scholarly journals Plasma Level of Adrenomedullin Is Influenced by a Single Nucleotide Polymorphism in the Adiponectin Gene

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e70335 ◽  
Author(s):  
Hoi Kin Wong ◽  
Kwok Leung Ong ◽  
Raymond Y. H. Leung ◽  
Tommy T. Cheung ◽  
Aimin Xu ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Plasma Level ◽  
Adiponectin Gene ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

The rs266729 single-nucleotide polymorphism in the adiponectin gene shows association with gestational diabetes

2013 ◽  
Vol 289 (4) ◽  
pp. 743-748 ◽  
Author(s):  
Olga Beltcheva ◽  
Mariya Boyadzhieva ◽  
Olga Angelova ◽  
Vanio Mitev ◽  
Radka Kaneva ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Gestational Diabetes ◽  
Adiponectin Gene ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Phenotypic realization of single nucleotide polymorphism rs950880 of IL1RL1 gene in healthy inhabitants of Vinnytsia region.

2021 ◽  
Vol 25 (3) ◽  
pp. 364-368
Author(s):  
D. A. Bahrij ◽  
O. L. Starzhyns'ka ◽  
V. M. Zhebel
Keyword(s):  
Cardiovascular Disease ◽  
Single Nucleotide Polymorphism ◽  
Plasma Level ◽  
Clinical Laboratory ◽  
Enzyme Linked Immunosorbent Assay ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Cardiovascular Pathology ◽  
Allele Specific ◽  
Instrumental Methods

Annotation. Soluble growth stimulating factor (sST2) is a new biomarker that has recently been used quite successfully in cardiology. However, the possible genetic component of peptide production has not been sufficiently studied. The aim of the study was to assess the plasma level of sST2 and other aspects of the phenotypic implementation of single nucleotide polymorphism (SNP) rs950880 of the IL1RL1 gene in men without cardiovascular disease in the Podillia region, Ukraine. 70 men who met the criteria for inclusion/non-inclusion in the study were examined, general clinical, laboratory and instrumental methods were used. Genotyping of SNP rs950880 variants of the IL1RL1 gene was performed using an allele-specific polymerase chain reaction, the concentration of sST2 in blood was investigated using the method of enzyme-linked immunosorbent assay. Mathematical processing of the obtained results was performed using the standard statistical package Statistica 12.0. The mean concentration of sST2 in the plasma of men without signs of cardiovascular disease is 22.14±0.86 ng/ml. It was found that among men without cardiovascular diseases, residents of Podillia, the most common carriers of the C allele and variants of CC and CA SNP rs950880 of the IL1RL1 gene, carriers of variant AA are four times less common (p<0.05). It was determined that the main phenotypic feature of SNP rs950880 of the IL1RL1 gene is a higher plasma level of sST2 in CC homozygotes (23.34±1.22 ng/ml) compared with AA homozygotes (18.13±0.85 ng/ml, p<0,01). The obtained results will be the basis for further studies of the phenotypic implementation of the SNP rs950880 gene of the IL1RL1 gene in patients with cardiovascular pathology, in particular, with essential hypertension.

scholarly journals THE ROLE OF GENETIC VARIATION SINGLE NUCLEOTIDE POLYMORPHISM T45G AND SINGLE NUCLEOTIDE POLYMORPHISM G276T OF THE ADIPONECTIN GENE IN FATTY LIVER PATHOMECHANISM ON OBESE MALE SUBJECT

2018 ◽  
Vol 11 (13) ◽  
pp. 229
Author(s):  
Sulaeman A ◽  
Wahid S ◽  
Sulaiman A ◽  
Lawrence Sg
Keyword(s):  
Insulin Resistance ◽  
Single Nucleotide Polymorphism ◽  
Genetic Variation ◽  
Fatty Liver ◽  
Adiponectin Gene ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Obese Subjects ◽  
High Level ◽  
Obese Male

  Objective: The aim of this study was to observe the role of genetic variation T45G and G276T of adiponectin gene in pathomechanism of fatty liver on obese subjects.Methods: An observational study with case–control design was conducted on 94 obese male subjects (50 subjects are obese male with fatty liver and 44 subjects are obese male without fatty liver). The research is taken place in Prodia Clinical Laboratory Makassar to determine genetic variation single nucleotide polymorphism (SNP) T45G (Genotype TT, thyroglobulin [TG], and GG) and SNP G276T (Genotype GG, GT, and TT) of adiponectin gene, technique of polymerase chain reaction-restriction fragment length polymorphism was used. The level of adiponectin, soluble tumor necrosis factor-α receptor 2 (sTNF-αR2), and insulin serum were measured by enzyme-linked immunosorbent assay method, meanwhile, fatty liver was detected by ultrasonography.Results: The result of the study showed genetic variation, T45G of adiponectin gene was genotype TT 62.8 %, genotype TG 30.9%, and genotype GG 6.3%; meanwhile, genetic variation G276T of adiponectin gene was genotype GG 43.6%, genotype GT 38.3 %, and genotype TT 18.1 %. There was no significant correlation of genetic variation T45G as well as G276T of adiponectin gene, to the level of adiponectin serum (>0.05). Insulin resistance was more frequent on genotype TT genetic variation T45G of adiponectin gene as compare to that on TG+GG (p=0.069). Genotype TT on genetic variation T45G of adiponectin gene was significant correlated with fatty liver (p=0.010). Genotype TG+TT on genetic variation G276T of adiponectin gene was more likely to have insulin resistance and fatty liver than that of genotype GG. Allele T carrier on genetic variation T45G and G276T of adiponectin gene had a higher chance to have insulin resistance and fatty liver as compare to that of allele G carrier. The odds ratio of having fatty liver insulin resistance is 5.3, genotype TT on genetic variation T45G of adiponectin gene is 3.8, low level of adiponectin is 3.4, and high level of sTNF-αR2 is 3.3.Conclusion: Genotype TT on genetic variation T45G of adiponectin gene has a role in fatty liver on obese subjects. Genotype TG+TT on genetic variation G276T of adiponectin gene was more high frequent to have fatty liver compare to that on genotype GG. Allele T carrier on genetic variation T45G of adiponectin gene had higher frequency on the occurrence of insulin resistance than that on allele G carrier. Insulin resistance has the highest influence as compare to genotype TT on genetic variation T45G of adiponectin gene, low level of adiponectin serum, high level of sTNF-αR2 serum in the pathomechanism of fatty liver in obese subjects.

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