Therapeutic Efficacy of Enterosorbents on the Model of Chronic Endotoxicosis

A comparative evaluation of detoxification properties of a powder of brown peat moss’s turf, activated charcoal and polisorb has been studied on a model of chronic endotoxicosis, simulated by the administration of tetrachloromethane and lipopolysaccharide S. thyphi to the experimental animals. The effectiveness of the investigated objects has been evaluated by their effect on serum biochemical parameters and histology of liver and kidney. The administration of tetrachloromethane and lipopolysaccharide to the rats in the chronic experiment has shown statistically significant increase of aspartataminotransferase, alaninaminotransferase and malondialdehyde, and have been decreased significantly protein and urea in serum. The administration of powder of brown peat moss’s turf to the animals with experimental chronic endotoxicosis has limited the toxicity of tetrachloromethane and lipopolysaccharide. This has been resulted in lower activities of aspartataminotransferase and alaninaminotransferase, and level of malondialdehyde. But levels of protein and urea have been increased in serum, that indicating of a partial normalization functions of liver. Thus, the course administration of investigated sorbents in steady of experimental chronic endotoxicosis is accompanied by a significant decrease of endotoxic reaction associated with disruption of the structure and functions of the cells of liver. The detoxification activity of the powder of brown peat moss’s turf doesn’t yield to the effects of polisorb and activated charcoal.

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The Study of Body Weight, Haematological and Serum Biochemical Parameters, Liver and Kidney Texture in Rats Fed Corn Oil

ZANCO Journal of Pure and Applied Sciences ◽

10.21271/zjpas.29.s4.8 ◽

2017 ◽

Vol 29 (s4) ◽

Keyword(s):

Body Weight ◽

Biochemical Parameters ◽

Corn Oil ◽

Serum Biochemical Parameters ◽

Liver And Kidney ◽

Serum Biochemical

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Evaluation of Phyllanthus amarus leaf meal for hepato nephro-protective potentials in broiler chickens

Journal of Veterinary and Biomedical Sciences ◽

10.36108/jvbs/1202.30.0141 ◽

2021 ◽

Vol 3 (1) ◽

pp. 126-135

Author(s):

Cyprian Robinson Unigwe

Keyword(s):

Uric Acid ◽

Biochemical Parameters ◽

Broiler Chickens ◽

Dependent Manner ◽

Phyllanthus Amarus ◽

Serum Biochemical Parameters ◽

Leaf Meal ◽

Liver And Kidney ◽

Serum Biochemical ◽

Dose Dependent

Phyllanthus amarus is an important medicinal plant that is widely distributed in all tropical and subtropical regions of the planet and has the ability to prevent and treat several human and animal diseases but has been associated with pathological defects on various organs on dose-dependent pattern. This study was carried out to evaluate Phyllanthus amarus leaf meal (PALM) for hepato-nephro-protective potentials in broiler chickens. One hundred and twenty (120) day old marshal broiler chickens were used for the experiment that lasted for 56 days. The birds were randomly allotted to five treatments of T0 (control, no PALM), T1 (2.5g/kg PALM), T2 (5.0g/kg PALM), T3 (7.5g/kg PALM) and T4 (10g/kg PALM) in a complete randomized design (CRD). Each treatment was replicated thrice with 8 birds per replicate. The birds were fed with commercial Top® feed and water was given ad-libitum. At the end of the experiment, blood was aseptically collected via venipuncture from a randomly selected bird per replicate to determine the serum biochemical parameters and later was humanely sacrificed for organs harvest. The liver and kidney were carefully dissected out and fixed in buffered 10% formalin for histological study. The biochemical data were subjected to analysis of variance (ANOVA) and statistical difference in means was separated using Duncan’s Multiple Range Test. The histo-pathological slides were interpreted by experts. ALT for T1 – T4 were statistically similar but differed significantly (P<0.05) from T1 . The ALP, however, showed T2 – T4 differing significantly (P<0.05) from T0 and T1 . The uric acid was highest in T4 and differed significantly (P<0.05) from other groups. The urea was highest in quantity in T3 and T4 and as well differed significantly (P<0.05) from other treatments. Therefore, the results showed significant differences (P<0.05) across treatment groups except for AST. PALM gradually increased the ALT, ALP, uric acid and urea in a dose dependent manner across treatments except urea that slightly decreased at T4 . The findings indicated that the PALM had varied time and dose dependent pathological effects on the liver and kidney of treated groups. It can therefore be concluded that PALM enhances serum biochemical parameters and has deleterious effects on the cyto-architecture of liver and kidney. It is recommended that PALM (crude) up to 2.5 g/kg should not be administered protractedly in chickens since it could constitute damage to visceral organs.

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Days-in-Milk and Parity Affected Serum Biochemical Parameters and Hormone Profiles in Mid-Lactation Holstein Cows

Animals ◽

10.3390/ani9050230 ◽

2019 ◽

Vol 9 (5) ◽

pp. 230

Author(s):

Xuehui Wu ◽

Hui-Zeng Sun ◽

Mingyuan Xue ◽

Diming Wang ◽

Leluo Guan ◽

...

Keyword(s):

Dairy Cows ◽

Biochemical Parameters ◽

Milk Protein ◽

Dairy Farm ◽

Serum Biochemical Parameters ◽

Serum Parameters ◽

Management Regime ◽

Milk Protein Content ◽

Liver And Kidney ◽

Serum Biochemical

It is well known that serum biochemical parameters and hormones contribute greatly to the physiological and metabolic status of dairy cows. However, few studies have focused on the variation of these serum parameters in multiparous mid-lactation cows without the interference of diet and management. A total of 287 Holstein dairy cows fed the same diet and maintained under the same management regime were selected from a commercial dairy farm to evaluate the effects of days-in-milk (DIM) and parity on serum biochemical parameters and hormone profiles. Milk yield and milk protein content were affected by DIM and parity (p < 0.05). Milk protein yield showed a numerically decreasing trend with parity, and it was relatively constant in cows with parities between 2 and 4 but lower in cows with parity 6 (p = 0.020). Ten and five serum biochemical parameters related to protein status, energy metabolism, liver and kidney function, and oxidative stress were affected by DIM and parity, respectively (p < 0.05). Glucagon, insulin-like growth factor 1 concentration, and the revised quantitative insulin sensitivity check index were significantly different (p < 0.05) among cows with different DIM. Parity had no effect on hormone concentrations. An interaction between DIM and parity effect was only detected for glucagon concentration (p = 0.015), which showed a significantly increasing trend with DIM and overall decreasing trend with parity. In summary, DIM and parity played an important role in affecting the serum biochemical parameters and/or hormones of dairy cows, with serum parameters affected more by DIM than parity.

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