A genome-wide association study for body weight in Japanese Thoroughbred racehorses clarifies candidate regions on chromosomes 3, 9, 15, and 18

ABSTRACTDelay discounting (DD), which is the tendency to discount the value of delayed versus current rewards, is elevated in a constellation of diseases and behavioral conditions. We performed a genome-wide association study of DD using 23,127 research participants of European ancestry. The most significantly associated SNP was rs6528024 (P = 2.40 × 10−8), which is located in an intron of the gene GPM6B. We also showed that 12% of the variance in DD was accounted for by genotype, and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition, and body weight.

Download Full-text

Genome-Wide Association Study of Weaning Traits in Lori-Bakhtiari Sheep

Annals of Animal Science ◽

10.2478/aoas-2020-0014 ◽

2020 ◽

Vol 20 (3) ◽

pp. 811-824

Author(s):

Mohammad Almasi ◽

Pouya Zamani ◽

Seyed Ziaeddin Mirhoseini ◽

Mohammad Hossein Moradi

Keyword(s):

Body Weight ◽

Association Study ◽

Growth Performance ◽

Candidate Genes ◽

Genome Wide Association Study ◽

Genome Wide Association ◽

Breeding Values ◽

Genome Wide ◽

A Genome ◽

Meat Type

AbstractWeaning traits, including preweaning daily gain (PWDG) and weaning weight (WW) are important economic traits, especially for meat type mammals, with high impacts on growth performance and survival rate in higher ages. This study was conducted to perform a genome-wide association study (GWAS) on weaning traits in a meat type breed of sheep. Body weight records of 7557 Lori-Bakhtiari sheep with PWDG and WW records were used to estimate breeding values (EBVs) using an animal mixed model. A total of 132 animals were selected by two-tailed selection strategy, based on EBVs for body weight and then were genotyped using Illumina 50k Ovine SNP chip. After quality control, a total of 130 animals and 41323 SNPs were remained for further analyses. De-regressed estimates of breeding values were used as a pseudo-phenotype in GWAS analysis. Based on Bonferroni-adjusted p-values, five SNPs, located on chromosomes 2, 3, 4, 12 and 22 were significantly (p < 0.05) associated with weaning traits and accounted for 5.06% and 0.37% of total genetic variations of PWDG and WW, respectively. Two SNPs on chromosomes 2 and 3 were located near to previously reported QTLs for weaning traits. Three genes, including ANGPTL7, mTOR and WDR11, were found within 50 kbp distances from the significant SNPs and thus could be considered as candidate genes for weaning traits. The detected QTLs and candidate genes could be studied for construction of breeding programs for genetic improvement of growth performance in meat type sheep.

Download Full-text

A genome-wide association study identifies genomic loci associated with backfat thickness, carcass weight, and body weight in two commercial pig populations

Journal of Applied Genetics ◽

10.1007/s13353-017-0405-6 ◽

2017 ◽

Vol 58 (4) ◽

pp. 499-508 ◽

Cited By ~ 13

Author(s):

Yuanmei Guo ◽

Hengqing Qiu ◽

Shijun Xiao ◽

Zhenfang Wu ◽

Ming Yang ◽

...

Keyword(s):

Body Weight ◽

Association Study ◽

Genome Wide Association Study ◽

Carcass Weight ◽

Genome Wide Association ◽

Backfat Thickness ◽

Genome Wide ◽

A Genome

Download Full-text

Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats

Frontiers in Veterinary Science ◽

10.3389/fvets.2021.752746 ◽

2021 ◽

Vol 8 ◽

Author(s):

Lei Zhang ◽

Fenghong Wang ◽

Gong Gao ◽

Xiaochun Yan ◽

Hongfu Liu ◽

...

Keyword(s):

Body Weight ◽

Association Study ◽

Inner Mongolia ◽

Molecular Mechanisms ◽

Genome Wide Association Study ◽

Mitogen Activated Protein Kinase ◽

Genome Wide Association ◽

Genome Wide ◽

A Genome ◽

Cashmere Goats

Objective: Body weight is an important economic trait for a goat, which greatly affects animal growth and survival. The purpose of this study was to identify genes associated with birth weight (BW), weaning weight (WW), and yearling weight (YW).Materials and Methods: In this study, a genome-wide association study (GWAS) of BW, WW, and YW was determined using the GGP_Goat_70K single-nucleotide polymorphism (SNP) chip in 1,920 Inner Mongolia cashmere goats.Results: We discovered that 21 SNPs were significantly associated with BW on the genome-wide levels. These SNPs were located in 10 genes, e.g., Mitogen-Activated Protein Kinase 3 (MAPK3), LIM domain binding 2 (LDB2), and low-density lipoprotein receptor-related protein 1B (LRP1B), which may be related to muscle growth and development in Inner Mongolia Cashmere goats. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that these genes were significantly enriched in the regulation of actin cytoskeleton and phospholipase D signaling pathway etc.Conclusion: In summary, this study will improve the marker-assisted breeding of Inner Mongolia cashmere goats and the molecular mechanisms of important economic traits.

Download Full-text