Controlled release triggered by enzymatic degradation for DDS using alginate hydrogel microparticles

2018 ◽  
Vol 2018 (0) ◽  
pp. J0220305
Author(s):  
Hideo MIYAHARA ◽  
Yuta KURASHINA ◽  
Yuki OGAWA ◽  
Ayumu KURIHARA ◽  
Tomohiko YOSHIDA ◽  
...  
Keyword(s):  
Controlled Release ◽  
Enzymatic Degradation ◽  
Alginate Hydrogel ◽  
Hydrogel Microparticles

scholarly journals Microfluidic fabrication of composite hydrogel microparticles in the size range of blood cells

RSC Advances ◽  
2016 ◽  
Vol 6 (105) ◽  
pp. 103532-103540 ◽  
Author(s):  
A. Pittermannová ◽  
Z. Ruberová ◽  
A. Zadražil ◽  
N. Bremond ◽  
J. Bibette ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Controlled Release ◽  
Blood Cells ◽  
Size Range ◽  
Composite Hydrogel ◽  
Alginate Hydrogel ◽  
Hydrogel Microparticles

The fabrication of alginate hydrogel microparticles with embedded liposomes and magnetic nanoparticles for radiofrequency controlled release of encapsulated chemical cargo was demonstrated.

scholarly journals Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Cheng Zhang ◽  
Romain Grossier ◽  
Nadine Candoni ◽  
Stéphane Veesler
Keyword(s):  
Mechanical Properties ◽  
Physicochemical Properties ◽  
Ease Of Use ◽  
Narrow Size Distribution ◽  
Future Perspectives ◽  
Alginate Hydrogel ◽  
Hydrogel Microparticles ◽  
Potential Applications ◽  
Excellent Control ◽  
On Chip

AbstractThis review examines the preparation of alginate hydrogel microparticles by using droplet-based microfluidics, a technique widely employed for its ease of use and excellent control of physicochemical properties, with narrow size distribution. The gelation of alginate is realized “on-chip” and/or “off-chip”, depending on where cross-linkers are introduced. Various strategies are described and compared. Microparticle properties such as size, shape, concentration, stability and mechanical properties are discussed. Finally, we consider future perspectives for the preparation of hydrogel microparticles and their potential applications.

Polymeric nanoparticles as carrier for targeted and controlled delivery of anticancer agents

2019 ◽  
Vol 10 (8) ◽  
pp. 527-550 ◽  
Author(s):  
Vahid Taghipour-Sabzevar ◽  
Tahere Sharifi ◽  
Mehrdad Moosazadeh Moghaddam
Keyword(s):  
Adverse Effect ◽  
Drug Delivery ◽  
Controlled Release ◽  
Anticancer Agents ◽  
Blood Circulation ◽  
Enzymatic Degradation ◽  
Water Solubility ◽  
Polymeric Nanoparticles ◽  
Controlled Delivery ◽  
Drug Adverse Effect

In recent decades, many novel methods by using nanoparticles (NPs) have been investigated for diagnosis, drug delivery and treatment of cancer. Accordingly, the potential of NPs as carriers is very significant for the delivery of anticancer drugs, because cancer treatment with NPs has led to the improvement of some of the drug delivery limitations such as low blood circulation time and bioavailability, lack of water solubility, drug adverse effect. In addition, the NPs protect drugs against enzymatic degradation and can lead to the targeted and/or controlled release of the drug. The present review focuses on the potential of NPs that can help the targeted and/or controlled delivery of anticancer agents for cancer therapy.

scholarly journals Composite chitosan/alginate hydrogel for controlled release of deferoxamine: A system to potentially treat iron dysregulation diseases

2016 ◽  
Vol 136 ◽  
pp. 1338-1347 ◽  
Author(s):  
Giovanna Rassu ◽  
Andrea Salis ◽  
Elena Piera Porcu ◽  
Paolo Giunchedi ◽  
Marta Roldo ◽  
...  
Keyword(s):  
Controlled Release ◽  
Alginate Hydrogel ◽  
Iron Dysregulation

Multilayer Capsules of Bovine Serum Albumin and Tannic Acid for Controlled Release by Enzymatic Degradation

2015 ◽  
Vol 7 (22) ◽  
pp. 11732-11740 ◽  
Author(s):  
Maria V. Lomova ◽  
Anna I. Brichkina ◽  
Maxim V. Kiryukhin ◽  
Elena N. Vasina ◽  
Anton M. Pavlov ◽  
...  
Keyword(s):  
Controlled Release ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Tannic Acid ◽  
Bovine Serum ◽  
Enzymatic Degradation

Enzymatically degradable, starch-based layer-by-layer films: application to cytocompatible single-cell nanoencapsulation

Soft Matter ◽  
2020 ◽  
Vol 16 (26) ◽  
pp. 6063-6071 ◽  
Author(s):  
Hee Chul Moon ◽  
Sol Han ◽  
João Borges ◽  
Tamagno Pesqueira ◽  
Hyunwoo Choi ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Controlled Release ◽  
Single Cell ◽  
Enzymatic Degradation ◽  
Layer By Layer

Starch-based layer-by-layer (LbL) nanofilms are formed and enzymatically degraded on individual Saccharomyces cerevisiae in a highly cytocompatible fashion. Their enzymatic degradation by α-amylase is also exploited for the controlled release of DNA.

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