Charactecteristics of Liver Tumors by means of ARFI-elastography

10.12737/7276 ◽  
2014 ◽  
Vol 21 (4) ◽  
pp. 86-92
Author(s):  
Гудилина ◽  
E. Gudilina ◽  
Вишленкова ◽  
E. Vishlenkova ◽  
Лепэдату ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatocellular Carcinoma ◽  
Liver Tumors ◽  
Normal Liver ◽  
Liver Parenchyma ◽  
Benign Tumors ◽  
Normal Liver Parenchyma ◽  
Large Size ◽  
Speed Performance ◽  
Arfi Elastography

The purpose of this study was to determine the possibility of ARFI- elastography for diagnosis of tumors of the liver. The study included 95 patients with liver tumors. 22 patients were excluded from the study because of the deep location of the formation or the inability to measure the speed performance. Therefore the tumors in 73 patients were obtained by ARFI-elastography and analyzed. Verification of the diagnosis was achieved by histological examination of the material in 93% of cases and by MRI, CT in 7% of cases. Patients were divided by diagnosis: 4 – with benign tumors, 33 – with hepatocellular carcinoma, 4 – with cholangio-carcinoma, 19 – with metastatic colorectal cancer, 13 – with metastases of other cancer. Benign tumors included two focal nodular hyperplasia and hepatocellular adenoma, one cavernous hemangioma a large size. The obtained results were compared with normal liver parenchyma in 77 people. Average speed was: 2.83 m/s in the benign, 1.55 m/s in the normal liver parenchyma, 2.5 m/s at the nodes of hepatocellular carcinoma, 2.66 m/s at the nodes cholangio-carcinomar, 2.79 m/s in the metastasis of colorectal cancer, 2.79 m/s in the remaining metastases. Associated threshold value for the diagnosis of the majority of malignant tumors, it is necessary to consider the speed of over 2 m/s. Sensitivity groups ranged from 59% to 100% and a specificity of 70% to 86%. The results indicate higher speed performance parameters (mean, median, threshold values > 2.3 m/s) in benign tumors. This is due to a small group, as well as the large size of entities – from 5.0 to 24.0 cm, indicating that the long-term course of the disease with the development of fibrosis in them, so the stiffness of education becomes higher. These data prove that the quantitative elastography shear wave can be used as an additional diagnostic tool in oncology, but further accumulation of scientific data, since the values of the groups overlap.

Qualitative elastography and arfi technology in the diagnosis of liver tumors

10.12737/6670 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 0-0
Author(s):  
Гудилина ◽  
E. Gudilina ◽  
Вишленкова ◽  
E. Vishlenkova ◽  
Лепэдату ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Liver Tumors ◽  
Malignant Tumors ◽  
Hepatocellular Adenoma ◽  
Liver Parenchyma ◽  
Benign Tumors ◽  
Area Of Interest ◽  
Arfi Elastography

The aim of this study was to evaluate the stiffness of liver tumors using compression and ARFI elastography. Compression and ARFI elastography was performed to study the color display rigidity in the foci of the liver in 69 and 81 patients, respectively. Area of interest was placed in the education and on the border with the surrounding liver parenchyma, to assess the visual difference tissue stiffness. Patients were divided by diagnosis: hepatocellular carcinoma – 36, cholangiocarcinoma – 6 metastases – 35, benign – 4 cases. Benign tumors included two focal nodular hyperplasia, hepatocellular adenoma and one cavernous hemangioma a large size. When compression elastography increased stiffness formations compared to the surrounding liver parenchyma was observed: in benign – 100%, hepatocellular carcinoma – in 71.9%, cholangiocarcinoma – 80%, metastases – in 72.4%. When ARFI elastography increased stiffness observed: in benign – 100%, hepatocellular carcinoma – 58.3%, cholangiocarcinoma – 100%, metastases – in 85.7%. Qualitative elastography improves the definition of clear boundaries neoplasm infiltration beyond the tumor, but can not differentiate between malignant and benign tumors. Sensitivity, accuracy, positive predictive value of the compressive elastography were as follows: 73, 69, 94%, and at ARFI elastography – 74, 70, 93%, respectively. Both techniques are qualitative elastography complement each other, with the specification of the internal structure of foci and their joint application sensitivity, accuracy, positive predictive value in the diagnosis of malignant tumors accounted for 83, 79, 95%, respectively. ARFI elastography in conjunction with compression elastography improves the visualization of malignant tumors of the liver and can be used as an additional diagnostic tool in oncohepatology.

scholarly journals Quantitative Ultrasound Spectroscopy for Differentiation of Hepatocellular Carcinoma from At-Risk and Normal Liver Parenchyma

2019 ◽  
Vol 25 (22) ◽  
pp. 6683-6691
Author(s):  
Isabelle Durot ◽  
Rosa M.S. Sigrist ◽  
Nishita Kothary ◽  
Jarrett Rosenberg ◽  
Jürgen K. Willmann ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
At Risk ◽  
Quantitative Ultrasound ◽  
Normal Liver ◽  
Liver Parenchyma ◽  
Normal Liver Parenchyma

CT attenuation of normal liver parenchyma on delayed scanning with iohexol

1992 ◽  
Vol 33 (5) ◽  
pp. 502-503
Author(s):  
G. Tidebrant ◽  
P. Lukes ◽  
A. Wihed
Keyword(s):  
Normal Liver ◽  
Liver Parenchyma ◽  
Normal Liver Parenchyma ◽  
Ct Attenuation

Eight years after introducing liver resection at the Oncology Institute of Vojvodina

2013 ◽  
Vol 21 (3-4) ◽  
pp. 101-104
Author(s):  
Ivan Majdevac ◽  
Nikola Budisin ◽  
Milan Ranisavljevic ◽  
Dejan Lukic ◽  
Imre Lovas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Resection ◽  
Liver Tumors ◽  
Liver Parenchyma ◽  
Malignant Neoplasms ◽  
Chemotherapy Treatment ◽  
Primary Liver Tumors ◽  
Cancer Metastases ◽  
Colorectal Cancer Metastases ◽  
Medical Histories

Background: Hepatectomies are mostly performed for the treatment of hepatic benign or malignant neoplasms, intrahepatic gallstones, or parasitic cysts of the liver. The most common malignant neoplasms of the liver are metastases from colorectal cancer. Anatomic liver resection involves two or more hepatic segments, while non-anatomic liver resection involves resection of the metastases with a margin of uninvolved tissue. The aim of this manuscript was to show results of hepatectomies performed at the Oncology Institute of Vojvodina. Methods: We performed 133 liver resections from January 1997 to December 2013. Clinical and histopathological data were obtained from operative protocols, histopathological reports, and patients? medical histories. Results: We did 80 metastasectomies, 51 segmentectomies, and 18 radiofrequent ablations (RFA). Average number of colorectal cancer metastases was 1.67 per patient. We also made 10 left hepatectomies. In all cases, we made non-anatomic resections. Conclusion: Decision about anatomic versus non-anatomic resections for colorectal metastasis and primary liver tumors should be made before surgical exploration. Preservation of liver parenchyma is important with respect to liver failure and postoperative chemotherapy treatment.

scholarly journals Transarterial Radioembolization of Hepatocellular Carcinoma, Liver-Dominant Hepatic Colorectal Cancer Metastases, and Cholangiocarcinoma Using Yttrium90 Microspheres: Eight-Year Single-Center Real-Life Experience

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 122
Author(s):  
Julie Pellegrinelli ◽  
Olivier Chevallier ◽  
Sylvain Manfredi ◽  
Inna Dygai-Cochet ◽  
Claire Tabouret-Viaud ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatocellular Carcinoma ◽  
Liver Tumors ◽  
Progression Free Survival ◽  
Single Center ◽  
Free Survival ◽  
Risk Of Death ◽  
Transarterial Radioembolization ◽  
Cancer Metastases ◽  
Colorectal Cancer Metastases

Liver tumors are common and may be unamenable to surgery or ablative treatments. Consequently, other treatments have been devised. To assess the safety and efficacy of transarterial radioembolization (TARE) with Yttrium-90 for hepatocellular carcinoma (HCC), liver-dominant hepatic colorectal cancer metastases (mCRC), and cholangiocarcinoma (CCA), performed according to current recommendations, we conducted a single-center retrospective study in 70 patients treated with TARE (HCC, n = 44; mCRC, n = 20; CCA, n = 6). Safety and toxicity were assessed using the National Cancer Institute Common Terminology Criteria. Treatment response was evaluated every 3 months on imaging studies using Response Evaluation Criteria in Solid Tumors (RECIST) or mRECIST criteria. Overall survival and progression-free survival were estimated using the Kaplan-Meier method. The median delivered dose was 1.6 GBq, with SIR-Spheres® or TheraSphere® microspheres. TARE-related grade 3 adverse events affected 17.1% of patients. Median follow-up was 32.1 months. Median progression-free survival was 5.6 months and median overall time from TARE to death was 16.1 months and was significantly shorter in men. Progression-free survival was significantly longer in women (HR, 0.49; 95%CI, 0.26–0.90; p = 0.031). Risk of death or progression increased with the number of systemic chemotherapy lines. TARE can be safe and effective in patients with intermediate- or advanced-stage HCC, CCA, or mCRC refractory or intolerant to appropriate treatments.

scholarly journals Longterm survival outcomes of patients undergoing treatment with radiofrequency ablation for hepatocellular carcinoma and metastatic colorectal cancer liver tumors

HPB ◽  
2016 ◽  
Vol 18 (9) ◽  
pp. 756-763 ◽  
Author(s):  
Iswanto Sucandy ◽  
Susannah Cheek ◽  
Benjamin J. Golas ◽  
Allan Tsung ◽  
David A. Geller ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Metastatic Colorectal Cancer ◽  
Liver Tumors ◽  
Survival Outcomes ◽  
Longterm Survival

Identification of new liver tumor biomarkers using proteomics.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e21091-e21091
Author(s):  
Peter J. Maimonis ◽  
Yoh Zen ◽  
David J. Britton ◽  
Andrew Brand ◽  
Malcolm Ward ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Liver Tumors ◽  
Early Stage ◽  
Normal Liver ◽  
Liver Parenchyma ◽  
Tissue Type ◽  
P Value ◽  
Tumor Biomarkers ◽  
Formalin Fixed Paraffin Embedded ◽  
New Biomarkers

e21091 Background: It is crucial to identify new biomarkers that help diagnose cancers at an early stage and contribute to the development of new anti-cancer drugs. Here, we identify new liver tumor biomarkers using proteomics. Methods: We evaluated 9 types of liver tissue from 55 patients: normal liver parenchyma (n=7), hepatocellular carcinoma (HCC) (n=7), normal bile duct (n=6), peripheral cholangiocarcinoma (CC) (n=7), hilar CC (n=7), CC associated with primary sclerosing cholangitis (PSC) (n=7), metastatic colorectal cancer (n=7), and mixed HCC/CC after trans-arterial chemoembolization (n=7; areas of HCC and areas of CC separately examined). Protein extracted from microdissected, formalin-fixed paraffin-embedded tissue (0.15 mm3 in total) was reduced, alkylated and digested with trypsin in a stacking gel. Peptides were analyzed using nano-liquid chromatography-Mass spectrometry. The raw data were searched using Mascot. Normalized spectral counts for each protein among each tissue type were compared. For each comparison, an unrelated t-test was computed to obtain the p value. q values (adjusted p values) were computed using a direct False Discovery Rate approach (q < 0.05 considered statistically significant). Results: The mean number of proteins identified per sample was 762 +/- 119 S.D, resulting in a total of 2643 proteins identified. Numbers of proteins with significantly different expression levels among different tissue types are shown below. Some of these proteins are being reported here for the first time in the context of liver carcinogenesis. Conclusions: This study revealed proteins that are significantly over/underexpressed in particular types of liver tumors. Clinically useful new biomarkers may be present among these proteins and are now undergoing validation using immunohistochemisty. [Table: see text]

Postsurgical multiple-sites sampling procedure for the precise detection of microvascular invasion of hepatocellular carcinoma.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15657-e15657
Author(s):  
Qian Zhou ◽  
Lili Chen ◽  
Shuling Chen ◽  
Qinghua Cao ◽  
Sui Peng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Size ◽  
Validation Cohort ◽  
Normal Liver ◽  
Liver Parenchyma ◽  
Sampling Procedure ◽  
Microvascular Invasion ◽  
Sampling Location ◽  
Sample Collection ◽  
Positive Rate

e15657 Background: Microvascular invasion (MVI) is an important risk factor of recurrence for hepatocellular carcinoma (HCC). We aimed to explore the relationship of the number of sampling sites (NuSS) and sampling location with positive rate of MVI, and investigate cut-off values for NuSS. Methods: From May 2010 to Feb 2017, 910 HCC patients undergone hepatectomy with well-preserved tissue blocks were retrospectively enrolled. Associations between NuSS and positive rates of MVI were investigated. The thresholds of NuSS according to different factors were determined by Chow test and Breakpoints function, and validated prospectively in 118 patients. In validation cohort, MVI positive rates in different sampling locations were estimated. Results: The positive rates of MVI increased as NuSS increased ( P < 0.001). Tumor size and number were two factors influencing NuSS. A minimum of four, six, eight and eight sampling sites were required for detecting MVI in solitary tumors measuring 1.0-3.0 cm, 3.1-4.9 cm and ≥ 5.0 cm and multiple tumors. The positive rates of MVI as per developed thresholds were significantly higher in all the tumor subgroups of validation cohort than those in routine clinical practice in training cohort (46.7% vs. 20.6%, P= 0.048; 44.4% vs. 24.4%, P= 0.025; 73.3% vs. 50.3%, P= 0.004; 67.7% vs. 45.4%, P= 0.026). The positive rates of MVI in tumor interface were higher than those in proximal and distal paracancerous and normal liver parenchyma. Conclusions: The different thresholds of NuSS according to tumor size and number, and sampling distribution according to location provided evidences of standardized sample collection of liver cancer specimen for accurate MVI diagnosis.

scholarly journals Effect of Repeated Normothermic Ischaemia on Normal Liver Parenchyma

1987 ◽  
Vol 28 (2) ◽  
pp. 215-219
Author(s):  
Hans Stridbeck ◽  
T. Holmin ◽  
I. Hägerstrand
Keyword(s):  
Normal Liver ◽  
Liver Parenchyma ◽  
Normal Liver Parenchyma

Management of Focal Nodular Hyperplasia and Hepatocellular Adenoma

Swiss Surgery ◽  
1999 ◽  
Vol 5 (3) ◽  
pp. 122-125 ◽  
Author(s):  
Mentha ◽  
Rubbia-Brandt ◽  
Howarth ◽  
Majno ◽  
Morel ◽  
...  
Keyword(s):  
Young Women ◽  
Focal Nodular Hyperplasia ◽  
Liver Tumors ◽  
Imaging Techniques ◽  
Young Patients ◽  
Hepatocellular Adenoma ◽  
Normal Liver ◽  
Liver Parenchyma ◽  
Diagnostic Error ◽  
Nodular Hyperplasia

Hepatocellular adenoma and focal nodular hyperplasia are two benign hepatic tumors which are mainly detected in healthy young women. Hepatocellular adenoma is an indication for surgery due to the risk of haemorrhage and malignant transformation. By contrast, focal nodular hyperplasia should be managed conservatively. However, precise diagnosis of these benign liver tumors remains difficult and sometimes impossible, despite new imaging techniques. Because of the risk of diagnostic error, resection or large biopsies of presumed liver tumors should be performed in young women (and a fortiori in men and older patients in whom focal nodular hyperplasia is less prevalent) when the diagnosis of focal nodular hyperplasia is not firmly established. The risk of liver surgery in young patients with normal liver parenchyma is, in the opinion of the authors, lower than the risk of a mistaken diagnosis.

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