Determination of glucose in whole blood samples by mid-infrared spectroscopy

2003 ◽  
Vol 42 (4) ◽  
pp. 745 ◽  
Author(s):  
Yoen-Joo Kim ◽  
Sangjoon Hahn ◽  
Gilwon Yoon
Keyword(s):  
Infrared Spectroscopy ◽  
Whole Blood ◽  
Mid Infrared ◽  
Blood Samples ◽  
Mid Infrared Spectroscopy ◽  
Whole Blood Samples

Determination of main raw material source in bar soaps using mid-infrared spectroscopy combined with classification tools

2021 ◽  
Vol 164 ◽  
pp. 106029
Author(s):  
Diego Maciel Gerônimo ◽  
Sheila Catarina de Oliveira ◽  
Frederico Luis Felipe Soares ◽  
Patricio Peralta-Zamora ◽  
Noemi Nagata
Keyword(s):  
Infrared Spectroscopy ◽  
Raw Material ◽  
Material Source ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy

scholarly journals Determination of 19 Psychoactive Substances in Premortem and Postmortem Whole Blood Samples Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry

Separations ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 78
Author(s):  
Sevasti Karampela ◽  
Jessica Smith ◽  
Irene Panderi
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Formic Acid ◽  
Whole Blood ◽  
High Performance ◽  
Tandem Mass ◽  
Psychoactive Substances ◽  
Blood Samples ◽  
Whole Blood Samples

An ever-increasing need exists within the forensic laboratories to develop analytical processes for the qualitative and quantitative determination of a broad spectrum of new psychoactive substances. Phenylethylamine derivatives are among the major classes of psychoactive substances available on the global market and include both amphetamine analogues and synthetic cathinones. In this work, an ultra-high-performance liquid chromatography-positive ion electrospray ionization tandem mass spectrometric method (UHPLC-ESI-MS/MS) has been developed and fully validated for the determination of 19 psychoactive substances, including nine amphetamine-type stimulants and 10 synthetic cathinone derivatives, in premortem and postmortem whole blood. The assay was based on the use of 1 mL premortem or postmortem whole blood, following solid phase extraction prior to the analysis. The separation was achieved on a Poroshell 120 EC-C18 analytical column with a gradient mobile phase of 0.1% formic acid in acetonitrile and 0.1% formic acid in water in 9 min. The dynamic multiple reaction monitoring used in this work allowed for limit of detection (LOD) and lower limit of quantitation (LOQ) values of 0.5 and 2 ng mL−1, respectively, for all analytes both in premortem and postmortem whole blood samples. A quadratic calibration model was used for the 12 quantitative analytes over the concentration range of 20–2000 ng mL−1, and the method was shown to be precise and accurate both in premortem and postmortem whole blood. The method was applied to the analysis of real cases and proved to be a valuable tool in forensic and clinical toxicology.

scholarly journals Simultaneous Determination of Cyclosporine A, Tacrolimus, Sirolimus, and Everolimus in Whole-Blood Samples by LC-MS/MS

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Mustafa Karapirli ◽  
Murat Kizilgun ◽  
Ozgur Yesilyurt ◽  
Husamettin Gul ◽  
Zeki Ilker Kunak ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Simultaneous Determination ◽  
Cyclosporine A ◽  
Whole Blood ◽  
Immunosuppressive Drugs ◽  
Tandem Mass ◽  
Blood Samples ◽  
Whole Blood Samples

Objectives. Cyclosporine A (CyA), tacrolimus (TRL), sirolimus (SIR), and everolimus (RAD) are immunosuppressive drugs frequently used in organ transplantation. Our aim was to confirm a robust sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for determination of CyA, TRL, SIR, and RAD in whole-blood samples.Materials and Methods. We used an integrated online solid-phase extraction-LC-MS/MS system and atmospheric pressure ionization tandem mass spectrometry (API-MS/MS) in the multiple reaction monitoring (MRM) detection mode. CyA, TRL, SIR, and RAD were simultaneously analyzed in whole blood treated with precipitation reagent taken from transplant patients.Results. System performance parameters were suitable for using this method as a high-throughput technique in clinical practice. The high concentration of one analyte in the sample did not affect the concentration of other analytes. Total analytical time was 2.5 min, and retention times of all analytes were shorter than 2 minutes.Conclusion. This LC-MS/MS method can be preferable for therapeutic drug monitoring of these immunosuppressive drugs (CyA, TRL, SRL, and RAD) in whole blood. Sample preparation was too short and simple in this method, and it permits robust, rapid, sensitive, selective, and simultaneous determination of these drugs.

Factorial and Doehlert Design Used as Optimization Procedures for the Direct Determination of Lead in Whole Blood Samples by Graphite Furnace Atomic Absorption Spectrometry

2010 ◽  
Vol 43 (3) ◽  
pp. 508-519
Author(s):  
Henrique José Ferraz Fabrino ◽  
Josianne Nicácio Silveira ◽  
Waldomiro Borges Neto ◽  
José Bento Borba da Silva
Keyword(s):  
Atomic Absorption Spectrometry ◽  
Whole Blood ◽  
Graphite Furnace ◽  
Direct Determination ◽  
Absorption Spectrometry ◽  
Doehlert Design ◽  
Blood Samples ◽  
Graphite Furnace Atomic Absorption ◽  
Whole Blood Samples

Development and validation of a dried blood spot–HPLC assay for the determination of metronidazole in neonatal whole blood samples

2010 ◽  
Vol 397 (2) ◽  
pp. 687-693 ◽  
Author(s):  
Maysa Faisal Suyagh ◽  
Godwill Iheagwaram ◽  
Prashant Laxman Kole ◽  
Jeff Millership ◽  
Paul Collier ◽  
...  
Keyword(s):  
Whole Blood ◽  
Dried Blood Spot ◽  
Hplc Assay ◽  
Blood Samples ◽  
Whole Blood Samples ◽  
Development And Validation ◽  
Blood Spot

scholarly journals Data for the Determination of Total Carbon in Biosolids using MID-Infrared Spectroscopy

Data in Brief ◽  
2020 ◽  
Vol 30 ◽  
pp. 105615
Author(s):  
N. Albuquerque ◽  
B. Meehan ◽  
J. Hughes ◽  
A. Surapaneni
Keyword(s):  
Infrared Spectroscopy ◽  
Total Carbon ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy

Determination of quinalphos in human whole blood samples by high-performance thin-layer chromatography for forensic applications

2019 ◽  
Vol 1594 ◽  
pp. 181-189 ◽  
Author(s):  
Praveen U Sanganalmath ◽  
Purigali M Nagaraju ◽  
Kuruba Sreeramulu
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Whole Blood ◽  
High Performance ◽  
Blood Samples ◽  
Human Whole Blood ◽  
Whole Blood Samples ◽  
Layer Chromatography

Diagnosis of basal cell carcinoma by infrared spectroscopy of whole blood samples applying soft independent modeling class analogy

2007 ◽  
Vol 133 (12) ◽  
pp. 1001-1010 ◽  
Author(s):  
Mohammadreza Khanmohammadi ◽  
Razieh Nasiri ◽  
Keyvan Ghasemi ◽  
Simin Samani ◽  
Amir Bagheri Garmarudi
Keyword(s):  
Infrared Spectroscopy ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Whole Blood ◽  
Blood Samples ◽  
Whole Blood Samples
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