scholarly journals Gemcitabine and Arabinosylcytosin Pharmacogenomics: Genome-Wide Association and Drug Response Biomarkers

PLoS ONE ◽  
2009 ◽  
Vol 4 (11) ◽  
pp. e7765 ◽  
Author(s):  
Liang Li ◽  
Brooke L. Fridley ◽  
Krishna Kalari ◽  
Gregory Jenkins ◽  
Anthony Batzler ◽  
...  
Keyword(s):  
Drug Response ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Drug Response Biomarkers ◽  
Response Biomarkers

Abstract 4907: Cell line panel profiling reveals novel drug response biomarkers for BTK and CDK4/6 inhibitors

2018 ◽  
Author(s):  
Joost C. Uitdehaag ◽  
Jeffrey J. Kooijman ◽  
Jeroen A.D.M. de Roos ◽  
Martine B.W. Prinsen ◽  
Jelle Dylus ◽  
...  
Keyword(s):  
Cell Line ◽  
Drug Response ◽  
Cell Line Panel ◽  
Drug Response Biomarkers ◽  
Response Biomarkers ◽  
Novel Drug

scholarly journals Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis

2012 ◽  
Vol 72 (8) ◽  
pp. 1375-1381 ◽  
Author(s):  
Maša Umiċeviċ Mirkov ◽  
Jing Cui ◽  
Sita H Vermeulen ◽  
Eli A Stahl ◽  
Erik J M Toonen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Association Analysis ◽  
Drug Response ◽  
Genome Wide Association ◽  
Genome Wide Association Analysis ◽  
Genome Wide

scholarly journals Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017

2018 ◽  
Vol 18 (2) ◽  
pp. 470-481 ◽  
Author(s):  
Joost C.M. Uitdehaag ◽  
Jeffrey J. Kooijman ◽  
Jeroen A.D.M. de Roos ◽  
Martine B.W. Prinsen ◽  
Jelle Dylus ◽  
...  
Keyword(s):  
Drug Response ◽  
Kinase Inhibitors ◽  
Clinical Use ◽  
Drug Response Biomarkers ◽  
Response Biomarkers

scholarly journals Modeling Gene-Wise Dependencies Improves the Identification of Drug Response Biomarkers in Cancer Studies

2017 ◽  
pp. btw836 ◽  
Author(s):  
Olga Nikolova ◽  
Russell Moser ◽  
Christopher Kemp ◽  
Mehmet Gönen ◽  
Adam A. Margolin
Keyword(s):  
Drug Response ◽  
Drug Response Biomarkers ◽  
Response Biomarkers ◽  
Cancer Studies

scholarly journals Coverage Rate of ADME Genes: Application to CYP2C8, CYP2D6 and CYP3A Genes for Personalized Chloroquine Treatment Against Coronavirus

2020 ◽  
Author(s):  
Nabil Zaid ◽  
Loubna Khalki ◽  
Imane Hadri ◽  
Jihane Toughza ◽  
Oussama Badad ◽  
...  
Keyword(s):  
Drug Response ◽  
Statistical Data ◽  
Association Studies ◽  
Therapeutic Targets ◽  
Coverage Rate ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Chloroquine Treatment ◽  
New Therapeutic Targets

Abstract Background: The latest studies have shown the effectiveness of Chloroquine against Coronavirus. However, since the tolerance and effectiveness of statistical data must be taken into account before proposing treatment to a patient, these promising results are often lacking.Since the CYP2C8, CYP2D6 and CYP3A Absorption, Distribution, Metabolism and Elimination (ADME) genes are involved in the drug response of Chloroquine, we are interested in studying the variations of these genes.Methods: The purpose of this study is to make a comparison between the various current genotyping and enrichment platforms, to know which of them allows the best coverage. Conclusions: This will allow us to carry out genome-wide association studies (GWAS) with the aim of finding new therapeutic targets against Coronavirus using Chloroquine.

scholarly journals Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine

2016 ◽  
Vol 16 (1) ◽  
pp. 70-70 ◽  
Author(s):  
Kathleen M. Giacomini ◽  
Sook Wah Yee ◽  
Taisei Mushiroda ◽  
Richard M. Weinshilboum ◽  
Mark J. Ratain ◽  
...  
Keyword(s):  
Drug Response ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Medicine ◽  
Genome Wide
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