Hematologic and coagulopathy parameter as a survival predictor among moderate to severe COVID-19 patients in non- ICU ward: a single-center study at the main referral hospital in Surabaya, East Java, Indonesia

Background : This research aimed to examine and analyze risk factors for death, hematologic parameters and coagulation in COVID-19 patients at RSUD Dr. Soetomo Surabaya, one of the referral centers for probable COVID-19 patient cases in East Java. Method : This was a retrospective analytical study by taking secondary data on patients with probable COVID-19 cases who were treated in hospital isolation rooms from May to September, 2020. Result : Of 538 probable COVID-19 patients, 217 tested positive, with an average age of 52.11±13.12 years, and there were 38 death cases. Hematologic parameters, such as white blood cell, neutrophil and lymphocyte counts, were significantly different in the deceased group. On the other hand, coagulation parameters, consisting of D-dimer, CRP, PT, and aPTT showed significantly similar value in the deceased group. Univatiate analysis concluded that chronic kidney disease, diabetes mellitus, coronary heart disease, WBC, NLR, and PPT counts could predict the mortality, while multivariate analysis revealed that coronary heart disease was the only significant independent predictor of mortality. Conclusion : This research shows that hematologic and coagulation parameters were increased in the majority of COVID-19 patients and the deceased group. While the number of neutrophils and WBC increases, the number of lymphocytes decreases significantly with increasing disease severity. Coronary heart disease is an independent predictor of mortality.

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Hematologic and coagulopathy parameter as a survival predictor among moderate to severe COVID-19 patients in non- ICU ward: a single-center study at the main referral hospital in Surabaya, East Java, Indonesia

F1000Research ◽

10.12688/f1000research.53803.3 ◽

2021 ◽

Vol 10 ◽

pp. 791

Author(s):

Siprianus Ugroseno Yudho Bintoro ◽

Ni Made Intan Dwijayanti ◽

Dana Pramudya ◽

Putu Niken Amrita ◽

Pradana Zaky Romadhon ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Analytical Study ◽

Independent Predictor ◽

Univariate Analysis ◽

Secondary Data ◽

Significant Independent Predictor ◽

Coagulation Parameters ◽

Single Center Study ◽

Death Cases

Background : This research aimed to examine and analyze risk factors for death, hematologic parameters and coagulation in COVID-19 patients at RSUD Dr. Soetomo Surabaya, one of the referral centers for probable COVID-19 patient cases in East Java. Method : This was a retrospective analytical study by taking secondary data on patients with probable COVID-19 cases who were treated in hospital isolation rooms from May to September, 2020. Result : Of 538 probable COVID-19 patients, 217 were tested positive, with an average age of 52.11±13.12 years, and there were 38 death cases. Hematologic parameters, such as white blood cell, neutrophil and lymphocyte counts, showed significantly different result in the deceased group. On the other hand, coagulation parameters, consisting of D-dimer, CRP, PT, and aPTT showed significantly similar value in the deceased group. Univariate analysis concluded that chronic kidney disease, diabetes mellitus, coronary heart disease, WBC, NLR, and PPT counts could predict the mortality, while multivariate analysis revealed that coronary heart disease was the only significant independent predictor of mortality. Conclusion : This research shows that hematologic and coagulation parameters increased in the majority of COVID-19 patients and the deceased group. While the number of neutrophils and WBC increases, the number of lymphocytes decreases significantly as the disease gets more severe.. Coronary heart disease is an independent predictor of mortality.

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Lipoprotein-Associated Phospholipase A2 Is an Independent Predictor of Incident Coronary Heart Disease in an Apparently Healthy Older Population

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2007.10.048 ◽

2008 ◽

Vol 51 (9) ◽

pp. 913-919 ◽

Cited By ~ 71

Author(s):

Lori B. Daniels ◽

Gail A. Laughlin ◽

Mark J. Sarno ◽

Ricki Bettencourt ◽

Robert L. Wolfert ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Phospholipase A2 ◽

Independent Predictor ◽

Older Population ◽

Incident Coronary Heart Disease ◽

Apparently Healthy

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Abstract P276: Differential Association of D-dimer with Stroke and Coronary Heart Disease: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Circulation ◽

10.1161/circ.127.suppl_12.ap276 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Neil A Zakai ◽

George Howard ◽

Leslie A McClure ◽

Suzanne E Judd ◽

Brett M Kissela ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Vascular Disease ◽

Racial Differences ◽

Statistical Significance ◽

Female Gender ◽

Cox Models ◽

The Difference ◽

Chd Risk Factors ◽

D Dimer

Introduction: D-dimer, a marker of coagulation activation, has higher levels in blacks than whites and has been variably associated with stroke and coronary heart disease (CHD). Methods: REGARDS recruited 30,239 participants in their homes across the continental US between 2003-07; by design 55% were female, 41% black, and 56% lived in the southeast. In a case-cohort study, D-dimer was measured in 646 participants with incident stroke, 515 with incident CHD, and 1104 in a cohort random sample. D-dimer was log transformed and modeled per 1-unit increase. Cox models were used to determine the HR for vascular disease for D-dimer and the difference in HR (95% CI) by race and vascular disease calculated by bootstrapping with 1000 replicate samples and using the 2.5 and 97.5 percentiles of the distribution (see Table for model variables). Results: Median D-dimer was higher in blacks (0.45 mcg/mL; IQR 0.26, 0.85) than whites (0.38 mcg/mL; IQR 0.23, 0.69); p <0.001. D-dimer was higher with increasing age, female gender, diabetes, hypertension and prebaseline cardiovascular disease (all p <0.05). The table shows the HR of stroke and CHD by baseline D-dimer. In minimally-adjusted models, D-dimer was associated with both stroke and CHD. Accounting for Framingham stroke and CHD risk factors, D-dimer remained associated with CHD (HR 1.45; 95% CI 1.18, 1.79), but was marginally associated with stroke (HR 1.20; 95% CI 0.99, 1.45). The difference in the HR of D-dimer between CHD and stroke was 0.22 in the basic model and 0.25 in the Framingham model, but this difference was of marginal statistical significance (Table). There was no difference in the HRs for stroke or CHD for D-dimer in blacks compared to whites (Table). Discussion: The association of D-dimer with stroke appeared smaller than for CHD with similar associations by race. Findings suggest that hemostasis activation may play a greater role in pathogenesis of CHD than stroke. Further study is needed to confirm these findings and evaluate the association of D-dimer with different stroke subtypes.

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Sense of coherence as an independent predictor of health-related quality of life among coronary heart disease patients

Quality of Life Research ◽

10.1007/s11136-011-0106-2 ◽

2012 ◽

Vol 21 (10) ◽

pp. 1863-1871 ◽

Cited By ~ 13

Author(s):

Barbora Silarova ◽

Iveta Nagyova ◽

Jaroslav Rosenberger ◽

Martin Studencan ◽

Daniela Ondusova ◽

...

Keyword(s):

Quality Of Life ◽

Coronary Heart Disease ◽

Heart Disease ◽

Sense Of Coherence ◽

Independent Predictor ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Is cardiothoracic ratio in healthy middle aged men an independent predictor of coronary heart disease mortality? Whitehall study 25 year follow up

BMJ ◽

10.1136/bmj.316.7141.1353 ◽

1998 ◽

Vol 316 (7141) ◽

pp. 1353-1354 ◽

Cited By ~ 8

Author(s):

H. Hemingway ◽

M. Shipley ◽

D. Christie ◽

M. Marmot

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Independent Predictor ◽

Coronary Heart Disease Mortality ◽

Middle Aged ◽

Cardiothoracic Ratio ◽

Disease Mortality

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Predictive value of the Wells score combined with D-dimer level in identifying acute pulmonary embolism in patients with coronary heart disease with chest pain

Chinese Medical Journal ◽

10.1097/cm9.0000000000000988 ◽

2020 ◽

Vol 133 (18) ◽

pp. 2253-2255

Author(s):

Jing Wang ◽

Xiao-Yan Wu ◽

Ying Liang ◽

Wei Guo

Keyword(s):

Coronary Heart Disease ◽

Pulmonary Embolism ◽

Heart Disease ◽

Chest Pain ◽

Predictive Value ◽

Acute Pulmonary Embolism ◽

Wells Score ◽

D Dimer

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Associations of von Willebrand factor, fibrin D-dimer and tissue plasminogen activator with incident coronary heart disease: British Women's Heart and Health cohort study

European Journal of Cardiovascular Prevention & Rehabilitation ◽

10.1097/hjr.0b013e3280e129d0 ◽

2007 ◽

Vol 14 (5) ◽

pp. 638-645 ◽

Cited By ~ 18

Author(s):

Margaret May ◽

Debbie A. Lawlor ◽

Rita Patel ◽

Ann Rumley ◽

Gordon Lowe ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Von Willebrand Factor ◽

Incident Coronary Heart Disease ◽

Tissue Plasminogen ◽

Von Willebrand ◽

Willebrand Factor ◽

D Dimer

Background Associations of three markers of thrombotic tendency, von Willebrand factor, tissue plasminogen activator antigen and fibrin D-dimer, with coronary heart disease have been reported in meta-analyses. It is not known, however, whether findings are generalizable to older women. Design Prospective cohort of 3582 women aged 60-79 years randomly selected from 23 towns without evidence of cardiovascular disease at entry into the British Women's Heart and Health Study. Methods Women were followed for 4.7 years for incident coronary heart disease. Cox proportional hazard models were used to compare the hazard ratio of coronary heart disease per doubling for each thrombotic factor. Results In models adjusting for age and town only there was no association between von Willebrand factor or D-dimer and incidence of coronary heart disease, but there was a positive association of tissue plasminogen activator: coronary heart disease hazard ratio per doubling was 1.37 (95% confidence interval: 1.08-1.75). Adjustment for potential confounders (socio-economic position, smoking, lung function, physical activity, alcohol consumption, body mass index, waist-to-hip ratio) attenuated association to 1.20 (0.92-1.58). Further adjustment for risk factors that may be part of the same pathophysiological process linking tissue plasminogen activator to coronary heart disease (high density lipoprotein cholesterol, triglycerides, blood pressure, fasting glucose, insulin, C-reactive protein, fibrinogen) attenuated the hazard ratio to 1.05 (0.79-1.40). Conclusion In older women, tissue plasminogen activator was associated with incident coronary heart disease, but does not appear to be an independent risk factor for coronary heart disease as the association was attenuated by adjustment for confounding and other metabolic and vascular risk factors. Eur J Cardiovasc Prev Rehabil 14:638-645 © 2007 The European Society of Cardiology

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