In Vitro Studies on Antibiotic Susceptibility Pattern of Methicillin Resistant and Sensitive Staphylococcus Aureus Isolates = دراسات معملية على حساسية عزالات من الميكروبات Staphylococcus Aureus المقاومة و الحساسة للميثاسيلين للمضادات الحيوية

2014 ◽  
Vol 23 (3) ◽  
pp. 1-8
Author(s):  
El-Hamahmy A. F. ◽  
Soheir Abdel-Latif Eissa ◽  
Safaa Shawky Hassan
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Susceptibility ◽  
In Vitro Studies ◽  
Susceptibility Pattern ◽  
Antibiotic Susceptibility Pattern ◽  
Methicillin Resistant

scholarly journals Antibiotic susceptibility pattern of staphylococcus aureus and methicillin-resistant staphylococcus aureus in a tertiary care hospital

2014 ◽  
Vol 4 (7) ◽  
pp. 548-551 ◽  
Author(s):  
CP Bhatt ◽  
BMS Karki ◽  
B Baral ◽  
S Gautam ◽  
A Shah ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Susceptibility ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Penicillin G ◽  
Care Hospital ◽  
Age Group ◽  
Susceptibility Pattern ◽  
Antibiotic Susceptibility Pattern ◽  
Methicillin Resistant ◽  
Drug Of Choice

Background: Methicillin resistant Staphylococcus aureushas emerged as one of the most important nosocomial pathogens. It invokes a tremendous financial burden and enhanced morbidity and mortality due to difficult to treat systemic infections.Aim of this study was to determine antibiotic susceptibility pattern of Staphylococcus aureus and Methicillin resistant Staphylococcus aureus. Materials and Methods: Different clinical specimens were collected and processed for routine culture and antibiotic sensitivity test by standard microbiology techniques. Results: Out of 1173 samples received for microbiological examination, 100 were found to be S. aureus with 19% cases were Methicillin resistant Staphylococcus aureus (MRSA). Fourteen MRSA were found from inpatient and 5 were from outpatient. MRSA was found higher in female than male and maximum number (31.5%) was found in age group 0-10 years. Staphylococcus aureus was 100% sensitive to Vancomycin followed by Amikacin (90%), Gentamycin (83%), and tetracycline (81%). On urine isolates Nitrofurantoin(91.6%) was drug of choice. All the isolates were resistant to Penicillin G. In case of Methicillin resistant Staphylococcus aureus showed 100% sensitive to Vancomycin followed by Amikacin (84.2%), Tetracycline (63.1%), Ciprofloxacin (42%) and Gentamycin (36.8%). Among urine isolates Nitrofutantoin showed 87.5% sensitive followed by Norfloxacin (75%). Conclusion: Methicillin resistant Staphylococcus aureus was found 19% of Staphylococcus aureus isolates. It was most common in females, hospitalized patients and young age group. Vancomycin seems to be drug of choice followed by Amikacin. It would be helpful to formulating and monitoring the antibiotic policy and ensure proper empiric treatment. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10297 Journal of Pathology of Nepal (2014) Vol. 4, 548-551   

scholarly journals Antibiotic Susceptibility Pattern of Methicillin-Resistant Staphylococcus aureus from the Isolated Wound Culture in the Northwest Region, Kingdom of Saudi Arabia

2016 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Ibrahim Al Balawi ◽  
Palanisamy Amirthalingam ◽  
Abdullah Abdul Khalig Alyoussef ◽  
Osama Salih Mohammed ◽  
Hyder Oman Mirghani ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Saudi Arabia ◽  
Fusidic Acid ◽  
Antibiotic Susceptibility ◽  
Susceptibility Pattern ◽  
Kingdom Of Saudi Arabia ◽  
Antibiotic Susceptibility Pattern ◽  
Methicillin Resistant ◽  
Surgical Department ◽  
Significant Difference

The present study aimed to investigate the antibiotic susceptibility pattern of Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) in isolated wound cultures of the patients admitted in King Khalid Hospital, Tabuk, Kingdom of Saudi Arabia. A retrospective cohort study of 54 patients admitted with wound infections in the surgical department. Ethics committee approval was granted by the University of Tabuk and King Khalid Hospital, Kingdom of Saudi Arabia. Fifty-four adult patients (&gt;18 years old) diagnosed with moderate to severe skin and soft tissue infections were included in the study. 26 patients with isolated cultures of MRSA were compared with 28 patients with Methicillin-sensitive <em>Staphylococcus aureus</em> (MSSA) isolated cultures using Graph pad prism 4.0 version statistical databases. Overall, there was no significant difference in sensitivity (P = 0.2445) and resistance (P = 0.4215) between MRSA and MSSA cultures. However, it is interesting findings that Oxacillin and Fusidic acid had higher resistance in MRSA isolated cultures compared MSSA culture, on the other hand, Linezolid, Tigecycline and Nitrofurantoin shows 100% sensitivity in both MRSA and MSSA isolates. No significant difference between male and female regarding the sensitivity (P = 0.0638) and resistance (P = 0.3638). The current study emphasizes that Tigecycline, Nitrofurantoin and Fusidic acid were the best drugs in both MRSA and MSSA isolates. While, oxacillin showed 100% resistance to MRSA; but retain its efficacy on MSSA isolates.

scholarly journals The Prevalence and the Resistance Profile of Methicillin-Resistant Staphylococcus aureus Colonized in the Nostrils of Cancer Patients in Namazi Teaching Hospital, Shiraz, Iran, 2011-12

2015 ◽  
Vol 4 (1) ◽  
pp. 21-25
Author(s):  
Mohammad Reza Kandehkar Ghahraman ◽  
Razyeh Hassanzadeh ◽  
Mohammad Motamedifar ◽  
Abdolsamad Ashrafzadeh ◽  
Zahra Hashemizadeh
Keyword(s):  
Staphylococcus Aureus ◽  
Cancer Patients ◽  
Antibiotic Susceptibility ◽  
Resistance Pattern ◽  
Susceptibility Pattern ◽  
In Vitro Susceptibility ◽  
Disk Diffusion Test ◽  
Vast Number ◽  
Methicillin Resistant

Background: Methicillin-resistant (MRSA) Staphylococcus aureus (S. aureus) are responsible for a vast number of nosocomial infections especially in immunocompromised subjects such as cancer patients. The presence of comorbidities including malignancies has been associated, with S. aureus bacteremia mortality. Thus, the detection of MRSA in this patients and the antibiotic susceptibility pattern of the isolates eases the selection of first-line medications and the prevention from further complications in cancer patients. The aim of this study was to determine the prevalence of MRSA infection and antibiotic susceptibility patterns of the isolates in pre and post-chemotherapy course in cancer patients.Materials and Methods: From May 2011 to July 2012, 200 nostril samples of cancerous patients were obtained and cultured on blood agar plates. After isolation and confirmation of S. aureus, antibiotic resistance pattern of the isolates was determined pre-chemotherapy and after the chemotherapy against vancomycin, tigecycline, linezolid, chloramphenicol, and oxacillin using disk diffusion test following CLSI guidelines. Chi-square test was used for data analysis.Results: Among a total number of 200 various cancer patients (64.5% females), 42 (21%) cases were positive for S. aureus and 7 (3.5 %) were MRSA carriers. Mean ages of MSSA and MRSA infected patients were 50.97±15.94 and 53.57±18.28 years old, respectively. In vitro susceptibility pattern of the MRSA and MSSA isolates to the 4 tested agents did not differed significantly after the chemotherapy in contrast with pre-chemotherapy state.Conclusions: This study showed that chemotherapy does not change the susceptibility pattern of MRSA species to antibiotics of choice in cancer patients. However, the importance of controlling methicillin resistant staphylococcal infections in critical cases, specifically cancer cases, necessitates the early detection, further investigations on more effective medications.

scholarly journals Antibiotic Susceptibility Pattern of Methicillin-Resistant Staphylococcus aureus from the Isolated Wound Culture in the Northwest Region, Kingdom of Saudi Arabia

2016 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Ibrahim Al Balawi ◽  
Palanisamy Amirthalingam ◽  
Abdullah Abdul Khalig Alyoussef ◽  
Osama Salih Mohammed ◽  
Hyder Oman Mirghani ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Saudi Arabia ◽  
Fusidic Acid ◽  
Antibiotic Susceptibility ◽  
Susceptibility Pattern ◽  
Kingdom Of Saudi Arabia ◽  
Antibiotic Susceptibility Pattern ◽  
Methicillin Resistant ◽  
Surgical Department ◽  
Significant Difference

The present study aimed to investigate the antibiotic susceptibility pattern of Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) in isolated wound cultures of the patients admitted in King Khalid Hospital, Tabuk, Kingdom of Saudi Arabia. A retrospective cohort study of 54 patients admitted with wound infections in the surgical department. Ethics committee approval was granted by the University of Tabuk and King Khalid Hospital, Kingdom of Saudi Arabia. Fifty-four adult patients (&gt;18 years old) diagnosed with moderate to severe skin and soft tissue infections were included in the study. 26 patients with isolated cultures of MRSA were compared with 28 patients with Methicillin-sensitive <em>Staphylococcus aureus</em> (MSSA) isolated cultures using Graph pad prism 4.0 version statistical databases. Overall, there was no significant difference in sensitivity (P = 0.2445) and resistance (P = 0.4215) between MRSA and MSSA cultures. However, it is interesting findings that Oxacillin and Fusidic acid had higher resistance in MRSA isolated cultures compared MSSA culture, on the other hand, Linezolid, Tigecycline and Nitrofurantoin shows 100% sensitivity in both MRSA and MSSA isolates. No significant difference between male and female regarding the sensitivity (P = 0.0638) and resistance (P = 0.3638). The current study emphasizes that Tigecycline, Nitrofurantoin and Fusidic acid were the best drugs in both MRSA and MSSA isolates. While, oxacillin showed 100% resistance to MRSA; but retain its efficacy on MSSA isolates.

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