scholarly journals Unicentric Castleman Disease and Pheochromocytoma

Author(s):  
Rosana Maia ◽  
Joana Couto ◽  
José Diogo Martins ◽  
Edgar Torre ◽  
Diana Guerra

Castleman disease is an uncommon and heterogenous lymphoproliferative disorder which is classified as unicentric or multicentric depending on the number of lymph nodes involved. Each type has a different clinical presentation, aetiology, treatment and prognosis. We report the case of a young woman who presented with cervical lymphadenopathy and a retroperitoneal mass, and was diagnosed with unicentric Castleman disease and pheochromocytoma. We describe the diagnostic steps, the complications that developed, and the importance of the differential diagnosis in the evaluation of these patients.

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Dhouha Bacha ◽  
Beya Chelly ◽  
Houda Kilani ◽  
Lamia Charfi ◽  
Amel Douggaz ◽  
...  

HHV8/EBV-associated germinotropic lymphoproliferative disorder (GLD) is a challenging diagnosis given its rarity, the particular clinical presentation, and the lack of expression of markers usually used in establishing hematopoietic lineage. We report a new case of HHV8/EBV GLD in an immunocompetent 78-year-old woman. The diagnosis was made in an incidentally discovered lymphadenopathy. Histological examination showed a nodular lymphoid proliferation centered by aggregates of atypical plasmablastic cells admixed with small lymphoid cells. Tumor cells were strongly positive with EMA, HHV8, LMP1, CD38, CD138, and kappa light chains. They were negative with common lymphoma-associated markers (CD20, CD3, CD15, CD30, CD10, and bcl2). In situ hybridization confirmed the monotypic kappa light chains and the EBV infection (EBER+). A polyclonal pattern of Ig gene rearrangement was detected by PCR analysis. In the adjacent lymph node parenchyma, some germinal centers mimicked Castleman disease. In this case, the differential diagnosis was discussed with an early stage of large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease. The clinical presentation, the immunophenotype, and the molecular results helped to make the accurate diagnosis. Through the review of the nine previously reported cases in literature, we discuss the clinical and pathologic features and the differential diagnosis of HHV8/EBV GLD.


2019 ◽  
Vol 4 (4) ◽  

Castleman Disease (CD) is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. There are two types: unicentric and multicentric. Unicentric, hyalinevascular type of Castleman’s disease can be treated successfully with complete surgical resection with monitoring for reoccurrence. Here we report a case of a patient originally diagnosed with sarcoidosis who was found to have Unicentric Castleman’s disease.


2017 ◽  
Vol 17 (2) ◽  
pp. 41-44 ◽  
Author(s):  
Mohanad Abusultan ◽  
Pavel Hanzel ◽  
D. Durcansky ◽  
A. Hajtman

AbstractProstate cancer usually metastasis to the regional lymph nodes and can rarely metastases to nonregional supradiaphragmatic lymph nodes. Cervical lymph node metastasis of prostate cancer is extremely rare. However, it should be considered in the differential diagnosis of cervical lymphadenopathy in male patients with adenocarcinoma of unknown primary site. In this report we present a rare case of metastatic prostate adenocarcinoma with left supraclavicular lymphadenopathy as the only clinical presentation with no other evidence of metastasis to the regional lymph nodes or bone metastasis.


Author(s):  
Mohammed Arafath Ali ◽  
◽  
Ramachandra C ◽  
Uday Karjol ◽  
Ravi Arjunan ◽  
...  

Castleman Disease (CD) is a rare non-clonal lymphoproliferative disorder. The clinical presentation of CD often overlaps with autoimmune, infectious, or other malignant diseases. The diagnosis is confirmed by a biopsy of the affected lymph-node tissue. A 39-year-old gentleman was evaluated for intractable abdominal pain fatigue of 2 months duration. CT scan showed a 4 X 4 X 5 cm right suprarenal mass. Laparotomy and near total excision was performed which showed reactive B cells expressing CD20 and PAX5, favoring CD. Patient received adjuvant 6 cycles of Rituximab and steroids. A follow up CT scan after 3 months showed a near complete resolution.


Author(s):  
Aída Gil-Díaz ◽  
Raju Daryanani-Daryanani ◽  
Rafael Estevez-Dominguez ◽  
Jose Gil-Reyes ◽  
Carlos Santana-Perez

Kikuchi-Fujimoto's disease is a self-limiting and rare disorder of unknown aetiology. The typical presentation includes fever, cervical lymphadenopathy and night sweats. Consequently, it is part of the differential diagnosis of infectious, lymphoproliferative and connective tissue diseases. Histology demonstrates necrotizing histiocytic lymphadenitis. Treatment is symptomatic with non-steroidal antiinflammatory agents, although there are reports of corticosteroid use in complicated cases. We present the case of a 23-year-old woman admitted to hospital for fever and cervical lymphadenopathies, and diagnosed with Kikuchi-Fujimoto's disease.


2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jane Date Hon ◽  
Maria Vergara-Lluri ◽  
Imran Siddiqi ◽  
Christopher Foss ◽  
Donald Feinstein ◽  
...  

Kikuchi-Fujimoto disease is a self-limited disease of unknown etiology that is clinically defined by fevers accompanied by tender posterior cervical lymphadenopathy. It often presents acutely or sub-acutely, and due to its non-specific features, the differential diagnosis is broad and includes infectious, autoimmune, and malignant causes. Although cases of extra-cervical disease are not uncommon, involvement of retroperitoneal lymph nodes has only rarely been reported. Here, we describe a patient with Kikuchi-Fujimoto disease who presented with fever of unknown origin, abdominal pain, and enlarged hypermetabolic retroperitoneal lymph nodes.


2014 ◽  
Vol 44 (1) ◽  
pp. 69
Author(s):  
Rina Hayati ◽  
Abdul Rachman Saragih

Latar belakang: tuberkulosis pada saluran nafas atas sangat jarang dijumpai dan biasanya disertai dengan penyakit paru primer. Dengan kemajuan pengobatan tuberkulosis saat ini, infeksi mycobacterium pada tonsil dan nasofaring jarang dijumpai. Limfadenopati servikal merupakan simptom yang sering terjadi, dan seharusnya didiagnosis banding dengan suatu massa di kepala dan leher. Tujuan: untuk menambah pengetahuan dalam mendiagnosis dan menangani tuberkulosis tonsil dan nasofaring yang jarang dijumpai. Kasus: Seorang anak laki-laki 14 tahun dikonsulkan dengan masa dileher bilateral disertai disfagia, demam dan malaise selama satu bulan. Penatalaksanaan: Pasien awalnya kami diagnosis banding sebagai suatu massa di kepala leher. Setelah ditegakkan diagnosis sebagai tuberkulosistonsil dan nasofaring disertai limfadenopati servikal dan tuberkulosis milier, diberikan terapi dengan anti tuberkulosis dan diperoleh hasil yang baik. Kesimpulan: Tuberkulosis sebaiknya dimasukkan sebagai diagnosis banding suatu massa di kepala dan leher terutama jika gambaran klinis dan pencitraan yang dijumpai tidak khas, sementara itu biopsi dan gambaran mikrobiologi selalu harus dipertimbangkan. Kata kunci: tuberkulosis nasofaring, tonsil, millier, limfadenopati. ABSTRACTBackground: Tuberculosis (TB) of the upper aerodigestive tract is rare and is usually associated with primary pulmonary disease. With recent advances in medical treatment of tuberculosis, mycobacterial infection of the nasopharynx and tonsil becomes very rare. The most common presenting symptom is cervical lymphadenopathy, so TB should be considered in the differential diagnosis of soft tissue masses of the head and neck. Purpose: To remind Otolaryngologists about the diagnosis and management of nasopharyngeal and tonsillar tuberculosis, which become rare case nowadays. Case: A 14-year-old boy was consulted with bilateral neck masses, disphagia, fever and malaise for one month. Case Management: At first we made a differential diagnosis of soft tissue masses of the head and neck. After he was diagnosed as nasopharyngeal and tonsilar tuberculosis with cervical lymphadenopathy and millier tuberculosis, the patient was treated with anti tuberculosis medication and the result was  good. Conclusion: TB should be considered in the differential diagnosis of soft tissue masses of the head and neck, particularly when the imaging findings and clinical presentation are atypical, at which point appropriate biopsies and microbiologic studies should be conducted. Keyword : Nasopharyngeal tuberculosis, tonsilar tuberculosis, cervical lymphadenopathy, milliertuberculosis


2020 ◽  
Vol 7 (11) ◽  
Author(s):  
Annabelle Pourbaix ◽  
Romain Guery ◽  
Julie Bruneau ◽  
Estelle Blanc ◽  
Gregory Jouvion ◽  
...  

Abstract We report a case of chronic hepatosplenic aspergillosis following immune reconstitution complicating colic aspergillosis in an AIDS patient with multicentric Castleman disease. Symptoms mimicked the clinical presentation of chronic disseminated candidiasis and responded to corticosteroid. This emerging entity enlarges the spectrum of fungal immune reconstitution inflammatory syndrome in the HIV setting.


2018 ◽  
Vol 21 (1) ◽  
pp. 106
Author(s):  
N. Beydon

Adolescent experiment widespread changes as he/ she goes through this transitional period from childhood to adulthood. Sleep is no exception to this changeover with, as consequences, modifications of the clinical pre- sentation of subjects with Obstructive Sleep Apnea- Hypopnea Syndrome (OSAHS) and potential different alternative diagnosis.


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