scholarly journals Novel Drug Delivery Systems for Rheumatoid Arthritis: An Approach to Better Patient Compliance

2019 ◽  
Vol 12 (1) ◽  
pp. 157-170 ◽  
Author(s):  
Sangeeta Mohanty ◽  
Sthitapragnya Panda ◽  
Aslesha Bhanja ◽  
Abhisek Pal ◽  
Si Sudam Chandra
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Human Life ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Future Perspectives ◽  
Conventional Drug ◽  
Potential Applications ◽  
Novel Drug

Recent advances in science and technology radically changed the way we detect, treat and prevent different diseases in all aspects of human life. Rheumatoid arthritis (RA) is a chronic, systemic, progressive, autoimmune disease in which the body’s immune system whose major role is to protect the health by attacking foreign bacteria and viruses are mistakenly, attacking the joints resulting in thickened synovium, pannus formation, & destruction of bone, cartilage. Still now researchers are unable to know the exact cause of this disease. However, it is believed that genes and environmental factors play a role in development of RA. In this review, we discuss the Pathophysiology, predictors, & factors involved in pathogenesis of RA. We also discuss the Conventional therapeutic agents for Rheumatoid Arthritis. More importantly, we extensively discuss the emerging novel drug delivery systems (NDDS) like nanoparticles, dendrimers, micelles, microspheres, liposomes, and so on as these are the promising tools having successful applications in overcoming the limitations associated with conventional drug delivery systems. Although several NDDS have been used for various purposes, liposomes have been focused on due to its potential applications in RA diagnosis and therapy. In addition, we discuss the therapeutic effectiveness and challenges for RA by using these novel drug delivery systems. Finally, we conclude by discussing the future perspectives.

Novel Nano Carriers for the Treatment of Progressive Auto Immune Disease Rheumatoid Arthritis

2020 ◽  
Vol 26 ◽  
Author(s):  
Ritu Mishra ◽  
Swati Gupta
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Autoimmune Disease ◽  
Drug Delivery Systems ◽  
Clinical Manifestations ◽  
Adaptive Immune Response ◽  
Delivery Systems ◽  
Current Therapy ◽  
Genetic And Environmental Factors ◽  
Novel Drug

Background: Rheumatoid arthritis (RA) is the most common occurring progressive, autoimmune disease, affecting 1% of the population and the ratio of affected women is three times as compared to men in most developing countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) in blood, tendered joints and soreness of the muscles. Some other factors which may lead to chronic inflammation are genetic and environmental factors as well as adaptive immune response. Several conventional drugs are available for the treatment of RA but have their own drawbacks which can be overcome by the use of novel drug delivery systems. : The objective of the present review is to focus on the molecular pathogenesis of the disease and its current conventional treatment with special reference to the role of novel drug delivery systems encapsulating anti rheumatic drugs and herbal drugs in passive and receptor mediated active targeting against RA. On reviewing the conventional and current therapeutics agains RA, we conclude that, although the current therapy for the treatment of RA is capable enough, yet more advances in the field of targeted drug delivery will sanguinely result in effective and appropriate treatment of this autoimmune disease.

Nanoparticulate Drug Delivery Systems: An update

2021 ◽  
pp. 312-316
Author(s):  
Pandey Swarnima ◽  
Sushant Kumar
Keyword(s):  
Drug Delivery ◽  
Carrying Capacity ◽  
Drug Delivery Systems ◽  
High Specificity ◽  
Delivery Systems ◽  
Classification Methods ◽  
Hydrophobic Drug ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Novel Drug

The paper is aimed to provide a comprehensive review on nanoparticles, methods of preparation, applications in drug delivery. In recent years, there has been an exponential interest within the development of novel drug delivery systems using nanoparticles. Nanoparticles offers significant advantages over the conventional drug delivery in terms of high stability, high specificity, high drug carrying capacity, ability for controlled release, possibility to use in several route of administration and therefore the capability to deliver both hydrophilic and hydrophobic drug molecules. This review focuses on classification, methods of preparation, characterization, application, advantages of nanoparticles and health perspectives.

Novel Drug Delivery System of Phytopharmaceuticals: A Review

2021 ◽  
Vol 07 ◽  
Author(s):  
Sumit Aroraa ◽  
Veerendra Dhoke ◽  
Keshav Moharir ◽  
Subhash Yende ◽  
Sapan Shah
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Distribution ◽  
Delivery Systems ◽  
Research Activity ◽  
Innovative Drug ◽  
Preparation Methods ◽  
Conventional Drug ◽  
Sites Of Action ◽  
Novel Drug

: Herbal extracts and isolated bioactives from plants have proven their therapeutic activities as evidenced by preclinical and clinical research. However, there seems some disconnect in their clinical utility as marked by lack of proper delivery mechanism at desired sites of action. This glitch nowadays is a task for global research activity and being addressed in the form of novel drug delivery systems. A steady progress is observed in integrating novel techniques of drug delivery with successful incorporation of phytochemicals marked by scores of advantages. Limitations of conventional drug delivery systems are overcome to considerable extent by innovative drug delivery methods which show improvement in targeted drug delivery, drug distribution, and protection of active substance, prolonged action and stability. The perspective of this review thus focuses on the progress in novel drug delivery systems with spotlight on nanocarriers for herbal active agents, their preparation methods with types, examples of active ingredients incorporated and biomedical applications.

Nanotechnology: Revolutionizing the Science of Drug Delivery

2019 ◽  
Vol 24 (43) ◽  
pp. 5086-5107 ◽  
Author(s):  
Mohini Mishra ◽  
Pramod Kumar ◽  
Jitendra Singh Rajawat ◽  
Ruchi Malik ◽  
Gitanjali Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Structural Features ◽  
Delivery Systems ◽  
The Novel ◽  
Drug Delivery Vehicles ◽  
Conventional Drug ◽  
Diagnostic Agents ◽  
Pros And Cons ◽  
Novel Drug

Growing interest in the field of nanotechnology has led to its emergence in the field of medicine too. Nanomedicines encompass the various medical tools, diagnostic agents and the drug delivery vehicles being evolved with the advancements in the aura of nanotechnology. This review emphasizes on providing a cursory literature on the past events that led to the procession of nanomedicines, various novel drug delivery systems describing their structural features along with the pros and cons associated with them and the nanodrugs that made a move to the clinical practice. It also focuses on the need of the novel drug delivery systems and the challenges faced by the conventional drug delivery systems.

Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: An overview

2018 ◽  
Vol 106 ◽  
pp. 1011-1023 ◽  
Author(s):  
Sourav Thakur ◽  
Bushra Riyaz ◽  
Akshay Patil ◽  
Amanjot Kaur ◽  
Bhupinder Kapoor ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Novel Drug

Nanoparticle Based Treatment for Cardiovascular Diseases

2019 ◽  
Vol 19 (1) ◽  
pp. 33-44 ◽  
Author(s):  
Purnima Gupta ◽  
Evelyn Garcia ◽  
Amrita Sarkar ◽  
Sumit Kapoor ◽  
Khadija Rafiq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Surface Modifications ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Cardiovascular Disorders ◽  
Conventional Drug ◽  
Phospholipid Nanoparticles ◽  
Target Sites ◽  
Pharmacodynamic Data

Nanotechnology has gained increased attention for delivering therapeutic agents effectively to the cardiovascular system. Heart targeted nanocarrier based drug delivery is a new, effective and efficacious approach for treating various cardiac related disorders such as atherosclerosis, hypertension, and myocardial infarction. Nanocarrier based drug delivery system circumvents the problems associated with conventional drug delivery systems, including their nonspecificity, severe side effects and damage to the normal cells. Modification of physicochemical properties of nanocarriers such as size, shape and surface modifications can immensely alter its invivo pharmacokinetic and pharmacodynamic data and will provide better treatment strategy. Several nanocarriers such as lipid, phospholipid nanoparticles have been developed for delivering drugs to the target sites within the heart. This review summarizes and increases the understanding of the advanced nanosized drug delivery systems for treating cardiovascular disorders with the promising use of nanotechnology.

Targeted drug-delivery systems in the treatment of rheumatoid arthritis: recent advancement and clinical status

2020 ◽  
Vol 11 (4) ◽  
pp. 269-284 ◽  
Author(s):  
Srividya Gorantla ◽  
Gautam Singhvi ◽  
Vamshi Krishna Rapalli ◽  
Tejashree Waghule ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Bone Erosion ◽  
Folate Receptor ◽  
Clinical Status ◽  
Joint Destruction ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Systemic Autoimmune Disease

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that is characterized by synovial inflammation, cellular infiltration in joints which leads to progressive joint destruction and bone erosion. RA is associated with many comorbidities including pulmonary disease, rheumatoid nodules and can have a pessimistic impact on quality of life. The current therapies of RA treatment comprise conventional, small molecule and biological antirheumatic drugs. Their utility as therapeutic agents is limited because of poor absorption, rapid metabolism and adverse effects (dose-escalation, systemic toxicity, lack of selectivity and safety). To overcome these limitations, the novel drug delivery systems are being investigated. This review has compiled currently approved therapies along with emerging advanced drug-delivery systems for RA treatment. Further, active targeting of therapeutic agents to inflamed joints via folate receptor, CD44, angiogenesis, integrins and other provided an improved therapeutic efficacy in the treatment of RA.

A Review On Lyotropic Liquid Crystals And Its Potential Applications

2021 ◽  
Vol 11 ◽  
Author(s):  
Hitesh Kumar ◽  
Aishwarya Sureshkumar ◽  
Nihal Badduri ◽  
Vikas Jain
Keyword(s):  
Drug Delivery ◽  
Liquid Crystals ◽  
Drug Delivery Systems ◽  
Liquid Crystalline ◽  
Structural Features ◽  
Delivery Systems ◽  
Lyotropic Liquid Crystals ◽  
Liquid Phases ◽  
Potential Applications ◽  
Novel Drug

Backgraound: Novel drug delivery systems have always been of immense interest for research. Majority of the drugs suffers from solubity related constraints. Lipid based drug delivery systems provide a promising approach to address this issue.Amogst various approaches, liquid crystalline systems offers distinct advantages over other available options. It maintains the phase stablility between solid and liquid phases. Backgraound: :Novel drug delivery systems have always been of immense interest for research. Majority of the drugs suffers from solubity related constraints. Lipid based drug delivery systems provide a promising approach to address this issue.Amogst various approaches, liquid crystalline systems offers distinct advantages over other available options. It maintains the phase stablility between solid and liquid phases. Objective: Lyotropic Liquid Crystals (LLCs) have highly ordered internal structure forming capabilities thereby assisting the controlled release of a therapeutic agent of varying sizes and polarities. Methods: The present article covers the structural features of dispersed mesophases (cubosomes and hexosomes), components used to prepare various mesophases, method of preparation, characterization techniques and potential applications. Results: LLCsoffers a distinct choice for delivering hydrophobic as well as hydrophilic drug. They are also suitable for the delivery of macromolecules such as peptide and protiens through various routes of administration.Lyotropic liquid crystals are extremely versatile drug delivery systems that can be used for delivering drugs across topical, oral, buccal, pulmonary and intravenous routes. Their use in the delivery of tough to deliver drugs, hormones, peptides, biomolecules and vaccines is particularly important. Conclusion: This review discussed the composition, methods of preparation and characterization of LLCs. The LLCs offer promsing delivery choice for the drugs with lower solubility and higher toxicity.

scholarly journals Recent advancesin the development of novel drug delivery systems for the prophylaxis of malaria

2018 ◽  
Vol 9 (3) ◽  
pp. 49
Author(s):  
Sahil Kumar ◽  
Kulvinder Singh ◽  
Rajesh K Singh ◽  
DN Prasad ◽  
TR Bhardwaj
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Methyl Cellulose ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Polyvinyl Pyrrolidone ◽  
Present Review ◽  
Targeted Drug ◽  
Novel Drug

<p>The present review high-lights the advancement in nanoparticles formulations for the prophylaxis of malaria. An attempt has been made to describe various novel drug delivery systems based on approaches such as polymeric, metallic, natural, chitosan/antisense (AS) and chitosan/sense (S) oligodeoxynucleotide based nanoparticles etc. for the treatment of malaria. The polymer such as chitosan, hydroxyl propyl methyl cellulose and polyvinyl pyrrolidone; the metal like gold and silver and other carriers such as glyceryl-dilaurate, albumin etc. have been explored for the development of novel nanoparticles formulations. These developed nanoparticles formulation have improved the targeted drug delivey of various clinically used antimalarial therapeutic agents such as hydroxychloroquine, curcumin, artemisinin, artemether and lumefantrine etc.</p>

scholarly journals CRYPTOSOMES: A REVOLUTIONARY BREAKTHROUGH IN NOVEL DRUG DELIVERY

2019 ◽  
Vol 11 (1) ◽  
pp. 7 ◽  
Author(s):  
Aiswarya M. U. ◽  
Keerthana Raju ◽  
Revathy B. Menon ◽  
Lakshmi V. S. ◽  
Sreeja C. Nair
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Phosphatidyl Ethanolamine ◽  
Delivery Systems ◽  
The Body ◽  
Solid Lipid ◽  
Conventional Drug ◽  
Novel Drug

The vesicular drug delivery systems are promising approaches to overthrown the problems of drugs having lesser bioavailability and rapid elimination from the body. The four type of lipid based drug delivery systems are: solid-lipid particulate system, emulsion based system, solid lipid tablet and vesicular system. Cryptosomes, a novel emerging vesicular drug delivery system which can overcome the disadvantages associated with conventional drug delivery systems like high stability, increased bioavailability, sustained release, decreased elimination of rapidly metabolizable drugs etc. The word Cryptosome was orginated from Greek word ‘’Crypto’’ means hidden and ‘’Soma’’ means body. It is formed from the mixture of phospholipids like distearoyl phosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG) with distearoylphosphatidylcholine. These entire information regarding its origin and formation is explained in Dinesh Kumar et al. Vesicular systems symbolizes the use of vesicles in the different fields as carrier system or additives. This review disclose various vesicular drug delivery system and point out the advancement of cryptosome in the world of drug delivery.This review would help researchers involved in the field of vesicular drug delivery.

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