scholarly journals Proportion and Associated Factors of Vitamin B12 Deficiency - A Retrospective Laboratory-Based Study

2019 ◽  
Vol 7 (3) ◽  
pp. 670-677
Author(s):  
K Sowndarya ◽  
Sridevi Hanaganahalli Basavaiah ◽  
Ramya Shenoy ◽  
Anupama Hegde
Keyword(s):  
Vitamin B12 ◽  
Associated Factors ◽  
Laboratory Data ◽  
Age Groups ◽  
Vitamin B12 Deficiency ◽  
Gastric Surgery ◽  
Folic Acid Deficiency ◽  
Age Group ◽  
Rbc Indices ◽  
B12 Deficiency

Vitamin B12 is a vital micronutrient involved in the hemopoetic, neurologic and cardio-metabolic function. Various factors are responsible for B12 deficiency, which can lead to anemia and irreversible neurological manifestations. The proportion of deficiency is not well known and hence studied in the hospital setup. The associated factors of B12 deficiency were also deduced in different age groups. Laboratory data of the past two years on vitamin B12 (B12), folate and red blood cell (RBC) indices were compiled. Based on B12 values, subjects were grouped as deficient, subclinical deficiency and normal. RBC indices especially, Mean corpuscular volume (MCV) was compared among all three groups. The deficient group was further categorized based on age to know the associated factors as per the diagnosis or medical impression recorded. The frequency of B12 and folic acid deficiency was found to be 28% and 18.8% respectively. The deficiency was more frequently detected in the younger age group (18-30years) with inadequate nutrition, pregnancy and vegetarian diet being the most frequently associated factors. Hyperthyroidism was an add-on in the mid-age group. In subjects aged 51-70 years, disorders of intestine, gastric surgery, cancer and pernicious anemia were the attributing factors. MCV > 100fL was found only in 4.8% of the B12 deficient population. Only 28% of B12 deficiency could be conclusively detected. Pregnancy and nutritional status were the most commonly associated factors of B12 deficiency. The use of MCV for the detection of B12 deficiency did not seem reliable.

scholarly journals Treatment of vitamin B12 deficiency in elderly decreases the high levels of lipid parameters: A retrospective study

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1093-1098
Author(s):  
Husni Farah ◽  
Bushra Abdul-Hadi ◽  
Jehad F. Alhmoud ◽  
Atef Al-Othman
Keyword(s):  
Vitamin B12 ◽  
Total Cholesterol ◽  
Age Groups ◽  
Vitamin B12 Deficiency ◽  
Density Lipoprotein ◽  
Age Group ◽  
Cross Sectional ◽  
B12 Deficiency ◽  
The Impact ◽  
Lipid Parameters

The majority of people around the world experience the effects of the inadequacy of vitamin B12. A cross-sectional study was carried out at the beginning of April to end of December 2019, to examine the impact of vitamin B12 inadequacy and its treatment in improving total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride (TG). The data that contains the levels of vitamin B12, lipid parameters (total cholesterol, LDL, HDL and TG) were gathered from 400 patients (n =400) from various clinical research centres situated in the capital of Jordan, Amman. The patient’s samples were classified into multiple age groups. The data of both total cholesterol and LDL levels were gathered from thirty-five (n=35) patients, their age group is between 55-66 and have begun treatment of vitamin B12 deficiency by intramuscular infusion (1.0 mg) of vitamin B12. Almost 20.5% of the studied individuals (n=400) are found to be vitamin B12 deficient, as the level of vitamin B12 was equal to (<190 ng/ml). The age group (56 - 66) years old was found to have a significant decrease in vitamin B 12 (p< 0.01) and this results was associated with a critical increment in the levels of both total cholesterols (p < 0.01) and LDL p< 0.02) on contrast with other age groups. Our results did not reveal any significant changes in the levels of other lipid parameters in all age groups. Intramuscular injection treatment for thirty days reduces significantly (p< 0.01) the level of vitamin B12. This treatment strategy leads to a decrease in both total cholesterols (p< 0.01) and LDL levels (p< 0.01) substantially.

scholarly journals Dietary Intake and Status of Vitamin B12 in Slovenian Population

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 334
Author(s):  
Živa Lavriša ◽  
Hristo Hristov ◽  
Maša Hribar ◽  
Katja Žmitek ◽  
Anita Kušar ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Age Groups ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
High Serum ◽  
Health Concern ◽  
Dietary Vitamin ◽  
Serum Homocysteine ◽  
Daily Vitamin ◽  
B12 Deficiency

Vitamin B12 deficiency poses a health concern, especially in vulnerable populations. Dietary vitamin B12 intake was obtained by two 24 h dietary recalls and food propensity questionnaires in a representative Slovenian cross-sectional food consumption survey, SI.Menu (n = 1248 subjects; 10–74 years). For a subgroup of 280 participants, data on serum vitamin B12 were available through the Nutrihealth study. The estimated usual population-weighted mean daily vitamin B12 intakes were 6.2 µg (adults), 5.4. µg (adolescents), and 5.0 µg (elderly). Lower intakes were observed in females. Inadequate daily vitamin B12 intake (<4 µg) was detected in 37.3% of adolescents, 31.7% of adults, and 58.3% elderlies. The significant predictors for inadequate daily vitamin B12 intake were physical activity score in all age groups, sex in adolescents and adults, financial status and smoking in elderly, and employment in adults. Meat (products), followed by milk (products), made the highest vitamin B12 contribution in all age groups. In adolescents, another important vitamin B12 contributor was cereals. The mean population-weighted serum vitamin B12 levels were 322.1 pmol/L (adults) and 287.3 pmol/L (elderly). Low serum vitamin B12 concentration (<148 nmol/L) and high serum homocysteine (>15 µmol/L) were used as criteria for vitamin B12 deficiency. The highest deficiency prevalence was found in elderlies (7.0%), particularly in males (7.9%). Factors associated with high serum homocysteine were also investigated. In conclusion, although vitamin B12 status was generally not critical, additional attention should be focused particularly to the elderly.

scholarly journals Differentiation between Vitamin B12—deficient and Folic Acid—deficient Megaloblastic Anemias with C14—Histidine

Blood ◽  
1963 ◽  
Vol 21 (4) ◽  
pp. 447-461 ◽  
Author(s):  
MATHEWS B. FISH ◽  
MYRON POLLYCOVE ◽  
THOMAS V. FEICHTMEIR
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Specific Activity ◽  
Megaloblastic Anemia ◽  
Vitamin B12 Deficiency ◽  
Normal Subjects ◽  
Intermediary Metabolism ◽  
Folic Acid Deficiency ◽  
Acid Deficiency ◽  
B12 Deficiency

Abstract Intermediary metabolism of the monocarbon pool and histidine in normal subjects and patients with megaloblastic anemia was studied by continuous measurement of pulmonary excretion of C14O2 and urinary excretion of C14 after injection of L-histidine-2(ring)-C14. Cumulative pulmonary and renal excretion of C14 for 1 month by two normal subjects approximates 45 per cent of the amount injected. Within 4 months after injection of the dose used in this study, the resultant average tissue radiation decreases below the average natural terrestrial and cosmic radiation level. Simultaneous determination of two parameters, (1) cumulative 1-hour pulmonary C14 excretion and (2) the time of occurrence of maximum C14O2specific activity (Tmax), may permit rapid and unequivocal differentiation between folic acid deficiency and vitamin B12 deficiency in the pathogenesis of megaloblastic anemia. Folio acid deficiency results in marked diminution of pulmonary C14 excretion (approximately 0.1 per cent of injection C14 in 1 hour) and marked prolongation of C14O2-specific activity Tmax (approximately 3 hours), while both parameters are normal (approximately 1 per cent and less than 1 hour, respectively) in patients with vitamin B12 deficiency and megaloblastic anemia. Measurement during periods of reticulocyte response to either folio acid or vitamin B12 demonstrate normal C14O2-specific activity Tmax but decreased pulmonary C14 excretion. These observations suggest that prolongation of C14O2-specific activity Tmax is a sensitive index of folic acid deficiency or block and that if Tmax is normal, pulmonary C14 excretion is a sensitive index of the relative partition of the active monocarbon pool between pathways for oxidation and pathways for nucleic acid synthesis. This type of breath analysis seems to provide a quantitative dynamic representation of metabolic function which may be particularly useful in differentiating between the alterations of intermediary metabolism that occur in patients with folic acid-deficient megaloblastic anemia and in patients with vitamin B12-deficient megaloblastic anemia.

scholarly journals Effect of vitamin B12 and folic acid deficiencies on neutrophil function

Blood ◽  
1976 ◽  
Vol 47 (5) ◽  
pp. 801-805 ◽  
Author(s):  
SS Kaplan ◽  
RE Basford
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Cell Function ◽  
Vitamin B12 Deficiency ◽  
Folic Acid Deficiency ◽  
Specific Therapy ◽  
Bacterial Killing ◽  
Leukocyte Function ◽  
Acid Deficiency ◽  
B12 Deficiency

Abstract Morphological and quantitative neutrophil abnormalities are common in the megaloblastic anemias of vitamin B12 and folic acid deficiency. Little is known, however, about the role of these vitamins in normal leukocyte function. Seven patients with megaloblastic bone marrows, four with vitamin B12 deficiency and three with folic acid deficiency, were studied to determine the effect, if any, of these deficiencies on leukocyte function. Phagocytosis of staphylococci, hexose monophosphate shunt activation with phagocytosis, and microbicidal capacity against Staphylococcus aureus were determined prior to the institution of specific therapy. In two instances, these studies were repeated following treatment. There was no impairment of phagocytosis per se, and resting metabolism was not significantly decreased. With phagocytosis, however, metabolic activation was decreased to 35%-36% of control values in the leukocytes of patients with vitamin B12 deficiency but not in the leukocytes of patients with folic acid deficiency. Bacterial killing was slightly decreased in vitamin B12 but not in folic acid deficiency. These abnormalities of function were reversed after specific therapy. These findings suggested a specific role for vitamin B12 in the production of intermediates necessary for normal cell function.

Vitamin B12 and folic acid associated megaloblastic anemia: Could it mislead the diagnosis of breast cancer?

2019 ◽  
Vol 89 (5-6) ◽  
pp. 255-260
Author(s):  
Inanc Karakoyun ◽  
Can Duman ◽  
Fatma Demet Arslan ◽  
Anil Baysoy ◽  
Banu Isbilen Basok
Keyword(s):  
Breast Cancer ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Megaloblastic Anemia ◽  
Vitamin B12 Deficiency ◽  
Normal Group ◽  
Ca 125 ◽  
Folic Acid Deficiency ◽  
Acid Deficiency ◽  
B12 Deficiency

Abstract. CA 15-3 is a tumor-associated antigen and is overexpressed in breast tumors, and may also be high in some other non-cancerous conditions. The aim of this study was to investigate the effect of megaloblastic anemia due to vitamin B12 or folic acid deficiency on the levels of tumor markers. Five-year patient data were retrospectively analyzed. The associations between megaloblastic anemia due to vitamin B12 deficiency and CA 15-3, CA 125, CA 19-9, CEA, and AFP levels were analyzed. Furthermore, association between CA 15-3 level and megaloblastic anemia due to folic acid deficiency was evaluated. Median CA 15-3 level was 38.1 U/mL in the group with megaloblastic anemia due to vitamin B12 deficiency(n = 15), 46.7 U/mL in the group with megaloblastic anemia related to folic acid deficiency (n = 3), and 17.8 U/mL in the normal group(n = 1724). CA 15-3 levels were significantly higher among patients with vitamin B12- and folic acid-associated megaloblastic anemia compared to the normal group (p = 0.001 and p = 0.005, respectively). Megaloblastic anemia due to vitamin B12 deficiency was not associated with any significant differences in CA 125, CA 19-9, CEA, or AFP levels compared to the normal group (p = 0.777, p = 0.327, p = 0.577, and p = 0.197, respectively). The numbers of anemic and normal subjects compared in these tests were 12 vs. 1501, 17 vs. 1827, 4 vs. 897, and 8 vs. 1041, respectively. In conclusion, megaloblastic anemia results in ineffective erythropoiesis, and increased levels of CA 15-3 may be associated with this issue. Clinicians should take this into account when evaluating for a pre-diagnosis of breast cancer.

Vitamin B12 Deficiency Related Syncope in a Young Military Pilot

2020 ◽  
Vol 91 (9) ◽  
pp. 746-748
Author(s):  
Roger R. Hesselbrock ◽  
Edwin V. Palileo ◽  
Eddie D. Davenport
Keyword(s):  
Vitamin B12 ◽  
Autonomic Dysfunction ◽  
Orthostatic Intolerance ◽  
Cardiovascular Response ◽  
Laboratory Data ◽  
Intrinsic Factor ◽  
Vitamin B12 Deficiency ◽  
Exercise Stress ◽  
Laboratory Findings ◽  
B12 Deficiency

BACKGROUND: Syncope and near-syncope are commonly encountered symptoms. Many cases are situationally specific or otherwise benign, with no adverse aeromedical implications. Autonomic dysfunction can produce orthostatic intolerance with resultant symptoms and is aeromedically concerning for potential occurrence in flight. Vitamin B12 deficiency is an insidious condition with protean manifestations, which can present with autonomic dysfunction. Neurological abnormalities are often reversible following adequate replacement.CASE REPORT: We describe a case of vitamin B12 deficiency in a pilot with atypical syncope and abnormal tilt-table testing who had progressively abnormal hematologic findings on review. He was also discovered to have intrinsic factor antibodies. After B12 replacement, he had normal cardiovascular response to exercise stress testing and an unremarkable centrifuge assessment.DISCUSSION: This case highlights the importance of recognizing subtle laboratory findings and serial laboratory data review in cases of atypical syncope to identify potential reversible etiologies.Hesselbrock RR, Palileo EV, Davenport ED. Vitamin B12 deficiency related syncope in a young military pilot. Aerosp Med Hum Perform. 2020; 91(9):746748.

scholarly journals Clinical profile of patients with infantile tremor syndrome in a tertiary care center

2020 ◽  
Vol 7 (11) ◽  
pp. 2172
Author(s):  
Gargi H. Pathak ◽  
Anuya V. Chauhan ◽  
Dhruti Pandya
Keyword(s):  
Vitamin B12 ◽  
Complementary Feeding ◽  
Severe Acute Malnutrition ◽  
Vitamin B12 Deficiency ◽  
Clinical Profile ◽  
Acute Malnutrition ◽  
Severe Anemia ◽  
Age Group ◽  
Nutritional Rehabilitation ◽  
B12 Deficiency

Background: Infantile tremor syndrome (ITS) is a condition reported from many areas of Indian subcontinent due to lack of proper nutrition, improper weaning or delayed introduction of complementary feeding. There is no proven macro or micro nutrient deficiency responsible for it but relation with vitamin B12 deficiency has been identified in some studies. The aim of this study was to study the clinical profile of patients with ITS.Methods: It is a prospective observational study including total 30 patients, from 6 months to 3-year age group, admitted to pediatric wards and nutritional rehabilitation centre, civil hospital, Ahmedabad, from June 2018 to December 2019.Results: Out of 30 patients studied, 69% had pre-ITS and rest had ITS, 61.5% were males and 38.4% were females, 69.2% had severe acute malnutrition, 84.6% had severe anemia and 23% of them presented with CCF, 15.4% patients had microcephaly and 23% had hypotonia. 23% had motor and speech delay. 61.5% belonged to lower socio-economic group. There was delayed introduction of complementary feeding in 63% of patients. 69% patients had severe vitamin B12 deficiency and 21% had moderate vitamin B12 deficiency.Conclusion: ITS, is commonly seen among male children belonging to lower socio-economic group among age group of 6 months to 24 months, presents with coarse tremors with moderate to severe anemia with moderate to severe acute malnutrition and is associated with deficiency of vitamin B12. Early diagnosis and treatment including nutritional rehabilitation grossly improved the outcome.

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