The Other Face of the Moon: Side Effects, Interactions and Molecules of Concerns

2017 ◽  
pp. 141-176
Author(s):  
Chiara Di Lorenzo ◽  
Aymeric Dopter ◽  
Sarah Vecchio ◽  
Saskia Lüde ◽  
Francesca Colombo ◽  
...  
Keyword(s):  
Side Effects ◽  
The Other ◽  
The Moon

scholarly journals Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections

2013 ◽  
Vol 2013 ◽  
pp. 1-21 ◽  
Author(s):  
Giuseppe Sautto ◽  
Nicasio Mancini ◽  
Giacomo Gorini ◽  
Massimo Clementi ◽  
Roberto Burioni
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Side Effects ◽  
Antiviral Activity ◽  
The Other ◽  
Viral Escape ◽  
Passive Immunotherapy ◽  
Medical Need

More than 150 arboviruses belonging to different families are known to infect humans, causing endemic infections as well as epidemic outbreaks. Effective vaccines to limit the occurrence of some of these infections have been licensed, while for the others several new immunogens are under development mostly for their improvements concerning safety and effectiveness profiles. On the other hand, specific and effective antiviral drugs are not yet available, posing an urgent medical need in particular for emergency cases. Neutralizing monoclonal antibodies (mAbs) have been demonstrated to be effective in the treatment of several infectious diseases as well as in preliminaryin vitroandin vivomodels of arbovirus-related infections. Given their specific antiviral activity as well-tolerated molecules with limited side effects, mAbs could represent a new therapeutic approach for the development of an effective treatment, as well as useful tools in the study of the host-virus interplay and in the development of more effective immunogens. However, before their use as candidate therapeutics, possible hurdles (e.g., Ab-dependent enhancement of infection, occurrence of viral escape variants) must be carefully evaluated. In this review are described the main arboviruses infecting humans and candidate mAbs to be possibly used in a future passive immunotherapy.

scholarly journals Assessment of Live Candidate Vaccines for Paratuberculosis in Animal Models and Macrophages

2009 ◽  
Vol 78 (3) ◽  
pp. 1383-1389 ◽  
Author(s):  
Gabriella M. Scandurra ◽  
Geoffrey W. de Lisle ◽  
Sonia M. Cavaignac ◽  
May Young ◽  
R. Pamela Kawakami ◽  
...  
Keyword(s):  
Side Effects ◽  
Bacterial Load ◽  
Economic Effect ◽  
Cost Effective ◽  
The Other ◽  
Murine Models ◽  
Initial Screening ◽  
Vaccine Candidates ◽  
Allelic Exchange ◽  
Potential Vaccine

ABSTRACT Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the causative agent of paratuberculosis, a chronic enteritis of ruminants. To control the considerable economic effect that paratuberculosis has on the livestock industry, a vaccine that induces protection with minimal side effects is required. We employed transposon mutagenesis and allelic exchange to develop three potential vaccine candidates, which were then tested for virulence with macrophages, mice, and goats. All three models identified the WAg906 mutant as being the most attenuated, but some differences in the levels of attenuation were evident among the models when testing the other strains. In a preliminary mouse vaccine experiment, limited protection was induced by WAg915, as evidenced by a reduced bacterial load in spleens and livers 12 weeks following intraperitoneal challenge with M. paratuberculosis K10. While we found macrophages and murine models to be rapid and cost-effective alternatives for the initial screening of M. paratuberculosis mutants for attenuation, it appears necessary to do the definitive assessment of attenuation with a ruminant model.

Beta-Blocker Attenuates Cardiotoxicity Related Anthracycline Usage

2021 ◽  
Vol 104 (8) ◽  
pp. 1389-1392
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Mortality Rate ◽  
Cancer Patients ◽  
Beta Blocker ◽  
The Other ◽  
Large Numbers ◽  
Therapy Effectiveness ◽  
Chemotherapy Agents

To summarize the recent trials and studies of the role of beta-blocker on the treatment for cancer patients treated with anthracycline to decrease morbidity and mortality rate. Good management of cancer will result in large numbers of cancer survivors. On the other hand, cancer therapy also has side effects, one of which is cardiotoxicity. Cardiotoxicity could reduce therapy effectiveness, hence, increase disease progression and mortality rate. Anthracyclines is one of the chemotherapy agents with cardiotoxicity as a side effect. Beta-blocker has the ability to reduce cardiotoxicity due to anthracyclines usage. Keywords: Beta-blocker; Cardiotoxicity; Anthracyclines

A trial construction of high durability railway viaducts with local aggregates

2019 ◽  
Author(s):  
Kotaro Kawamura ◽  
Joe Takemura ◽  
Shigenobu Iguchi ◽  
Tsutomu Yoshida ◽  
Masashi Kobayashi
Keyword(s):  
Fly Ash ◽  
Side Effects ◽  
Portland Cement ◽  
Ordinary Portland Cement ◽  
The Other ◽  
Strength Concrete ◽  
High Durability ◽  
Sound Barrier ◽  
Early Strength ◽  
Structural Measure

<p>We are carrying out a construction project of new railroad viaducts. These new railroad viaducts are constructing using about 110,000 m<span>3</span> volume concrete. In this construction place, it is difficult for us to get low ASR-reactive aggregates and it is expected to be supplied with snowmelt water on the viaducts in winter. Then we tested ASR-reactive these local aggregates and found an effective mixed ratio of fly-ash is 20% of cement. On the other hand, various side effects were also expected by using fly-ash. For example, initial cracking due to contraction, early strength concrete, bleeding, etc. Therefore, we repeated various tests and examined and carried out a method that could ensure the same construction method and quality as when using ordinary Portland cement, even with fly-ash. Also, we adopted a structure that is unlikely to be affected by rainwater as a structural measure. For example, the entire adoption of a ramen type viaduct that has eliminated bearings, adoption of FRP sound barrier, etc. Then we made it possible to build highly durable railway viaducts by these various measures of materials and structures.</p>

A Double-Blind Comparative Clinical Trial of Floctafenine and Four Other Analgesics Conducted in General Practice

1976 ◽  
Vol 4 (3) ◽  
pp. 179-182 ◽  
Author(s):  
D M Lomas ◽  
J Gay ◽  
R N Midha ◽  
D L Postlethwaite
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Analgesic Effect ◽  
Rank Order ◽  
Controlled Trial ◽  
The Other ◽  
Double Blind ◽  
Comparative Clinical Trial

Three hundred and twelve patients suffering from painful conditions were admitted to a multicentre, double-blind controlled trial, conducted in general practice in which five analgesics—floctafenine (Idarac), paracetamol, aspirin, dihydrocodeine and pentazocine—were compared. Overall ratings of analgesic effect placed floctafenine first in rank order. Floctafenine was statistically significantly superior in effect to pentazocine but not to the other three agents as far as doctor ratings were concerned; and superior to both pentazocine and dihydrocodeine in the opinion of patients. Fewer patients experienced side-effects on floctafenine than on the other four analgesics and this difference between floctafenine and pentazocine, and floctafenine and dihydrocodeine was statistically significant.

scholarly journals Lunar

JOGED ◽  
2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Dewi Sinta Fajawati
Keyword(s):  
Full Moon ◽  
Big Bang ◽  
The Other ◽  
The Sun ◽  
The Moon ◽  
Big Bang Theory ◽  
Essential Idea ◽  
Visual Reaction ◽  
Night Sky ◽  
The One

Bulan merupakan sumber inspiratif dalam penggarapan karya tari ini. Secara ilmu pengetahuan, Bulan adalah benda langit yang disebut satelit, satelit satu-satunya yang dimiliki Bumi dan tercipta secara alami. Banyak teori yang mengatakan tentang terbentuknya Bulan, salah satunya adalah teori Big bang atau dentuman besar. Pada dasarnya Bulan hanyalah sebuah Benda besar berbentuk bulat yang tidak bisa bercahaya, cahaya yang kita lihat pada malam hari merupakan refleksi dari cahaya matahari. Akan tetapi keindahannya memang tidak bisa dipungkiri, karena dia paling bercahaya diantara hamparan langit yang gelap. Cahayanya tidak selalu terang, bahkan tidak selalu bulat, terkadang hanya terlihat setengah atau terlihat seperti sabit..            Penata tari memetaforakan objek bulan yang berada di tempat yang sangat tinggi sebagai sebuah cita-cita yang ingin dicapai. Seringkali lagu anak-anak yang menjadi pengalaman auditif penata tari, menjadikan bulan sebagai objek yang ingin digapai, misal lagu ‘Ambilkan Bulan Bu’. Namun intisari yang akan dipakai dalam penggarapan koregrafinya adalah tentang fase bulan yang tercipta. Bersumber dari rangsang awal melihat bulan atau rangsang visual, penata tari menginterpretasikan fase-fase bulan yang terjadi sebagai fase kehidupan yang dijalani untuk menggapai sebuah cita-cita tersebut.            Koreografi diwujudkan dalam bentuk kelompok dengan membagi dua karate penari. Delapan penari merupakan simbolisasi Bulan, dan satu penari sebagai manusia yang bercita-cita. Dengan bentuk tari dramatik, penyajiannya dibagi menjadi 5 adegan, yaitu Introduksi Big bang, Adegan 1 Moon happen, Adegan 2 Mengejar Impian, Adegan 3 Dancing with Moon, dan Ending ‘Catch Your Dream’. The moon is the essential inspirations of this choreograph. Theoretically, the moon is a sky object which is called as satellite. The one and only naturally created satellite belongs to the planet Earth. There are many theories that explain how the moon was created. One of those theories is Big Bang theory or massive crash. Basically, the moon is just a huge circle thing which is unable to shine its glow. The light that we experience in the evening is the reflection of the sun. However, thebeauty of the moonlight is undeniable as it has the significant light within the darkest night sky. Its light is not always the strongest, even it’s not always circle (full), every so often it is seemed only the half part of it or crescent moon.            The choreographer interpreted the moon that belongs in the highest as the goals that she wants to reach. Most of the time, the children songs (lullaby) that pick the moon as the main object that is desired to be reached, for example the song “Ambilkan Bulan, Bu”. The essential idea that is explored in this choreograph is the creational phase of the moon itself. It was started by way of visual reaction when the choreographer observed the moon, she interpret the moon’s phases as the phases in human’s life which are gone through to reaching their goals. Fall and recovery, passionate, and even sometimes they give it in, are interpreted from the moonlight. The full moon which has the brightest and the most perfect light is likened as the strong spirit. The crescent moon with its soft light is interpreted as low spirit and unconfident.             This in-group-choreograph is separated into two characters with 8 female dancers that are the symbolization of the moon and the other one female dancer symbolizes a human with aspire. With dramatic dance form, this choreograph is presented into five parts, including introduction part of Big Bang, Moon Happen in part one, Chasing Dream is part two, Dancing With The Moon in part three, Catch Your Dream in the ending part.

scholarly journals AKTUALISASI REVOLUSI MENTAL DALAM PENGELOLAAN DANA DESA (ANALISIS TAFSIR EKONOMI Q.S.YUSUF [12]: 55)

2020 ◽  
Vol 5 (2) ◽  
pp. 226-246
Author(s):  
Muhammad Amin ◽  
Azima Azima
Keyword(s):  
Side Effects ◽  
The Other ◽  
Other Hand ◽  
The Village

Dana Desa are one of the most effective policies in village development with the completion of various kinds of infrastructure in the village. On the other hand, this policy caused side effects in the form of criminal acts of corruption against these funds. Through the interpretation of Q.S. Yusuf verse 55, the author offers the actualization of the spirit of mental revolution in the management of village funds through measures to strengthen integrity, increase professionalism, innovation, responsibility, and broaden horizons. Through these steps, the village fund policy can be implemented completely and right on target.

Solar Motion and Lunar Eclipses in Philolaus’ Cosmological System

Apeiron ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Dirk L. Couprie
Keyword(s):  
The Other ◽  
The Sun ◽  
The Moon ◽  
Internal Logic ◽  
Wrong Side ◽  
The Earth ◽  
Solar Motion ◽  
Length Of The Day

Abstract In this paper, three problems that have hardly been noticed or even gone unnoticed in the available literature in the cosmology of Philolaus are addressed. They have to do with the interrelationships of the orbits of the Earth, the Sun, and the Moon around the Central Fire and all three of them constitute potentially insurmountable obstacles within the context of the Philolaic system. The first difficulty is Werner Ekschmitt’s claim that the Philolaic system cannot account for the length of the day (νυχϑήμερον). It is shown that this problem can be solved with the help of the distinction between the synodic day and the sidereal day. The other two problems discussed in this paper are concerned with two hitherto unnoticed deficiencies in the explanation of lunar eclipses in the Philolaic system. The Philolaic system cannot account for long-lasting lunar eclipses and according to the internal logic of the system, during lunar eclipses the Moon enters the shadow of the Earth from the wrong side. It is almost unbelievable that nobody, from the Pythagoreans themselves up to recent authors, has noticed these two serious deficiencies, and especially the latter, in the cosmology of Philolaus the Pythagorean.

Mysticism

1999 ◽  
pp. 185-204
Author(s):  
Louis Jacobs
Keyword(s):  
The Other ◽  
The Moon ◽  
Jewish Mysticism ◽  
The Creation ◽  
Mystical Theology

This chapter highlights Jewish mysticism. It talks about Rabbi Yitshak Horowitz, also known as Reb Yitshak Masmid who is a leading exponent of mystical theology in the Habad vein. Reb Yitshak Masmid seemed to be a typical ascetic whose head reached to the heavens. He ate very little but drank heavily in the belief that alcohol could act as a stimulant to the deeper longings of the soul. The chapter also describes the traditional ceremony of the benediction over the moon (kidush levanah), which is considered to be a mystical rite. In this ceremony, carried out preferably in the open, at the beginning of the month, a benediction is recited in which God is praised for the creation of the moon and the other heavenly bodies.

The New Messengers

2021 ◽  
pp. 36-52
Author(s):  
Gianfranco Bertone
Keyword(s):  
Gravitational Waves ◽  
Nobel Prize ◽  
Direct Contact ◽  
Thin Shell ◽  
Electromagnetic Waves ◽  
Scientific Community ◽  
The Other ◽  
The Moon ◽  
New Era ◽  
The Universe

I present the momentous discovery of gravitational waves, announced in 2016, starting from a confused Einstein who in 1936 tries to convince the scientific community that gravitational waves cannot exist (!), and then illustrating the extraordinary insights and breakthroughs that led 2017 Nobel Prize winners B. Barish, K. Thorne and R. Weiss to open an entirely new window on the Universe. This achievement has marked the beginning of a new era in science, and upcoming experiments have the potential to truly revolutionize our understanding of the Universe. Accounts of the perception of extra-terrestrial reality with senses beyond sight, such as those offered by astronauts who have been on the Moon, are exceedingly rare. That is hardly unsurprising: touch and taste require direct contact, while hearing and smell operate only over short distances, and are in any case confined to the Earth’s thin shell of atmosphere. Sight, on the other hand, allows us to collect the electromagnetic waves emitted by extraordinarily remote celestial objects.

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