Background: Intraarticular pulsed radiofrequency (IAPRF) for the treatment of painful knee
osteoarthritis (KOA) is a less invasive treatment method. It has fewer adverse effects and can
quickly reduce KOA-related pain and improve knee joint dysfunction.
Objectives: We compared the effectiveness of high- and low-voltage IAPRF for the treatment
of chronic knee pain.
Study Design: Retrospective comparative study design.
Setting: This study took place at Shengjing Hospital of China Medical University.
Methods: A total of 57 patients with KOA who were hospitalized between July 2018 and July
2019 were randomly allocated into the high-voltage (n = 29) and low-voltage (n = 28) IAPRF
groups. IAPRF was performed under the guidance of computed tomography (CT). Numeric
Rating Scale (NRS-11), Oxford Knee Score (OKS), degree of pain relief, global perceived effect,
and side effects at baseline and 1 week, 2 weeks, 1 month, 3 months, and 6 months after the
procedure were recorded and analyzed.
Results: NRS-11 scores decreased significantly in both groups after the procedure, but
gradually increased after the 6-month follow-up period. There was a significant difference in
NRS-11 scores between the 2 groups at all follow-up periods postprocedure. OKS were similar
between the 2 groups. Patients with pain relief rate 50% or greater at 1, 3, and 6 months after
the procedure accounted for 72.41%, 72.41%, and 55.17% in the high-voltage group, and
46.43%, 46.43%, and 28.57% in the low-voltage group, respectively. The difference between
the 2 groups was statistically significant. No significant adverse reactions were observed in
the 2 groups, however, patient satisfaction in the high-voltage group was significantly higher
compared with patients in the low-voltage group.
Limitations: This study was a single-center retrospective study with a relatively small sample
cohort and short follow-up period.
Conclusions: CT-guided high-voltage IAPRF is more beneficial in reducing knee pain and
improving knee function compared with low-voltage IAPRF. In addition, patients who received
high-voltage IAPRF were more satisfied with their treatment.
Key words: Pulsed radiofrequency, knee osteoarthritis, intraarticular, high voltage, Oxford
Knee Score, Numeric Rating Scale