scholarly journals Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e83371 ◽  
Author(s):  
John Macleod ◽  
Lie Tang ◽  
F. D. Richard Hobbs ◽  
Brian Wharton ◽  
Roger Holder ◽  
...  
Keyword(s):  
Birth Weight ◽  
Randomised Controlled Trial ◽  
Disease Risk ◽  
Controlled Trial ◽  
Nutritional Supplementation ◽  
Adult Disease ◽  
Randomised Controlled ◽  
Infant Birth

scholarly journals Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial

2015 ◽  
Vol 115 (4) ◽  
pp. 644-649 ◽  
Author(s):  
Linlin Wang ◽  
Zuguo Mei ◽  
Hongtian Li ◽  
Yali Zhang ◽  
Jianmeng Liu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Randomised Controlled Trial ◽  
Pregnant Women ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomised Controlled ◽  
Hb Concentration ◽  
Infant Birth ◽  
Very High

AbstractConcerns have been raised about the benefits of Fe-containing supplements on infant birth weight among women with normal/high Hb levels at baseline. Thus far, no clinical trials have examined whether the effects of prenatal Fe-containing supplements on birth weight vary by maternal Hb levels. We compared the effects of Fe–folic acid (IFA) or multiple micronutrients (MMN) with folic acid (FA) supplements on birth weight among pregnant women with mild/no anaemia or high Hb levels. A double-blind randomised controlled trial was conducted in 2006–2009. In total, 18 775 pregnant women with mild/no anaemia (<100 g/l) were enrolled from five counties in north China. During the period from before 20 weeks of gestation to delivery, the women randomly received a daily supplement containing the following: (1) FA (400 μg); (2) IFA (FA, 400 μg; Fe, 30 mg); or (3) MMN (FA, Fe and thirteen additional vitamins and minerals). Birth weight was measured within the 1st hour of birth. Maternal Hb concentration was determined at enrolment. Among women with normal (≤132 g/l) or high (133–145 g/l) baseline Hb levels, IFA or MMN supplementation had no effect on birth weight. Among women with very high (>145 g/l) baseline Hb levels, IFA and MMN supplements increased birth weight by 91·44 (95 % CI 3·37, 179·51) g and 107·63 (95 % CI 21·98, 193·28) g (P<0·05), respectively, compared with the FA group. No differences were found between the IFA and the MMN group, regardless of maternal Hb concentration. In conclusion, the effects of Fe-containing supplements on birth weight depended on baseline Hb concentrations. The Fe-containing supplements improved birth weight in women with very high Hb levels before 20 weeks of gestation.

scholarly journals Does antenatal micronutrient supplementation improve children’s cognitive function? Evidence from the follow-up of a double-blind randomised controlled trial in Nepal

2018 ◽  
Vol 3 (1) ◽  
pp. e000527 ◽  
Author(s):  
Sophiya Dulal ◽  
Frédérique Liégeois ◽  
David Osrin ◽  
Adam Kuczynski ◽  
Dharma S Manandhar ◽  
...  
Keyword(s):  
Executive Function ◽  
Birth Weight ◽  
Cognitive Function ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Absolute Difference ◽  
Double Blind ◽  
Randomised Controlled ◽  
Parent Trial

IntroductionMultiple Micronutrient (MMN) supplementation during pregnancy can decrease the proportion of infants born low birth weight and small for gestational age. Supplementation could also enhance children’s cognitive function by improving access to key nutrients during fetal brain development and increasing birth weight, especially in areas where undernutrition is common. We tested the hypothesis that children whose mothers received MMN supplementation during pregnancy would have higher intelligence in early adolescence compared with those receiving Iron and Folic Acid (IFA) only.MethodsWe followed up children in Nepal, whose mothers took part in a double-blind Randomised Controlled Trial (RCT) that compared the effects on birth weight and gestational duration of antenatal MMN versus IFA supplementation. We assessed children’s Full Scale Intelligence Quotient (FSIQ) using the Universal Non-verbal Intelligence Test (UNIT), and their executive function using the counting Stroop test. The parent trial was registered as ISRCTN88625934.ResultsWe identified 813 (76%) of the 1069 children whose mothers took part in the parent trial. We found no differences in FSIQ at 12 years between MMN and IFA groups (absolute difference in means (diff): 1.25, 95% CI −0.57 to 3.06). Similarly, there were no differences in mean UNIT memory (diff: 1.41, 95% CI −0.48 to 3.30), reasoning (diff: 1.17, 95% CI −0.72 to 3.06), symbolic (diff: 0.97, 95% CI −0.67 to 2.60) or non-symbolic quotients (diff: 1.39, 95% CI −0.60 to 3.38).ConclusionOur follow-up of a double-blind RCT in Nepal found no evidence of benefit from antenatal MMN compared with IFA for children’s overall intelligence and executive function at 12 years.

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