First Order Derivative Spectrophotometric Determination of Thorium in Geological Samples Using Diacetylmonoxime p-hydroxybenzoylhydrazone

2012 ◽  
Vol 11 (1) ◽  
pp. 15-30
Author(s):  
Anitha Varghese ◽  
A M A Khadar
Keyword(s):  
Spectrophotometric Method ◽  
Molar Absorptivity ◽  
Order Derivative ◽  
Geological Samples ◽  
Trace Level ◽  
First Order ◽  
Quantitation Limit ◽  
Triton X ◽  
Trace Level Determination

A simple, selective and sensitive spectrophotometric method has been developed for the determination of trace amounts of thorium using a newly synthesised reagent diacetylmonoximep-hydroxybenzoylhydrazone (DMPHBH) in the presence of Triton X-100. The molar absorptivity and Sandell’s sensitivity of the coloured species at pH 4.4 were found to be 4.20 x 104 L mol-1 cm-1 and 5.5 ng cm-2, respectively. Beer’s law is obeyed in the range 0.35 -3.8 mg mL-1 of thorium(IV) at 410 nm. The stoichiometry of the complex was found to be 1:2 (Th(IV): DMPHBH). A highly selective first order derivative spectrophotometric method for the determination of thorium in the presence of uranium is also reported. The detection limit and quantitation limit of first order derivative spectrophotometry were found to be 0.03 and 0.11 mg mL-1, respectively. The developed procedure has been successfully applied for the trace level determination of thorium in rock samples and synthetic mixtures.

scholarly journals Highly Selective Derivative Spectrophotometric Determination of Vanadium(V) in Steels, Minerals and Soil Samples

2008 ◽  
Vol 7 (1) ◽  
pp. 13-25
Author(s):  
Anitha Varghese ◽  
A. M. A. Khadar
Keyword(s):  
Spectrophotometric Method ◽  
Molar Absorptivity ◽  
Calibration Graph ◽  
Soil Samples ◽  
Trace Level ◽  
Acetic Acid Medium ◽  
First Order ◽  
First Derivative ◽  
Selective Derivative

A simple, selective and sensitive spectrophotometric method has been developed for the determination of trace amounts of Vanadium(V) in acetic acid medium using a newly synthesized reagent acetoacetanilide salicyloylhydrazone (AASH). The molar absorptivity and Sandell's sensitivity of the coloured species were found to be 1.20 x 104 L mol-1cm-1 and 4.2 ng cm-2 respectively. Beer's law is obeyed in the range 0.3 -3.0μ.g mL-1 of vanadium (V) at 405 nm. The stochiometry of the complex was found to be 1:1 (V (V): AASH). A highly selective first order derivative spectrophotometric method for the determination of vanadium is also reported. A calibration graph was derived by measuring first derivative amplitudes at 430 nm (trough depth). The metal ions which are normally associated with vanadium in minerals and alloys do not interfere. The developed procedure has been successfully applied for the trace level determination of vanadium in steels, minerals and soil samples.

NOVEL ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF BROMOFENAC SODIUM IN BULK AND PHARMACEUTICAL DOSAGE FORM BY DERIVATIVE AND AUC SPECTROSCOPIC METHOD

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (01) ◽  
pp. 87-90
Author(s):  
S Raghu ◽  
S. Muneer. ◽  
K.B. Chandra sekhar ◽  
kiran B. Siva Sai ◽  
Keyword(s):  
Spectrophotometric Method ◽  
Method Development ◽  
Spectroscopic Method ◽  
Zero Order ◽  
Order Derivative ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
First Order ◽  
Significant Difference

The present study was carried out to develop a simple and reliable derivative spectrophotometric method for the determination of bromofenac sodium in pharmaceutical dosage forms .The solutions of standard and the sample were prepared in distilled water The quantitative determination of the drug was carried out with zero order derivative (method A) values measured at 268 nm and first order (method B) derivative values measured at 258 nm , and two wavelengths 262nm and 274nm were selected for the determination AUC (method C) of integrated areas. Calibration graphs constructed at their wavelengths of determination, were linear within the concentration range of 2-12 μg/mL (r2 = 0.999) for zero order and (r2 = 0.997) first order derivative spectrophotometric method. No significant difference between the performance of the proposed methods regarding the mean values and standard deviations and is suitable for the routine quality control application of bromofenac sodium in its pharmaceutical formulations.

QUANTITATIVE DETERMINATION OF RALOXIFENE HYDROCHLORIDE IN BULK AND TABLET FORMULATION BY UV-SPECTROPHOTOMETRY AND FIRST ORDER DERIVATIVE USING AREA UNDER CURVE METHOD

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (09) ◽  
pp. 40-43
Author(s):  
R. E Mutha ◽  
◽  
D. M Dhumal ◽  
P. H. Patil ◽  
A. A. Shirkhedkar ◽  
...  
Keyword(s):  
Spectrophotometric Method ◽  
Area Under Curve ◽  
Order Derivative ◽  
Uv Spectrophotometry ◽  
Uv Spectrum ◽  
First Order ◽  
Treatment And Prevention ◽  
Receptor Modulator ◽  
Raloxifene Hydrochloride

Raloxifene hydrochloride (RLF) is a non-steroidal, selective estrogen receptor modulator used in the treatment and prevention of osteoporosis in postmenopausal women. Two simple, rapid and economical 'zero order UV-spectrophotometric (method I)' and first order derivative spectrophotometric (method II) using area under curve (AUC) technique have been developed for estimation of RLF in bulk and tablets. In 0.1N NaOH, RLF showed maximum absorbance at 303.5 nm. In method I, AUC between two wavelengths 275.0 nm & 350.0 nm were selected. In method II, UV-spectrum of RLF was derivatized into first order and two wavelengths 303.0 nm and 385.0 nm were selected for determination of AUC. In both these methods, RLF obeyed linearity in the concentration range of 2-10 mcg/mL (r2>0.99). Proposed methods were applied for tablet formulations and amounts of RLF estimated by method I and method II were found to be 100.08±0.68 and 99.78±0.94, respectively. Both these methods were validated statistically and by recovery experiments.

scholarly journals Derivative spectrophotometric determination of acetamiprid in the presence of 6-chloronicotinic acid

2012 ◽  
Vol 77 (7) ◽  
pp. 911-917 ◽  
Author(s):  
Valéria Guzsvány ◽  
Sanja Lazic ◽  
Natasa Vidakovic ◽  
Zsigmond Papp
Keyword(s):  
Simultaneous Determination ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Detection Limits ◽  
Model Systems ◽  
Order Derivative ◽  
Zero Crossing ◽  
First Order ◽  
Relative Standard

A simple first-order derivative spectrophotometric method was developed for the simultaneous determination of acetamiprid and 6-chloronicotinic acid (6-CNA) at pH 7.0. By using the zero-crossing approach, acetamiprid was determined at 269.0 nm and 6-CNA at 216.0 nm with the detection limits of 7.19x10-7 and 8.25x10-7 mol dm-3, respectively and relative standard deviations not exceeding 1.2% in the case of model systems.

scholarly journals SPECTROPHOTOMETRIC DETERMINATION OF NEVIRAPINE USING TETRATHIOCYANATOCOBALT(II) ION AS A REAGENT

2018 ◽  
Vol 35 (3) ◽  
pp. 93
Author(s):  
T. V. Badiadka ◽  
Badiadka Narayana
Keyword(s):  
Detection Limit ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Statistical Evaluation ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Optical Parameters ◽  
Quantitation Limit ◽  
Optimum Reaction

A simple and rapid spectrophotometric method for the determination of nevirapine is described. The method is based on the reaction of nevirapine with tetrathiocyanatocobalt(II) ion in buffer of pH 4 to form the corresponding complex. Beer’s law is obeyed in the range of 0.2 – 2.0 μg mL-1 for nevirapine. The optical parameters such as molar absorptivity, Sandell’s sensitivity, detection limit and quantitation limit were found to be 1.16× 104 Lmol-1cm-1, 2.09 X 10-3 μg cm-2, 0.073 μg mL-1 and 0.222 μg mL-1 respectively. The optimum reaction conditionsand other analytical parameters were evaluated. The statistical evaluation of the method was examined by determining intra-day and inter-day precision. The proposed method has been successfully applied for the determination of nevirapine in pharmaceutical formulations.

Colorimetric Determination of Fluoride in Drinking Groundwater using a Polymeric Zirconium Complex of 5-(2-Carboxyphenylazo)-8-Hydroxyquinoline

2013 ◽  
Vol 12 (7) ◽  
pp. 460-465
Author(s):  
Sameer Amereih ◽  
Zaher Barghouthi ◽  
Lamees Majjiad
Keyword(s):  
Drinking Water ◽  
Detection Limit ◽  
Complex Formation ◽  
Molar Absorptivity ◽  
Colorimetric Determination ◽  
Zirconium Complex ◽  
Reliable Determination ◽  
Percentage Recovery ◽  
Quantitation Limit

A sensitive colorimetric determination of fluoride in drinking water has been developed using a polymeric zirconium complex of 5-(2-Carboxyphenylazo)-8-Hydroxyquinoline as fluoride reagents. The method allowed a reliable determination of fluoride in range of (0.0-1.5) mg L-1. The molar absorptivity of the complex formation is 7695 ± 27 L mol-1 cm-1 at 460 nm. The sensitivity, detection limit, quantitation limit, and percentage recovery for 1.0 mg L-1 fluoride for the proposed method were found to be 0.353 ± 0.013 μg mL-1, 0.1 mg L-1, 0.3 mg L-1, and 101.7 ± 4.1, respectively.

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