scholarly journals Antibiotic Susceptibility Pattern of Methicillin-Resistant Staphylococcus aureus from the Isolated Wound Culture in the Northwest Region, Kingdom of Saudi Arabia

2016 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Ibrahim Al Balawi ◽  
Palanisamy Amirthalingam ◽  
Abdullah Abdul Khalig Alyoussef ◽  
Osama Salih Mohammed ◽  
Hyder Oman Mirghani ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Saudi Arabia ◽  
Fusidic Acid ◽  
Antibiotic Susceptibility ◽  
Susceptibility Pattern ◽  
Kingdom Of Saudi Arabia ◽  
Antibiotic Susceptibility Pattern ◽  
Methicillin Resistant ◽  
Surgical Department ◽  
Significant Difference

The present study aimed to investigate the antibiotic susceptibility pattern of Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) in isolated wound cultures of the patients admitted in King Khalid Hospital, Tabuk, Kingdom of Saudi Arabia. A retrospective cohort study of 54 patients admitted with wound infections in the surgical department. Ethics committee approval was granted by the University of Tabuk and King Khalid Hospital, Kingdom of Saudi Arabia. Fifty-four adult patients (&gt;18 years old) diagnosed with moderate to severe skin and soft tissue infections were included in the study. 26 patients with isolated cultures of MRSA were compared with 28 patients with Methicillin-sensitive <em>Staphylococcus aureus</em> (MSSA) isolated cultures using Graph pad prism 4.0 version statistical databases. Overall, there was no significant difference in sensitivity (P = 0.2445) and resistance (P = 0.4215) between MRSA and MSSA cultures. However, it is interesting findings that Oxacillin and Fusidic acid had higher resistance in MRSA isolated cultures compared MSSA culture, on the other hand, Linezolid, Tigecycline and Nitrofurantoin shows 100% sensitivity in both MRSA and MSSA isolates. No significant difference between male and female regarding the sensitivity (P = 0.0638) and resistance (P = 0.3638). The current study emphasizes that Tigecycline, Nitrofurantoin and Fusidic acid were the best drugs in both MRSA and MSSA isolates. While, oxacillin showed 100% resistance to MRSA; but retain its efficacy on MSSA isolates.

scholarly journals Antibiotic Susceptibility Pattern of Methicillin-Resistant Staphylococcus aureus from the Isolated Wound Culture in the Northwest Region, Kingdom of Saudi Arabia

2016 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Ibrahim Al Balawi ◽  
Palanisamy Amirthalingam ◽  
Abdullah Abdul Khalig Alyoussef ◽  
Osama Salih Mohammed ◽  
Hyder Oman Mirghani ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Saudi Arabia ◽  
Fusidic Acid ◽  
Antibiotic Susceptibility ◽  
Susceptibility Pattern ◽  
Kingdom Of Saudi Arabia ◽  
Antibiotic Susceptibility Pattern ◽  
Methicillin Resistant ◽  
Surgical Department ◽  
Significant Difference

The present study aimed to investigate the antibiotic susceptibility pattern of Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) in isolated wound cultures of the patients admitted in King Khalid Hospital, Tabuk, Kingdom of Saudi Arabia. A retrospective cohort study of 54 patients admitted with wound infections in the surgical department. Ethics committee approval was granted by the University of Tabuk and King Khalid Hospital, Kingdom of Saudi Arabia. Fifty-four adult patients (&gt;18 years old) diagnosed with moderate to severe skin and soft tissue infections were included in the study. 26 patients with isolated cultures of MRSA were compared with 28 patients with Methicillin-sensitive <em>Staphylococcus aureus</em> (MSSA) isolated cultures using Graph pad prism 4.0 version statistical databases. Overall, there was no significant difference in sensitivity (P = 0.2445) and resistance (P = 0.4215) between MRSA and MSSA cultures. However, it is interesting findings that Oxacillin and Fusidic acid had higher resistance in MRSA isolated cultures compared MSSA culture, on the other hand, Linezolid, Tigecycline and Nitrofurantoin shows 100% sensitivity in both MRSA and MSSA isolates. No significant difference between male and female regarding the sensitivity (P = 0.0638) and resistance (P = 0.3638). The current study emphasizes that Tigecycline, Nitrofurantoin and Fusidic acid were the best drugs in both MRSA and MSSA isolates. While, oxacillin showed 100% resistance to MRSA; but retain its efficacy on MSSA isolates.

Description of Antibiotic Susceptibility Pattern Analysis on Methicillin-Susceptible Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus Clothing Gene Panton-Valentine Leukocidin from Clinic Isolate

2020 ◽  
Vol 17 (7) ◽  
pp. 3085-3091
Author(s):  
Yoeke Dewi Rasita ◽  
Kuntaman ◽  
Kartuti Debora
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Susceptibility ◽  
High Rate ◽  
Gene Carrier ◽  
Susceptibility Pattern ◽  
Bacterial Strains ◽  
Antibiotic Susceptibility Pattern ◽  
Methicillin Resistant ◽  
Significant Difference ◽  
Carrier Strain

Staphylococcus aureus is the most common cause of health care acquired infection and has a high rate of morbidity and mortality. S. aureus has a number of virulent factors that facilitate these bacteria to adhesion to the tissues of the host, avoiding the body’s defense system, and damaging the host cell. PVL cytotoxin is one of the virulent factors that causes hypervirulent in S. aureus. The infections caused are varied, ranging from severe skin infections, peneumonia, and sepsis. To obtain a description of the antibiotic susceptibility pattern in Methicillin-sensitive Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococcus aureus (MRSA) carriers of the pvl gene that causes infection. Isolate S. aureus derived from clinical isolates of inpatients who have identified and tested phenotypic antibiotic susceptibility using BD Phoenix TM Automated Microbiology System or Vitek2 Compact bioMérieux system followed by genotypic testing using PCR to detect the presence of the pvl gene. Of 85 S. aureus isolates, 65 isolates (76.5%) included MSSA bacterial strains and 20 isolates (23.5%) including strains of MRSA bacteria. Of the 65 isolates of MSSA bacterial strains, 9 isolates (13.84%) had the pvl gene, and of the 20 isolates of the MRSA strain, 1 isolate (5%) had the pvl gene. The susceptibility of non betalactam antibiotics to MSSA virus strains of pvl gene carriers ranged from 77.8%-100%. MSSA bacterial strains that did not carry the pvl gene also showed a non-betallactam antibiotic susceptibility ranging from 69.1%-100%. The susceptibility of tetracycline antibiotics to both MSSA strains of both pvl and non-carriers of pvl genes was 55.6% and 39.3% respectively. There was no significant difference between the antibiotic susceptibility pattern in the MSSA carrier strain of the pvl gene carrier and the proportion of the MRSA carrier strain of the pvl gene carrier.

scholarly journals Prevalence and antibiotic susceptibility pattern of methicillin resistant Staphylococcus aureus at Armed Forces Hospital in Saudi Arabia

2009 ◽  
Vol 35 (1) ◽  
pp. 28-30 ◽  
Author(s):  
Shamweel Ahmad ◽  
Faris Q. Alenzi ◽  
Nami Fawazan Al-Juaid ◽  
Shad Ahmed
Keyword(s):  
Staphylococcus Aureus ◽  
Saudi Arabia ◽  
Antibiotic Susceptibility ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Armed Forces ◽  
Susceptibility Pattern ◽  
Antibiotic Susceptibility Pattern ◽  
Methicillin Resistant

Keywords: Antibiotic; Armed Forces Hospital; Methicillin resistant; Saudi Arabia; Staphylococcus aureusOnline: 22 May 2009DOI: 10.3329/bmrcb.v35i1.1983Bangladesh Med Res Counc Bull 2009; 35: 28-30

scholarly journals Antibiotic susceptibility pattern of staphylococcus aureus and methicillin-resistant staphylococcus aureus in a tertiary care hospital

2014 ◽  
Vol 4 (7) ◽  
pp. 548-551 ◽  
Author(s):  
CP Bhatt ◽  
BMS Karki ◽  
B Baral ◽  
S Gautam ◽  
A Shah ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Susceptibility ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Penicillin G ◽  
Care Hospital ◽  
Age Group ◽  
Susceptibility Pattern ◽  
Antibiotic Susceptibility Pattern ◽  
Methicillin Resistant ◽  
Drug Of Choice

Background: Methicillin resistant Staphylococcus aureushas emerged as one of the most important nosocomial pathogens. It invokes a tremendous financial burden and enhanced morbidity and mortality due to difficult to treat systemic infections.Aim of this study was to determine antibiotic susceptibility pattern of Staphylococcus aureus and Methicillin resistant Staphylococcus aureus. Materials and Methods: Different clinical specimens were collected and processed for routine culture and antibiotic sensitivity test by standard microbiology techniques. Results: Out of 1173 samples received for microbiological examination, 100 were found to be S. aureus with 19% cases were Methicillin resistant Staphylococcus aureus (MRSA). Fourteen MRSA were found from inpatient and 5 were from outpatient. MRSA was found higher in female than male and maximum number (31.5%) was found in age group 0-10 years. Staphylococcus aureus was 100% sensitive to Vancomycin followed by Amikacin (90%), Gentamycin (83%), and tetracycline (81%). On urine isolates Nitrofurantoin(91.6%) was drug of choice. All the isolates were resistant to Penicillin G. In case of Methicillin resistant Staphylococcus aureus showed 100% sensitive to Vancomycin followed by Amikacin (84.2%), Tetracycline (63.1%), Ciprofloxacin (42%) and Gentamycin (36.8%). Among urine isolates Nitrofutantoin showed 87.5% sensitive followed by Norfloxacin (75%). Conclusion: Methicillin resistant Staphylococcus aureus was found 19% of Staphylococcus aureus isolates. It was most common in females, hospitalized patients and young age group. Vancomycin seems to be drug of choice followed by Amikacin. It would be helpful to formulating and monitoring the antibiotic policy and ensure proper empiric treatment. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10297 Journal of Pathology of Nepal (2014) Vol. 4, 548-551   

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