Nanotechnology: Revolutionizing the Science of Drug Delivery

2019 ◽  
Vol 24 (43) ◽  
pp. 5086-5107 ◽  
Author(s):  
Mohini Mishra ◽  
Pramod Kumar ◽  
Jitendra Singh Rajawat ◽  
Ruchi Malik ◽  
Gitanjali Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Structural Features ◽  
Delivery Systems ◽  
The Novel ◽  
Drug Delivery Vehicles ◽  
Conventional Drug ◽  
Diagnostic Agents ◽  
Pros And Cons ◽  
Novel Drug

Growing interest in the field of nanotechnology has led to its emergence in the field of medicine too. Nanomedicines encompass the various medical tools, diagnostic agents and the drug delivery vehicles being evolved with the advancements in the aura of nanotechnology. This review emphasizes on providing a cursory literature on the past events that led to the procession of nanomedicines, various novel drug delivery systems describing their structural features along with the pros and cons associated with them and the nanodrugs that made a move to the clinical practice. It also focuses on the need of the novel drug delivery systems and the challenges faced by the conventional drug delivery systems.

scholarly journals Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

2019 ◽  
Vol 87 (3) ◽  
pp. 20 ◽  
Author(s):  
Miléna Lengyel ◽  
Nikolett Kállai-Szabó ◽  
Vince Antal ◽  
András József Laki ◽  
István Antal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Freeze Drying ◽  
Delivery Systems ◽  
The Novel ◽  
Practical Applications ◽  
Inhaled Insulin ◽  
Formulation Factors ◽  
Novel Drug ◽  
Significant Production

Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1–1000 µm size range, serve as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve the effectiveness, tolerability, and patient compliance. This paper reviews their evolution, significance, and formulation factors (excipients and procedures), as well as their most important practical applications (inhaled insulin, liposomal preparations). The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too. The most significant production processes (spray drying, extrusion, coacervation, freeze-drying, microfluidics), the drug release mechanisms, and the commonly used excipients, the characterization, and the novel drug delivery systems (microbubbles, microsponges), as well as the preparations used in therapy are discussed in detail.

Nanoparticulate Drug Delivery Systems: An update

2021 ◽  
pp. 312-316
Author(s):  
Pandey Swarnima ◽  
Sushant Kumar
Keyword(s):  
Drug Delivery ◽  
Carrying Capacity ◽  
Drug Delivery Systems ◽  
High Specificity ◽  
Delivery Systems ◽  
Classification Methods ◽  
Hydrophobic Drug ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Novel Drug

The paper is aimed to provide a comprehensive review on nanoparticles, methods of preparation, applications in drug delivery. In recent years, there has been an exponential interest within the development of novel drug delivery systems using nanoparticles. Nanoparticles offers significant advantages over the conventional drug delivery in terms of high stability, high specificity, high drug carrying capacity, ability for controlled release, possibility to use in several route of administration and therefore the capability to deliver both hydrophilic and hydrophobic drug molecules. This review focuses on classification, methods of preparation, characterization, application, advantages of nanoparticles and health perspectives.

Short Review on Novel Dosage Form

2021 ◽  
pp. 301-303
Author(s):  
Tushar N. Sonawane ◽  
Pradip D. Dhangar ◽  
Sagar D Patil ◽  
Azam Z. Shaikh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Drug Effects ◽  
Short Review ◽  
Delivery Systems ◽  
The Novel ◽  
Novel Drug Delivery System ◽  
Novel Drug

Novel Drug Delivery Systems are one of the widely use delivery system in the presence scenario. Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. In the form of a Novel Drug Delivery System an existing drug molecule can get a new life. The novel drug delivery system is Increases bioavailability and it Can be used for long-term treatments of chronic illness, Sustained maintenance of plasma drug levels as well as it Decreased adverse drug effects in the total amount of drugs required thus reducing side effects it Improved patient compliance due to reduction in number and frequency of doses required. There is less damage sustained by normal tissue due to targeted drug delivery. In this paper our main focus to give the throughout knowledge of some newer (Novel drug delivery system) to understand the concept of the Novel dossage form.

An Overview of the Recent Developments and Patents in The Field of Pharmaceutical Nanotechnology

2020 ◽  
Vol 14 ◽  
Author(s):  
Deepika Purohit ◽  
Deeksha Manchanda ◽  
Manish ◽  
Jyoti Rathi ◽  
Ravinder Verma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Carbon Nanomaterials ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Correlation Spectroscopy ◽  
Colloidal System ◽  
The Novel ◽  
Pharmaceutical Nanotechnology ◽  
Novel Drug

Background: Compared to traditional dosage methods, the novel drug delivery systems (NDDS) provide various advantages. In the last few years, tremendous focus has been given to work focused on the novel drug delivery methods for small and large molecular drug carriers utilizing particulate drug delivery systems as well. It is evident from last decade as seen in number of patents cited in this field that the technology has evolved tremendously. Objective: Drug carriers utilized by this novel technology includes liposomes, dendrimers, polymeric nanoparticles, magnetic nanoparticles, solid lipid nanoparticles, carbon nanomaterials. Various forms of polymers have been used in the production of nanocarriers. Methods: Nanocarriers are colloidal system varying in size from 10 to 1000 nm. This technology now used to identify, manage and monitor numerous diseases and physical methods to alter and enhance the pharmacokinetic and pharmacodynamic properties of specific types of drug molecules. Results: Nanoparticles can be formulated by a number of techniques including ionic gelation, cross-linking, coacervation/precipitation, nanoprecipitation, spray drying, emulsion- droplet coalescence, nano sonication techniques etc. Several methods are used with which these nanoparticles can be characterized. These methods include nuclear magnetic resonance, optical microscopy, atomic force microscopy, photon correlation spectroscopy and electron microscopy, surface charge, in-vitro drug release, etc. Conclusion: In the present review, authors have tried to summarize the recent advances in the field of pharmaceutical nanotechnology and also focuses on the application and new patents in the area related to NDDS.

Novel Drug Delivery System of Phytopharmaceuticals: A Review

2021 ◽  
Vol 07 ◽  
Author(s):  
Sumit Aroraa ◽  
Veerendra Dhoke ◽  
Keshav Moharir ◽  
Subhash Yende ◽  
Sapan Shah
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Distribution ◽  
Delivery Systems ◽  
Research Activity ◽  
Innovative Drug ◽  
Preparation Methods ◽  
Conventional Drug ◽  
Sites Of Action ◽  
Novel Drug

: Herbal extracts and isolated bioactives from plants have proven their therapeutic activities as evidenced by preclinical and clinical research. However, there seems some disconnect in their clinical utility as marked by lack of proper delivery mechanism at desired sites of action. This glitch nowadays is a task for global research activity and being addressed in the form of novel drug delivery systems. A steady progress is observed in integrating novel techniques of drug delivery with successful incorporation of phytochemicals marked by scores of advantages. Limitations of conventional drug delivery systems are overcome to considerable extent by innovative drug delivery methods which show improvement in targeted drug delivery, drug distribution, and protection of active substance, prolonged action and stability. The perspective of this review thus focuses on the progress in novel drug delivery systems with spotlight on nanocarriers for herbal active agents, their preparation methods with types, examples of active ingredients incorporated and biomedical applications.

The Ameliorating Approach of Nanorobotics in the Novel Drug Delivery Systems: A Mechanistic Review

2021 ◽  
pp. 1-22
Author(s):  
Rakesh K Sindhu ◽  
Harnoor Kaur ◽  
Manish Kumar ◽  
Moksha Sofat ◽  
Evren Algın Yapar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Novel ◽  
Novel Drug

scholarly journals Novel Drug Delivery Systems for Rheumatoid Arthritis: An Approach to Better Patient Compliance

2019 ◽  
Vol 12 (1) ◽  
pp. 157-170 ◽  
Author(s):  
Sangeeta Mohanty ◽  
Sthitapragnya Panda ◽  
Aslesha Bhanja ◽  
Abhisek Pal ◽  
Si Sudam Chandra
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Human Life ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Future Perspectives ◽  
Conventional Drug ◽  
Potential Applications ◽  
Novel Drug

Recent advances in science and technology radically changed the way we detect, treat and prevent different diseases in all aspects of human life. Rheumatoid arthritis (RA) is a chronic, systemic, progressive, autoimmune disease in which the body’s immune system whose major role is to protect the health by attacking foreign bacteria and viruses are mistakenly, attacking the joints resulting in thickened synovium, pannus formation, & destruction of bone, cartilage. Still now researchers are unable to know the exact cause of this disease. However, it is believed that genes and environmental factors play a role in development of RA. In this review, we discuss the Pathophysiology, predictors, & factors involved in pathogenesis of RA. We also discuss the Conventional therapeutic agents for Rheumatoid Arthritis. More importantly, we extensively discuss the emerging novel drug delivery systems (NDDS) like nanoparticles, dendrimers, micelles, microspheres, liposomes, and so on as these are the promising tools having successful applications in overcoming the limitations associated with conventional drug delivery systems. Although several NDDS have been used for various purposes, liposomes have been focused on due to its potential applications in RA diagnosis and therapy. In addition, we discuss the therapeutic effectiveness and challenges for RA by using these novel drug delivery systems. Finally, we conclude by discussing the future perspectives.

scholarly journals Clinical implications of novel polymer and lipid based drug delivery systems

2020 ◽  
Vol 2 (3) ◽  
pp. 60-65
Author(s):  
Kallem Sharat Venkat Reddy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Clinical Implications ◽  
Clinical Settings ◽  
The Past ◽  
Long Time ◽  
Pros And Cons ◽  
Novel Drug

The use of lipids in drug delivery is not a new trend, some of the lipid dosage forms have been in use for a long time such as suppositories, creams, and emulsions. However, there has been much advancement in the designs of lipid carriers over the past decade. In the same way from the past two decades, new approaches in biodegradable and bio-reducible polymers have paved a way for many recent drug delivery systems. Applications of these novel drug delivery formulations have been promising clinically. However, each system has its pros and cons in various factors depending upon their use and intended route of administration. This review focuses on upbringing the challenges in the use of novel lipid and polymer drug delivery systems in clinical settings and few insights on how to overcome them.

A Review On Lyotropic Liquid Crystals And Its Potential Applications

2021 ◽  
Vol 11 ◽  
Author(s):  
Hitesh Kumar ◽  
Aishwarya Sureshkumar ◽  
Nihal Badduri ◽  
Vikas Jain
Keyword(s):  
Drug Delivery ◽  
Liquid Crystals ◽  
Drug Delivery Systems ◽  
Liquid Crystalline ◽  
Structural Features ◽  
Delivery Systems ◽  
Lyotropic Liquid Crystals ◽  
Liquid Phases ◽  
Potential Applications ◽  
Novel Drug

Backgraound: Novel drug delivery systems have always been of immense interest for research. Majority of the drugs suffers from solubity related constraints. Lipid based drug delivery systems provide a promising approach to address this issue.Amogst various approaches, liquid crystalline systems offers distinct advantages over other available options. It maintains the phase stablility between solid and liquid phases. Backgraound: :Novel drug delivery systems have always been of immense interest for research. Majority of the drugs suffers from solubity related constraints. Lipid based drug delivery systems provide a promising approach to address this issue.Amogst various approaches, liquid crystalline systems offers distinct advantages over other available options. It maintains the phase stablility between solid and liquid phases. Objective: Lyotropic Liquid Crystals (LLCs) have highly ordered internal structure forming capabilities thereby assisting the controlled release of a therapeutic agent of varying sizes and polarities. Methods: The present article covers the structural features of dispersed mesophases (cubosomes and hexosomes), components used to prepare various mesophases, method of preparation, characterization techniques and potential applications. Results: LLCsoffers a distinct choice for delivering hydrophobic as well as hydrophilic drug. They are also suitable for the delivery of macromolecules such as peptide and protiens through various routes of administration.Lyotropic liquid crystals are extremely versatile drug delivery systems that can be used for delivering drugs across topical, oral, buccal, pulmonary and intravenous routes. Their use in the delivery of tough to deliver drugs, hormones, peptides, biomolecules and vaccines is particularly important. Conclusion: This review discussed the composition, methods of preparation and characterization of LLCs. The LLCs offer promsing delivery choice for the drugs with lower solubility and higher toxicity.

scholarly journals CRYPTOSOMES: A REVOLUTIONARY BREAKTHROUGH IN NOVEL DRUG DELIVERY

2019 ◽  
Vol 11 (1) ◽  
pp. 7 ◽  
Author(s):  
Aiswarya M. U. ◽  
Keerthana Raju ◽  
Revathy B. Menon ◽  
Lakshmi V. S. ◽  
Sreeja C. Nair
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Phosphatidyl Ethanolamine ◽  
Delivery Systems ◽  
The Body ◽  
Solid Lipid ◽  
Conventional Drug ◽  
Novel Drug

The vesicular drug delivery systems are promising approaches to overthrown the problems of drugs having lesser bioavailability and rapid elimination from the body. The four type of lipid based drug delivery systems are: solid-lipid particulate system, emulsion based system, solid lipid tablet and vesicular system. Cryptosomes, a novel emerging vesicular drug delivery system which can overcome the disadvantages associated with conventional drug delivery systems like high stability, increased bioavailability, sustained release, decreased elimination of rapidly metabolizable drugs etc. The word Cryptosome was orginated from Greek word ‘’Crypto’’ means hidden and ‘’Soma’’ means body. It is formed from the mixture of phospholipids like distearoyl phosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG) with distearoylphosphatidylcholine. These entire information regarding its origin and formation is explained in Dinesh Kumar et al. Vesicular systems symbolizes the use of vesicles in the different fields as carrier system or additives. This review disclose various vesicular drug delivery system and point out the advancement of cryptosome in the world of drug delivery.This review would help researchers involved in the field of vesicular drug delivery.

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