Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

PLoS ONE ◽

10.1371/journal.pone.0055972 ◽

2013 ◽

Vol 8 (2) ◽

pp. e55972 ◽

Author(s):

Servio H. Ramirez ◽

Shongshan Fan ◽

Holly Dykstra ◽

Slava Rom ◽

Aaron Mercer ◽

...

Keyword(s):

Endothelial Cells ◽

Tight Junction ◽

Half Life ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Life Extension ◽

Glycogen Synthase Kinase 3Β ◽

Brain Endothelial Cells

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Glycogen Synthase Kinase 3β Inhibition Prevents Monocyte Migration across Brain Endothelial Cells via Rac1-GTPase Suppression and Down-Regulation of Active Integrin Conformation

American Journal Of Pathology ◽

10.1016/j.ajpath.2012.06.018 ◽

2012 ◽

Vol 181 (4) ◽

pp. 1414-1425 ◽

Author(s):

Slava Rom ◽

Shongshan Fan ◽

Nancy Reichenbach ◽

Holly Dykstra ◽

Servio H. Ramirez ◽

...

Keyword(s):

Endothelial Cells ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β ◽

Brain Endothelial Cells ◽

Down Regulation ◽

Monocyte Migration ◽

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Inhibition of Glycogen Synthase Kinase 3β (GSK3β) Decreases Inflammatory Responses in Brain Endothelial Cells

American Journal Of Pathology ◽

10.2353/ajpath.2010.090671 ◽

2010 ◽

Vol 176 (2) ◽

pp. 881-892 ◽

Author(s):

Servio H. Ramirez ◽

Shongshan Fan ◽

Ming Zhang ◽

Anil Papugani ◽

Nancy Reichenbach ◽

...

Keyword(s):

Endothelial Cells ◽

Inflammatory Responses ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β ◽

Brain Endothelial Cells

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Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase–glycogen synthase kinase-3β signaling in endothelial cells

Life Sciences ◽

10.1016/j.lfs.2007.12.005 ◽

2008 ◽

Vol 82 (9-10) ◽

pp. 512-518 ◽

Author(s):

Zeran Yang ◽

Ji-Cheng Li

Keyword(s):

Gene Expression ◽

Endothelial Cells ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β ◽

Endothelin 1 ◽

Phosphoinositide 3 Kinase ◽

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Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells

Bioscience Reports ◽

10.1042/bsr20160174 ◽

2016 ◽

Vol 36 (5) ◽

Author(s):

Karen A. Weikel ◽

José M. Cacicedo ◽

Neil B. Ruderman ◽

Yasuo Ido

Keyword(s):

Endothelial Cells ◽

Protein Kinase ◽

Blood Vessels ◽

Glycogen Synthase ◽

Cellular Material ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β ◽

Aortic Endothelial Cells ◽

Amp Activated Protein Kinase ◽

Human Aortic Endothelial Cells

Suppression of the enzyme glycogen synthase kinase 3β (GSK3β) increases both the turnover of damaged cellular material and the activity of the enzyme AMP-activated protein kinase (AMPK) to potentially attenuate the damage inflicted by excess sugar and fat on blood vessels.

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Endothelial Cells Stimulate T Cell NFAT Nuclear Translocation in the Presence of Cyclosporin A: Involvement of the wnt/Glycogen Synthase Kinase-3β Pathway

The Journal of Immunology ◽

10.4049/jimmunol.169.7.3717 ◽

2002 ◽

Vol 169 (7) ◽

pp. 3717-3725 ◽

Author(s):

Lisa L. Salazar Murphy ◽

Christopher C. W. Hughes

Keyword(s):

Endothelial Cells ◽

T Cell ◽

Cyclosporin A ◽

Nuclear Translocation ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β

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AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane

Journal of Biological Chemistry ◽

10.1074/jbc.m110.186932 ◽

2011 ◽

Vol 286 (19) ◽

pp. 16879-16890 ◽

Author(s):

Li Zhang ◽

Francois Jouret ◽

Jesse Rinehart ◽

Jeff Sfakianos ◽

Ira Mellman ◽

...

Keyword(s):

Plasma Membrane ◽

Protein Kinase ◽

Tight Junction ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Ampk Activation ◽

Glycogen Synthase Kinase 3Β ◽

Gsk 3Β ◽

Amp Activated Protein Kinase

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Follistatin-Like 3 Enhances the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Facilitating β-Catenin Nuclear Translocation Through Inhibition of Glycogen Synthase Kinase-3β Activity

10.1002/stem.2820 ◽

2018 ◽

Vol 36 (7) ◽

pp. 1033-1044 ◽

Author(s):

Sophia Kelaini ◽

Marta Vilà-González ◽

Rachel Caines ◽

David Campbell ◽

Magdalini Eleftheriadou ◽

...

Keyword(s):

Endothelial Cells ◽

Pluripotent Stem Cells ◽

Nuclear Translocation ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β

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Glycogen Synthase Kinase 3β Inhibition Protects the Cardiomyocytes from Anoxia/Reoxygenation Injury by Modulating Inﬂammatory Response and Reducing the Opening of mPTP

Journal of Anesthesia and Perioperative Medicine ◽

10.24015/japm.2015.0033 ◽

2015 ◽

Vol 2 (5) ◽

pp. 244-250

Author(s):

Yi Cheng ◽

Jun Ma ◽

Fu-Shan Xue ◽

Xin-Long Cui

Keyword(s):

Inflammatory Response ◽

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β ◽

Reoxygenation Injury

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Faculty Opinions recommendation of Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3β.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13688957.15104057 ◽

2012 ◽

Author(s):

Judith Black ◽

Brian Oliver ◽

Janette Burgess

Keyword(s):

Smooth Muscle ◽

Airway Smooth Muscle ◽

Muscle Hypertrophy ◽

Glycogen Synthase ◽

Mechanical Stretch ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β ◽

Human Airway Smooth Muscle ◽

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Is Going for Cure in CML Targeting Aberrant Glycogen Synthase Kinase 3β?

Current Drug Targets ◽

10.2174/1389450117666160817151723 ◽

2017 ◽

Vol 18 (4) ◽

pp. 396-404

Author(s):

Concetta Saponaro ◽

Michele Maffia ◽

Nicola Renzo ◽

Addolorata Coluccia

Keyword(s):

Glycogen Synthase ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β

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