 ◽

2018 ◽

pp. 1178-1181

Author(s):

Daniel Perry ◽

Megan Caram ◽

Monika Leja

Keyword(s):

Prostate Cancer ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Side Effects ◽

Systemic Therapy ◽

Treatment Strategies ◽

Current Evidence ◽

Cardiovascular Risks ◽

Prostate Cancer Treatment ◽

Cardiovascular Side Effects

Among patients with prostate cancer, non-cancer-related deaths outnumber cancer-related deaths. Given that the majority of men with prostate cancer are over the age of 70 years, cardiovascular disease is one of the primary co-morbidities to consider when deciding on treatment strategies. This chapter discusses the current evidence on the cardiovascular risks of common treatments for prostate cancer, with emphasis on androgen deprivation therapy, chemotherapy, and newer secondary hormonal agents. Additionally it provides recommendations for monitoring patients for cardiovascular side effects when the decision is made to start systemic therapy. It is important to note that there are a limited number of randomized trials studying this field, and further research is needed given the continuous advancements being made in prostate cancer treatment.

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Development and Validation of an Interpretable Artificial Intelligence Model to Predict 10-Year Prostate Cancer Mortality

Cancers ◽

10.3390/cancers13123064 ◽

2021 ◽

Vol 13 (12) ◽

pp. 3064

Author(s):

Jean-Emmanuel Bibault ◽

Steven Hancock ◽

Mark K. Buyyounouski ◽

Hilary Bagshaw ◽

John T. Leppert ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Treatment ◽

Cancer Mortality ◽

Treatment Strategies ◽

Gradient Boosting ◽

Prostate Cancer Treatment ◽

Prospective Data ◽

Prostate Cancer Mortality ◽

Development And Validation

Prostate cancer treatment strategies are guided by risk-stratification. This stratification can be difficult in some patients with known comorbidities. New models are needed to guide strategies and determine which patients are at risk of prostate cancer mortality. This article presents a gradient-boosting model to predict the risk of prostate cancer mortality within 10 years after a cancer diagnosis, and to provide an interpretable prediction. This work uses prospective data from the PLCO Cancer Screening and selected patients who were diagnosed with prostate cancer. During follow-up, 8776 patients were diagnosed with prostate cancer. The dataset was randomly split into a training (n = 7021) and testing (n = 1755) dataset. Accuracy was 0.98 (±0.01), and the area under the receiver operating characteristic was 0.80 (±0.04). This model can be used to support informed decision-making in prostate cancer treatment. AI interpretability provides a novel understanding of the predictions to the users.

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Few physicians prescribe 5-alpha reductase inhibitors for prostate cancer prevention

CA A Cancer Journal for Clinicians ◽

10.3322/caac.20100 ◽

2011 ◽

Vol 61 (1) ◽

pp. 1-2 ◽

Cited By ~ 2

Author(s):

Mary Kay Barton

Keyword(s):

Prostate Cancer ◽

Cancer Prevention ◽

Reductase Inhibitors ◽

Prostate Cancer Prevention ◽

5 Alpha Reductase Inhibitors

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Mapping the prevalence of the neglected sexual side effects after prostate cancer treatment and the questionnaires used in their screening: a scoping review protocol

Systematic Reviews ◽

10.1186/s13643-020-01473-9 ◽

2020 ◽

Vol 9 (1) ◽

Author(s):

Pierre Röscher ◽

Jacqueline M. van Wyk

Keyword(s):

Prostate Cancer ◽

Side Effects ◽

Scoping Review ◽

Research Question ◽

Prostate Cancer Treatment ◽

Eligibility Criteria ◽

Sexual Stimulation ◽

Sexual Side Effects ◽

Review Team ◽

Review Protocol

Abstract Background Interventions to treat early prostate cancer (PCa) can leave men with debilitating sexual side effects. The cluster of side effects referred to as the neglected sexual side effects (NSSE) may remain permanent, undiagnosed and untreated because men are hesitant to disclose them. Questionnaires offer a discreet way into the discussion, subsequent diagnosis and possible treatment of the NSSE. This study will be conducted to map the evidence about the prevalence of the neglected sexual side effects (NSSE) after PCa treatment, and use of questionnaires in its diagnosis and screening. Methods This systematic scoping review will involve searching the following electronic databases: PubMed, Science Direct and Google Scholar. Following title searching, two-independent reviewers will conduct screening of abstracts and full articles. Eligibility criteria will guide the screenings. Data will be extracted from the included studies, and the emerging themes will be analysed. The review team will analyse the implications of the findings concerning the research question and aim of the study. The mixed method appraisal tool (MMAT) will be employed for quality appraisal of included studies. Discussion We anticipate finding a number of studies that describe the prevalence of NSSE after early PCa treatment and that report on using questionnaires to screen for the presence of symptoms including orgasm-associated incontinence, urinary incontinence during sexual stimulation, altered perceptions of orgasm, orgasm associated pain, penile shortening and penile deformity. The study findings will be disseminated through publication in a peer-reviewed journal, peer presentations and presentations at relevant conferences.

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