scholarly journals Evaluation of Phyllanthus amarus leaf meal for hepato nephro-protective potentials in broiler chickens

2021 ◽  
Vol 3 (1) ◽  
pp. 126-135
Author(s):  
Cyprian Robinson Unigwe
Keyword(s):  
Uric Acid ◽  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Dependent Manner ◽  
Phyllanthus Amarus ◽  
Serum Biochemical Parameters ◽  
Leaf Meal ◽  
Liver And Kidney ◽  
Serum Biochemical ◽  
Dose Dependent

Phyllanthus amarus is an important medicinal plant that is widely distributed in all tropical and subtropical regions of the planet and has the ability to prevent and treat several human and animal diseases but has been associated with pathological defects on various organs on dose-dependent pattern. This study was carried out to evaluate Phyllanthus amarus leaf meal (PALM) for hepato-nephro-protective potentials in broiler chickens. One hundred and twenty (120) day old marshal broiler chickens were used for the experiment that lasted for 56 days. The birds were randomly allotted to five treatments of T0 (control, no PALM), T1 (2.5g/kg PALM), T2 (5.0g/kg PALM), T3 (7.5g/kg PALM) and T4 (10g/kg PALM) in a complete randomized design (CRD). Each treatment was replicated thrice with 8 birds per replicate. The birds were fed with commercial Top® feed and water was given ad-libitum. At the end of the experiment, blood was aseptically collected via venipuncture from a randomly selected bird per replicate to determine the serum biochemical parameters and later was humanely sacrificed for organs harvest. The liver and kidney were carefully dissected out and fixed in buffered 10% formalin for histological study. The biochemical data were subjected to analysis of variance (ANOVA) and statistical difference in means was separated using Duncan’s Multiple Range Test. The histo-pathological slides were interpreted by experts. ALT for T1 – T4 were statistically similar but differed significantly (P<0.05) from T1 . The ALP, however, showed T2 – T4 differing significantly (P<0.05) from T0 and T1 . The uric acid was highest in T4 and differed significantly (P<0.05) from other groups. The urea was highest in quantity in T3 and T4 and as well differed significantly (P<0.05) from other treatments. Therefore, the results showed significant differences (P<0.05) across treatment groups except for AST. PALM gradually increased the ALT, ALP, uric acid and urea in a dose dependent manner across treatments except urea that slightly decreased at T4 . The findings indicated that the PALM had varied time and dose dependent pathological effects on the liver and kidney of treated groups. It can therefore be concluded that PALM enhances serum biochemical parameters and has deleterious effects on the cyto-architecture of liver and kidney. It is recommended that PALM (crude) up to 2.5 g/kg should not be administered protractedly in chickens since it could constitute damage to visceral organs.

scholarly journals Carcass traits, haematology and serum biochemical parameters of Nigerian indigenous chickens and their crosses with marshall

2020 ◽  
Vol 45 (3) ◽  
Author(s):  
U. Akpan ◽  
O. A. Bassey ◽  
C.O.N. Ikeobi ◽  
A.V. Jegede ◽  
O.A. Adebambo
Keyword(s):  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Carcass Traits ◽  
Blood Parameters ◽  
Study Data ◽  
Serum Biochemical Parameters ◽  
Naked Neck ◽  
Statistical Analysis System ◽  
Serum Biochemical ◽  
Analysis System

This study investigated the genetic variation in carcass traits and blood parameters of local naked neck and normal-feathered chickens and their crosses with Marshall broiler chickens. Two hundred and sixty three chickens consisting of 50 purebred Marshalls (M), 38 naked neck (Nk) and 48 normal-feathered (N), 61Marshall x naked neck (MNk) and 66Marshall x normal-feathered(MN) chickens were used for the study. Data were collected on carcass traits, haematology and serum biochemical parameters and were analysed using the General Linear Model procedure of Statistical Analysis System. Carcass traits such as eviscerated weight and weights of thigh, drumstick, breast, wings and organs were significantly (P < 0.0001) affected by genotype. Results showed that the purebred Marshall had the highest values in most of the traits followed by their crossbreds. In organs such as gizzard, liver and heart the local normal feathered ranked equal with its crossbred. Sex significantly (P< 0.05) affected carcass traits. Males consistently had higher values than females in all the parameters measured. Genotype significantly (P

Therapeutic Efficacy of Enterosorbents on the Model of Chronic Endotoxicosis

10.12737/5918 ◽  
2014 ◽  
Vol 21 (3) ◽  
pp. 131-135
Author(s):  
Дзюман ◽  
A. Dzyuman ◽  
Иванов ◽  
V. Ivanov ◽  
Чучалин ◽  
...  
Keyword(s):  
Activated Charcoal ◽  
Therapeutic Efficacy ◽  
Comparative Evaluation ◽  
Biochemical Parameters ◽  
Chronic Experiment ◽  
Serum Biochemical Parameters ◽  
Experimental Animals ◽  
Liver And Kidney ◽  
Serum Biochemical ◽  
Structure And Functions

A comparative evaluation of detoxification properties of a powder of brown peat moss’s turf, activated charcoal and polisorb has been studied on a model of chronic endotoxicosis, simulated by the administration of tetrachloromethane and lipopolysaccharide S. thyphi to the experimental animals. The effectiveness of the investigated objects has been evaluated by their effect on serum biochemical parameters and histology of liver and kidney. The administration of tetrachloromethane and lipopolysaccharide to the rats in the chronic experiment has shown statistically significant increase of aspartataminotransferase, alaninaminotransferase and malondialdehyde, and have been decreased significantly protein and urea in serum. The administration of powder of brown peat moss’s turf to the animals with experimental chronic endotoxicosis has limited the toxicity of tetrachloromethane and lipopolysaccharide. This has been resulted in lower activities of aspartataminotransferase and alaninaminotransferase, and level of malondialdehyde. But levels of protein and urea have been increased in serum, that indicating of a partial normalization functions of liver. Thus, the course administration of investigated sorbents in steady of experimental chronic endotoxicosis is accompanied by a significant decrease of endotoxic reaction associated with disruption of the structure and functions of the cells of liver. The detoxification activity of the powder of brown peat moss’s turf doesn’t yield to the effects of polisorb and activated charcoal.

scholarly journals Influence of salicylate administration on weight gain and serum biochemical parameters in broiler chickens

2010 ◽  
Vol 66 (10) ◽  
pp. 675-679 ◽  
Author(s):  
Poźniak B. ◽  
Yuan H. ◽  
J. Yi ◽  
Guo C. ◽  
Deng S. ◽  
...  
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Clinical Manifestations ◽  
Weight Ratio ◽  
Serum Biochemical Parameters ◽  
Serum Total Protein ◽  
Weight Gains ◽  
Serum Biochemical

The aim of the study was to investigate the effects of different doses of acetylsalicylic acid (ASA) and sodium salicylate (SS) administration on weight gains and serum biochemical parameters in broiler chickens. This study was performed to investigate the safety of ASA and SS in chickens in conditions of moderate overdose. Seventy five broiler chickens (Sanhuangji breed) were divided into control and experimental groups. The chickens were administered orally with ASA or SS in the following daily doses: 50, 100 and 200 mg/kg for 20 days. In the course of the experiment weight gains were recorded. On day 14 and day 20 the chickens were sampled for blood biochemical analysis. Investigated parameters included serum total protein, albumin, uric acid, creatinine, potassium, sodium and calcium contents as well as alanine transaminase activity. After the last samplings the chickens were dissected and liver and kidney to body weight ratios were recorded. It was demonstrated that SS at a dose of 200 mg/kg increased serum total protein level. ASA increased serum proteins at a dose of 100 mg/kg but not at a higher dose. At the dose of 200 mg/kg ASA increased the kidney to body weight ratio. In all salicylate treated groups the liver weights were lower as compared to the control. No clinical manifestations of intolerance were observed. It is assumed that chickens tolerate ASA and SS well, even in doses producing distinct side effects in several mammalian species.

scholarly journals Production performance, egg quality characteristics and serum biochemical parameters on Brahma laying hens (Gallus gallus domesticus) fed with supplemented Chromolaena odorata leaf meal

2021 ◽  
Vol 6 (6) ◽  
pp. 202-208
Author(s):  
M. O. S Ghomsi ◽  
◽  
B. L. Tientcheu ◽  
T. G. Nguemmogne ◽  
P. N. Bahebeck ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Laying Hens ◽  
Egg Quality ◽  
Quality Characteristics ◽  
Production Performance ◽  
Average Weight ◽  
Serum Biochemical Parameters ◽  
Chromolaena Odorata ◽  
Leaf Meal ◽  
Serum Biochemical

An experiment was conducted to evaluate the effect of graded levels of Chromolaena odorata leaf meal (COLM) on production performance, egg quality characteristics, and serum biochemical parameters on Brahma laying hens. A total of forty-five local laying hens aged 4 to 5 months were weighed and assigned to three treatment groups in a completely randomized design. COLM was used as a supplement and incorporated into the diets at 0, 1, and 2% in diets T0, T1, and T2 respectively. Data were collected on production performance, egg quality characteristics, and serum biochemistry. Results from the study indicate that body weight gain, average weight, and egg volume were low (p<0.05) with treatment T2 compared to control (T0) and the best was obtained with treatment T1. The Haugh unit and percentage hen day production were not negatively affected by the treatment levels of COLM. There were significant (p<0.05) differences in triglyceride, total cholesterol, and urea. Results obtained from this study revealed that the inclusion of 1% of COLM improved the egg quality as well as the health status of the birds without having any detrimental effect on the birds.

scholarly journals Influence of Hempedu bumi (Andrographis paniculata) on serum biochemical parameters and liver morphology in broiler chickens

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Masnindah Malahubban ◽  
Zakry Fitri Ab Ab Aziz
Keyword(s):  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Basal Diet ◽  
Normal Structure ◽  
Andrographis Paniculata ◽  
Control Group ◽  
Serum Biochemical Parameters ◽  
Treatment Groups ◽  
Liver Morphology ◽  
Serum Biochemical

Serum biochemical parameters data was evaluated in broilers fed diets supplemented with  hempedu bumi (Andrographis paniculata, AP) ground leaf. Birds (n = 160) were assigned in four treatment groups with five replication and each group contain eight birds. Broilers in the control group were fed the basal diet without additives, the group dietary treatments, Diet AP2 (Basal diet + 2g/kg Andrographis paniculata); Diet AP4 (Basal diet + 4g/kg Andrographis paniculata) and Diet AP8 (Basal diet + 8g/kg Andrographis paniculata). During day-21 and day-42, five birds from each treatment groups were randomly selected for serum biochemical analysis which involve pancreatic, renal, and hepatic functions (aspartate transaminase (AST), alkaline transaminase (ALT), alkaline phosphatase (ALP), glucose, cholesterol, triglycerides, total protein, albumin, urea, sodium, potassium, chlorine, and globulins). Liver morphology was determined after slaughtering two birds and collected the liver samples. Based on these results AP at 8g/kg diet lowered serum cholesterol, glucose and triglycerides. It also maintain the normal structure of liver indicating that no toxic effect from AP supplementation at a rate up to 8 g/kg, it also that AP lowered ALP and ALT in blood of chicken. In conclusion, supplementation of AP at 8g/kg in diet its beneficial effects on health and safe for broiler chicken production.

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