Qualitative elastography and arfi technology in the diagnosis of liver tumors

10.12737/6670 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 0-0
Author(s):  
Гудилина ◽  
E. Gudilina ◽  
Вишленкова ◽  
E. Vishlenkova ◽  
Лепэдату ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Liver Tumors ◽  
Malignant Tumors ◽  
Hepatocellular Adenoma ◽  
Liver Parenchyma ◽  
Benign Tumors ◽  
Area Of Interest ◽  
Arfi Elastography

The aim of this study was to evaluate the stiffness of liver tumors using compression and ARFI elastography. Compression and ARFI elastography was performed to study the color display rigidity in the foci of the liver in 69 and 81 patients, respectively. Area of interest was placed in the education and on the border with the surrounding liver parenchyma, to assess the visual difference tissue stiffness. Patients were divided by diagnosis: hepatocellular carcinoma – 36, cholangiocarcinoma – 6 metastases – 35, benign – 4 cases. Benign tumors included two focal nodular hyperplasia, hepatocellular adenoma and one cavernous hemangioma a large size. When compression elastography increased stiffness formations compared to the surrounding liver parenchyma was observed: in benign – 100%, hepatocellular carcinoma – in 71.9%, cholangiocarcinoma – 80%, metastases – in 72.4%. When ARFI elastography increased stiffness observed: in benign – 100%, hepatocellular carcinoma – 58.3%, cholangiocarcinoma – 100%, metastases – in 85.7%. Qualitative elastography improves the definition of clear boundaries neoplasm infiltration beyond the tumor, but can not differentiate between malignant and benign tumors. Sensitivity, accuracy, positive predictive value of the compressive elastography were as follows: 73, 69, 94%, and at ARFI elastography – 74, 70, 93%, respectively. Both techniques are qualitative elastography complement each other, with the specification of the internal structure of foci and their joint application sensitivity, accuracy, positive predictive value in the diagnosis of malignant tumors accounted for 83, 79, 95%, respectively. ARFI elastography in conjunction with compression elastography improves the visualization of malignant tumors of the liver and can be used as an additional diagnostic tool in oncohepatology.

Charactecteristics of Liver Tumors by means of ARFI-elastography

10.12737/7276 ◽  
2014 ◽  
Vol 21 (4) ◽  
pp. 86-92
Author(s):  
Гудилина ◽  
E. Gudilina ◽  
Вишленкова ◽  
E. Vishlenkova ◽  
Лепэдату ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatocellular Carcinoma ◽  
Liver Tumors ◽  
Normal Liver ◽  
Liver Parenchyma ◽  
Benign Tumors ◽  
Normal Liver Parenchyma ◽  
Large Size ◽  
Speed Performance ◽  
Arfi Elastography

The purpose of this study was to determine the possibility of ARFI- elastography for diagnosis of tumors of the liver. The study included 95 patients with liver tumors. 22 patients were excluded from the study because of the deep location of the formation or the inability to measure the speed performance. Therefore the tumors in 73 patients were obtained by ARFI-elastography and analyzed. Verification of the diagnosis was achieved by histological examination of the material in 93% of cases and by MRI, CT in 7% of cases. Patients were divided by diagnosis: 4 – with benign tumors, 33 – with hepatocellular carcinoma, 4 – with cholangio-carcinoma, 19 – with metastatic colorectal cancer, 13 – with metastases of other cancer. Benign tumors included two focal nodular hyperplasia and hepatocellular adenoma, one cavernous hemangioma a large size. The obtained results were compared with normal liver parenchyma in 77 people. Average speed was: 2.83 m/s in the benign, 1.55 m/s in the normal liver parenchyma, 2.5 m/s at the nodes of hepatocellular carcinoma, 2.66 m/s at the nodes cholangio-carcinomar, 2.79 m/s in the metastasis of colorectal cancer, 2.79 m/s in the remaining metastases. Associated threshold value for the diagnosis of the majority of malignant tumors, it is necessary to consider the speed of over 2 m/s. Sensitivity groups ranged from 59% to 100% and a specificity of 70% to 86%. The results indicate higher speed performance parameters (mean, median, threshold values > 2.3 m/s) in benign tumors. This is due to a small group, as well as the large size of entities – from 5.0 to 24.0 cm, indicating that the long-term course of the disease with the development of fibrosis in them, so the stiffness of education becomes higher. These data prove that the quantitative elastography shear wave can be used as an additional diagnostic tool in oncology, but further accumulation of scientific data, since the values of the groups overlap.

scholarly journals Role of annexin A2 and osteopontin for early diagnosis of hepatocellular carcinoma in hepatitis C virus patients

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Abd El-Fattah F. Hanno ◽  
Fatma M. Abd El-Aziz ◽  
Akram A. Deghady ◽  
Ehab H. El-Kholy ◽  
Aborawy I. Aborawy
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Early Diagnosis ◽  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Chronic Hepatitis C ◽  
Predictive Value ◽  
Annexin A2 ◽  
Alpha Fetoprotein

Abstract Background Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-related death globally. Early stages of hepatocellular carcinoma (0&A) can be treated with curative procedures. The aim of this work was to evaluate the role of annexin A2 and osteopontin for early diagnosis of hepatocellular carcinoma in hepatitis C virus patients. Methods The study was carried out on 80 patients classified into two groups. Group A had 40 chronic hepatitis C patients without hepatocellular carcinoma, while group B had 40 chronic hepatitis C patients with early hepatocellular carcinoma (stages; 0&A). All patients were subjected to thorough history taking, clinical examination, liver function tests, renal function tests, serum alpha-fetoprotein, serum osteopontin, and serum annexin A2. Results Serum alpha-fetoprotein was found to be statistically significantly higher in patients with the hepatocellular carcinoma group than the chronic hepatitis C group. The ROC curve for alpha-fetoprotein for detection of HCC was significant, its diagnostic performance was 0.818* (p < 0.001*), and the cutoff point for predicting the probability for HCC was 6.0 (ng/ml) with sensitivity of 77.50%, specificity of 82.50%, positive predictive value of 81.60%, negative predictive value of 78.6%, and accuracy of 80%. Serum osteopontin was found to be statistically significantly higher in patients from the hepatocellular carcinoma group than the chronic hepatitis C group. The ROC curve for osteopontin was significant, its diagnostic performance was 0.739* (p < 0.001*), the cutoff point was 13.2 (ng/ml) with sensitivity of 65.0%, specificity of 90.0%, positive predictive value of 86.70%, negative predictive value of 72.0%, and accuracy of 77.0%. Serum annexin A2 was found to be statistically significantly higher in patients from the hepatocellular carcinoma group than the chronic hepatitis C group. The ROC curve for annexin A2 was significant, its diagnostic performance was 0.927* (p < 0.001*), the cutoff point was 10.1(ng/ml) with sensitivity of 85.0%, specificity of 85.0%, positive predictive value of 85.0%, negative predictive value of 85.0%, and accuracy of 85.0%. Conclusions Osteopontin had better specificity but lower sensitivity than serum alpha-fetoprotein for early diagnosis of hepatocellular carcinoma. Annexin A2 had better diagnostic sensitivity and specificity than alpha-fetoprotein for early diagnosis of hepatocellular carcinoma.

scholarly journals Comparison of RMI 3 and RMI 4 in pre-operative evaluation of ovarian masses

2019 ◽  
Vol 8 (9) ◽  
pp. 3602
Author(s):  
Badugu Rao Bahadur ◽  
Gangadhara Rao Koneru ◽  
Prabha Devi Kodey ◽  
Jyothi Melam
Keyword(s):  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Malignant Tumors ◽  
Clinical Approach ◽  
Ovarian Mass ◽  
Medical College ◽  
Operative Evaluation ◽  
Sensitivity Specificity ◽  
Final Confirmation

Background: To differentiate ovarian mass as benign or malignant could change clinical approach. Finding a screening and diagnostic method for ovarian cancer is challenging due to high mortality and insidious symptoms. Risk malignancy index (RMI) has the advantage of rapid and exact triage of patients with ovarian mass.Methods: Prospective study carried for 2 years at NRI Medical College and General Hospital, Chinakakani, Mangalagiri, Andhra Pradesh, India. 79 patients with ovarian mass were investigated and risk malignancy index (RMI-3 and RMI-4) calculated. Final confirmation was done based on histopathological report. Sensitivity, specificity, positive predictive value and negative predictive value were calculated for RMI 3 and RMI 4 taking histopathology as control and comparison was done.Results: (n=79); 50 (63.29%) cases were benign and 29 (36.70%) were malignant based on histopathology. RMI 4 is more sensitive (68.96%) than RMI 3 (62.06%), but RMI 3 is more specific (94%) than RMI 4 (92%).The positive predictive value of RMI-3 and RMI-4 were 85.71%  and 83.33% respectively. The negative predictive value for RMI-4 and RMI-3 were 83.63% and 81.03% respectively.Conclusions: With increasing age, chance of malignancy increases. RMI 4 was more sensitive than RMI-3, however less specific than RMI 3 in differentiating benign and malignant tumors. The positive predictive value is slightly more for RMI 3, than RMI 4. Negative predictive value is slightly more for RMI 4, than RMI 3. 

scholarly journals Spontaneous Tumors and Non-Neoplastic Proliferative Lesions in Pet Degus (Octodon degus)

2020 ◽  
Vol 7 (1) ◽  
pp. 32
Author(s):  
Tanja Švara ◽  
Mitja Gombač ◽  
Alessandro Poli ◽  
Jožko Račnik ◽  
Marko Zadravec
Keyword(s):  
Malignant Tumors ◽  
Single Case ◽  
Case Reports ◽  
Hepatocellular Adenoma ◽  
Benign Tumors ◽  
Malignant Neoplasms ◽  
Octodon Degus ◽  
Hind Limbs ◽  
Neoplastic Lesion ◽  
Veterinary Faculty

In recent years, degus (Octodon degus), rodents native to South America, have been becoming increasingly popular as pet animals. Data about neoplastic diseases in this species are still sparse and mainly limited to single-case reports. The aim of this study was to present neoplastic and non-neoplastic proliferative changes in 16/100 pet degus examined at the Veterinary Faculty University of Ljubljana from 2010 to 2015 and to describe the clinic-pathological features of these lesions. Twenty different lesions of the integumentary, musculoskeletal, genitourinary and gastrointestinal systems were diagnosed: amongst these were 13 malignant tumors, six benign tumors, and one non-neoplastic lesion. Cutaneous fibrosarcoma was the most common tumor (7/16 degus). It was detected more often in females (6/7 degus) and lesions were located mainly in hind limbs. The gastrointestinal tract was frequently affected, namely with two malignant neoplasms - an intestinal lymphoma and a mesenteric mesothelioma, four benign tumors – two biliary cystadenomas, an oral squamous papilloma and a hepatocellular adenoma, and a single non-neoplastic proliferative lesion. In one animal, two organic systems were involved in neoplastic lesions.

scholarly journals Identification of a new methylation site in the Sept9 promoter region for the diagnosis of hepatocellular carcinoma

2019 ◽  
Vol 6 (4) ◽  
pp. 26-37
Author(s):  
N. L. Lazarevich ◽  
P. M. Abramov ◽  
M. D. Fedorova ◽  
I. F. Kustova ◽  
D. A. Shavochkina ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Peripheral Blood ◽  
Liver Tissue ◽  
Promoter Region ◽  
Experimental Validation ◽  
Liver Tumors ◽  
Hepatocellular Adenoma ◽  
Clinical Samples ◽  
Non Invasive ◽  
Healthy Donors

Background. Over 600,000 people die from hepatocellular carcinoma (HCC) each year worldwide. The disease is often detected at advanced stages and in many cases is not curable. Early diagnostic and monitoring of HCC recurrences remains a substantial problem in clinical oncology. That determines the need for a search for highly sensitive and specific biomarkers for the non-invasive of HCC diagnostics. The objective of the study. Identification of the hypermethylated locus in the promoter region of the septin 9 (Sept9) gene based on the annotated methylomes from the public databases. Experimental validation of methylation on a pilot panel of paired clinical samples of patients with HCC, as well as tissue samples from patients with benign liver tumors and lymphocytes from healthy donors. Materials and methods. To analyze the methyl data, samples of HCC from TCGA, hepatocellular adenoma from GEO (Gene Expression Omnibus) depository, peripheral blood cells and tissues of healthy donors from Methbank were used. Experimental validation of methylation levels of the identified site was carried out on a pilot panel of clinical samples by bisulphite pyrosequencing using PyroMark Q24.Results. Based on the analysis of methylome data, we selected cg20275528 site, which is characterized by high level of methylation in HCC tissues and minimal levels of methylation in non-tumor liver tissue, hepatocellular adenoma and peripheral blood of healthy donors. Experimental testing on a pilot panel of clinical specimens showed that the level of marker site methylation in HCC (42 % median) is significantly higher than in non-tumor liver tissues (3 % median) and benign neoplasms (1.5 % median) and exceeds the threshold value in HCC compared to paired samples of adjacent non-tumor liver tissue in 20 out of 30 studied cases (66.6 %). The general possibility for cg20275528 methylation detection in circulating DNA of plasma in HCC patients was shown.Conclusion. The obtained results indicate that the approach to the detection and experimental verification of diagnostically significant markers developed and tested in this study can be used to identify new differentially methylated sites and to establish new approaches for non-invasive HCC diagnosis.

Management of Focal Nodular Hyperplasia and Hepatocellular Adenoma

Swiss Surgery ◽  
1999 ◽  
Vol 5 (3) ◽  
pp. 122-125 ◽  
Author(s):  
Mentha ◽  
Rubbia-Brandt ◽  
Howarth ◽  
Majno ◽  
Morel ◽  
...  
Keyword(s):  
Young Women ◽  
Focal Nodular Hyperplasia ◽  
Liver Tumors ◽  
Imaging Techniques ◽  
Young Patients ◽  
Hepatocellular Adenoma ◽  
Normal Liver ◽  
Liver Parenchyma ◽  
Diagnostic Error ◽  
Nodular Hyperplasia

Hepatocellular adenoma and focal nodular hyperplasia are two benign hepatic tumors which are mainly detected in healthy young women. Hepatocellular adenoma is an indication for surgery due to the risk of haemorrhage and malignant transformation. By contrast, focal nodular hyperplasia should be managed conservatively. However, precise diagnosis of these benign liver tumors remains difficult and sometimes impossible, despite new imaging techniques. Because of the risk of diagnostic error, resection or large biopsies of presumed liver tumors should be performed in young women (and a fortiori in men and older patients in whom focal nodular hyperplasia is less prevalent) when the diagnosis of focal nodular hyperplasia is not firmly established. The risk of liver surgery in young patients with normal liver parenchyma is, in the opinion of the authors, lower than the risk of a mistaken diagnosis.

ARFI ELASTOGRAPHY IN THE DIAGNOSIS OF FOCAL BREAST LESIONS

2017 ◽  
pp. 23-29
Author(s):  
Thi Kim Yen Vo ◽  
Phuoc Bao Quan Nguyen ◽  
Thanh Thao Nguyen
Keyword(s):  
Malignant Tumors ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Acoustic Radiation Force Impulse ◽  
Benign Tumors ◽  
Breast Lesions ◽  
Focal Lesions ◽  
Arfi Elastography ◽  
2D Ultrasound

Objective: To describe the sonographic characteristics of the focal breasst lesions using Acoustic Radiation Force Impulse Imaging (ARFI), and to evaluate the role of ARFI technique in combination with 2D Ultrasound in diagnosing focal breast lesions. Methods: 2D Ultrasound and ARFI Elastography were caried out in 52 patients who have focal lesions of breast. Images of 2D Ultrasound were classified according to ACR 2013. ARFI Elastography was performed by 2 techniques: “Virtual Touch HD tissue imaging” in order to image of strain distribution and “Virtual Touch HD Tissue quantification imaging” to measure the shear wave velocity (SWV) in the tissue. Strain distribution was classified according to Ako Itoh scale. SWV were measured in 4 positions: internal the lesion (SWVi), boundary zone (SWVb), glandular tissue and fatty tissue next to lesion (SWg and SWf). According to the results of pathology, we determine and compare the value between 2D Ultrasound plus ARFI elastography and 2D Ultrasound alone. Results: 52 patients with breast focal lesions: 22 malignant tumors and 30 benign tumors. Mean Ako Itoh scale of benign tumors were 2.19 ± 1.13 and malignant tumors were 4.72 ± 0.55; the cut-off value was between E3 và E4. SWVi, SWVb, SWVf, SWVg of benign tumors were lower than malignant tumors with cut-off values were 3.32 m/s; 6.01m/s; 1.08m/s; 2.37m/s, respectively. 2D Ultrasound plus ARFI Elastography: Se 100%, Sp 90%, PPV 88%, NPV 100%, Acc 94.2% (p<0.001, K = 0.884). Conclutions: In addition to the morphologic characteristics of breast lesions, ARFI provides information about lesion’s tissue elasticity, which can be a useful tool to differentitate malignant lesions from benign ones. Key words: elastography, focal breast lesions, Acoustic Radiation Force Impulse Imaging

scholarly journals DIFFERENTIAL DIAGNOSTICS OF LIVER HYPERECHOIC LESIONS

2017 ◽  
pp. 19-25 ◽  
Author(s):  
S. N. Berdnikov ◽  
V. N. Sholokhov ◽  
G. T. Siniukova ◽  
E. A. Goodilina ◽  
M. G. Abgarian ◽  
...  
Keyword(s):  
Positive Predictive Value ◽  
Liver Metastases ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Colorectal Liver Metastases ◽  
Malignant Tumors ◽  
Threshold Level ◽  
Differential Diagnostics ◽  
Manual Compression ◽  
Liver Hemangioma

PURPOSE. Development of elastometry and elastography in differential diagnostics of liver hyperechoic lesions (hemangioma and colorectal cancer metastases) MATERIALS AND METHODS. 180 patients examined due to liver hyperechoic lesions. All patients underwent elastography in manual compression mode, ultrasound examination in the аcoustic radiationforce impulse (ARFI) mode and in shear wave velocity (SWV) mode. RESULTS. According to the data from elastography in manual compression mode in patient's group with colorectal liver metastases in 71 % cases lesions were rigid. In patient's group with hemangioma lesions in 88 % cases were soft. According to the data from elastography in the ARFI mode in patient's group with colorectal liver metastases in 71 % cases lesions were rigid. In group of patients with liver hemangioma in 88 % cases lesions were soft. According to the tumor tissue elastometry data in patients with colorectal liver metastases RSTW was high - 3,24 m/sec (range 1,4-4,22 m/sec), median of RTSW was 3,38 m/sec. In patient's group with liver hemangioma RSTW was the lowest -1,07 m/sec (range 0,75-3,86 m/sec), median - 0,93 m/sec. CONCLUSION. Informativeness of elastography in manual compression mode for colorectal liver metastases (n=110): 98 % sensitivity, 98 % accuracy, 100 % positive predictive value. Informativeness of elastography in manual compression mode for liver hemangioma (n=70): 94 % sensitivity, 94 % accuracy, 100 % negative predictive value._ 19 ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА ОЧАГОВЫХ ГИПЕРЭХОГЕННЫХ ОБРАЗОВАНИЙ В ПЕЧЕНИ Informativeness of elastography in ARFI mode for colorectal liver metastases (n=110): 100 % sensitivity, 100 % accuracy, 100 % positive predictive value. Informativeness of elastography in ARFI mode for liver hemangioma (n=45): 94 % sensitivity, 100 % accuracy, 100 % negative predictive value. Elastometry data for liver malignant tumors detection were more informative when RSTW threshold level was 2,0 m/sec (if more than 2,0 m/sec then malignant tumor, if less than 2 m/sec then benign tumor): 94 % accuracy, 91 % sensitivity, 97 % specificity, 92 % negative predictive value.

scholarly journals SENSITIVITY AND SPESIFICITY VALUE OF PLATELETS, MALIGNANCY RATIO INDEX AND BOTH COMBINED IN DIAGNOSING OVARIAN CANCER AT GENERAL HOSPITAL HAJI ADAM MALIK MEDAN FROM 2016-2018

2020 ◽  
pp. 121-125
Author(s):  
YOVITA V. ◽  
TALA MRZ ◽  
DINA S. ◽  
LUMBANRAJA S. N. ◽  
LUBIS D. L. ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Positive Predictive Value ◽  
General Hospital ◽  
Predictive Value ◽  
Diagnostic Value ◽  
Benign Tumors ◽  
Test Design ◽  
Ovarian Mass ◽  
Diagnostic Modality ◽  
Sensitivity Specificity

Objective: This research aimed to analyze sensitivity and specificity values of platelets, RMI and both combined as ovarian cancer diagnostic modality in Haji Adam Malik Hospital in 2016-2018. Methods: This is analytic research with a diagnostic test design on 204 patients who had been diagnosed with ovarian cancer and patients with ovary benign tumors which have been examined the value of full blood and the malignancy ratio index and ovarian mass that has been proven by the results of anatomic pathology at General Hospital Haji Adam Malik Medan in 2016-2018. The data is tabulated into 2x2 table and then calculated for each sensitivity, specificity, positive predictive value and negative predictive value. Result: By using platelet cut-off value>450000 per mm3 in diagnosing ovarian cancer with sensitivity 55.44% and specificity 83.65% were obtained. IRK has a sensitivity 83.16% and specificity 76.92%. Platelet and IRK values ​​provided the highest diagnostic value (specificity) compared to when they were each single which was 97.11% while the combination of platelet and IRK values ​​had a sensitivity of 49.50%. Conclusion: Platelet and IRK values ​​gives the highest diagnostic value (specificity) compared to when both are used, namely 97.11%.

ATL

2014 ◽  
Vol 24 (3) ◽  
pp. 454-460 ◽  
Author(s):  
Yuko Tanizaki ◽  
Aya Kobayashi ◽  
Michihisa Shiro ◽  
Nami Ota ◽  
Rei Takano ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Fdg Pet ◽  
Clear Cell ◽  
Benign Tumors ◽  
Clear Cell Adenocarcinoma ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Fdg Accumulation

ObjectiveThe objective of this study was to investigate the preoperative diagnostic value of18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography and computed tomography (PET/CT) in patients with ovarian cancer.MethodsOne hundred sixty patients suspected of having malignant ovarian tumors were included in this study. All patients underwent FDG-PET/CT scans before operation, and the maximum standardized uptake value (SUVmax) of the primary tumor was measured. We evaluated the diagnostic accuracy of SUVmaxfor detecting malignancy and its relationship with histological findings.ResultsPostoperative pathological diagnoses showed that 67 were malignant, 14 were borderline malignant, and 79 were benign tumors. With the use of a cutoff SUVmaxof 2.9 obtained from the receiver operating characteristic curve analysis, the sensitivity, specificity, positive predictive value, and negative predictive value for detecting malignancy were 80.6%, 94.6%, 91.5%, and 87.1%, respectively. Positive FDG accumulation (SUVmax≥ 2.9) was shown in 89.5% of serous adenocarcinoma and in 92.3% of endometrioid adenocarcinoma. In contrast, lower frequencies of positive FDG accumulation were shown in clear cell adenocarcinoma (54.5%), mucinous adenocarcinoma (66.7%), and metastatic carcinoma (66.7%), and the median SUVmaxof these 3 histological types were significantly lower than those of serous and endometrioid types. In addition, a positive FDG accumulation was shown in all patients with malignant transformation of mature cystic teratoma. Finally, of the 14 borderline malignant tumors, only 2 (14.3%) showed positive FDG accumulation.ConclusionsThe SUVmaxon FDG-PET/CT is useful for differentiating ovarian cancer from borderline or benign tumor with a high specificity and positive predictive value. However, our data also demonstrated a lower FDG uptake value in clear cell or mucinous histological finding, suggesting that SUVmaxmay vary depending on the tumor histological subtype.

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