Profiling of histone 3 lysine 27 acetylation reveals its role in a chronic DSS-induced colitis mouse model

2019 ◽  
Vol 15 (4) ◽  
pp. 296-307
Author(s):  
Meng Chen ◽  
Qinglan Li ◽  
Nan Cao ◽  
Yanan Deng ◽  
Lianyun Li ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Mouse Model ◽  
Bowel Disease ◽  
Inflammatory Condition ◽  
Histone 3 ◽  
Chronic Inflammatory Condition ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract.

Prescribing for patients with inflammatory bowel disease

2019 ◽  
Vol 1 (3) ◽  
pp. 124-128
Author(s):  
Linda Nazarko
Keyword(s):  
Primary Care ◽  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Clinical Features ◽  
Bowel Disease ◽  
Response To Treatment ◽  
Inflammatory Condition ◽  
Chronic Inflammatory Condition ◽  
Inflammatory Bowel ◽  
Specific Symptoms

Inflammatory bowel disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract. People with IBD normally present in primary care and may have non-specific symptoms. Diagnosis may be delayed and this can have an impact on response to treatment. This article aims to enable prescribers to be aware of the clinical features, investigations and management of IBD.

Effects of dietary tryptophan supplementation in the acetic acid-induced colitis mouse model

2018 ◽  
Vol 9 (8) ◽  
pp. 4143-4152 ◽  
Author(s):  
Shuai Chen ◽  
Meiwei Wang ◽  
Lanmei Yin ◽  
Wenkai Ren ◽  
Peng Bin ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Acetic Acid ◽  
Gastrointestinal Tract ◽  
Mouse Model ◽  
Chronic Inflammation ◽  
Bowel Disease ◽  
Intestinal Immunity ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and is strongly associated with intestinal immunity and the microbiome.

Experimental and Clinical Evidence of Endothelial Dysfunction in Inflammatory Bowel Disease

2020 ◽  
Vol 26 (30) ◽  
pp. 3733-3747 ◽  
Author(s):  
Mariana Ferreira-Duarte ◽  
Joana Beatriz Sousa ◽  
Carmen Diniz ◽  
Teresa Sousa ◽  
Margarida Duarte-Araújo ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Endothelial Dysfunction ◽  
Bowel Disease ◽  
Clinical Evidence ◽  
High Cardiovascular Risk ◽  
Considerable Evidence ◽  
Chronic Inflammatory Condition ◽  
Inflammatory Bowel ◽  
Repurposed Drugs ◽  
Main Effects

The endothelium has a crucial role in proper hemodynamics. Inflammatory bowel disease (IBD) is mainly a chronic inflammatory condition of the gastrointestinal tract. However, considerable evidence points to high cardiovascular risk in patients with IBD. This review positions the basic mechanisms of endothelial dysfunction in the IBD setting (both clinical and experimental). Furthermore, we review the main effects of drugs used to treat IBD in endothelial (dys)function. Moreover, we leave challenging points for enlarging the therapeutic arsenal for IBD with new or repurposed drugs that target endothelial dysfunction besides inflammation.

S1740 The Effects of Rapamycin in the TNBS Mouse Model of Inflammatory Bowel Disease

2008 ◽  
Vol 134 (4) ◽  
pp. A-260
Author(s):  
Gary C. Bruns ◽  
Dave Cody ◽  
Russell J. Sheldon ◽  
George Zhang
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mouse Model ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Mouse model of ulcerative colitis using trinitrobenzene sulfonic acid

2015 ◽  
Vol 10 (4) ◽  
pp. 860
Author(s):  
Irfan Ahmad Rather ◽  
Vivek K. Bajpai ◽  
Nam Gyeong-Jun
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Mouse Model ◽  
Bowel Disease ◽  
Sulfonic Acid ◽  
Intestinal Inflammation ◽  
Cost Effective ◽  
Trinitrobenzene Sulfonic Acid ◽  
Clinical Presentations ◽  
Inflammatory Bowel

<p>Animal model of intestinal inflammation is of paramount significance that aids in discerning the pathologies underlying ulcerative colitis and Crohn’s disease, the two clinical presentations of inflammatory bowel disease. The 2,4,6-trinitrobenzene sulfonic acid (TNBS) colitis model represents one such intestinal inflammation-prototype that is generated in susceptible strains of mice through intra-rectal instillation of compound TNBS. In this paper, we demonstrate the experimental induction of TNBS-mediated colitis in a susceptible strain of ICR mice. This can be done by the following steps: a) acclimation, b) induction and c) observation. TNBS-mouse model provides the information in shortest possible time and simultaneously represents a cost effective and highly reproducible model method of studying the pathogenesis of inflammatory bowel disease.</p><p><strong>Video Clips</strong></p><p><a href="https://youtube.com/v/6MsuIGzH3uA">Acclimation and induction of TNBS</a>:          4.5 min</p><p><a href="https://youtube.com/v/ya66SNwoVag">Observation and drug administration</a>:      1.5 min</p>

scholarly journals Alterations of Colonic Contractility in an Interleukin-10 Knockout Mouse Model of Inflammatory Bowel Disease

2015 ◽  
Vol 21 (1) ◽  
pp. 051-061 ◽  
Author(s):  
Jae Hyung Park ◽  
Joong Goo Kwon ◽  
Sun Joo Kim ◽  
Dae Kyu Song ◽  
Seok Guen Lee ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mouse Model ◽  
Bowel Disease ◽  
Knockout Mouse ◽  
Interleukin 10 ◽  
Knockout Mouse Model ◽  
Inflammatory Bowel

scholarly journals The absence of Syndecan‐1 leads to more inflammation in the mouse model of inflammatory bowel disease (IBD)

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Laura Dosh ◽  
Abdo Jurjus ◽  
Rita Ayoub ◽  
Joel Hassanieh ◽  
Angelo Leone ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mouse Model ◽  
Bowel Disease ◽  
Inflammatory Bowel
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