scholarly journals We need to keep a reproducible trace of facts, predictions, and hypotheses from gene to function in the era of big data

PLoS Biology ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. e3000999
Author(s):  
Simon Kasif ◽  
Richard J. Roberts
Keyword(s):  
Artificial Intelligence ◽  
Big Data ◽  
Dna Sequence ◽  
Gene Function ◽  
Ground Truth ◽  
Biological Knowledge ◽  
Omics Data ◽  
Biological Functions ◽  
Functional Linkage ◽  
Network Methods

How do we scale biological science to the demand of next generation biology and medicine to keep track of the facts, predictions, and hypotheses? These days, enormous amounts of DNA sequence and other omics data are generated. Since these data contain the blueprint for life, it is imperative that we interpret it accurately. The abundance of DNA is only one part of the challenge. Artificial Intelligence (AI) and network methods routinely build on large screens, single cell technologies, proteomics, and other modalities to infer or predict biological functions and phenotypes associated with proteins, pathways, and organisms. As a first step, how do we systematically trace the provenance of knowledge from experimental ground truth to gene function predictions and annotations? Here, we review the main challenges in tracking the evolution of biological knowledge and propose several specific solutions to provenance and computational tracing of evidence in functional linkage networks.

A Study on the Development of Appointment Algorithm of CT With Big Data using AI (Artificial Intelligence)

2018 ◽  
Vol 20 (2) ◽  
pp. 1-5
Author(s):  
Sang-ho Jeon ◽  
Sung-yeul Yang ◽  
In-beom Shin ◽  
Dae-mok Son ◽  
Tae-han Kwon ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Big Data

scholarly journals Evolving scenario of big data and Artificial Intelligence (AI) in drug discovery

2021 ◽  
Author(s):  
Manish Kumar Tripathi ◽  
Abhigyan Nath ◽  
Tej P. Singh ◽  
A. S. Ethayathulla ◽  
Punit Kaur
Keyword(s):  
Artificial Intelligence ◽  
Big Data ◽  
Drug Discovery

scholarly journals Blockchain Disrupting Fintech and the Banking System

Proceedings ◽  
2021 ◽  
Vol 74 (1) ◽  
pp. 24
Author(s):  
Eduard Alexandru Stoica ◽  
Daria Maria Sitea
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Big Data ◽  
Financial Institutions ◽  
New World ◽  
Great Part ◽  
Banking System ◽  
Daily Activities ◽  
Blockchain Technology ◽  
Almost All

Nowadays society is profoundly changed by technology, velocity and productivity. While individuals are not yet prepared for holographic connection with banks or financial institutions, other innovative technologies have been adopted. Lately, a new world has been launched, personalized and adapted to reality. It has emerged and started to govern almost all daily activities due to the five key elements that are foundations of the technology: machine to machine (M2M), internet of things (IoT), big data, machine learning and artificial intelligence (AI). Competitive innovations are now on the market, helping with the connection between investors and borrowers—notably crowdfunding and peer-to-peer lending. Blockchain technology is now enjoying great popularity. Thus, a great part of the focus of this research paper is on Elrond. The outcomes highlight the relevance of technology in digital finance.

scholarly journals Anomaly Identification during Polymerase Chain Reaction for Detecting SARS-CoV-2 Using Artificial Intelligence Trained from Simulated Data

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 20
Author(s):  
Reynaldo Villarreal-González ◽  
Antonio J. Acosta-Hoyos ◽  
Jaime A. Garzon-Ochoa ◽  
Nataly J. Galán-Freyle ◽  
Paola Amar-Sepúlveda ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Big Data ◽  
Real Time ◽  
Binary Classification ◽  
Simulated Data ◽  
Classification Model ◽  
Rt Pcr ◽  
Simon Bolivar ◽  
Polymerase Chain ◽  
Available Information

Real-time reverse transcription (RT) PCR is the gold standard for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), owing to its sensitivity and specificity, thereby meeting the demand for the rising number of cases. The scarcity of trained molecular biologists for analyzing PCR results makes data verification a challenge. Artificial intelligence (AI) was designed to ease verification, by detecting atypical profiles in PCR curves caused by contamination or artifacts. Four classes of simulated real-time RT-PCR curves were generated, namely, positive, early, no, and abnormal amplifications. Machine learning (ML) models were generated and tested using small amounts of data from each class. The best model was used for classifying the big data obtained by the Virology Laboratory of Simon Bolivar University from real-time RT-PCR curves for SARS-CoV-2, and the model was retrained and implemented in a software that correlated patient data with test and AI diagnoses. The best strategy for AI included a binary classification model, which was generated from simulated data, where data analyzed by the first model were classified as either positive or negative and abnormal. To differentiate between negative and abnormal, the data were reevaluated using the second model. In the first model, the data required preanalysis through a combination of prepossessing. The early amplification class was eliminated from the models because the numbers of cases in big data was negligible. ML models can be created from simulated data using minimum available information. During analysis, changes or variations can be incorporated by generating simulated data, avoiding the incorporation of large amounts of experimental data encompassing all possible changes. For diagnosing SARS-CoV-2, this type of AI is critical for optimizing PCR tests because it enables rapid diagnosis and reduces false positives. Our method can also be used for other types of molecular analyses.

Impact of Big Data and Artificial Intelligence on Industry: Developing a Workforce Roadmap for a Data Driven Economy

2021 ◽  
Author(s):  
Marina Johnson ◽  
Rashmi Jain ◽  
Peggy Brennan-Tonetta ◽  
Ethne Swartz ◽  
Deborah Silver ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Big Data ◽  
Data Driven

scholarly journals A Detailed Catalogue of Multi-Omics Methodologies for Identification of Putative Biomarkers and Causal Molecular Networks in Translational Cancer Research

2021 ◽  
Vol 22 (6) ◽  
pp. 2822
Author(s):  
Efstathios Iason Vlachavas ◽  
Jonas Bohn ◽  
Frank Ückert ◽  
Sylvia Nürnberg
Keyword(s):  
Cancer Research ◽  
Clinical Information ◽  
Disease Diagnosis ◽  
Molecular Data ◽  
Molecular Networks ◽  
Biological Knowledge ◽  
Omics Data ◽  
Translational Cancer Research ◽  
Using Data ◽  
Biological Entities

Recent advances in sequencing and biotechnological methodologies have led to the generation of large volumes of molecular data of different omics layers, such as genomics, transcriptomics, proteomics and metabolomics. Integration of these data with clinical information provides new opportunities to discover how perturbations in biological processes lead to disease. Using data-driven approaches for the integration and interpretation of multi-omics data could stably identify links between structural and functional information and propose causal molecular networks with potential impact on cancer pathophysiology. This knowledge can then be used to improve disease diagnosis, prognosis, prevention, and therapy. This review will summarize and categorize the most current computational methodologies and tools for integration of distinct molecular layers in the context of translational cancer research and personalized therapy. Additionally, the bioinformatics tools Multi-Omics Factor Analysis (MOFA) and netDX will be tested using omics data from public cancer resources, to assess their overall robustness, provide reproducible workflows for gaining biological knowledge from multi-omics data, and to comprehensively understand the significantly perturbed biological entities in distinct cancer types. We show that the performed supervised and unsupervised analyses result in meaningful and novel findings.

scholarly journals Out of the loop? On the radical and the routine in urban big data

Urban Studies ◽  
2021 ◽  
pp. 004209802110140
Author(s):  
Sarah Barns
Keyword(s):  
Artificial Intelligence ◽  
Big Data ◽  
Computational Models ◽  
Data Driven ◽  
Urban Systems ◽  
Out Of The Loop ◽  
Urban Futures ◽  
Urban Behaviour ◽  
The City

This commentary interrogates what it means for routine urban behaviours to now be replicating themselves computationally. The emergence of autonomous or artificial intelligence points to the powerful role of big data in the city, as increasingly powerful computational models are now capable of replicating and reproducing existing spatial patterns and activities. I discuss these emergent urban systems of learned or trained intelligence as being at once radical and routine. Just as the material and behavioural conditions that give rise to urban big data demand attention, so do the generative design principles of data-driven models of urban behaviour, as they are increasingly put to use in the production of replicable, autonomous urban futures.

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