Serum Heat Shock Protein 70 Concentration in Relation to Polycystic Ovary Syndrome in a Non-Obese Chinese Population

AbstractInduction of heat shock protein expression and the heat shock (stress) response are seen in exercise. This exercise-induced response is thought protective against cellular stress through the expression of heat shock proteins. The highly inducible heat shock protein 72 (HSP72) has been shown to be expressed in a number of stress-related conditions, but not investigated in women with polycystic ovary syndrome (PCOS). Twenty-one women (10 controls, 11 with PCOS) concluded an 8-week supervised, moderate-intensity exercise programme. Monocytes and lymphocytes were analysed by flow cytometry for HSP72 expression from blood samples prior to, mid-way and at the completion of the programme. The monocyte HSP72 expression showed an increase from baseline values through mid-way (p = 0.025), and at the completion of the programme (p = 0.011) only in the control group, the PCOS group showed no significant change. This pattern was similar for lymphocyte HSP72 expression where a significant increase was found at the completion of the programme (p = 0.01) only in the control group. The magnitude of increased HSP72 expression following completion of the programme was linked to baseline values only in the control group. In conclusion, increased HSP72 expression to exercise over an 8-week period was seen in control but not in PCOS women, suggesting that there is an impairment of HSP72 expression in response to exercise in these women.

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The Role of Heat Shock Protein 90B1 in Patients with Polycystic Ovary Syndrome

PLoS ONE ◽

10.1371/journal.pone.0152837 ◽

2016 ◽

Vol 11 (4) ◽

pp. e0152837 ◽

Cited By ~ 9

Author(s):

Li Li ◽

Hui Mo ◽

Jing Zhang ◽

Yongxian Zhou ◽

Xiuhong Peng ◽

...

Keyword(s):

Heat Shock ◽

Polycystic Ovary Syndrome ◽

Heat Shock Protein ◽

Polycystic Ovary ◽

Ovary Syndrome

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Stress-induced activation of ovarian heat shock protein 90 in a rat model of polycystic ovary syndrome

Fertility and Sterility ◽

10.1016/j.fertnstert.2014.07.474 ◽

2014 ◽

Vol 102 (3) ◽

pp. e138

Author(s):

M.H. Jung ◽

Y.I. Ji

Keyword(s):

Heat Shock ◽

Polycystic Ovary Syndrome ◽

Heat Shock Protein ◽

Rat Model ◽

Polycystic Ovary ◽

Heat Shock Protein 90 ◽

Ovary Syndrome

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Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population

Acta Endocrinologica ◽

10.1530/eje-14-0615 ◽

2015 ◽

Vol 172 (3) ◽

pp. 227-233 ◽

Cited By ~ 10

Author(s):

Rong Ju ◽

Wei Wu ◽

Juan Fei ◽

Yufeng Qin ◽

Qiuqin Tang ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Chinese Population ◽

Chinese Women ◽

Polycystic Ovary ◽

Control Group ◽

Model Assessment ◽

Nucleotide Polymorphisms ◽

Ovary Syndrome ◽

Significant Difference ◽

High Level

ObjectiveTo assess whether single nucleotide polymorphisms of HSD17B5 (AKR1C3) (rs1937845 and rs12529) and HSD17B6 (rs898611) are associated with polycystic ovary syndrome (PCOS) in a Chinese population.DesignA case–control study was conducted to investigate the relation between HSD17B5 and HSD17B6 polymorphisms and PCOS.MethodsIn this study, 335 patients with PCOS and 354 controls were recruited. The genotypes of HSD17B5 (rs1937845 and rs12529) and HSD17B6 (rs898611) were detected by the TaqMan method.Results and conclusionsWe found that the genotypic frequencies of the rs1937845 polymorphism were different in subjects with PCOS compared with control, with the CT genotype being more commonly found in patients with PCOS than in controls (P=0.005). We observed a significantly 1.74-fold higher risk of CT genotype in the polymorphism rs1937845 in women with PCOS vs the control group (adjusted odds ratio (OR), 1.74; 95% CI=1.19–2.54; P=0.005). A similar, significant 1.47-fold higher risk (adjusted OR, 1.47; 95% CI=1.07–2.03; P=0.018) was demonstrated for T allele of polymorphism rs1937845 associated with PCOS. In patients with PCOS, the rs12529 (G>C) and rs1937845 (C>T) polymorphisms were strongly associated with the high level of testosterone. The TT carriers of polymorphism rs1937845 had a significantly increased homeostatic model assessment-B% (HOMA-B%) (P=0.045) and that might be associated with the high risk of insulin resistance. However, no significant difference was found in genotype or allele distributions of the polymorphisms rs12529 of HSD17B5 and rs898611 of HSD17B6 between patients with PCOS and controls. Additionally, the two polymorphisms of HSD17B5 are associated with hyperandrogenemia in patients with PCOS. In conclusion, our findings showed a significant statistical association between HSD17B5 rs1937845 and PCOS risk in Chinese women. The CT genotype and T allele frequency are influenced significantly to a higher extent in patients with PCOS than controls. Further studies are needed to confirm the results and find out the exact molecular mechanism of the polymorphism on the risk of hyperandrogenemia and PCOS.

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