scholarly journals Prostatic Squamous Metaplasia in a Cat with Interstitial Cell Neoplasia in a Retained Testis

2008 ◽  
Vol 45 (6) ◽  
pp. 905-909 ◽  
Author(s):  
A. R. Tucker ◽  
J. R. Smith
Keyword(s):  
Interstitial Cell ◽  
Steroid Hormone ◽  
Squamous Metaplasia ◽  
Clinical Signs ◽  
Cell Tumor ◽  
Histopathologic Diagnosis ◽  
History Of ◽  
Prostatic Epithelium ◽  
Poorly Differentiated ◽  
Well Differentiated

An 11-year-old cat with a retained testis was presented with a chronic history of dysuria and bladder atony. Medical therapy failed to alleviate the clinical signs. Contrast radiography demonstrated a diffusely narrowed urethra. During a celiotomy and prepubic urethrostomy, a retained testis, stenosed urethra, and irregularly enlarged prostate were observed. Histopathologic diagnosis was retained testis with a well-differentiated interstitial cell tumor, a poorly differentiated interstitial cell tumor, and marked squamous metaplasia of the prostatic epithelium with suppurative prostatitis. Neoplastic interstitial cells were immunoreactive for Melan A, consistent with reports of Melan A expression in steroid hormone-producing tissue. This is the first report of prostatic squamous metaplasia associated with testicular neoplasia in a felid.

Dedifferentiated Liposarcoma With a Paraganglioma-like Histologic Pattern: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (7) ◽  
pp. 788-791
Author(s):  
Dating Liu ◽  
Guillermo Quinonez ◽  
Steven Latosinsky
Keyword(s):  
Neuron Specific Enolase ◽  
Malignant Neoplasm ◽  
Neuroendocrine Differentiation ◽  
Growth Patterns ◽  
Dedifferentiated Liposarcoma ◽  
Tissue Mass ◽  
Histologic Pattern ◽  
History Of ◽  
Poorly Differentiated ◽  
Well Differentiated

Abstract A 53-year-old man presented with a 4-month history of increasing abdominal discomfort and distension. A large retroperitoneal mass was found on imaging. Image-guided needle core biopsy demonstrated a poorly differentiated malignant neoplasm. A 30 × 32 × 33-cm soft tissue mass was removed. Microscopically, the tumor consisted of predominantly epithelioid malignant cells arranged in a paraganglioma-like growth pattern. Immunohistochemically, these cells were strongly positive for neuron-specific enolase. Stains for synaptophysin and chromogranin, however, were negative. There was no ultrastructural evidence of neuroendocrine differentiation. Adjacent sarcomatous areas were composed of spindled cells arranged in storiform and fibrosarcoma-like growth patterns. A small area of well-differentiated liposarcoma was identified, and a diagnosis of dedifferentiated liposarcoma was established. To the best of our knowledge, this represents the first reported case of dedifferentiated liposarcoma with a paraganglioma-like histologic pattern. A brief review focusing on the morphologic variations of dedifferentiated liposarcoma is also presented.

scholarly journals Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor in a 16-Year-Old Single Woman: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ahmed Abu-Zaid ◽  
Ayman Azzam ◽  
Lama Abdulhamid Alghuneim ◽  
Mona Tarek Metawee ◽  
Tarek Amin ◽  
...  
Keyword(s):  
Literature Review ◽  
Leydig Cell ◽  
Ovarian Neoplasms ◽  
Case Reports ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Single Woman ◽  
History Of ◽  
Poorly Differentiated ◽  
Sex Cord Stromal Tumors

Sertoli-Leydig cell tumor (SLCT) of ovary is an exceedingly unusual neoplasm that belongs to a group of sex cord-stromal tumors of ovary and accounts for less than 0.5% of all primary ovarian neoplasms. Very few case reports have been documented in the literature so far. Herein, we report a case of primary poorly differentiated ovarian Sertoli-Leydig cell tumor (SLCT) involving the left ovary in a 16-year-old single woman who presented with a 3-month history of a pelviabdominal mass, acne, hirsutism, and menstrual irregularities. In addition, a literature review on ovarian SLCTs is provided.

scholarly journals Case Report on Sertoli Cell Tumor of Ovary

2017 ◽  
Vol 31 (1) ◽  
pp. 54-56
Author(s):  
Kohinoor Begum ◽  
Kamil Ara Khanom ◽  
Joysree Saha
Keyword(s):  
Sertoli Cell ◽  
Leydig Cells ◽  
Histopathological Examination ◽  
Cell Tumor ◽  
Solid Mass ◽  
Sertoli Cell Tumor ◽  
Hormonal Function ◽  
History Of ◽  
Well Differentiated ◽  
Sertoli Cell Tumors

A 33 years old lady presented with history of irregular menstrual cycle followed by menorrhagia. USG revealed left ovarian solid mass but all tumor markers were within normal range. A solid mass on left sided ovary was found on laparotomy. Histopathological examination of the mass showed well differentiated sertoli cell tumor. Tumors of the stroma (Leydig cells) and/or sex cords (Sertoli cells) represent approximately 8% of ovarian tumors and develop from the connective tissue (respectively, interstitial and nurse cells) of the ovary. Because these cells participate in ovarian hormonal function, most of the sex-cord or stromal tumors are able to secrete hormones (estrogens, androgens, corticoids), which explains the hormonal dysfunctions associated with these tumors. Their prognosis are difficult to establish; some of the tumors are almost always benign (Sertoli cell tumors, Leydig cell tumors), whereas others are malignant but with more-or-less delayed local-regional or metastatic relapses.Bangladesh J Obstet Gynaecol, 2016; Vol. 31(1) : 54-56

scholarly journals Análisis epidemiológico de cáncer de vesícula

2019 ◽  
Vol 111 (2) ◽  
pp. 90-94
Author(s):  
Mauricio J. Linzey ◽  
◽  
Marcelo E. López Avellaneda ◽  
Germán A. Alanis ◽  
Marcelo E. Ferraro
Keyword(s):  
Gallbladder Cancer ◽  
Squamous Metaplasia ◽  
Young Patients ◽  
Cancer Control ◽  
Staging System ◽  
Cancer Staging ◽  
Papillary Adenocarcinoma ◽  
Female Ratio ◽  
Poorly Differentiated ◽  
Well Differentiated

Background: Gallbladder cancer is characterized by poor prognosis and late diagnosis. Objective: The aim of our study is to describe the epidemiological variables of gallbladder cancer at our centre and to compare them with data from the worldwide literature. Material and methods: Patients undergoing cholecystectomy between January 1, 2006, and December 31, 2015. The following variables were analyzed: sex, age, male to female ratio, reason for cholecystectomy, urgent or scheduled. In case of gallbladder cancer, sex, age, histopathology, cell differentiation, gallbladder layer invasion, lymphovascular, cystic lymph node, adjacent tissues and liver invasion; and cancer staging according to Nevin staging system and the Union for International Cancer Control (UICC). Results: Ninety-two gallbladder neoplasms were found, representing 1.26% of all cholecystectomies. Mean age of patients with gallbladder cancer was 57.9 years (range, 22-88 years) of whom 69.5% (n=64) were women, with the same female to men ratio of 2:1 described for cholecystectomy. The histopathology of the 92 gallbladder cancers corresponded to adenocarcinoma, 93.4% (n= 86); squamous cell carcinoma, 4.4% (n= 4); and undifferentiated malignancy with elements of epithelial and mesenchymal origin, 2.2% (n= 2). There were two cases of adenocarcinoma with squamous metaplasia, two mucinous carcinomas, one papillary adenocarcinoma and one case of antral-type and intestinal metaplasia. Sixty tumors (65.4%) were moderately differentiated; 12 (13%) well differentiated; 11 (11.9%) poorly differentiated; and 4 (4.3%) were undifferentiated. In 5 cases (5.4%) the type of differentiation was not described. Conclusion: In gallbladder cancer diagnosed after a cholecystectomy, it is more frequent in the female sex, with adenocarcinoma being the most common histological type. Interestingly, the number of young patients with gallbladder cancer is noteworthy.

scholarly journals Tracheal stenosis in a Holstein cow

2020 ◽  
Vol 50 (8) ◽  
Author(s):  
Franciéli Adriane Molossi ◽  
Regina Tose Kemper ◽  
Bianca Santana de Cecco ◽  
Rafael Biondo Rosa ◽  
Luciana Sonne ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Plasma Cells ◽  
Clinical Signs ◽  
Tracheal Mucosa ◽  
First Report ◽  
Holstein Cow ◽  
Adjacent Mucosa ◽  
Squamous Cell Metaplasia ◽  
History Of ◽  
Well Differentiated

ABSTRACT: Tracheal stenosis, also known as “Honker syndrome”, is characterized by tracheal edema and hemorrhage, leading to partial obstruction of the lumen; therefore, death. Its etiology is not yet well elucidated. A 3-year-old Holstein cow, with a history of dyspnea, and a large amount of reddish foam flowing from the mouth and nose, had died after 10 minutes of clinical signs. Macroscopic examination revealed focally extensive hemorrhage and clot organization in tracheal mucosa extending to the submucosa, surrounded by well-differentiated fibrous connective tissue. In adjacent mucosa was observed moderate multifocal inflammatory infiltrate composed by lymphocytes and plasma cells, as well as moderate squamous cell metaplasia. The bacterial culture showed growth of contaminant and environmental bacteria and the RT-PCR to detect Herpesvirus 1 (BoHV-1) and 5 (BoHV-5) was negative. To the author’s knowledge, this is the first report of tracheal stenosis in South America, as well as the first report of this condition described in a Holstein cow.

Colocalized Granular Cell Tumor and Infiltrating Ductal Carcinoma of the Breast

2002 ◽  
Vol 126 (6) ◽  
pp. 731-733 ◽  
Author(s):  
Hikmat Al-Ahmadie ◽  
Per-Olof Hasselgren ◽  
Rawia Yassin ◽  
George Mutema
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Granular Cell Tumor ◽  
Ductal Carcinoma ◽  
Granular Cell ◽  
Cell Tumor ◽  
Palpable Mass ◽  
First Case ◽  
History Of ◽  
Well Differentiated ◽  
The Right

Abstract A 57-year-old woman presented with a 2-year history of a palpable mass in the upper inner quadrant of the right breast. A 1.1-cm, poorly circumscribed, firm tumor nodule was noted, consisting of 2 histologically distinct lesions in the same location, with some areas showing purely well-differentiated invasive ductal carcinoma and others composed of granular cell tumor. In 1 area, the 2 tumors collided and infiltrated each other. The invasive ductal carcinoma was admixed with ductal carcinoma in situ of solid and cribriform types. To our knowledge, this is the first case report demonstrating colocalization of these 2 neoplasms, which raises questions regarding causal relationship. We also review the literature on granular cell tumor of the breast.

Motility of leukemic lymphocytes

1990 ◽  
Vol 48 (3) ◽  
pp. 368-369
Author(s):  
Manoj Raje ◽  
Karvita B. Ahluwalia
Keyword(s):  
Quantitative Data ◽  
Laser Doppler Velocimetry ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Cellular Space ◽  
Differentiated Cells ◽  
Poorly Differentiated ◽  
Solid Tissues ◽  
Well Differentiated ◽  
Reduced Mobility

In Acute Lymphocytic Leukemia motility of lymphocytes is associated with dissemination of malignancy and establishment of metastatic foci. Normal and leukemic lymphocytes in circulation reach solid tissues where due to in adequate perfusion some cells get trapped among tissue spaces. Although normal lymphocytes reenter into circulation leukemic lymphocytes are thought to remain entrapped owing to reduced mobility and form secondary metastasis. Cell surface, transmembrane interactions, cytoskeleton and level of cell differentiation are implicated in lymphocyte mobility. An attempt has been made to correlate ultrastructural information with quantitative data obtained by Laser Doppler Velocimetry (LDV). TEM of normal & leukemic lymphocytes revealed heterogeneity in cell populations ranging from well differentiated (Fig. 1) to poorly differentiated cells (Fig. 2). Unlike other cells, surface extensions in differentiated lymphocytes appear to originate by extrusion of large vesicles in to extra cellular space (Fig. 3). This results in persistent unevenness on lymphocyte surface which occurs due to a phenomenon different from that producing surface extensions in other cells.

Intraocular tuberculosis, a challenge in diagnosis and treatment

2020 ◽  
Vol 3 ◽  
pp. 4
Author(s):  
Martina Larroude ◽  
Gustavo Ariel Budmann
Keyword(s):  
Developing Countries ◽  
Clinical Signs ◽  
Steady Increase ◽  
Ocular Tuberculosis ◽  
Industrial Countries ◽  
Choroidal Granuloma ◽  
History Of ◽  
And Migration ◽  
Ocular Tb

Ocular tuberculosis (TB) is an extrapulmonary tuberculous condition and has variable manifestations. The incidence of TB is still high in developing countries, and a steady increase in new cases has been observed in industrial countries as a result of the growing number of immunodeficient patients and migration from developing countries. Choroidal granuloma is a rare and atypical location of TB. We present a case of a presumptive choroidal granuloma. This case exposes that diagnosis can be remarkably challenging when there is no history of pulmonary TB. The recognition of clinical signs of ocular TB is extremely important since it provides a clinical pathway toward tailored investigations and decision making for initiating anti-TB therapy and to ensure a close follow-up to detect the development of any complication.

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