scholarly journals Blood Interferon Signatures Putatively Link Lack of Protection Conferred by the RTS,S Recombinant Malaria Vaccine to an Antigen-specific IgE Response

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 919 ◽  
Author(s):  
Darawan Rinchai ◽  
Scott Presnell ◽  
Damien Chaussabel

Malaria remains a major cause of mortality and morbidity worldwide. Progress has been made in recent years with the development of vaccines that could pave the way towards protection of hundreds of millions of exposed individuals. Here we used a modular repertoire approach to re-analyze a publically available microarray blood transcriptome dataset monitoring the response to malaria vaccination. We report the seminal identification of interferon signatures in the blood of subjects on days 1, 3 and 14 following administration of the third dose of the RTS,S recombinant malaria vaccine. These signatures at day 1 correlate with protection, and at days 3 and 14 to susceptibility to subsequent challenge of study subjects with live parasites. In addition we putatively link the decreased abundance of interferon-inducible transcripts observed at days 3 and 14 post-vaccination with the elicitation of an antigen specific IgE response in a subset of vaccine recipients that failed to be protected by the RTS,S vaccine.

F1000Research ◽  
2017 ◽  
Vol 4 ◽  
pp. 919
Author(s):  
Darawan Rinchai ◽  
Scott Presnell ◽  
Marta Vidal ◽  
Sheetij Dutta ◽  
Virander Chauhan ◽  
...  

Malaria remains a major cause of mortality and morbidity worldwide. Progress has been made in recent years with the development of vaccines that could pave the way towards protection of hundreds of millions of exposed individuals. Here we used a modular repertoire approach to re-analyze a publically available microarray blood transcriptome dataset monitoring the response to malaria vaccination. We report the seminal identification of interferon signatures in the blood of subjects on days 1, 3 and 14 following administration of the third dose of the RTS,S recombinant malaria vaccine. These signatures at day 1 correlate with protection, and at days 3 and 14 to susceptibility to subsequent challenge of study subjects with live parasites. In addition we putatively link the decreased abundance of interferon-inducible transcripts observed at days 3 and 14 post-vaccination with the elicitation of an antigen-specific IgE response in a subset of vaccine recipients that failed to be protected by the RTS,S vaccine. Furthermore, profiling of antigen-specific levels of IgE in a Mozambican cohort of malaria-exposed children vaccinated with RTS,S identified an association between elevated baseline IgE levels and subsequent development of naturally acquired malaria infection during follow up. Taken together these findings warrant further investigation of the role of antigen-specific IgE in conferring susceptibility to malaria infection.


Moreana ◽  
2010 ◽  
Vol 47 (Number 181- (3-4) ◽  
pp. 9-68
Author(s):  
Jean Du Verger

The philosophical and political aspects of Utopia have often shadowed the geographical and cartographical dimension of More’s work. Thus, I will try to shed light on this aspect of the book in order to lay emphasis on the links fostered between knowledge and space during the Renaissance. I shall try to show how More’s opusculum aureum, which is fraught with cartographical references, reifies what Germain Marc’hadour terms a “fictional archipelago” (“The Catalan World Atlas” (c. 1375) by Abraham Cresques ; Zuane Pizzigano’s portolano chart (1423); Martin Benhaim’s globe (1492); Martin Waldseemüller’s Cosmographiae Introductio (1507); Claudius Ptolemy’s Geographia (1513) ; Benedetto Bordone’s Isolario (1528) ; Diogo Ribeiro’s world map (1529) ; the Grand Insulaire et Pilotage (c.1586) by André Thevet). I will, therefore, uncover the narrative strategies used by Thomas More in a text which lies on a complex network of geographical and cartographical references. Finally, I will examine the way in which the frontispiece of the editio princeps of 1516, as well as the frontispiece of the third edition published by Froben at Basle in 1518, clearly highlight the geographical and cartographical aspect of More’s narrative.


Author(s):  
В. Зинько ◽  
V. Zin'ko ◽  
А. Зверев ◽  
A. Zverev ◽  
М. Федин ◽  
...  

The seismoacoustical investigations was made in the western part of the Kerch strait (Azov sea) near Kamysh-Burun spit. The fracture zone with dislocated sedimentary rocks layers and buried erosional surface was revealed to the west of spit. Three seismofacial units was revealed to the east of spit. The first unit was modern sedimentary cover. The second ones has cross-bedding features and was, probably, the part of early generation of Kamysh-Burun spit, which lied to the east of its modern position. The lower border of the second unit is the erosional surface supposed of phanagorian age. The third unit is screened by acoustic shedows in large part.


1996 ◽  
Vol 13 (1) ◽  
pp. 1-12
Author(s):  
John Obert Voll

The relationships between Islam and the West are complex. Even theperceptions of those relations have an important impact on the nature ofthe interactions. If the basic images that are used in discussing “Islam andthe West” are themselves ill-defiied or viewed in inconsistent ways, therelationships themselves are affected in sometimes dangerous ways.Inconsistent and contradictory terms of analysis can lead to misunderstandingand conflict.One of the most frequent conceptual mistakes made in discussingIslam and the West in the modem era is the identification of “the West”with “modemity.” This mistake has a significant impact on the way peeple view the processes of modernization in the Islamic world as well as onthe way people interpret the relationships between Islam and the West inthe contemporary era.The basic generalizations resulting from the following analysis can bestated simply: 1) “modernity“ is not uniquely “western”; 2) “the West” isnot simply “modernity”; and 3) the identifixation of “the West” with“modemity” has important negative consequences for understanding therelationships between Islam and the West. Modernity and the West aretwo different concepts and historic entities. To use the terms interchangeablyis to invite unnecessary confusion and create possible conflict’andinconsistency. This article will address the problem of definition and theapplication of the defined terms to interpreting actual experiences andrelationships.Understanding the difficulties raised by the identification of theWest with modernity involves a broader analysis within the frameworkof world history and global historical perspectives. In such an analysis, ...


SUHUF ◽  
2015 ◽  
Vol 2 (1) ◽  
pp. 53-72
Author(s):  
Ahmad Fathoni
Keyword(s):  

The object of the study of the knowledge of the variety of the Quranic reading  is the  Qur'an itself. The focus is on the difference of the reading and its articulation. The method is based on the riwayat or narration which is originated from the Prophet (Rasulullah saw) and its use is to be one of the instruments to keep the originality of the Qur’an. The validity of the reading the Qur’an is to be judged based on the valid chain  (sanad ¡a¥ī¥)  in accord with the Rasm U£mānÄ« as well as with the  Arabic grammar. Whereas the qualification of its originality is divided into six stages as follow: the first is mutawātir, the second is masyhÅ«r, the third is āhād, the fourth is syaz, the fifth is maudū‘, and the six is mudraj. Of this six catagories, the readings which can be included in the catagory of mutawātir are Qiraat Sab‘ah (the seven readings) and Qiraat ‘Asyrah  (the ten readings). To study this knowledge of reading the Qur’an (ilmu qiraat), one is advised to know about special terms being used such as  qiraat  (readings), riwayat (narration), tarÄ«q (the way), wajh (aspect), mÄ«m jama‘, sukÅ«n mÄ«m jama‘ and many others.


Author(s):  
Nicola Clark
Keyword(s):  
The Core ◽  
Made In ◽  

While there were clear strategic aims in the way that marriages were made in the Howard dynasty during this period, the family was only unusual in that it operated at the very top of the aristocratic hierarchy and was therefore able to use marital alliances to successfully recover and bolster both status and finances. Where they were different, however, was in the experience of some of these women within marriage. By and large, the marriages made by and for members of the family, including women, seem to have been as successful as others of their class. However, three women close to the core of the dynasty experienced severe marital problems, even ‘failed’ marriages, almost simultaneously during the 1520s and 1530s. The records generated by these episodes tell us about the way in which the family operated as a whole, and the agency of women in this context, and this chapter therefore reconstructs these disputes for this purpose.


Author(s):  
Nora Goldschmidt ◽  
Barbara Graziosi

The Introduction sheds light on the reception of classical poetry by focusing on the materiality of the poets’ bodies and their tombs. It outlines four sets of issues, or commonplaces, that govern the organization of the entire volume. The first concerns the opposition between literature and material culture, the life of the mind vs the apprehensions of the body—which fails to acknowledge that poetry emerges from and is attended to by the mortal body. The second concerns the religious significance of the tomb and its location in a mythical landscape which is shaped, in part, by poetry. The third investigates the literary graveyard as a place where poets’ bodies and poetic corpora are collected. Finally, the alleged ‘tomb of Virgil’ provides a specific site where the major claims made in this volume can be most easily be tested.


1944 ◽  
Vol 151 (1) ◽  
pp. 70-86
Author(s):  
W. Littlejohn Philip

The paper is limited to the application of hydraulic power to lathes designed for shell making although, in the author's opinion, there is an immense field for the application of the same principles in other directions. Self-contained hydraulic machine tools have been dealt with by Mr. H. C. Town,† but in the system to be described all the machines are operated from a central hydraulic plant. Three complete installations on this principle have been established by the author, and the present paper contains an account of this work from the first experiments in 1915 until about four years ago. The first plant was constructed in 1915 for the production of 3·29-inch shells, known as “18-pounders”, from the solid bar. The output was 2,000 shells per week of 135 hours, with girl operators working on three shifts. The second plant was put down in 1916–17 for an output of 500 9·2-inch howitzer shells per week of 135 hours, also with girls working on three shifts. The third plant is of recent design. It was started in 1938 for the production of 3·45-inch shells, known as “25-pounders”; and was laid out for an output of 1,000 shells per week of 47 hours. This plant included four types of hydraulic lathes which the author was engaged to design for the War Office. Soon after the commencement of the last war in 1914 it became evident that shell production would have to be greatly increased, and engineering firms were pressed to take up shell manufacture. The author, on behalf of his firm, undertook to help in the movement, and he at once set about the construction of some simple machines for the job. These conformed on general lines to the practice of the period as regards design and operation. He soon realized, however, that drastic changes would have to be made if production was to reach the high level that circumstances demanded. Although quite familiar with hydraulic machinery of various types and of many applications in presses and certain types of heavy tools, he was not aware of any instance in which hydraulic power had been applied to the movements of a lathe. It appeared to him, nevertheless, that it would be possible to construct a very useful machine on these lines, and he accordingly started immediately to carry out experiments and to prepare designs. It was considered essential that machines for the duty which the author had in mind should be much heavier and more rigid than the ordinary machines of the time, so that they should be free from vibration and “chatter” or spring with the heaviest possible cutting. The standard of rigidity aimed at was that which would permit a half-crown coin to remain balanced on edge on the moving saddle or turret while the tools were making the heaviest cuts. This object was achieved, and the demonstration was frequently made in the presence of those who came to see the lathes at work.


2021 ◽  
Vol 24 (1) ◽  
pp. 28-44
Author(s):  
Alyson Cole

Until the l970s, ‘survivor’ referred predominantly to individuals who outlived others in the aftermath of disaster, or stood to inherit the remains of an estate; it was not imbued with evaluative connotations. In the United States today, however, survivorship abounds with positive meanings. This transvaluation rests on three intersecting trajectories that together transformed survivorship from denoting that one sustained or was spared a hardship to signifying a superior social status. The first trajectory follows the aftermath of the Shoah, when survivors acquired moral authority as victims of and public witnesses to a new violation, ‘crimes against humanity’. The second tracks the stigmatization of the term ‘victim’ in American public discourse. A consequence of struggles over the welfare state and other progressive policies, victimhood is now associated less with specific harms or injuries, and more with the supposed negative attributes of the victim herself. The third traces how survivorship became integral to the recuperative strategies of new therapeutic disciplines addressing the traumatized – from war veterans and rape victims to cancer patients. These three processes coalesced to create and legitimize a hierarchical opposition between ‘victims’ and ‘survivors’, transforming these terms into political categories and emblems of personal and group identity. In this essay, I argue that the victim/survivor binary constitutes one juncture where neoliberalism converges with Trump-era populism.


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