scholarly journals Hematologic and coagulopathy parameter as a survival predictor among moderate to severe COVID-19 patients in non- ICU ward: a single-center study at the main referral hospital in Surabaya, East Java, Indonesia

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 791
Author(s):  
Siprianus Ugroseno Yudho Bintoro ◽  
Ni Made Intan Dwijayanti ◽  
Dana Pramudya ◽  
Putu Niken Amrita ◽  
Pradana Zaky Romadhon ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Analytical Study ◽  
Independent Predictor ◽  
Univariate Analysis ◽  
Secondary Data ◽  
Significant Independent Predictor ◽  
Coagulation Parameters ◽  
Single Center Study ◽  
Death Cases

Background : This research aimed to examine and analyze risk factors for death, hematologic parameters and coagulation in COVID-19 patients at RSUD Dr. Soetomo Surabaya, one of the referral centers for probable COVID-19 patient cases in East Java. Method : This was a retrospective analytical study by taking secondary data on patients with probable COVID-19 cases who were treated in hospital isolation rooms from May to September, 2020. Result : Of 538 probable COVID-19 patients, 217 were tested positive, with an average age of 52.11±13.12 years, and there were 38 death cases. Hematologic parameters, such as white blood cell, neutrophil and lymphocyte counts, showed significantly different result in the deceased group. On the other hand, coagulation parameters, consisting of D-dimer, CRP, PT, and aPTT showed significantly similar value in the deceased group. Univariate analysis concluded that chronic kidney disease, diabetes mellitus, coronary heart disease, WBC, NLR, and PPT counts could predict the mortality, while multivariate analysis revealed that coronary heart disease was the only significant independent predictor of mortality. Conclusion : This research shows that hematologic and coagulation parameters increased in the majority of COVID-19 patients and the deceased group.  While the number of neutrophils and WBC increases, the number of lymphocytes decreases significantly as the disease gets more severe.. Coronary heart disease is an independent predictor of mortality.

scholarly journals Hematologic and coagulopathy parameter as a survival predictor among moderate to severe COVID-19 patients in non- ICU ward: a single-center study at the main referral hospital in Surabaya, East Java, Indonesia

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 791
Author(s):  
Siprianus Ugroseno Yudho Bintoro ◽  
Ni Made Intan Dwijayanti ◽  
Dana Pramudya ◽  
Putu Niken Amrita ◽  
Pradana Zaky Romadhon ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Analytical Study ◽  
Independent Predictor ◽  
Secondary Data ◽  
Significant Independent Predictor ◽  
Coagulation Parameters ◽  
Single Center Study ◽  
Death Cases ◽  
D Dimer

Background : This research aimed to examine and analyze risk factors for death, hematologic parameters and coagulation in COVID-19 patients at RSUD Dr. Soetomo Surabaya, one of the referral centers for probable COVID-19 patient cases in East Java. Method : This was a retrospective analytical study by taking secondary data on patients with probable COVID-19 cases who were treated in hospital isolation rooms from May to September, 2020. Result : Of 538 probable COVID-19 patients, 217  tested positive, with an average age of 52.11±13.12 years, and there were 38 death cases. Hematologic parameters, such as white blood cell, neutrophil and lymphocyte counts, were significantly different in the deceased group. On the other hand, coagulation parameters, consisting of D-dimer, CRP, PT, and aPTT showed significantly similar value in the deceased group. Univatiate analysis concluded that chronic kidney disease, diabetes mellitus, coronary heart disease, WBC, NLR, and PPT counts could predict the mortality, while multivariate analysis revealed that coronary heart disease was the only significant independent predictor of mortality. Conclusion : This research shows that hematologic and coagulation parameters were increased in the majority of COVID-19 patients and the deceased group. While the number of neutrophils and WBC increases, the number of lymphocytes decreases significantly with increasing disease severity. Coronary heart disease is an independent predictor of mortality.

scholarly journals Hematologic and coagulopathy parameter as a survival predictor among moderate to severe COVID-19 patients in non- ICU ward: a single-center study at the main referral hospital in Surabaya, East Java, Indonesia

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 791
Author(s):  
Siprianus Ugroseno Yudho Bintoro ◽  
Ni Made Intan Dwijayanti ◽  
Dana Pramudya ◽  
Putu Niken Amrita ◽  
Pradana Zaky Romadhon ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Analytical Study ◽  
Independent Predictor ◽  
Secondary Data ◽  
Significant Independent Predictor ◽  
Coagulation Parameters ◽  
Single Center Study ◽  
Death Cases ◽  
D Dimer

Background : This research aimed to examine and analyze risk factors for death, hematologic parameters and coagulation in COVID-19 patients at RSUD Dr. Soetomo Surabaya, one of the referral centers for probable COVID-19 patient cases in East Java. Method : This was a retrospective analytical study by taking secondary data on patients with probable COVID-19 cases who were treated in hospital isolation rooms from May to September, 2020. Result : Of 538 probable COVID-19 patients, 217  tested positive, with an average age of 52.11±13.12 years, and there were 38 death cases. Hematologic parameters, such as white blood cell, neutrophil and lymphocyte counts, were significantly different in the deceased group. On the other hand, coagulation parameters, consisting of D-dimer, CRP, PT, and aPTT showed significantly similar value in the deceased group. Univatiate analysis concluded that chronic kidney disease, diabetes mellitus, coronary heart disease, WBC, NLR, and PPT counts could predict the mortality, while multivariate analysis revealed that coronary heart disease was the only significant independent predictor of mortality. Conclusion : This research shows that hematologic and coagulation parameters were increased in the majority of COVID-19 patients and the deceased group. While the number of neutrophils and WBC increases, the number of lymphocytes decreases significantly with increasing disease severity. Coronary heart disease is an independent predictor of mortality.

scholarly journals Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China

2017 ◽  
Vol 42 (2) ◽  
pp. 808-823 ◽  
Author(s):  
Qiao-Wei Jia ◽  
Zhao-Hong Chen ◽  
Xiao-Qing Ding ◽  
Jie-Yin Liu ◽  
Peng-Cheng Ge ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Independent Predictor ◽  
Univariate Analysis ◽  
Positive Association ◽  
Ethnic Population ◽  
Reverse Transcription Pcr ◽  
Potential Risk Factors ◽  
Circulating Levels ◽  
Plasma Mirnas

Background: Differences in microRNA (miRNA) profiles between patients with and without coronary heart disease (CHD)have not been fully determined. The purpose of the study was to evaluate in a multi-ethnic population in China the predictive value of miRNAs previously suggested to have a role in CHD. Subject and method: 932 participants were included, and plasma samples obtained. A quantitative reverse-transcription PCR(RT-qPCR) assay was conducted to confirm the concentration of plasma miRNAs. Circulating levels of miRNAs were quantified using the 2-Δct method. The severity of coronary atherosclerosis was evaluated via Gensini Scores. Result: The circulating levels of the nine proposed miRNAs were not different among the five main ethnicities examined (all p > 0.05). The Spearman correlation analyses indicated that miR-221 and miR-130a were negatively associated with the severity of CHD as indicated by Gensini Scores (r = -0.106, p = 0.001;r = -0.073, p = 0.026). Results of the univariate analysis showed that lower circulating miR-221 (OR, 1.663; 95 % CI, 1.255-2.202, p = <0.001), miR-155 (OR, 1.520; 95 % CI, 1.132-2.042, p = 0.005), and miR-130a (OR, 1.943; 95% CI, 1.410-2.678, p = <0.001) were potential risk factors for CHD. Moreover, miR-130a (OR, 2.405; 95 % CI, 1.691-3.421, p = <0.001) remained independently associated with the risk of CHD after adjusting for potential confounding factors. The analysis of the possible positive/negative associations between miR-221, miR-155 and miR-130awere conducted. A positive association between miR-130a and miR-155 was found (SI = 1.60, SIM = 1.21 and AP = 0.22), and in these groups, the proportion of CHD attributable to the interaction between miR-130a and miR-155 was as high as 22 %. A negative interaction was found between miR-221 and miR-130a (SI = 0.68, SIM = 0.60 and AP = 0.27). Conclusion: Plasma levels of miR-221, miR-130a and miR-155 decreased in patients with CHD, and miR-130a may be an independent predictor for CHD.

scholarly journals Sense of coherence as an independent predictor of health-related quality of life among coronary heart disease patients

2012 ◽  
Vol 21 (10) ◽  
pp. 1863-1871 ◽  
Author(s):  
Barbora Silarova ◽  
Iveta Nagyova ◽  
Jaroslav Rosenberger ◽  
Martin Studencan ◽  
Daniela Ondusova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Sense Of Coherence ◽  
Independent Predictor ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Association of Derived Neutrophil-To-Lymphocyte Ratio With Prognosis of Coronary Heart Disease After PCI

2021 ◽  
Vol 8 ◽  
Author(s):  
Gang-Qiong Liu ◽  
Wen-Jing Zhang ◽  
Jia-Hong Shangguan ◽  
Xiao-Dan Zhu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cox Regression ◽  
Univariate Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Major Adverse Cardiovascular Events ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
The Third

Aims: The present study aimed to investigate the prognostic role of derived neutrophil-to-lymphocyte ratio (dNLR) in patients with coronary heart disease (CHD) after PCI.Methods: A total of 3,561 post-PCI patients with CHD were retrospectively enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The patients (3,462) were divided into three groups according to dNLR tertiles: the first tertile (dNLR &lt; 1.36; n = 1,139), second tertile (1.36 ≥ dNLR &lt; 1.96; n = 1,166), and third tertile(dNLR ≥ 1.96; n = 1,157). The mean follow-up time was 37.59 ± 22.24 months. The primary endpoint was defined as mortality (including all-cause death and cardiac death), and the secondary endpoint was major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs).Results: There were 2,644 patients with acute coronary syndrome (ACS) and 838 patients with chronic coronary syndrome (CCS) in the present study. In the total population, the all-cause mortality (ACM) and cardiac mortality (CM) incidence was significantly higher in the third tertile than in the first tertile [hazard risk (HR) = 1.8 (95% CI: 1.2–2.8), p = 0.006 and HR = 2.1 (95% CI: 1.23–3.8), p = 0.009, respectively]. Multivariate Cox regression analyses suggested that compared with the patients in the first tertile than those in the third tertile, the risk of ACM was increased 1.763 times (HR = 1.763, 95% CI: 1.133–2.743, p = 0.012), and the risk of CM was increased 1.763 times (HR = 1.961, 95% CI: 1.083–3.550, p = 0.026) in the higher dNLR group during the long-term follow-up. In both ACS patients and CCS patients, there were significant differences among the three groups in the incidence of ACM in univariate analysis. We also found that the incidence of CM was significantly different among the three groups in CCS patients in both univariate analysis (HR = 3.541, 95% CI: 1.154–10.863, p = 0.027) and multivariate analysis (HR = 3.136, 95% CI: 1.015–9.690, p = 0.047).Conclusion: The present study suggested that dNLR is an independent and novel predictor of mortality in CHD patients who underwent PCI.

scholarly journals Hubungan antara Jenis Kelamin dan Kejadian Kematian Mendadak di RSUP Prof. Dr. R. D Kandou Manado

e-CliniC ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Gerrit J. Pangemanan ◽  
Djemi Tomuka ◽  
Nola T.S. Mallo
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Sudden Death ◽  
Analytical Study ◽  
Sampling Method ◽  
P Value ◽  
Chi Square ◽  
Common Cause ◽  
Chi Square Test ◽  
The Relationship

Abstract: Sudden death could occur in anyone regardless of gender either male or female. This study was aimed to determine the relationship between gender and the incidence of sudden death at Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study with across sectional design using total sampling method. The results showed 345 cases of sudden deaths consisted of 209 males and 136 females. The age ranges were 0-1 years (7 cases), 1-18 years (7 cases), 18-40 years (38 cases), 40-60 years (138 cases), and >60 years (155 cases). Coronary heart disease was the leading cause of sudden deaths (40 cases). Data analyzed by using Chi-square test showed a P value of 0.838. Conclusion: There was no relationship between gender and the incidence of sudden death. Sudden deaths were most common among males, age >60 years, with coronary heart disease as the most common cause of sudden death.Keywords: gender, sudden death Abstrak: Kematian mendadak dapat terjadi pada siapa saja, tidak memandang jenis kelamin baik laki-laki maupun perempuan. Penelitian ini bertujuan untuk mengetahui hubungan antara jenis kelamin dan kejadian kematian mendadak di RSUP Prof. Dr. R. D Kandou Manado. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang menggunakan metode total sampling. Hasil penelitian mendapatkan 345 kasus kematian mendadak terdiri dari 209 laki-laki dan 136 perempuan. Rentang usia 0-1 tahun berjumlah 7 kasus, usia 1-18 tahun berjumlah 7 kasus, usia 18-40 tahun berjumlah 38 kasus, usia 40-60 tahun berjumlah 138 kasus, dan usia >60 tahun berjumlah 155 kasus. Penyakit jantung koroner merupakan penyebab kematian mendadak terbanyak dengan jumlah 40 kasus. Analisis data menggunakan uji chi-kuadrat mendapatkan P=0,838. Simpulan: Tidak terdapat hubungan antara jenis kelamin dengan kejadian kematian mendadak. Sebagian besar kematian mendadak ditemukan pada laki-laki, kelompok usia >60 tahun, dengan penyebab penyakit jantung koroner.Kata kunci: jenis kelamin, kematian mendadak

scholarly journals THE DESCRIPTION OF MODIFIABLE RISK FACTORS IN CORONARY HEART DISEASE AT DR. SOETOMO REGIONAL PUBLIC HOSPITAL

2019 ◽  
Vol 7 (2) ◽  
pp. 85
Author(s):  
Mayla Renata Sandi ◽  
Santi Martini ◽  
Kurnia Dwi Artanti ◽  
Sri Widati
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Public Hospital ◽  
Communicable Disease ◽  
Univariate Analysis ◽  
Sampling Technique ◽  
Primary Data ◽  
Modifiable Risk Factors ◽  
Cross Sectional

Background: Coronary heart disease (CHD) is a non-communicable disease that causes the highest mortality in the world, including in Indonesia. Risk factors for CHD are divided into modifiable and non- modifiable risk factors. Purpose: This study aims to discover the description of risk factors that are modifiable in coronary heart disease patients at Dr Soetomo Regional Public Hospital. Methods: It was a descriptive observational study with cross sectional study design. The study population was coronary heart disease patients who were doing outpatient treatment at the Integrated Heart Service Center (PPJT) of Dr. Soetomo Regional Public Hospital. The number of study sample was 72 respondents using accidental sampling technique. Data sources used are primary data using questionnaires and secondary data using medical record. Data were collected during November 2018. The location of this study was Dr. Soetomo Regional Public Hospital. The data analysis technique chosen was univariate analysis and presented in the form of a frequency distribution table. Results: The results of the study showed that the characteristics of respondents were mostly between 56-65 years old (43,05%) and male (70,84%). Risk factors found on the respondents were smoking (84,72%), hypertension (72,22%), hyperlipidemia (68,05%), diabetes mellitus (81,94%) and poor physical activity (77,77%). Conclusion: Modifiable risk factor that was mostly found on coronary heart patients was smoking, while least one was hiperlipidemia.

scholarly journals Microalbumin: Urinary Biomarker of Cardiovascular Risk Assessment

2016 ◽  
Vol 5 (2) ◽  
pp. 98-103
Author(s):  
Tabassum Samad ◽  
Wasim Md Mohosin ul Haque
Keyword(s):  
Risk Assessment ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Independent Predictor ◽  
Urinary Biomarker ◽  
Cardiovascular Risk Assessment ◽  
Normal Range ◽  
Incident Coronary Heart Disease ◽  
All Cause Mortality

Microalbuminuria is an early sign of vascular damage. Now-a-days it is considered as a predictor of worse outcome for both renal and cardiac patients. In this review we investigate the magnitude of relationship between microalbuminuria and incident coronary heart disease and mortality. Microalbuminuria is an independent predictor of coronary heart disease and all cause mortality. It is demonstrated that cardiovascular and renal risk is elevated even in the high normal range of microalbuminuria. Early detection of microalbuminuria, or therapies that prevent or delay the development of microalbuminuria, and all measures that prevent it, may help to prevent or delay cardiovascular eventsBirdem Med J 2015; 5(2): 98-103

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