scholarly journals Aging Impairs Recipient T Cell Intrinsic and Extrinsic Factors in Response to Transplantation

PLoS ONE ◽  
2009 ◽  
Vol 4 (1) ◽  
pp. e4097 ◽  
Author(s):  
Hua Shen ◽  
Bethany M. Tesar ◽  
Wei Du ◽  
Daniel R. Goldstein
Keyword(s):  
T Cell ◽  
Extrinsic Factors ◽  
Intrinsic And Extrinsic Factors

scholarly journals Cell-Extrinsic Differentiation Block Mediated by EphA3 in Pre-Leukaemic Thymus Contributes to Disease Progression

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3858
Author(s):  
Adriana C. Pliego Zamora ◽  
Hansini Ranasinghe ◽  
Jessica E. Lisle ◽  
Chun Ki Ng ◽  
Stephen Huang ◽  
...  
Keyword(s):  
T Cell ◽  
Wild Type ◽  
Developmental Pathway ◽  
Complex Interplay ◽  
Cell Competition ◽  
Extrinsic Factors ◽  
Self Renewal ◽  
Abnormal Accumulation ◽  
Differentiation Block ◽  
Intrinsic And Extrinsic Factors

We recently characterised the NUP98-HOXD13 (NHD13) mouse as a model of T-cell pre-leukaemia, featuring thymocytes that can engraft in recipient animals and progress to T-cell acute lymphoblastic leukaemia (T-ALL). However, loss of this engraftment ability by deletion of Lyl1 did not result in any loss of leukemogenesis activity. In the present study, we observe that NHD13 thymocytes overexpress EPHA3, and we characterise thymocyte behaviour in NHD13 mice with deletion of EphA3, which show a markedly reduced incidence of T-ALL. Deletion of EphA3 from the NHD13 mice does not prevent the abnormal accumulation or transplantation ability of these thymocytes. However, upon transplantation, these cells are unable to block the normal progression of recipient wild type (WT) progenitor cells through the normal developmental pathway. This is in contrast to the EphA3+/+ NHD13 thymocytes, which block the progression of incoming WT progenitors past the DN1 stage. Therefore, EphA3 is not critical for classical self-renewal, but is essential for mediating an interaction between the abnormally self-renewing cells and healthy progenitors—an interaction that results in a failure of the healthy cells to differentiate normally. We speculate that this may orchestrate a loss of healthy cell competition, which in itself has been demonstrated to be oncogenic, and that this may explain the decrease in T-ALL incidence in the absence of EphA3. We suggest that pre-leukaemic self-renewal in this model is a complex interplay of cell-intrinsic and -extrinsic factors, and that multiple redundant pathways to leukaemogenesis are active.

scholarly journals Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors

2012 ◽  
Vol 21 (3) ◽  
pp. 327-338 ◽  
Author(s):  
J. J. Phillips ◽  
Y. Javadi ◽  
C. Millership ◽  
E. R. G. Main
Keyword(s):  
Extrinsic Factors ◽  
Intrinsic And Extrinsic Factors

Intrinsic and extrinsic factors that may influence DNA preservation in skeletal remains: A review

2021 ◽  
Vol 325 ◽  
pp. 110859
Author(s):  
Caterina Raffone ◽  
Miriam Baeta ◽  
Nicole Lambacher ◽  
Eva Granizo-Rodríguez ◽  
Francisco Etxeberria ◽  
...  
Keyword(s):  
Skeletal Remains ◽  
Extrinsic Factors ◽  
Dna Preservation ◽  
Intrinsic And Extrinsic Factors

scholarly journals Conceptualizing Mobility Inequality: Mobility and Accessibility for the Marginalized

2021 ◽  
pp. 088541222110128
Author(s):  
Isti Hidayati ◽  
Wendy Tan ◽  
Claudia Yamu
Keyword(s):  
Conceptual Understanding ◽  
Thought Experiments ◽  
Future Research ◽  
Planning Practice ◽  
Extrinsic Factors ◽  
Research Directions ◽  
Future Research Directions ◽  
Intrinsic And Extrinsic Factors

The burgeoning landscape of literature on mobility inequalities has led to discrepancies between a conceptual understanding of mobility inequalities and its implementation in planning practice. Reviewing 270 publications across five decades, this article identifies intrinsic and extrinsic factors and approaches for understanding and analyzing mobility inequality. Using two thought experiments to critically locate variations in factors and approaches, dilemmas and challenges in addressing mobility inequality for the marginalized are exposed. The article concludes with future research directions for investigating mobility inequality.

scholarly journals Effect of Intrinsic and Extrinsic Factors on Global and Regional Cortical Thickness

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96429 ◽  
Author(s):  
Koushik A. Govindarajan ◽  
Leorah Freeman ◽  
Chunyan Cai ◽  
Mohammad H. Rahbar ◽  
Ponnada A. Narayana
Keyword(s):  
Cortical Thickness ◽  
Extrinsic Factors ◽  
Intrinsic And Extrinsic Factors

Modulation of both intrinsic and extrinsic factors additively promotes rewiring of corticospinal circuits after spinal cord injury

2021 ◽  
pp. JN-RM-2649-20
Author(s):  
Yuka Nakamura ◽  
Masaki Ueno ◽  
Jesse K. Niehaus ◽  
Richard A Lang ◽  
Yi Zheng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Extrinsic Factors ◽  
Cord Injury ◽  
Intrinsic And Extrinsic Factors

scholarly journals Prevalence of postural deviations and associated factors in children and adolescents: a cross-sectional study

2016 ◽  
Vol 29 (4) ◽  
pp. 777-786 ◽  
Author(s):  
Mariana Vieira Batistão ◽  
Roberta de Fátima Carreira Moreira ◽  
Helenice Jane Cote Gil Coury ◽  
Luis Ernesto Bueno Salasar ◽  
Tatiana de Oliveira Sato
Keyword(s):  
Physical Activity ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Associated Factors ◽  
Multiple Logistic Regression Analysis ◽  
Extrinsic Factors ◽  
Cross Sectional ◽  
Postural Changes ◽  
Intrinsic And Extrinsic Factors

Abstract Introduction: Postural deviations are frequent in childhood and may cause pain and functional impairment. Previously, only a few studies have examined the association between body posture and intrinsic and extrinsic factors. Objective: To assess the prevalence of postural changes in school children, and to determine, using multiple logistic regression analysis, whether factors such as age, gender, BMI, handedness and physical activity might explain these deviations. Methods: The posture of 288 students was assessed by observation. Subjects were aged between 6 and 15 years, 59.4% (n = 171) of which were female. The mean age was 10.6 (± 2.4) years. Mean body weight was 38.6 (± 12.7) kg and mean height was 1.5 (± 0.1) m. A digital scale, a tapeline, a plumb line and standardized forms were used to collect data. The data were analyzed descriptively using the chi-square test and logistic regression analysis (significance level of 5%). Results: We found the following deviations to be prevalent among schoolchildren: forward head posture, 53.5%, shoulder elevation, 74.3%, asymmetry of the iliac crests, 51.7%, valgus knees, 43.1%, thoracic hyperkyphosis, 30.2%, lumbar hyperlordosis, 37.2% and winged shoulder blades, 66.3%. The associated factors were age, gender, BMI and physical activity. Discussion: There was a high prevalence of postural deviations and the intrinsic and extrinsic factors partially explain the postural deviations. Conclusion: These findings contribute to the understanding of how and why these deviations develop, and to the implementation of preventive and rehabilitation programs, given that some of the associated factors are modifiable.

Influence of intrinsic and extrinsic factors on rheology of pectin–calcium gels

2009 ◽  
Vol 23 (8) ◽  
pp. 2069-2077 ◽  
Author(s):  
Ilse Fraeye ◽  
Eugénie Doungla ◽  
Thomas Duvetter ◽  
Paula Moldenaers ◽  
Ann Van Loey ◽  
...  
Keyword(s):  
Extrinsic Factors ◽  
Intrinsic And Extrinsic Factors
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