Prescribing for patients with inflammatory bowel disease

2019 ◽  
Vol 1 (3) ◽  
pp. 124-128
Author(s):  
Linda Nazarko
Keyword(s):  
Primary Care ◽  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Clinical Features ◽  
Bowel Disease ◽  
Response To Treatment ◽  
Inflammatory Condition ◽  
Chronic Inflammatory Condition ◽  
Inflammatory Bowel ◽  
Specific Symptoms

Inflammatory bowel disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract. People with IBD normally present in primary care and may have non-specific symptoms. Diagnosis may be delayed and this can have an impact on response to treatment. This article aims to enable prescribers to be aware of the clinical features, investigations and management of IBD.

Profiling of histone 3 lysine 27 acetylation reveals its role in a chronic DSS-induced colitis mouse model

2019 ◽  
Vol 15 (4) ◽  
pp. 296-307
Author(s):  
Meng Chen ◽  
Qinglan Li ◽  
Nan Cao ◽  
Yanan Deng ◽  
Lianyun Li ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Mouse Model ◽  
Bowel Disease ◽  
Inflammatory Condition ◽  
Histone 3 ◽  
Chronic Inflammatory Condition ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract.

Experimental and Clinical Evidence of Endothelial Dysfunction in Inflammatory Bowel Disease

2020 ◽  
Vol 26 (30) ◽  
pp. 3733-3747 ◽  
Author(s):  
Mariana Ferreira-Duarte ◽  
Joana Beatriz Sousa ◽  
Carmen Diniz ◽  
Teresa Sousa ◽  
Margarida Duarte-Araújo ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Endothelial Dysfunction ◽  
Bowel Disease ◽  
Clinical Evidence ◽  
High Cardiovascular Risk ◽  
Considerable Evidence ◽  
Chronic Inflammatory Condition ◽  
Inflammatory Bowel ◽  
Repurposed Drugs ◽  
Main Effects

The endothelium has a crucial role in proper hemodynamics. Inflammatory bowel disease (IBD) is mainly a chronic inflammatory condition of the gastrointestinal tract. However, considerable evidence points to high cardiovascular risk in patients with IBD. This review positions the basic mechanisms of endothelial dysfunction in the IBD setting (both clinical and experimental). Furthermore, we review the main effects of drugs used to treat IBD in endothelial (dys)function. Moreover, we leave challenging points for enlarging the therapeutic arsenal for IBD with new or repurposed drugs that target endothelial dysfunction besides inflammation.

Evaluation of the Risk of Inflammatory Bowel Disease after the HPV Vaccination in Primary Care in Spain: A Time-Varying Cohort Analysis of Around 390,000 Girls

Drug Safety ◽  
2021 ◽  
Author(s):  
Elisa Martín-Merino ◽  
Belén Castillo-Cano ◽  
Mar Martín-Pérez ◽  
Ana Llorente-García ◽  
Dolores Montero-Corominas
Keyword(s):  
Primary Care ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Cohort Analysis ◽  
Hpv Vaccination ◽  
Time Varying ◽  
Inflammatory Bowel

scholarly journals OC-004 Thiopurine Induced Pancreatitis In Inflammatory Bowel Disease: Clinical Features And Genetic Determinants

Gut ◽  
2014 ◽  
Vol 63 (Suppl 1) ◽  
pp. A2.2-A3 ◽  
Author(s):  
GA Heap ◽  
A Singh ◽  
C Bewshea ◽  
MN Weedon ◽  
A Cole ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Clinical Features ◽  
Bowel Disease ◽  
Genetic Determinants ◽  
Inflammatory Bowel

scholarly journals Health Maintenance and Vaccination of Patients With Inflammatory Bowel Disease: Practice and Perception of Responsibility of Gastroenterologists vs Primary Care Providers

2019 ◽  
Vol 19 (3) ◽  
pp. 210-219
Author(s):  
Muhammad B. Hammami ◽  
Pratik Pandit ◽  
Rebecca T. Salamo ◽  
Florence-Damilola Odufalu ◽  
Katie Schroeder
Keyword(s):  
Primary Care ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Primary Care Providers ◽  
Care Providers ◽  
Health Maintenance ◽  
Inflammatory Bowel

scholarly journals Interfering With Inflammation: Heterogeneous Effects of Interferons in Graft-Versus-Host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Eileen Haring ◽  
Robert Zeiser ◽  
Petya Apostolova
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Graft Versus Host Disease ◽  
Bowel Disease ◽  
Intestinal Barrier Function ◽  
Type I ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Inflammatory Bowel

The intestine can be the target of several immunologically mediated diseases, including graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD). GVHD is a life-threatening complication that occurs after allogeneic hematopoietic stem cell transplantation. Involvement of the gastrointestinal tract is associated with a particularly high mortality. GVHD development starts with the recognition of allo-antigens in the recipient by the donor immune system, which elicits immune-mediated damage of otherwise healthy tissues. IBD describes a group of immunologically mediated chronic inflammatory diseases of the intestine. Several aspects, including genetic predisposition and immune dysregulation, are responsible for the development of IBD, with Crohn’s disease and ulcerative colitis being the two most common variants. GVHD and IBD share multiple key features of their onset and development, including intestinal tissue damage and loss of intestinal barrier function. A further common feature in the pathophysiology of both diseases is the involvement of cytokines such as type I and II interferons (IFNs), amongst others. IFNs are a family of protein mediators produced as a part of the inflammatory response, typically to pathogens or malignant cells. Diverse, and partially paradoxical, effects have been described for IFNs in GVHD and IBD. This review summarizes current knowledge on the role of type I, II and III IFNs, including basic concepts and controversies about their functions in the context of GVHD and IBD. In addition, therapeutic options, research developments and remaining open questions are addressed.

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