Anaphylactic Reaction to a Dietary Supplement Containing Willow Bark

2003 ◽  
Vol 37 (6) ◽  
pp. 832-835 ◽  
Author(s):  
Joseph I Boullata ◽  
Patrick J McDonnell ◽  
Cynthia D Oliva
Keyword(s):  
Weight Loss ◽  
Adverse Effects ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Anaphylactic Reaction ◽  
Medication History ◽  
Herbal Products ◽  
Initial Symptoms ◽  
History Of ◽  
Willow Bark

OBJECTIVE: To report a case of anaphylaxis resulting from the use of a willow bark–containing dietary supplement in a patient with a history of an aspirin allergy. CASE SUMMARY: A 25-year-old white woman presented to the emergency department of a community teaching hospital with anaphylaxis requiring epinephrine, diphenhydramine, methylprednisolone, and volume resuscitation to which she responded favorably. Medication history revealed that she had ingested 2 capsules of Stacker 2 (NVE Pharmaceuticals, Newton, NJ), a dietary supplement promoted for weight loss, prior to experiencing her initial symptoms. Among other active ingredients, this product contains willow bark. Of significance is that this patient also reported a history of allergy to acetylsalicylic acid. No other causes for anaphylaxis were identified. She continued to receive routine supportive care and the remaining hospital course was uncomplicated. DISCUSSION: Dietary supplements, including herbal products, are used by many individuals who consider them to be inherently safe despite limited regulatory oversight by the Food and Drug Administration. While there may be value to specific botanical ingredients, a potential for adverse effects also exists. The popular product consumed by our patient is used for weight loss and contains willow bark, a source of salicylates. Based on the Naranjo probability scale, it is probable that this case of anaphylaxis was due to this dietary supplement. CONCLUSIONS: The use of any willow bark–containing dietary supplement may present a risk of anaphylactic reaction to patients with a history of allergy to salicylates. Clinicians need to recognize the potential for adverse effects from dietary supplements.

scholarly journals Acute Liver Failure Caused by ‘Fat Burners’ and Dietary Supplements: A Case Report and Literature Review

2011 ◽  
Vol 25 (3) ◽  
pp. 157-160 ◽  
Author(s):  
Y Radha Krishna ◽  
V Mittal ◽  
P Grewal ◽  
MI Fiel ◽  
T Schiano
Keyword(s):  
Adverse Effects ◽  
Dietary Supplements ◽  
Green Tea ◽  
Histopathological Examination ◽  
Present Report ◽  
Healthy Woman ◽  
Usnic Acid ◽  
Herbal Remedies ◽  
Herbal Extracts ◽  
Herbal Products

Globally, people are struggling with obesity. Many effective, non-conventional methods of weight reduction, such as herbal and natural dietary supplements, are increasingly being sought. Fat burners are believed to raise metabolism, burn more calories and hasten fat loss. Despite patient perceptions that herbal remedies are free of adverse effects, some supplements are associated with severe hepatotoxicity. The present report describes a young healthy woman who presented with fulminant hepatic failure requiring emergent liver transplantation caused by a dietary supplement and fat burner containing usnic acid, green tea and guggul tree extracts. Thorough investigation, including histopathological examination, revealed no other cause of hepatotoxicity. The present case adds to the increasing number of reports of hepatotoxicity associated with dietary supplements containing usnic acid, and highlights that herbal extracts from green tea or guggul tree may not be free of adverse effects. Until these products are more closely regulated and their advertising better scrutinized, physicians and patients should become more familiar with herbal products that are commonly used as weight loss supplements and recognize those that are potentially harmful.

Importance of Dietary Supplements to the Health

2020 ◽  
Vol 16 ◽  
Author(s):  
Amarnath Mishra ◽  
Arvind K. Singh Chandel ◽  
Dixit V. Bhalani ◽  
Richa Shrivastava
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Dosage Forms ◽  
Recommended Dose ◽  
Herbal Products ◽  
Other Substances ◽  
Enzyme Supplement

: The term “dietary supplement” defines a comprehensive and diverse category of products that are essential to our health but those are absent or insufficient into the diet that may be needed to take separately, requirement of dietary supplements are varies at different stages of life such as infant, child-adult, pregnancy, lactation, and geriatrics. Dietary supplements are not medicines, nor should they be considered a substitute for food. USFDA defines dietary supplements in part as a product taken by mouth that contains a “dietary ingredients.” Nutritional ingredients comprise vitamins, minerals, amino acids, and herbs or botanicals, in addition to other substances that can be considered to supplement the diet. The market flooded with various dosage forms of dietary supplements such as capsules, tablets, powders, energy bars, liquids, etc. These include Vitamin, Mineral, Herbal Products containing extracts from herbs as well as algae and fungi, Concentrate, metabolite, constituent, or extract, Enzyme supplement, Essential amino, and fatty acids. This chapter describes the importance of the dietary supplement, source, disease arises by deficiency, and recommended dose for different groups.

Survey of Preoperative Patients' Use of Herbal Products and Other Selected Dietary Supplements

2002 ◽  
Vol 37 (12) ◽  
pp. 1301-1306 ◽  
Author(s):  
Tricia A. Meyer ◽  
Clinton E. Baisden ◽  
Charles R. Roberson ◽  
David F. Gloyna ◽  
Mohammad H. Rajab ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Dietary Supplements ◽  
Surgical Procedures ◽  
Demographic Data ◽  
Surgical Patients ◽  
Herbal Products ◽  
Saw Palmetto ◽  
Anesthetic Drugs ◽  
Assessment Unit ◽  
Orthopedic Patients

Purpose This study was designed to determine the prevalence of herbal and selected dietary product use among preoperative patients. Methods A questionnaire listing 26 herbal/dietary supplements was given to 979 preoperative patients in the anesthesia assessment unit. Subjects were asked to indicate the amounts and durations of products taken. Demographic data and proposed surgical procedures were noted. Results One hundred and seventy surgical patients (17.4%) reported taking herbal or dietary supplements. Neurosurgical, gynecological, and orthopedic surgical patients reported the highest incidences of use at 21%, 21%, and 20%, respectively. Of patients taking these agents, 34.7% took only one product, 23.5% took two products, 11.2% took three products, and 10.6% took four or more products. The most commonly used herbals, in descending order of frequency, were ginkgo, garlic, ginseng, St. John's wort, and echinacea. Glucosamine, chondroitin, and chromium were the surveyed dietary supplements most widely used. More than 40 herbs were taken occasionally. The median age of users and nonusers was 62 years. Orthopedic patients took glucosamine and chondroitin most commonly, ophthalmic patients took ginkgo most commonly, and urology patients took saw palmetto most commonly. Conclusion The adverse effects of herbals and dietary products during surgical procedures and the interactions between these products and anesthetic drugs warrant further research. The use of herbal or dietary supplements may indicate alteration of patients' perioperative regimens.

scholarly journals The preferences in selecting dietary supplements used in slimming

2016 ◽  
Vol 126 (4) ◽  
pp. 170-174 ◽  
Author(s):  
Izabela Cichocka ◽  
Jan Krupa
Keyword(s):  
Weight Loss ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Health Risks ◽  
Pharmaceutical Market ◽  
The Internet ◽  
Sources Of Information ◽  
The People ◽  
The Moment

Abstract Introduction. The interest in weight loss supplements can be noticed in Poland at the moment. It is related to people’s trying to look good as fast as possible. The pharmaceutical market puts an emphasis only on the benefits and majority of the people purchasing the supplements do not regard doctor’s advice as necessary. Therefore, in order to learn about consumers’ awareness about the use of dietary supplements is gaining importance. Aim. The objective of the study was to gain knowledge about choice preferences of dietary supplements used in weight loss, like also to learn about consumer’s awareness about the use of dietary supplements. Material and methods. An anonymous survey was conducted in Mielec in 2015 among 112 women. The questionnaire included questions concerning their knowledge of dietary supplements, the type and amount of consumption, the reasons for using supplements, benefits and health risks of their use. Results. 90.2% of women admitted that they are using or they used dietary supplements in order to reduce weight. Respondents most often derive the information about these preparations from the pharmacist (62.5%), television (46.4%), a doctor (36.6%), radio (30.4%), the Internet (29.5%). 72.4% of female respondents pay attention to the composition of dietary supplement, with the emphasis on the amount of the ingredients (64.3%), its dosage (55.4%), the origin of the ingredients (natural or synthetic) (37.5%). Female respondents prefer dietary supplements either in the form of tablets (83.9%) and capsules (54.7%), as well as in liquid (52.7%). Conclusions. Respondents showed an increased interest in supplements used for weight loss and they usually use it in forms of tablets and capsules. As the role of the Internet increases, it is necessary to educate consumers about ability to search reliable sources of information about dietary supplements used for weight loss.

scholarly journals Interaction of Carbamazepine with Herbs, Dietary Supplements, and Food: A Systematic Review

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Sophia Yui Kau Fong ◽  
Qiong Gao ◽  
Zhong Zuo
Keyword(s):  
Systematic Review ◽  
Drug Interactions ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Plasma Concentrations ◽  
Inclusion Criteria ◽  
First Line ◽  
Pharmacodynamic Interaction ◽  
Herbal Products ◽  
Therapeutic Outcomes

Background. Carbamazepine (CBZ) is a first-line antiepileptic drug which may be prone to drug interactions. Systematic review of herb- and food-drug interactions on CBZ is warranted to provide guidance for medical professionals when prescribing CBZ.Method. A systematic review was conducted on six English databases and four Chinese databases.Results. 196 out of 3179 articles fulfilled inclusion criteria, of which 74 articles were reviewed and 33 herbal products/dietary supplement/food interacting with CBZ were identified. No fatal or severe interactions were documented. The majority of the interactions were pharmacokinetic-based (80%). Traditional Chinese medicine accounted for most of the interactions (n=17), followed by food (n=10), dietary supplements (n=3), and other herbs/botanicals (n=3). Coadministration of 11 and 12 of the studied herbal products/dietary supplement/food significantly decreased or increased the plasma concentrations of CBZ. Regarding pharmacodynamic interaction, Xiao-yao-san, melatonin, and alcohol increased the side effects of CBZ while caffeine lowered the antiepileptic efficacy of CBZ.Conclusion. This review provides a comprehensive summary of the documented interactions between CBZ and herbal products/food/dietary supplements which assists healthcare professionals to identify potential herb-drug and food-drug interactions, thereby preventing potential adverse events and improving patients’ therapeutic outcomes when prescribing CBZ.

scholarly journals DAPSONE HYPERSENSITIVITY SYNDROME: A COMPLICATION OF DAPSONE THERAPY

2021 ◽  
pp. 7-8
Author(s):  
LAKSHMI NARASIMHA GUNTURU ◽  
SUNAINA V ◽  
REDDY SANTHOSH C ◽  
HARI KIRAN VN
Keyword(s):  
Adverse Effects ◽  
General Hospital ◽  
Treatment Regimen ◽  
Hypersensitivity Syndrome ◽  
Medication History ◽  
Dermatological Examination ◽  
Leprosy Patients ◽  
History Of ◽  
Laboratory Investigations ◽  
Multibacillary Leprosy

Dapsone is chemically sulfonamide with its leprostatic mechanism used in the treatment of Hansen’s disease. It is one of the safest drugs in leprosy patients. Apart from its safety, it is associated with various adverse effects such as hemolytic anemia, allergic dermatitis, agranulocytosis, methaemoglobinemia, and dapsone hypersensitivity syndrome (DHS). DHS typically presents with fever, skin eruptions, Jaundice, and hepatomegaly (organ involvement). We present a case of 35-year-old female attended to Government General Hospital with complaints of fever, skin rashes, and yellowish discoloration of the eyes. She had past medication history of dapsone taken for paucibacillary leprosy for 4 weeks. Her symptoms appeared after a month and become intolerable to dapsone. Laboratory investigations revealed hepatomegaly, anemic with jaundice. Based on dermatological examination, her diagnosis was confirmed as DHS. The drug was stopped and the patient was treated with drugs for the symptomatic cure. She was recovered from her condition and the multibacillary leprosy multidrug treatment regimen was continued without dapsone.

scholarly journals Severe spruelike enteropathy and collagenous colitis caused by olmesartan

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shiho Kaneko ◽  
Kana Matsuda ◽  
Yasuko Mizuta ◽  
Shoya Shiratori ◽  
Kazuma Kishi ◽  
...  
Keyword(s):  
Weight Loss ◽  
Clinical Symptoms ◽  
Villous Atrophy ◽  
Collagenous Colitis ◽  
Clinical History ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Medication History ◽  
Severe Diarrhea ◽  
History Of

Abstract Background Olmesartan, which is an angiotensin II receptor blocker, reportedly causes spruelike enteropathy, with intestinal villous atrophy as its typical histopathological finding. Interestingly, collagenous and/or lymphocytic gastritis and colitis occur in some patients. We report the case of a 73-year-old Japanese man with a 2-month clinical history of severe diarrhea and weight loss. There were few reports in which spruelike enteropathy and collagenous colitis were both observed and could be followed up. Case presentation We report a case of a 73-year-old man with a 2-month clinical history of severe diarrhea and weight loss. He had taken olmesartan for hypertension treatment for 5 years. Endoscopic examination with biopsies revealed intestinal villous atrophy and collagenous colitis. Suspecting enteropathy caused by olmesartan, which was discontinued on admission because of hypotension, we continued to stop the drug. Within 3 weeks after olmesartan discontinuation, his clinical symptoms improved. After 3 months, follow-up endoscopy showed improvement of villous atrophy but not of the thickened collagen band of the colon. However, the mucosa normalized after 6 months, histologically confirming that the preexistent pathology was finally resolved. Conclusions This report presents a case in which spruelike enteropathy and collagenous colitis were both observed and could be followed up. In unexplained cases of diarrhea, medication history should be reconfirmed and this disease should be considered a differential diagnosis.

scholarly journals Frequency of Dietary Supplements usage in the Saudi Arabian Public and Gym Users

2021 ◽  
Vol 6 (6) ◽  
Author(s):  
Muhammad Raihan Sajid ◽  
Lama Quraiba ◽  
Noara Khaled Alhusseini ◽  
Haifa Alsheikh ◽  
Nabel Basha ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
General Population ◽  
Adverse Effects ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Online Survey ◽  
Cross Sectional ◽  
Physically Active ◽  
Supplement Use ◽  
Active Adults

In the recent years, dietary supplements use among adults has increased dramatically to maintain good health and prevent diseases. Since some individuals find maintaining a balanced meal a challenge, they use dietary supplements to replace inadequate energy and micro/macro-nutrient intake. The aim of the study is to explore the use of dietary supplements and to assess awareness of its positive/adverse effects among physically active adults and the general population in Saudi Arabia. We conducted a cross-sectional online survey-based study and received 574 responses showing frequencies and types of dietary supplements. The results show that 44.6% of respondents use dietary supplements. The most used dietary supplements were Vitamin C and multivitamins, consumed by 44% of the respondents, Vitamin D (44%), Iron (41%), and Calcium (39%).  Protein sports bars and powder were consumed mainly by gym members, particularly those practicing weight-training exercises. Approximately 4% of respondents reported side-effects secondary to the usage of the dietary supplements. We conclude that the dietary supplement usage is widespread in Saudi Arabia among both gym members and the general public. It is highly recommended to increase awareness measures from official health entities by educating the general population and physically active adults about dietary supplement use and adverse effects to ensure safe practices.

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