scholarly journals Dynamic Disorder in Quasi-Equilibrium Enzymatic Systems

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. e12364 ◽  
Author(s):  
Srabanti Chaudhury ◽  
Oleg A. Igoshin
Optimization ◽  
2021 ◽  
pp. 1-26
Author(s):  
Pedro Jorge S. Santos ◽  
Paulo Sérgio M. Santos ◽  
Susana Scheimberg

Author(s):  
Huatao Chen ◽  
Kun Zhao ◽  
Juan L.G. Guirao ◽  
Dengqing Cao

AbstractFor the entry guidance problem of hypersonic gliding vehicles (HGVs), an analytical predictor–corrector guidance method based on feedback control of bank angle is proposed. First, the relative functions between the velocity, bank angle and range-to-go are deduced, and then, the analytical relation is introduced into the predictor–corrector algorithm, which is used to replace the traditional method to predict the range-to-go via numerical integration. To eliminate the phugoid trajectory oscillation, a method for adding the aerodynamic load feedback into the control loop of the bank angle is proposed. According to the quasi-equilibrium gliding condition, the function of the quasi-equilibrium glide load along with the velocity variation is derived. For each guidance period, the deviation between the real-time load and the quasi-equilibrium gliding load is revised to obtain a smooth reentry trajectory. The simulation results indicate that the guidance algorithm can adapt to the mission requirements of different downranges, and it also has the ability to guide the vehicle to carry out a large range of lateral maneuvers. The feedback control law of the bank angle effectively eliminates the phugoid trajectory oscillation and guides the vehicle to complete a smooth reentry flight. The Monte Carlo test indicated that the guidance precision and robustness are good.


1958 ◽  
Vol 195 (2) ◽  
pp. 476-480 ◽  
Author(s):  
Nelicia Maier ◽  
Henry Haimovici

Succinic dehydrogenase and cytochrome oxidase activities were determined in homogenates of three aortic segments (ascending and arch, descending thoracic, abdominal) and liver of man, the rabbit and the dog. Both enzymes exhibited the lowest activity in human aorta. Succinic dehydrogenase exhibited the highest activity in the thoracic aorta of the dog and intermediate activity in the latter's abdominal segment and the rabbit's aorta. Cytochrome oxidase, in contrast, exhibited the highest activity in the rabbit's aorta. A slight gradient of decreasing activity from thoracic to abdominal aorta was noted for cytochrome oxidase in both the rabbit and dog and for succinic dehydrogenase in the rabbit, whereas a significant decrease in the latter enzyme was noted in the abdominal segment of the dog. No gradient of activity was apparent in man. Liver exhibited the lowest activity for both enzymes in man, highest in the dog and intermediate in the rabbit. The above findings suggest a biologic species difference between the aorta of man, the rabbit and the dog, which may be partly ascribed to a difference in the components of the above two enzymatic systems. The same species difference holds true for hepatic tissue.


2020 ◽  
Vol 500 (3) ◽  
pp. 3394-3412
Author(s):  
Steven R Furlanetto

ABSTRACT In recent years, simple models of galaxy formation have been shown to provide reasonably good matches to available data on high-redshift luminosity functions. However, these prescriptions are primarily phenomenological, with only crude connections to the physics of galaxy evolution. Here, we introduce a set of galaxy models that are based on a simple physical framework but incorporate more sophisticated models of feedback, star formation, and other processes. We apply these models to the high-redshift regime, showing that most of the generic predictions of the simplest models remain valid. In particular, the stellar mass–halo mass relation depends almost entirely on the physics of feedback (and is thus independent of the details of small-scale star formation) and the specific star formation rate is a simple multiple of the cosmological accretion rate. We also show that, in contrast, the galaxy’s gas mass is sensitive to the physics of star formation, although the inclusion of feedback-driven star formation laws significantly changes the naive expectations. While these models are far from detailed enough to describe every aspect of galaxy formation, they inform our understanding of galaxy formation by illustrating several generic aspects of that process, and they provide a physically grounded basis for extrapolating predictions to faint galaxies and high redshifts currently out of reach of observations. If observations show violations from these simple trends, they would indicate new physics occurring inside the earliest generations of galaxies.


2020 ◽  
Vol 21 (11) ◽  
pp. 4084 ◽  
Author(s):  
Paola Checconi ◽  
Marta De Angelis ◽  
Maria Elena Marcocci ◽  
Alessandra Fraternale ◽  
Mauro Magnani ◽  
...  

Viruses use cell machinery to replicate their genome and produce viral proteins. For this reason, several intracellular factors, including the redox state, might directly or indirectly affect the progression and outcome of viral infection. In physiological conditions, the redox balance between oxidant and antioxidant species is maintained by enzymatic and non-enzymatic systems, and it finely regulates several cell functions. Different viruses break this equilibrium and induce an oxidative stress that in turn facilitates specific steps of the virus lifecycle and activates an inflammatory response. In this context, many studies highlighted the importance of redox-sensitive pathways as novel cell-based targets for therapies aimed at blocking both viral replication and virus-induced inflammation. In the review, we discuss the most recent findings in this field. In particular, we describe the effects of natural or synthetic redox-modulating molecules in inhibiting DNA or RNA virus replication as well as inflammatory pathways. The importance of the antioxidant transcription factor Nrf2 is also discussed. Most of the data reported here are on influenza virus infection. We believe that this approach could be usefully applied to fight other acute respiratory viral infections characterized by a strong inflammatory response, like COVID-19.


Sign in / Sign up

Export Citation Format

Share Document