Assessment of Coronary Artery Calcification in Hemodialysis Patients Using Multi-Detector Spiral CT Scan

Background/Aim: Vascular calcification is common and contributes to increased cardiovascular mortality in hemodialysis (HD) patients. In this prospective study, we aimed to investigate the associations of serum S100A12 in the presence of severe coronary artery calcification (CAC) and the progression of CAC in HD patients. Methods: Sixty maintenance HD patients and 30 controls were enrolled. Serum S100A12 levels were measured using ELISA. CAC scores (CACs) were measured twice at a 4-year interval using multislice spiral CT. The HD patients were classified as rapid progressors or slow progressors according to the change in the CACs across these 2 measurements (ΔCACs). Results: The incidences of rapid progression of CAC in patients with baseline CACs ≤10, CACs >10 and CACs >400 were 12.5, 40.0 and 64.3%, respectively. Both baseline and 4-year serum S100A12 levels were significantly higher in the rapid progressors than in the slow progressors (medians of 45.6 vs. 30.2 ng/ml, p < 0.001 and 62.3 vs. 39.4 ng/ml, p = 0.002, respectively). The serum S100A12 levels were significantly correlated with baseline CACs (r = 0.466, p < 0.001), 4-year CACs (r = 0.440, p < 0.001) and ΔCACs (r = 0.392, p < 0.001). Importantly, the ΔCACs were significantly correlated with ΔS100A12 levels (r = 0.396, p < 0.001). Logistic regression analysis revealed that the serum S100A12 level was as an independent determinant of the presence of severe CAC and that the increment in the serum S100A12 level was a factor that was significantly independently associated with the progression of CAC. Conclusions: Serum S100A12 levels were significantly associated with the presence of severe CAC, and the increment in serum S100A12 levels was an independent determinant of the progression of CAC.

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Estimation of coronary artery calcium by multislice spiral CT scan in asymptomatic high risk cases above forty (40) years of age

Indian Journal of Forensic and Community Medicine ◽

10.5958/2394-6776.2016.00048.5 ◽

2016 ◽

Vol 3 (3) ◽

pp. 220

Author(s):

Umesh Giradkar ◽

Sandesh Chaudhari ◽

Mandar Ramchandra Sane ◽

Anand B. Mugadlimath ◽

Naresh Kumar

Keyword(s):

Coronary Artery ◽

High Risk ◽

Ct Scan ◽

Coronary Artery Calcium ◽

Spiral Ct ◽

Multislice Spiral Ct ◽

Spiral Ct Scan

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Study of estimation of coronary artery calcium by multi-slice spiral CT scan in post myocardial infarction cases

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20173730 ◽

2017 ◽

Vol 4 (5) ◽

pp. 1293 ◽

Cited By ~ 1

Author(s):

Rajesh V. Gosavi ◽

Milind Vyawahare ◽

Shrigopal Mandhania

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Coronary Artery ◽

Ct Scan ◽

Coronary Artery Calcium ◽

Spiral Ct ◽

Post Myocardial Infarction ◽

Systemic Hypertension ◽

History Of ◽

Spiral Ct Scan

Background: Strong relationship has been demonstrated between the presence of occlusive CAD and coronary artery calcification (CAC) detected at autopsy, fluoroscopy and computed tomography (CT scan). CT scan quantifies the relative burden of CAC deposits as a marker of atherosclerosis. Study explored utility of multi-slice spiral CT scan for detection of CAC in post myocardial infarction cases.Methods: Fifty-one post myocardial infarction cases were enrolled in the study. Detailed clinical history was recorded in every case regarding age, sex, history of risk factors for CAD like systemic hypertension, diabetes mellitus, smoking and family history of CAD. Every case was evaluated for fasting and postprandial blood sugar and fasting lipid profile. Body mass index (BMI) was also calculated. Coronary artery calcium was estimated in each patient by multi -slice spiral CT scan. Conventional angiography was also undertaken in 18 patients. Co-relation of coronary calcium with different age groups, sex, risk factors, electrocardiography and angiography was drawn.Results: Out of 51 cases scanned, 40 cases (78.4%) had detectable CAC. In 30 cases (58.8%), CAC score ranged from 1 to 100 (mild score); 6 cases (11.8%) had score between 101-400 (moderate score) while in 4 cases (7.8%) CAC score was more than 400 (severe score %). For detection of angiographically detectable disease, the sensitivity of multi-slice CT was 100% and the specificity was 33.3%.Conclusions: CAC is a valid measure of atherosclerotic plaque burden and is recommended as a screening tool for demonstrating significant atherosclerosis in susceptible subjects.

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Study of coronary artery calcium by multi-slice spiral CT as a tool for high risk cardiovascular screening

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20173723 ◽

2017 ◽

Vol 5 (9) ◽

pp. 3902

Author(s):

Rajesh V. Gosavi ◽

Madhuri P. Holey ◽

Umesh A. Giradkar

Keyword(s):

Risk Factors ◽

Coronary Artery ◽

High Risk ◽

Ct Scan ◽

Coronary Artery Calcium ◽

Strong Relationship ◽

Spiral Ct ◽

Systemic Hypertension ◽

History Of ◽

Spiral Ct Scan

Background: Strong relationship has been demonstrated between the presence of occlusive CAD and coronary artery calcification (CAC) detected at autopsy, fluoroscopy and computed tomography (CT scan). CT scan quantifies the relative burden of CAC deposits as a marker of atherosclerosis. We explored utility of multi-slice spiral CT scan for detection of CAC as a tool for screening in asymptomatic high-risk cases above 40 years of age.Methods: Fifty-eight asymptomatic cardiovascular high-risk cases were included as per selection criteria. Detailed clinical history was recorded in every case regarding age, sex, history of risk factors for CAD like systemic hypertension, diabetes mellitus, smoking and family history of CAD. Every case was evaluated for fasting and postprandial blood sugar and fasting lipid profile. Body mass index (BMI) was calculated. An ECG was also recorded. Coronary artery calcium was estimated in each patient by multi -slice spiral CT scan. Fifty age and gender matched consenting participants were enrolled as controls and comparisons drawn.Results: Out of 58 cases scanned, 41 had no detectable CAC by multi-slice CT scan whereas in 17 cases (29.2%), calcium was detected. Mean CAC score was observed to increase as number of risk factors increased.Conclusions: Multi-slice CT scan is a useful tool for detection of coronary artery calcium (CAC) when utilised for high risk screening in older adults having one or more known cardiovascular risk factors.

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Comparison of Coronary Artery Calcification in Peritoneal and Hemodialysis Patients

Journal of Experimental & Clinical Medicine ◽

10.1016/j.jecm.2010.12.012 ◽

2011 ◽

Vol 3 (2) ◽

pp. 89-92 ◽

Cited By ~ 2

Author(s):

Chi-Ming Lee ◽

Pzen-Wen Chen ◽

Ting-Kai Leung ◽

Hung-Jung Wang ◽

Ching-Huei Kung ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Calcification ◽

Hemodialysis Patients

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Effect of CT digital image compression on detection of coronary artery calcification

Acta Radiologica ◽

10.1080/028418500127345064 ◽

2000 ◽

Vol 41 (2) ◽

pp. 116-121 ◽

Cited By ~ 4

Author(s):

L.-M. Zheng ◽

S. Sone ◽

Y. Itani ◽

Q. Wang ◽

K. Hanamura ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Calcification ◽

Image Data ◽

Spiral Ct ◽

Diagnostic Value ◽

Ct Images ◽

Detection Accuracy ◽

Characteristic Analysis ◽

High Attenuation ◽

Significant Difference

Purpose: To test the effect of digital compression of CT images on the detection of small linear or spotted high attenuation lesions such as coronary artery calcification (CAC). Material and Methods: Fifty cases with and 50 without CAC were randomly selected from a population that had undergone spiral CT of the thorax for screening lung cancer. CT image data were compressed using JPEG (Joint Photographic Experts Group) or wavelet algorithms at ratios of 10:1, 20:1 or 40:1. Five radiologists reviewed the uncompressed and compressed images on a cathode-ray-tube. Observer performance was evaluated with receiver operating characteristic analysis. Results: CT images compressed at a ratio as high as 20:1 were acceptable for primary diagnosis of CAC. There was no significant difference in the detection accuracy for CAC between JPEG and wavelet algorithms at the compression ratios up to 20:1. CT images were more vulnerable to image blurring on the wavelet compression at relatively lower ratios, and "blocking" artifacts occurred on the JPEG compression at relatively higher ratios. Conclusion: JPEG and wavelet algorithms allow compression of CT images without compromising their diagnostic value at ratios up to 20:1 in detecting small linear or spotted high attenuation lesions such as CAC, and there was no difference between the two algorithms in diagnostic accuracy.

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