Bone Age at Onset of Pubertal Growth Spurt and Final Height in Normal Children

Objective. To evaluate growth and to compare anthropometric measures and the degree of physical maturation in children with shunted hydrocephalus with those in healthy children. Methods. One hundred fourteen patients (62 male) and 73 healthy subjects (38 male) 5 to 20 years of age were analyzed for growth data and current auxology, stage of puberty, and bone age. Results. Boys with hydrocephalus were shorter than control boys during their first 8 years of age, and no catch-up growth was observed until puberty. Girls with hydrocephalus were of the same size at birth as the control girls, but their linear growth retarded during the first years of life, leading to reduced relative height between the age of 5 to 8 years. The pubertal growth spurt occurred earlier in boys with hydrocephalus (age at midgrowth spurt, 12.1 vs 13.3 years), and a similar trend was seen in girls (10.0 vs 10.7 years). The final height was again reduced, especially in boys. Patients with hydrocephalus were more obese than control subjects, girls more often than boys. Relative bone age was retarded in prepubertal (-0.42 vs 0.32 SD) and accelerated in pubertal patients (0.54 vs -0.19 SD). Conclusions. Children with hydrocephalus experience slow linear growth in prepuberty, but they have an earlier adolescent growth spurt. Together these factors result in a reduced final height. An increase in relative weight emerges in the preadolescent period, and this phenomenon is accentuated after puberty, leading to an increased prevalence of obesity.

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Age of onset of a normally timed pubertal growth spurt affects the final height of children

Pediatric Research ◽

10.1038/pr.2015.104 ◽

2015 ◽

Vol 78 (3) ◽

pp. 351-355 ◽

Cited By ~ 16

Author(s):

Yehuda Limony ◽

Sławomir Kozieł ◽

Michael Friger

Keyword(s):

Age Of Onset ◽

Final Height ◽

Growth Spurt ◽

Pubertal Growth Spurt ◽

Pubertal Growth

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Management of Puberty for Optimal Auxological Results in β-Thalassaemia Major

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2001-s205 ◽

2001 ◽

Vol 14 (s2) ◽

Cited By ~ 4

Author(s):

Manuela Caruso-Nicoletti ◽

V. De Sanctis ◽

L. Cavallo ◽

G. Raiola ◽

L. Ruggiero ◽

...

Keyword(s):

Short Stature ◽

Final Height ◽

Growth Failure ◽

Normal Growth ◽

Growth Spurt ◽

Endocrine Disorders ◽

Thalassaemia Major ◽

Pubertal Growth Spurt ◽

Pubertal Growth ◽

Height Gain

AbstractShort stature is present in a significant percentage of patients affected by β-thalassaemia major. Growth failure of patients with thalassaemia is multifactorial. The most important contribution is attributed to the toxic effect desferrioxamine and to endocrine disorders, due to iron overload. The commonest endocrine complication is hypogonadism. The growth pat- tern of patients with thalassaemia is characterized by normal growth during childhood, a deceleration of growth velocity around age 9-10 years, and a reduced pubertal growth spurt. In addition, reduced growth of the trunk is often present. Short stature and short trunk are more evident at pubertal age. Hypogonadism is usually considered responsible for the pubertal growth failure, as well as the aggravation of body disproportion at pubertal age. However, data suggest that pubertal height gain and final height are reduced in both patients with spontaneous puberty and patients with induced puberty. It is concluded that several aspects of peripubertal growth in patients with thalassaemia remain to be clarified.

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Pubertal Growth and Final Height in Hypopituitary Boys: A Minor Role of Bone Age at Onset of Puberty*

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem-63-2-376 ◽

1986 ◽

Vol 63 (2) ◽

pp. 376-382 ◽

Cited By ~ 51

Author(s):

JEAN-PIERRE BOURGUIGNON ◽

MARK VANDEWEGHE ◽

MAGDA VANDERSCHUEREN-LODEWEYCKX ◽

PAUL MALVAUX ◽

RENÉE WOLTER ◽

...

Keyword(s):

Final Height ◽

Age At Onset ◽

Bone Age ◽

Minor Role ◽

Pubertal Growth ◽

A Minor

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26 PUBERTAL GROWTH AND FINAL HEIGHT IN HYPOPITUITARY BOYS ARE NOT RELATED TO BONE AGE AT ONSET OF PUBERTY

Pediatric Research ◽

10.1203/00006450-198506000-00046 ◽

1985 ◽

Vol 19 (6) ◽

pp. 607-607

Author(s):

J P Bourguignon ◽

M Vandeweghe ◽

M Vanderschueren-Lodeweyckx ◽

P Malvaux ◽

R Wolter ◽

...

Keyword(s):

Final Height ◽

Age At Onset ◽

Bone Age ◽

Pubertal Growth

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Estimation of Pubertal Growth Spurt Parameters in Children and Adolescents Living at Moderate Altitude in Colombia

Frontiers in Endocrinology ◽

10.3389/fendo.2021.718292 ◽

2021 ◽

Vol 12 ◽

Author(s):

Marco Antonio Cossio-Bolaños ◽

Ruben Vidal-Espinoza ◽

Juan Minango-Negrete ◽

Pedro R. Olivares ◽

Luis Urzua-Alul ◽

...

Keyword(s):

Children And Adolescents ◽

Final Height ◽

Peak Height ◽

Height Velocity ◽

Growth Spurt ◽

Moderate Altitude ◽

Biological Parameters ◽

Pubertal Growth Spurt ◽

Peak Height Velocity ◽

Pubertal Growth

ObjectiveKnowledge of the biological parameters of pubertal growth spurt allows verification of secular changes and exploration of the timing of puberty. The aim of the study was to estimate final height, age at peak height velocity (APHV), and peak height velocity PHV (cm/y) in children and adolescents living at moderate altitude in Colombia.MethodsA cross-sectional study was designed in 2.295 schoolchildren from Bogotá (Colombia) with an age range from 5.0 to 18.9 years. Height (cm) was assessed. Preece–Baines model 1 (1PB) was used to make inferences about mathematical and biological parameters.ResultsThe five mathematical parameters estimated in general have reflected quality in the fit to the model, reflecting a small residual error. Final height was reached in boys at 170.8 ± 0.4 cm and in girls at 157.9 ± 0.2 cm. APHV was estimated at 12.71 ± 0.1 years in boys and 10.4 ± 0.2 years in girls. Girls reached APHV 2.2 years earlier than boys. In relation to PHV (cm/y), boys reached higher growth speed in height (7.4 ± 0.4 cm/y), and in girls it was (7.0 ± 0.2 cm/y).ConclusionIt was determined that final height was reached at 170.8 ± 0.4 cm in boys and 157.9 ± 0.2 cm in girls, and APHV (years) and PHV (cm/ye) were reached relatively early and with average peak velocity similar to Asian and Western populations. A large-scale longitudinal study is needed to confirm these findings.

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Growth Response to Growth-Hormone Administration during the Decelerating Phase of the Pubertal Growth Spurt in Short Normal Children

Hormone Research ◽

10.1159/000181826 ◽

1990 ◽

Vol 34 (5-6) ◽

pp. 204-208 ◽

Cited By ~ 1

Author(s):

M. Colle ◽

L. Sagnard ◽

J.P. Ducret ◽

J. Auzerie

Keyword(s):

Growth Hormone ◽

Growth Response ◽

Growth Spurt ◽

Pubertal Growth Spurt ◽

Normal Children ◽

Growth Hormone Administration ◽

Pubertal Growth ◽

Hormone Administration

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Growth and development in girls with Turner's syndrome during early therapy with low doses of estradiol

Acta Endocrinologica ◽

10.1530/acta.0.112s157 ◽

1986 ◽

Vol 113 (4_Suppl) ◽

pp. S157-S163 ◽

Cited By ~ 8

Author(s):

K.W. KASTRUP ◽

_ _

Keyword(s):

Growth Velocity ◽

Final Height ◽

Bone Age ◽

Growth Spurt ◽

First Year ◽

Turner's Syndrome ◽

Turner’S Syndrome ◽

Early Therapy ◽

Group I ◽

Group Ii

Abstract Early therapy with a low dose of estrogen (estradiol-17β) was given to 33 girls with Turner's syndrome (T.s.) for a period of 4 years. The dose (0.25-2 mg/day) was adjusted every 3 months to maintain plasma estradiol in the normal concentration range for bone age. Growth velocity was compared with that of untreated girls with T.s. All girls were above age 10 years. Bone age was below 10 years in 11 girls (group I) and above 10 years in 22 girls (group II). Growth velocity in the first year of treatment in group I 7.5 ± 1.3 cm (SD) with mean SD score (SDS) of +4.3 and in group II 4.9 ± 1.3 with mean SDS of +3.5. Growth velocity decreased in the following years to 1.6 ± 1.0 cm, SDS -1.44 in group I and 0.9 ± 0.6cm, SDS -2.34 in group II during the fourth year. Withdrawal bleeding occurred in 16 girls of group II after the mean of 23 (range 15-33) months and in 3 girls of group I after 15 to 51 months of treatment. The treatment did not cause an inappropriate acceleration of pubertal development. Breast development appeared in most girls by 3 months of treatment. Pubic hair appeared by 12 months of treatment in group I; it was present in most girls in group II at start of treatment. Final height is known for 12 girls of group II; it was 144.2 ± 4.5 cm. The final height as predicted at the start of therapy was 142.2 ± 5.3 cm. Bone age advanced in the first year of treatment by 2 years. Early treatment with small doses of estrogens induces a growth spurt and normalizes the events of puberty. This will presumably decrease the psychological risks associated with abnormally delayed development.

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A new type of pubertal height reference based on growth aligned for onset of pubertal growth

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0127 ◽

2020 ◽

Vol 33 (9) ◽

pp. 1173-1182

Author(s):

Kerstin G. Albertsson-Wikland ◽

Aimon Niklasson ◽

Anton Holmgren ◽

Lars Gelander ◽

Andreas F.M. Nierop

Keyword(s):

Pubertal Timing ◽

Age At Onset ◽

Individual Growth ◽

Growth Spurt ◽

Growth Monitoring ◽

Total Height ◽

Pubertal Growth ◽

Longitudinal Length ◽

New Type ◽

Growth References

AbstractObjectivesGrowth references of today traditionally describe growth in relation to chronological age. Despite the broad variation in age of pubertal maturation, references related to biological age are lacking. To fill this knowledge gap, we aimed to develop a new type of pubertal height reference for improved growth evaluation during puberty, considering individual variation in pubertal timing.MethodsLongitudinal length/height measures were obtained from birth to adult height in 1,572 healthy Swedish children (763 girls) born at term ∼1990 to nonsmoking mothers and Nordic parents, a subgroup of GrowUp1990Gothenburg cohort. A total height reference was constructed from Quadratic-Exponential-Puberty-Stop (QEPS)-function-estimated heights from individual height curves that had been aligned for time/age at onset of pubertal growth (5% of P-function growth). References that separated growth into specific pubertal heightSDS (P-function growth) and basic heightSDS (QES-function growth) were also generated.ResultsReferences (cm and SDS) are presented for total height, and height subdivided into that specific to puberty and to basic growth arising independently of puberty. The usefulness of the new pubertal growth reference was explored by identifying differences in the underlying growth functions that translate into differences in pubertal height gain for children of varying body mass, height, and with different pubertal timings.ConclusionsA new type of height reference allowing alignment of individual growth curves, based on the timing of the pubertal growth spurt was developed using QEPS-model functions. This represents a paradigm shift in pubertal growth research and growth monitoring during the adolescent period.

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