Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression

Cell Lines ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Nsclc Cell ◽

Egfr Tyrosine Kinase ◽

Reversion of mesenchymal behaviour by AZD9291 (osimertinib) in EGFR mutant NSCLC cell lines resistant to first generation EGFR tyrosine kinase inhibitors

Annals of Oncology ◽

10.1093/annonc/mdw362.12 ◽

2016 ◽

Vol 27 ◽

pp. vi3

Author(s):

B. Savastano ◽

C.M. Della Corte ◽

F. Papaccio ◽

V. Giuseppe ◽

G. Esposito ◽

...

Keyword(s):

Tyrosine Kinase ◽

Cell Lines ◽

First Generation ◽

Kinase Inhibitors ◽

Nsclc Cell ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

Abstract 742: Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors

10.1158/1538-7445.am2015-742 ◽

2015 ◽

Author(s):

Yuho Maki ◽

Shinsuke Hashida ◽

Hiromasa Yamamoto ◽

Kazuhiko Shien ◽

Tomoaki Ohtsuka ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Cell Lines ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Hsp90 Inhibitor ◽

Adenocarcinoma Cell ◽

Egfr Tyrosine Kinase ◽

Sequential use of vinorelbine followed by gefitinib enhances the antitumor effect in NSCLC cell lines poorly responsive to reversible EGFR tyrosine kinase inhibitors

International Journal of Cancer ◽

10.1002/ijc.29647 ◽

2015 ◽

Vol 137 (12) ◽

pp. 2947-2958 ◽

Cited By ~ 6

Author(s):

M.G. Dal Bello ◽

A. Alama ◽

G. Barletta ◽

S. Coco ◽

A. Truini ◽

...

Keyword(s):

Tyrosine Kinase ◽

Cell Lines ◽

Antitumor Effect ◽

Kinase Inhibitors ◽

Nsclc Cell ◽

Egfr Tyrosine Kinase ◽

Anti-cancer synergy of dichloroacetate and EGFR tyrosine kinase inhibitors in NSCLC cell lines

European Journal of Pharmacology ◽

10.1016/j.ejphar.2016.08.004 ◽

2016 ◽

Vol 789 ◽

pp. 458-467 ◽

Cited By ~ 10

Author(s):

Zheng Yang ◽

Kin Y. Tam

Keyword(s):

Tyrosine Kinase ◽

Cell Lines ◽

Kinase Inhibitors ◽

Nsclc Cell ◽

Egfr Tyrosine Kinase ◽

Anti Cancer ◽

P76.85 Afatinib and Necitumumab in EGFR mutant NSCLC with Acquired Resistance to 1st or 3rd Generation EGFR Tyrosine Kinase Inhibitors

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2021.01.1142 ◽

2021 ◽

Vol 16 (3) ◽

pp. S626

Author(s):

S. Padda ◽

J. Whisenant ◽

J. Neal ◽

S. York ◽

W. Iams ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors

BMC Cancer ◽

10.1186/s12885-020-06920-3 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Svenja Wagener-Ryczek ◽

Carina Heydt ◽

Juliane Süptitz ◽

Sebastian Michels ◽

Markus Falk ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Mutational Spectrum ◽

Egfr Tyrosine Kinase ◽

Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors

Oncology Reports ◽

10.3892/or.2015.3735 ◽

2015 ◽

Vol 33 (3) ◽

pp. 1499-1504 ◽

Cited By ~ 10

Author(s):

SHINSUKE HASHIDA ◽

HIROMASA YAMAMOTO ◽

KAZUHIKO SHIEN ◽

TOMOAKI OHTSUKA ◽

KEN SUZAWA ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cell Lines ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Radiation Sensitivity ◽

Hsp90 Inhibitor ◽

Lung Cancer Cell ◽

An activation of LC3A-mediated autophagy contributes tode novoand acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma

The Journal of Pathology ◽

10.1002/path.4354 ◽

2014 ◽

pp. n/a-n/a ◽

Cited By ~ 9

Author(s):

Kaito Nihira ◽

Yasuhiro Miki ◽

Shinya Iida ◽

Sodai Narumi ◽

Katsuhiko Ono ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Acquired Resistance to EGFR Tyrosine Kinase Inhibitors is Associated With Low Efficacy of Radiation Therapy for Brain Metastases From EGFR-mutant Lung Adenocarcinoma

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2012.07.166 ◽

2012 ◽

Vol 84 (3) ◽

pp. S102

Author(s):

H. Hirata ◽

K. Nakamura ◽

N. Kunitake ◽

Y. Shioyama ◽

T. Sasaki ◽

...

Keyword(s):

Radiation Therapy ◽

Brain Metastases ◽

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

Abstract 77: Therapeutic potential of ERK inhibitors in overcoming acquired resistance to third generation EGFR tyrosine kinase inhibitors

10.1158/1538-7445.am2019-77 ◽

2019 ◽

Author(s):

Yiting Li ◽

Guoqing Qian ◽

Taofeek K. Owonikoko ◽

Suresh S. Ramalingam ◽

Shi-Yong Sun

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Therapeutic Potential ◽

Acquired Resistance ◽

Third Generation ◽

Egfr Tyrosine Kinase ◽