Cutaneous Angiomatosis in a Young Dog

2005 ◽  
Vol 42 (3) ◽  
pp. 378-381 ◽  
Author(s):  
Y. Kim ◽  
S. Reinecke ◽  
D. E. Malarkey
Keyword(s):  
Blood Vessels ◽  
Skin Lesions ◽  
Punch Biopsy ◽  
Cutaneous Lesions ◽  
Mixed Breed ◽  
Skin Punch Biopsy ◽  
Surgical Preparation ◽  
Well Differentiated ◽  
The Right ◽  
Extensive Involvement

A 1-year-old, spayed, female, mixed-breed dog had two reddish-purple cutaneous lesions, one on the right dorsal antebrachium and the other on the right shoulder. The lesions consisted of approximately 13 x 3 cm and 15 x 10 cm, irregular, patchy regions of 0.5-3.0 cm, circular, sometimes raised, reddish-purple swellings resembling ecchymoses. The lesion on the antebrachium had been noticed since the dog was adopted at 6 months of age and appeared to have increased in size over an 11-week period, at which time skin punch biopsy revealed an infiltrative pattern of well-differentiated blood vessels leading to an interpretation that the lesion was a well-differentiated hemangiosarcoma. The second lesion was revealed when the dog had its fur shaved in that area during surgical preparation to excise the antebrachial lesion. No other skin lesions were found on the dog. Microscopically, there was a widely disseminated and infiltrative-like pattern of benign-appearing small blood vessels, which were throughout the superficial and deep dermis and subcutis. Although the disseminated nature suggested malignancy, the histologic appearance of well-differentiated small blood vessels and nonprogressive clinical features indicate that the lesions were benign. The dog has been followed for 6 years and to date has no evidence of progression of the antebrachial lesion or shoulder lesion. To the authors' knowledge, this is the first report of a congenital angiomatosis-like lesion in a young dog, with extensive involvement of the forelimb.

scholarly journals Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Jason E. Cohn ◽  
Hilary M. Caruso Sales ◽  
Giang Huong Nguyen ◽  
Harvey Spector ◽  
Kenneth Briskin
Keyword(s):  
Nasal Septum ◽  
Skin Lesions ◽  
Low Grade ◽  
Cutaneous Lesions ◽  
Epithelial Tumor ◽  
Vegf Inhibitor ◽  
Central Crater ◽  
Well Differentiated ◽  
The Right ◽  
Endothelial Growth Factor

Keratoacanthoma (KA) is a benign epithelial tumor that typically presents as a firm, cone-shaped, flesh-colored nodule with a central horn-filled crater. KA is considered to be a low-grade variant of squamous cell carcinoma (SCC). We report a rare case of a 72-year-old male who presented with a KA involving the nasal septum, possibly related to ranibizumab use. A flesh-colored lesion on the right anterior nasal septum lesion was visualized on examination. Histologic examination revealed a well-circumscribed, dome-shaped central crater filled with keratin, well-differentiated squamous epithelium with ground-glass cytoplasm with pushing margins, and intraepithelial microabscesses establishing the diagnosis of KA. KA of the nasal septum has only been reported once in the literature. This case is unusual because it normally presents on sun-exposed areas. Additionally, this patient was taking ranibizumab, a vascular endothelial growth factor (VEGF) inhibitor for macular degeneration. Despite ranibizumab not being directly linked to precancerous and cancerous skin lesions, agents in this medication class have been. Although it is difficult to prove associations in this isolated case, the role of ranibizumab causing cutaneous lesions should be further investigated.

Invasive cutaneous cryptococcosis of the nasal planum in a cat – case report

2018 ◽  
Vol XXIII (133) ◽  
pp. 56-62
Author(s):  
Ana Cláudia Balda ◽  
Juliana Cristina Gonçalves ◽  
Renata Cristina Menezes ◽  
Ana Cristina Fascetti de Souza ◽  
Guilherme Durante Cruz
Keyword(s):  
Private Practice ◽  
Infectious Agent ◽  
Skin Lesions ◽  
The Body ◽  
Small Animals ◽  
Cutaneous Lesions ◽  
Mixed Breed ◽  
Deep Mycosis ◽  
The City ◽  
Cutaneous Cryptococcosis

Crytococcosis is the most common deep mycosis in cats, despite its rarity in the medical practice of small animals. The infectious agent of the disease is Cryptococcus sp, an opportunistic fungus that can spread throughout the body. An approximately two-year-old mixed breed cat, weighting 3 kg was presented to a private practice in the city of São Paulo, Brazil. Physical examination relealed pyogranulomatous skin lesions, mainly on the nasal planum and the second digit of the left thoracic lim. The animal presented no neurological or respiratory signs. The response to antifulgal on cutaneous lesions was favorable, but the animal did not resist a second sedation and died within twenty-eight days after starting treatment. This report shows an atypical case of cryptococcosis due to the lack of immunodeficiency.

scholarly journals Lupus vulgaris mimicking cutaneous leishmaniasis: A case report

2022 ◽  
Vol 13 (1) ◽  
pp. 53-56
Author(s):  
Nouf Faihan Bin Rubaian ◽  
Haya Fahad Alzamami ◽  
Gadah Abdulatif Alhosawi ◽  
Leena Abdulrahman Almuhaish
Keyword(s):  
Delayed Diagnosis ◽  
Punch Biopsy ◽  
Lupus Vulgaris ◽  
Cutaneous Tuberculosis ◽  
Dorsal Aspect ◽  
Skin Punch Biopsy ◽  
Diagnostic Difficulties ◽  
Anti Tubercular Therapy ◽  
The Right ◽  
Saudi Male

Lupus vulgaris (LV) is a progressive, chronic form of cutaneous tuberculosis (CTB). The head and neck regions are the most commonly affected sites, followed by the arms and legs. Occurring in unusual sites may pose diagnostic difficulties. Herein, we report a case of LV present on the dorsal aspect of the right hand in a twenty-year-old Saudi male. It was misdiagnosed as leishmaniasis as the patient lived in an area in which it was endemic, and was treated accordingly with no benefit. A skin punch biopsy was taken and the diagnosis of LV was confirmed. The lesion responded well to anti-tubercular therapy (ATT), yet healed with atrophic scarring. Although rare, clinicians must be aware of the importance of considering CTB as an important differential, as misdiagnosis or delayed diagnosis of this entity may eventually cause prolonged morbidity.

scholarly journals Case Report: Borrelia-DNA Revealed the Cause of Arthritis and Dermatitis During Treatment With Rituximab

2021 ◽  
Vol 12 ◽  
Author(s):  
Johanna Sjöwall ◽  
Georgios Xirotagaros ◽  
Chris D. Anderson ◽  
Christopher Sjöwall ◽  
Charlotte Dahle
Keyword(s):  
Bacterial Genome ◽  
Punch Biopsy ◽  
Calcium Pyrophosphate ◽  
Young Female ◽  
Monosodium Urate ◽  
Patient History ◽  
Skin Punch Biopsy ◽  
The Right ◽  
Antibody Levels ◽  
Urate Crystals

Borrelia-specific antibodies in serum did not contribute to the diagnosis of Borrelia arthritis or Borrelia-associated dermatitis in a young woman with ongoing treatment with rituximab due to multiple sclerosis. The diagnosis was confirmed by the detection of Borrelia-DNA in a skin punch biopsy. The patient history did not reveal any tick exposure. She had suffered for several months from fluctuating pain and swelling of the right knee as well as skin involvement with redness and oedema around the ankle of the same leg. Monoarthritis was confirmed by a rheumatologist. Knee puncture was performed but the synovial fluid was only sufficient for microscopic examination of crystals. Neither monosodium urate crystals nor calcium pyrophosphate crystals were found. Borrelia serology in blood revealed borderline levels of immunoglobulin (Ig)M and IgG, respectively. Treatment with doxycycline resulted in resolution of the joint and skin manifestations within a month. This case highlights that Borrelia-specific antibody levels cannot be reliably interpreted in patients who have received B-cell depleting therapy. Under these circumstances, detection of the bacterial genome in different body fluids, such as in the skin, can be a useful complement to the diagnosis of Lyme disease. In this young female, the diagnosis would certainly have been further delayed without the detection of Borrelia-DNA in the skin.

scholarly journals Hydroxyurea Associated Cutaneous Lesions: A Case Report

2018 ◽  
Vol 6 (8) ◽  
pp. 1458-1461 ◽  
Author(s):  
Viktor Simeonovski ◽  
Hristina Breshkovska ◽  
Silvija Duma ◽  
Ivana Dohcheva-Karajovanov ◽  
Katerina Damevska ◽  
...  
Keyword(s):  
Side Effects ◽  
Actinic Keratosis ◽  
Myeloproliferative Disorders ◽  
Skin Lesions ◽  
Term Therapy ◽  
Cutaneous Lesions ◽  
Cutaneous Side Effects ◽  
Dermatological Examination ◽  
The Right ◽  
Hands And Feet

BACKGROUND: Hydroxyurea (HU) is an antimetabolite agent that interferes with the S-phase of cellular replication and inhibits DNA synthesis, with little or no effect on RNA or protein synthesis. It is used in the treatment of many myeloproliferative disorders (MD) and is particularly a first line treatment drug for intermediate to high-risk essential thrombocythemia. Although safe and very well tolerated by the patients suffering from MD, there have been numerous reports of a broad palette of cutaneous side effects associated with prolonged intake of the medication. These may include classical symptoms such as xerosis, diffuse hyperpigmentation, brown-nail discolouration, stomatitis and scaling of the face, hands, and feet or more serious side effects such as actinic keratosis lesions, leg ulcers and multiple skin carcinomas.CASE REPORT: We report a case of a 52-year-old man, on long-term therapy with HU for essential thrombocytosis, with several concurrent skin lesions. Despite the perennial use of HU, the cutaneous changes were neglected. The local dermatological examination revealed oval perimalleolar ulcer on the right leg, with dimensions 6 x 4 cm, clearly demarcated from the surroundings with regular margins, periulcerous erythema, with very deep and highly fibrinous bed of the ulcer, positive for bacterial infection. The ulcer was treated with topical wound therapy with alginate and parenteral antibiotics. The extended dermatological screening also showed two nummular lesions in the right brachial region, presenting as erythematous papules with sharp margins from the surrounding skin, gritty desquamation and dotted hyperpigmentations inside the lesion. Further dermoscopy and biopsy investigations confirmed a diagnosis of basal cell carcinoma. Nasal actinic keratosis was also noted. The patient was advised for discontinuing or substituting the HU therapy.CONCLUSION: We present this case to draw attention to the various cutaneous side effects that occur with perennial HU use and suggest an obligatory reference to a dermatological consult.

scholarly journals Localized Bullous Pemphigoid on the Site of Knee Arthroplasty: A Case Report

2016 ◽  
Vol 8 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Lucija Kosi ◽  
Jelena Perić ◽  
Milica Pantović ◽  
Gorana Bijelić ◽  
Jelica Vukićević Sretenović ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Knee Arthroplasty ◽  
Skin Lesions ◽  
Direct Immunofluorescence ◽  
Topical Steroids ◽  
Cutaneous Lesions ◽  
Predisposing Factor ◽  
Dermatological Examination ◽  
The Right ◽  
Split Skin

Abstract Localized bullous pemphigoid is a rare variant of bullous pemphigoid, and its exact etiopathogenesis is yet to be elucidated. We present a case of a 74-year-old Caucasian male with a 3-month history of skin lesions that appeared 9 months after he underwent a knee arthroplasty. Dermatological examination showed several pruritic tense bullae on the right knee, localized around the surgical scar, as well as erosions covered with crusts. The diagnosis of localized bullous pemphigoid was confirmed by direct immunofluorescence test (conventional and split-skin). The patient was treated with potent topical steroids, which led to complete resolution of cutaneous lesions. We suppose that the occurrence of localized bullous pemphigoid in our patient may be explained by the concept of “immunocompromised district” in which one disease (surgery) caused an immunological alteration which is a predisposing factor for the development of secondary disease such as localized bullous pemphigoid.

scholarly journals Blaschkoian Lichen Planus in an Amazghi; A Rare Case Report

2014 ◽  
Vol 8 (1) ◽  
pp. 45-50
Author(s):  
Ebtisam Elghblawi
Keyword(s):  
Lichen Planus ◽  
Previous History ◽  
Unknown Origin ◽  
Skin Lesions ◽  
Punch Biopsy ◽  
Late Presentation ◽  
Inflammatory Dermatosis ◽  
Rare Case Report ◽  
Lines Of Blaschko ◽  
The Right

Lichen planus (LP) is a common acquired inflammatory dermatosis of unknown origin with several morphological forms. Linear lichen planus is frequently seen but cases of zonal/ zosteriform/ dermatomal/ blaschkoid LP are rare. Typically LP is merely acknowledged as an old companion to a dermatologist in the clinic. Nonetheless sometimes it comes in masquerades. Many reports have documented LP to occur in scars of previous herpes zoster (HZ) lesions. Zosteriform LP without evidence of HZ is an extremely rare occurrence in the head and neck area. To the best of my knowledge such a condition has not been reported in the literature previously. I report a healthy 53-year old Amazaghi woman with grouped lichenoid, unilateral linear plaque skin lesion on the right side of the face that followed the lines of Blaschko with no previous history of HZ on the involved area. The punch biopsy specimen confirmed the typical histology of lichen planus. A clinical diagnosis was made based on the clinical picture and biopsy reading. Usually Blaschko linear skin lesions develop later in life with distinctive features, and thus it should be differentiated from other acquired skin dermatoses. I report this case of LP type for its scarcity and to add one more case to the list of existing literature, with the idiosyncrasy of late presentation onset.

scholarly journals Multiple Bluish Nodules in a 20-Year-Old Female with Similar Lesions in Her Father

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Punyawee Ongsri ◽  
Supenya Varothai
Keyword(s):  
Blood Vessels ◽  
Rare Case ◽  
Vascular Malformations ◽  
Skin Lesions ◽  
Young Female ◽  
Cutaneous Lesions ◽  
Glomus Tumors ◽  
Lower Back ◽  
Healthy Young Female

Glomuvenous malformations are congenital, benign, vascular malformations classified as subtypes of glomus tumors with predominant blood vessels, usually present at birth or childhood with multiple, bluish, soft papules and nodules or plaque-like cutaneous lesions. Later present with pronounced segmental lesions, superimposed on the primary lesions, suggesting type 2 segmental mosaicism. We present a rare case of familial glomuvenous malformations, a healthy young female presented with multiple bluish papules since birth which later developed dissemination later in her adolescence. Moreover, her father also had similar skin lesions on his left lower back.

scholarly journals Lipoblast-Like Morphology in a Uveal Melanoma with Delayed Metastasis to the Liver

2019 ◽  
Vol 6 (2) ◽  
pp. 87-92
Author(s):  
Aimi Toyama ◽  
W. Robert Bell ◽  
Alessio Giubellino ◽  
Faqian Li
Keyword(s):  
Uveal Melanoma ◽  
Spindle Cell ◽  
Skin Lesions ◽  
Unique Case ◽  
Spindle Cell Proliferation ◽  
History Of ◽  
The Right ◽  
Extensive Involvement ◽  
History Of Cancer ◽  
Uveal Melanomas

Uveal melanomas are typically described as having epithelial or spindled cell morphology; however, as is the nature of melanomas, the morphology of the malignant melanocytes can be varied. We describe a unique case of metastatic uveal melanoma with lipoblast-like morphology, identified in the liver during an autopsy of a 75-year-old woman. Apart from a remote history of uveal melanoma in the right eye, there was no other history of cancer, and there were no concerning skin lesions present. The liver exhibited hepatomegaly with diffuse and extensive involvement of malignant tumor cells. Histopathological evaluation of liver sections showed malignant epithelioid and spindle cell proliferation. A distinct, spiculated, tan-white area revealed sheets of malignant cells with small and large vacuoles within the cytoplasm and scalloped nuclei, mimicking lipoblasts and adipocytes. Immunohistochemical stains confirmed these cells to be malignant melanoma cells. Being aware of this morphology in uveal melanomas is important especially when there is metastasis to the liver, so that it is not mistaken for more benign processes such as steatosis.

scholarly journals Degos disease: a case report and review of the literature

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Santosh Tummidi ◽  
Prabhakaran Nagendran ◽  
Swaroopa Gedela ◽  
Jami Rupa Ramani ◽  
Arundhathi Shankaralingappa
Keyword(s):  
Central Nervous System ◽  
Specific Treatment ◽  
Skin Lesions ◽  
Punch Biopsy ◽  
Review Of The Literature ◽  
Thrombotic Occlusion ◽  
Case Presentation ◽  
Degos Disease ◽  
Skin Punch Biopsy ◽  
Hindu Woman

Abstract Background Degos disease is a very rare syndrome with multisystem vasculopathy of unknown cause. It can affect the skin, gastrointestinal tract, and central nervous system. However, other organs such as the kidney, lungs, pleura, and liver can also be involved. Case presentation A 35-year-old Hindu woman presented to our dermatology outpatient department with complaints of depigmented painful lesions. A skin punch biopsy taken from the porcelain white atrophic papules which revealed features of Degos disease. Conclusion The diagnosis of Degos disease is usually based on the presence of the pathognomonic skin lesions and a tissue biopsy demonstrating a wedge-shaped area of necrosis with thrombotic occlusion of the small arterioles. No specific treatment is currently available for this disease.

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