scholarly journals Xylometazoline and oxymetazoline - unusual effects of everyday drugs (literature review)

2021 ◽  
Vol 11 (9) ◽  
pp. 272-281
Author(s):  
Jakub Klas ◽  
Natalia Kluz ◽  
Klaudia Piwowar
Keyword(s):  
Side Effects ◽  
Adrenergic Receptors ◽  
Lower Respiratory Tract ◽  
The Other ◽  
Angina Attack ◽  
Nasal Sprays ◽  
Drug List ◽  
Imidazoline Derivatives ◽  
Carious Lesions ◽  
Pharmacological Potential

The aim of the study is to systematize the knowledge about xylometazoline and oxymetazoline - commonly used nasal sprays with sympathicomimetic effect, mainly directly on α-adrenergic receptors [1]. A review of recent reports on possible side effects and new therapeutic options will be presented. Results: Over several years, reports have been published regarding descriptions of unusual cases of side effects, such as angina attack [4], a case of respiratory failure in a newborn [5], ischemic stroke [6], or anaphylactic reaction during routine surgery. In experiments using rats, on the other hand, it has been shown that these substances can also cause increased inflammation of the lower respiratory tract [7], as well as numerous ophthalmic problems [8]. Recent reports also suggest new uses for xylometazoline and oxymetazoline. In combination with lidocaine, an intranasal solution of xylometazoline has shown efficacy in the anesthesia of maxillary teeth in patients with minor carious lesions [9], and a beneficial therapeutic combination of oxymetazoline and dye laser (PDL) has also been reported for the treatment of rosacea, among others [10]. Conclusions: Although imidazoline derivatives were admitted to the drug list decades ago, still their pharmacological potential has not been fully exploited. Finding applications of these drugs in dermatology and dentistry may not only improve the efficacy and comfort of treatment, but also significantly reduce the costs of the whole therapy. The aforementioned reports on the side effects of xylometazoline and oxymetazoline should not be forgotten. It is possible that the presented examples will increase awareness to use these drugs with more respect, according to the recommendations on the leaflet.

scholarly journals Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections

2013 ◽  
Vol 2013 ◽  
pp. 1-21 ◽  
Author(s):  
Giuseppe Sautto ◽  
Nicasio Mancini ◽  
Giacomo Gorini ◽  
Massimo Clementi ◽  
Roberto Burioni
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Side Effects ◽  
Antiviral Activity ◽  
The Other ◽  
Viral Escape ◽  
Passive Immunotherapy ◽  
Medical Need

More than 150 arboviruses belonging to different families are known to infect humans, causing endemic infections as well as epidemic outbreaks. Effective vaccines to limit the occurrence of some of these infections have been licensed, while for the others several new immunogens are under development mostly for their improvements concerning safety and effectiveness profiles. On the other hand, specific and effective antiviral drugs are not yet available, posing an urgent medical need in particular for emergency cases. Neutralizing monoclonal antibodies (mAbs) have been demonstrated to be effective in the treatment of several infectious diseases as well as in preliminaryin vitroandin vivomodels of arbovirus-related infections. Given their specific antiviral activity as well-tolerated molecules with limited side effects, mAbs could represent a new therapeutic approach for the development of an effective treatment, as well as useful tools in the study of the host-virus interplay and in the development of more effective immunogens. However, before their use as candidate therapeutics, possible hurdles (e.g., Ab-dependent enhancement of infection, occurrence of viral escape variants) must be carefully evaluated. In this review are described the main arboviruses infecting humans and candidate mAbs to be possibly used in a future passive immunotherapy.

scholarly journals Assessment of Live Candidate Vaccines for Paratuberculosis in Animal Models and Macrophages

2009 ◽  
Vol 78 (3) ◽  
pp. 1383-1389 ◽  
Author(s):  
Gabriella M. Scandurra ◽  
Geoffrey W. de Lisle ◽  
Sonia M. Cavaignac ◽  
May Young ◽  
R. Pamela Kawakami ◽  
...  
Keyword(s):  
Side Effects ◽  
Bacterial Load ◽  
Economic Effect ◽  
Cost Effective ◽  
The Other ◽  
Murine Models ◽  
Initial Screening ◽  
Vaccine Candidates ◽  
Allelic Exchange ◽  
Potential Vaccine

ABSTRACT Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the causative agent of paratuberculosis, a chronic enteritis of ruminants. To control the considerable economic effect that paratuberculosis has on the livestock industry, a vaccine that induces protection with minimal side effects is required. We employed transposon mutagenesis and allelic exchange to develop three potential vaccine candidates, which were then tested for virulence with macrophages, mice, and goats. All three models identified the WAg906 mutant as being the most attenuated, but some differences in the levels of attenuation were evident among the models when testing the other strains. In a preliminary mouse vaccine experiment, limited protection was induced by WAg915, as evidenced by a reduced bacterial load in spleens and livers 12 weeks following intraperitoneal challenge with M. paratuberculosis K10. While we found macrophages and murine models to be rapid and cost-effective alternatives for the initial screening of M. paratuberculosis mutants for attenuation, it appears necessary to do the definitive assessment of attenuation with a ruminant model.

Beta-Blocker Attenuates Cardiotoxicity Related Anthracycline Usage

2021 ◽  
Vol 104 (8) ◽  
pp. 1389-1392
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Mortality Rate ◽  
Cancer Patients ◽  
Beta Blocker ◽  
The Other ◽  
Large Numbers ◽  
Therapy Effectiveness ◽  
Chemotherapy Agents

To summarize the recent trials and studies of the role of beta-blocker on the treatment for cancer patients treated with anthracycline to decrease morbidity and mortality rate. Good management of cancer will result in large numbers of cancer survivors. On the other hand, cancer therapy also has side effects, one of which is cardiotoxicity. Cardiotoxicity could reduce therapy effectiveness, hence, increase disease progression and mortality rate. Anthracyclines is one of the chemotherapy agents with cardiotoxicity as a side effect. Beta-blocker has the ability to reduce cardiotoxicity due to anthracyclines usage. Keywords: Beta-blocker; Cardiotoxicity; Anthracyclines

A trial construction of high durability railway viaducts with local aggregates

2019 ◽  
Author(s):  
Kotaro Kawamura ◽  
Joe Takemura ◽  
Shigenobu Iguchi ◽  
Tsutomu Yoshida ◽  
Masashi Kobayashi
Keyword(s):  
Fly Ash ◽  
Side Effects ◽  
Portland Cement ◽  
Ordinary Portland Cement ◽  
The Other ◽  
Strength Concrete ◽  
High Durability ◽  
Sound Barrier ◽  
Early Strength ◽  
Structural Measure

<p>We are carrying out a construction project of new railroad viaducts. These new railroad viaducts are constructing using about 110,000 m<span>3</span> volume concrete. In this construction place, it is difficult for us to get low ASR-reactive aggregates and it is expected to be supplied with snowmelt water on the viaducts in winter. Then we tested ASR-reactive these local aggregates and found an effective mixed ratio of fly-ash is 20% of cement. On the other hand, various side effects were also expected by using fly-ash. For example, initial cracking due to contraction, early strength concrete, bleeding, etc. Therefore, we repeated various tests and examined and carried out a method that could ensure the same construction method and quality as when using ordinary Portland cement, even with fly-ash. Also, we adopted a structure that is unlikely to be affected by rainwater as a structural measure. For example, the entire adoption of a ramen type viaduct that has eliminated bearings, adoption of FRP sound barrier, etc. Then we made it possible to build highly durable railway viaducts by these various measures of materials and structures.</p>

A Double-Blind Comparative Clinical Trial of Floctafenine and Four Other Analgesics Conducted in General Practice

1976 ◽  
Vol 4 (3) ◽  
pp. 179-182 ◽  
Author(s):  
D M Lomas ◽  
J Gay ◽  
R N Midha ◽  
D L Postlethwaite
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Analgesic Effect ◽  
Rank Order ◽  
Controlled Trial ◽  
The Other ◽  
Double Blind ◽  
Comparative Clinical Trial

Three hundred and twelve patients suffering from painful conditions were admitted to a multicentre, double-blind controlled trial, conducted in general practice in which five analgesics—floctafenine (Idarac), paracetamol, aspirin, dihydrocodeine and pentazocine—were compared. Overall ratings of analgesic effect placed floctafenine first in rank order. Floctafenine was statistically significantly superior in effect to pentazocine but not to the other three agents as far as doctor ratings were concerned; and superior to both pentazocine and dihydrocodeine in the opinion of patients. Fewer patients experienced side-effects on floctafenine than on the other four analgesics and this difference between floctafenine and pentazocine, and floctafenine and dihydrocodeine was statistically significant.

The Other Face of the Moon: Side Effects, Interactions and Molecules of Concerns

2017 ◽  
pp. 141-176
Author(s):  
Chiara Di Lorenzo ◽  
Aymeric Dopter ◽  
Sarah Vecchio ◽  
Saskia Lüde ◽  
Francesca Colombo ◽  
...  
Keyword(s):  
Side Effects ◽  
The Other ◽  
The Moon

scholarly journals AKTUALISASI REVOLUSI MENTAL DALAM PENGELOLAAN DANA DESA (ANALISIS TAFSIR EKONOMI Q.S.YUSUF [12]: 55)

2020 ◽  
Vol 5 (2) ◽  
pp. 226-246
Author(s):  
Muhammad Amin ◽  
Azima Azima
Keyword(s):  
Side Effects ◽  
The Other ◽  
Other Hand ◽  
The Village

Dana Desa are one of the most effective policies in village development with the completion of various kinds of infrastructure in the village. On the other hand, this policy caused side effects in the form of criminal acts of corruption against these funds. Through the interpretation of Q.S. Yusuf verse 55, the author offers the actualization of the spirit of mental revolution in the management of village funds through measures to strengthen integrity, increase professionalism, innovation, responsibility, and broaden horizons. Through these steps, the village fund policy can be implemented completely and right on target.

Medical Management of Trigeminal Neuralgia

2019 ◽  
pp. 591-609
Author(s):  
Niushen Zhang
Keyword(s):  
Side Effects ◽  
Trigeminal Neuralgia ◽  
Side Effect Profile ◽  
Clinical Use ◽  
Line Treatment ◽  
Nasal Sprays ◽  
Surgical Methods ◽  
Methods Of Treatment ◽  
First Line Treatment ◽  
Selection Of

The first-line treatment of trigeminal neuralgia can be very effective, but side effects are often difficult for patients to tolerate. This chapter is a guide to the broad selection of medical therapies currently available for the treatment of trigeminal neuralgia which includes oral therapies and other non-surgical methods of treatment such as IV medications, nasal sprays, topical ointments, and injections. The discussion of each treatment includes discussion of its evidence in current literature, its proposed mechanism of action, its dosing and appropriate setting for clinical use, and its side effect profile.

Antimicrobial Applications of Nanoparticles

2022 ◽  
pp. 269-288
Author(s):  
Ayesha Kanwal ◽  
Zeeshan Ahmad Bhutta ◽  
Ambreen Ashar ◽  
Ashar Mahfooz ◽  
Rizwan Ahmed ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Side Effects ◽  
Antibacterial Agent ◽  
Antibacterial Agents ◽  
The Other ◽  
Drug Resistant ◽  
Short Term ◽  
Human Mortality ◽  
Recent Developments

Human mortality due to drug-resistant infections is becoming more prevalent in our society. Antibiotics are impotent due to abuse and/or misuse, leading to new, more expensive, and more effective medicines and treatments. Therefore, it causes many short-term and long-term side effects in the patient. On the other hand, nanoparticles have exhibited antibacterial activity against various pathogens due to their small size and ability to destroy cells by various mechanisms. Unlike antibiotics for the treatment of patients' diseases and infections, nanomaterials provide an exciting way to limit the growth of microorganisms due to infections in humans. This has led to the development of a number of nanoparticles as active antibacterial agents. Therefore, the authors have carefully reviewed the recent developments in the use of nanomaterials for antibacterial applications and the mechanisms that make them an effective alternate antibacterial agent.

scholarly journals Comparative Evaluation of Intestinal Absorption and Functional Value of Iron Dietary Supplements and Drug with Different Delivery Systems

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5989
Author(s):  
Paolo Pastore ◽  
Marco Roverso ◽  
Erik Tedesco ◽  
Marta Micheletto ◽  
Etienne Mantovan ◽  
...  
Keyword(s):  
Side Effects ◽  
Dietary Supplements ◽  
Iron Absorption ◽  
Therapeutic Targets ◽  
Iron Bioavailability ◽  
The Other ◽  
Time Dependent ◽  
Nutritional Deficiencies ◽  
Deficiency Anemia ◽  
Iron Supplements

Iron is a fundament micronutrient, whose homeostasis is strictly regulated. Iron deficiency anemia is among the most widespread nutritional deficiencies and its therapy, based on dietary supplement and drugs, may lead to severe side effects. With the aim of improving iron bioavailability while reducing iron oral therapy side effects, novel dietary supplements based on innovative technologies—microencapsulation, liposomes, sucrosomes—have been produced and marketed. In the present work, six iron dietary supplements for different therapeutic targets were compared in terms of bioaccessibility, bioavailability, and safety by using an integrated in vitro approach. For general-purpose iron supplements, ME + VitC (microencapsulated) showed a fast, burst intestinal iron absorption kinetic, which maintained iron bioavailability and ferritin expression constant over time. SS + VitC (sucrosomes), on the other side, showed a slower, time-dependent iron absorption and ferritin expression trend. ME + Folate (microencapsulated) showed a behavior similar to that of ME + VitC, albeit with a lower bioavailability. Among pediatric iron supplements, a time-dependent bioavailability increase was observed for LS (liposome), while PIC (polydextrose-iron complex) bioavailability is severely limited by its poor bioaccessibility. Finally, except for SS + VitC, no adverse effects on intestinal mucosa vitality and barrier integrity were observed. Considering obtained results and the different therapeutic targets, microencapsulation-based formulations are endowed with better performance compared to the other formulations. Furthermore, performances of microencapsulated products were obtained with a lower iron daily dose, limiting the potential onset of side effects.

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