scholarly journals Women Up, Men Down: The Clinical Impact of Replacing the Framingham Risk Score with the Reynolds Risk Score in the United States Population

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44347 ◽  
Author(s):  
Matthew C. Tattersall ◽  
Ronald E. Gangnon ◽  
Kunal N. Karmali ◽  
Jon G. Keevil
Keyword(s):  
United States ◽  
Risk Score ◽  
Framingham Risk Score ◽  
The United States ◽  
Clinical Impact ◽  
United States Population ◽  
Framingham Risk ◽  
Reynolds Risk Score

Abstract P320: Discordance of Framingham Risk Score and Reynolds Risk Score to Global Vascular Risk Score: Results from the Hispanic Community Health Study/Study of Latinos

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Molly Jung ◽  
Hector M Medina ◽  
Martha Daviglus ◽  
Marina DelRios ◽  
Mario Garcia ◽  
...  
Keyword(s):  
Family History ◽  
High Risk ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Demographic Characteristics ◽  
Vascular Risk ◽  
Framingham Risk ◽  
Chd Risk ◽  
History Of ◽  
Reynolds Risk Score

Introduction: The Framingham Risk Score (FRS) is a coronary heart disease (CHD) risk model established using an ethnically homogeneous population that predicts 10-year hard CHD events, myocardial infarction (MI) and coronary death. The Reynolds Risk Score (RRS) and Global Vascular Risk Score (GVRS) are validated CHD risk models that, in addition to hard CHD events, predict stroke and other CHD outcomes. In addition to major CHD risk factors, RRS adds systemic inflammation and family history of MI as GVRS adds behavioral and anthropometric measures. This study aims to compare agreement of RRS and GVRS with FRS among Hispanic/Latino adults and to describe discordance in RRS and GVRS with FRS categories, by socio-demographic characteristics. Methods: HCHS/SOL is a population-based cohort study of Hispanics/Latinos in four US communities. The analytic sample includes 6,058 non-diabetic participants 45-74 years of age with no past history of CHD and stroke who underwent comprehensive baseline examination. 10-year hard CHD risk score was calculated; participants were categorized as low (<10%), moderate (10-<20%), and high (≥20%) risk. Kappa scores were calculated to compare agreement of RRS and GVRS with FRS. Socio-demographic characteristics of concordance and discordance were characterized overall; multinomial logistic regression models was used to examine age-sex-adjusted likelihood of in discordance by these factors. Results: Mean age of the participants was 55 (SE=0.15) years, 54.3% were women, 41% had family history of CHD, and 90% were foreign born. Overall, 4,805 (74%) had low FRS, 1,143 (24%) had moderate FRS, and 110 (2%) had high FRS. There was poor agreement between RRS and FRS (Kappa=0.16, P<0.01) and fair agreement between GVRS and FRS (Kappa=0.36, P<0.01). In age-sex-adjusted analyses, RRS and GVRS were both more likely to classify persons of moderate and high risk who are between the ages of 60-74; GVRS classified more moderate and high risk women than the FRS. RRS and GVRS discordance with FRS was not associated with nativity and length of time in US. Conclusion: Significant discordance was observed between RRS and GVRS compared to FRS. Among Hispanic/Latino adults, use of RRS or GVRS may be more inclusive in classifying older age adults and women at high 10-year CHD risk.

scholarly journals Longitudinal Progression of Subclinical Coronary Atherosclerosis in Swiss HIV-Positive Compared With HIV-Negative Persons Undergoing Coronary Calcium Score Scan and CT Angiography

2020 ◽  
Vol 7 (10) ◽  
Author(s):  
Philip E Tarr ◽  
Bruno Ledergerber ◽  
Alexandra Calmy ◽  
Thanh Doco-Lecompte ◽  
Isabella C Schoepf ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Subclinical Atherosclerosis ◽  
The United States ◽  
Related Factors ◽  
Coronary Segment ◽  
Framingham Risk ◽  
Hiv Negative

Abstract Background People with HIV (HIV+) may have increased cardiovascular event rates compared with HIV-negative (HIV-) persons. Cross-sectional data from the United States and Switzerland, based on coronary artery calcium scan (CAC) and coronary computed tomography angiography (CCTA), suggest, respectively, increased and similar prevalence of subclinical atherosclerosis in HIV+ vs HIV- persons. Methods We repeated CAC/CCTA in 340 HIV+ and 90 HIV- study participants &gt;2 years after baseline CAC/CCTA. We assessed the association of HIV infection, Framingham risk score (FRS), and HIV-related factors with the progression of subclinical atherosclerosis. Results HIV+ were younger than HIV- participants (median age, 52 vs 56 years; P &lt; .01) but had similar median 10-year FRS (8.9% vs 9.0%; P = .82); 94% had suppressed HIV viral load. In univariable and multivariable analyses, FRS was associated with the incidence rate ratio (IRR) of new subclinical atherosclerosis at the follow-up CAC/CCTA, but HIV infection was not: any plaque (adjusted IRR for HIV+ vs HIV- participants, 1.21; 95% CI, 0.62–2.35), calcified plaque (adjusted IRR for HIV+ vs HIV- participants, 1.06; 95% CI, 0.56–2), noncalcified/mixed plaque (adjusted IRR for HIV+ vs HIV- participants, 1.24; 95% CI, 0.69–2.21), and high-risk plaque (adjusted IRR for HIV+ vs HIV- participants, 1.46; 95% CI, 0.66–3.20). Progression of CAC score between baseline and follow-up CAC/CCTA was similar in HIV+ (median annualized change [interquartile range {IQR}], 0.41 [0–10.19]) and HIV- participants (median annualized change [IQR], 2.38 [0–16.29]; P = .11), as was progression of coronary segment severity score (HIV+: median annualized change [IQR], 0 [0–0.47]; HIV-: median annualized change [IQR], 0 [0–0.52]; P = .10) and coronary segment involvement score (HIV+: median annualized change [IQR], 0 [0–0.45]; HIV-: median annualized change [IQR], 0 [0–0.41]; P = .25). Conclusions In this longitudinal CAC/CCTA study from Switzerland, Framingham risk score was associated with progression of subclinical atherosclerosis, but HIV infection was not.

STUDY OF HS-CRP IN PEOPLE OF HUE CITY

2015 ◽  
pp. 35-43
Author(s):  
Anh Tien Hoang ◽  
Kim Phuong Le
Keyword(s):  
Risk Factor ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Strong Predictor ◽  
High Sensitivity ◽  
Cerebrovascular Risk Factor ◽  
Framingham Risk ◽  
Cerebrovascular Risk ◽  
Hs Crp ◽  
Positive Significant Correlation

Background: High sensitivity C reactive protein is a protein that occur in acute phase of inflammation. hs-CRP is considered as a predict factor of cardiovascular and cerebrovascular risk. Framingham risk score is a strong predictor of cardiovascular and cerebrovascular risk and death. In Viet Nam there was still few studies about hs-CRP and Framingham risk score. Objective: To study the concentration of hs-CRP in peoples in Hue city, also the correlation of hs-CRP and cardiovascular and cerebrovascular risk factor, Framingham risk score. Methods: Clinical data of 1471 people age from 30-74 living in Hue city. We do clinical exam, paraclinical exam. We find out the correlations between hs-CRP and the cardiovascular and cerebrovascular risk factor, the correlations between hs-CRP and Framingham risk score. Results: (i) The concentration of hs-CRP of people in Hue city was 1.54 ± 3.81 mg/l. The concentration of hs-CRP in hyper cholesterol, hyper LDL, hypertension, smoke, obesity and hypo HDL group was significant higher than in the others groups (p<0.05). There was positive significant correlation between the concentration of hs-CRP and systolic blood pressure r=0.061(p< 0.05); (ii) There was positive significant correlation betwee the concentration of hs-CRP and cardiovascular risk (r=0.083; p<0.01) cerebrovascular risk (r=0.068; p<0.05). Conclusions: hs-CRP was a predict risk factor in cardiovascular and cerebrovascular. Key words: hs-CRP, Framingham, cardiovascular, cerebrovascular

The utility of coronary artery calcium in non-gated high resolution CT thorax scans in predicting cardiac events as compared to the Framingham risk score: a retrospective study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Saluja ◽  
H Contractor ◽  
M Daniells ◽  
J Sobolewska ◽  
K Khan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Retrospective Study ◽  
Coronary Artery ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Cardiac Events ◽  
End Point ◽  
Framingham Risk ◽  
Good Concordance

Abstract Background There is existing evidence to suggest a correlation between coronary artery calcification (CAC) measured using ECG-triggered chest computed tomography and cardiovascular disease. Further evidence has emerged to suggest a correlation between CAC measured using non-gated CT scans and cardiovascular disease. Herein, we sought to ascertain the utility of incidental findings of CAC on non-triggered high resolution CT (HRCT) thorax used for patients undergoing lung cancer screening or follow-up for interstitial lung disease and Framingham risk score (FRS) in predicting cardiovascular events. Methods The Computerised Radiology Information Service (CRIS) database was manually searched to determine all HRCT scans performed in a single trust from 05/2015 to 05/2016. The reports issued by Radiologists and images of selected studies were reviewed. For patients with CAC, we calculated the calcium score for patients using the Agatston method. Clinical events were determined from the electronic medical record without knowledge of patients' CAC findings. For these patients, the Framingham Risk Score (FRS) was also calculated. The primary end point of the study was composite of all-cause mortality and cardiac events (non-fatal myocardial infarction, coronary revascularization, new atrial fibrillation or heart failure episode requiring hospitalization). Results We selected 300 scans from a total of approximately 2000 scans performed over this time. Data at follow up was available for 100% of the patients, with a median duration of follow up of 1.6 years. Moderate to severe CAC was found in 35% of people. Multivariable analysis showed good concordance between CAC and FRS in predicting composite clinical end point. The Odds Ratio for cardiac events in patients with moderate to severe CAC was 5.3 (p&lt;0.01) and for composite clinical end point was 3.4 (p&lt;0.01). This is similar to the OR predicted by the FRS: 4.8; p&lt;0.01 and 3.1; p&lt;0.01 respectively. Only 6.2% of patients with moderate to severe CAC were currently statin treated. Conclusion In this retrospective study of patients with respiratory disease attending for HRCT scanning, co-incidentally detected CAC predicts cardiac events, with good concordance with the FRS. The incidental finding of CAC on non-gated CT scanning should be reported with Agatston score calculation allowing consideration of intervention to mitigate cardiovascular risk and optimize. Further multi-centre prospective studies of this strategy, with a larger patient cohort should be conducted to clarify the utility of CAC as a prediction tool to modify cardiac risk. Funding Acknowledgement Type of funding source: None

scholarly journals A Retrospective Exploratory Analysis on Cardiovascular Risk and Cognitive Dysfunction in Multiple Sclerosis

2021 ◽  
Vol 11 (4) ◽  
pp. 502
Author(s):  
Antonio Reia ◽  
Martina Petruzzo ◽  
Fabrizia Falco ◽  
Teresa Costabile ◽  
Matteo Conenna ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Cognitive Function ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Verbal Learning ◽  
Macrovascular Disease ◽  
Cardiovascular Comorbidities ◽  
Cholesterol Levels ◽  
Framingham Risk ◽  
Input Variables

Background. Cardiovascular comorbidities have been associated with cognitive decline in the general population. Objectives. To evaluate the associations between cardiovascular risk and neuropsychological performances in MS. Methods. This is a retrospective study, including 69 MS patients. For all patients, we calculated the Framingham risk score, which provides the 10-year probability of developing macrovascular disease, using age, sex, diabetes, smoking, systolic blood pressure, and cholesterol levels as input variables. Cognitive function was examined with the Brief International Cognitive Assessment for MS (BICAMS), including the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-II (CVLT-II), and the Brief Visuospatial Memory Test-Revised (BVMT-R). Results. Each point increase of the Framingham risk score corresponded to 0.21 lower CVLT-II score. Looking at Framingham risk score components, male sex and higher total cholesterol levels corresponded to lower CVLT scores (Coeff = −8.54; 95%CI = −15.51, −1.57; and Coeff = −0.11; 95%CI = −0.20, −0.02, respectively). No associations were found between cardiovascular risk and SDMT or BVMT-R. Conclusions. In our exploratory analyses, cardiovascular risk was associated with verbal learning dysfunction in MS. Lifestyle and pharmacological interventions on cardiovascular risk factors should be considered carefully in the management of MS, given the possible effects on cognitive function.

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