Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein Synthesis

Faculty Opinions recommendation of Rpn10 promotes tumor progression by regulating hypoxia-inducible factor 1 alpha through the PTEN/Akt signaling pathway in hepatocellular carcinoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734911165.793580826 ◽

2020 ◽

Author(s):

Leonardo Salmena

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Progression ◽

Signaling Pathway ◽

Akt Signaling ◽

Akt Signaling Pathway ◽

Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α (HIF-1α) through inhibiting protein synthesis

Journal of Cellular Biochemistry ◽

10.1002/jcb.21851 ◽

2008 ◽

Vol 105 (2) ◽

pp. 546-553 ◽

Cited By ~ 40

Author(s):

Dae-Hee Lee ◽

Yong J. Lee

Keyword(s):

Protein Synthesis ◽

Inhibiting Protein

Involvement of decreased hypoxia-inducible factor 1 activity and resultant G1–S cell cycle transition in radioresistance of perinecrotic tumor cells

Oncogene ◽

10.1038/onc.2012.223 ◽

2012 ◽

Vol 32 (16) ◽

pp. 2058-2068 ◽

Cited By ~ 18

Author(s):

Y Zhu ◽

T Zhao ◽

S Itasaka ◽

L Zeng ◽

C J Yeom ◽

...

Keyword(s):

Cell Cycle ◽

Tumor Cells ◽

Hypoxia Inducible Factor 1 ◽

Cell Cycle Transition

Rpn10 promotes tumor progression by regulating hypoxia-inducible factor 1 alpha through the PTEN/Akt signaling pathway in hepatocellular carcinoma

Cancer Letters ◽

10.1016/j.canlet.2019.01.020 ◽

2019 ◽

Vol 447 ◽

pp. 1-11 ◽

Cited By ~ 2

Author(s):

Zhiyuan Jiang ◽

Qingqing Zhou ◽

Chao Ge ◽

Jing Yang ◽

Hong Li ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Progression ◽

Signaling Pathway ◽

Akt Signaling ◽

Akt Signaling Pathway ◽

Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1α

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-009-1238-8 ◽

2010 ◽

Vol 66 (5) ◽

pp. 899-911 ◽

Cited By ~ 45

Author(s):

Sreenivasulu Chintala ◽

Károly Tόth ◽

Shousong Cao ◽

Farukh A. Durrani ◽

Mary M. Vaughan ◽

...

Keyword(s):

Tumor Cells ◽

Hypoxic Tumor

Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1α

Biochemical Pharmacology ◽

10.1016/j.bcp.2006.06.038 ◽

2006 ◽

Vol 72 (8) ◽

pp. 992-1000 ◽

Cited By ~ 77

Author(s):

Dah-Yuu Lu ◽

Houng-Chi Liou ◽

Chih-Hsin Tang ◽

Wen-Mei Fu

Keyword(s):

Signaling Pathway ◽

Inos Expression ◽

Pi3 Kinase ◽

Mtor Signaling ◽

Mtor Signaling Pathway ◽

Hypoxia Inducible Factor 1Α

Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1α

FEBS Journal ◽

10.1111/j.1742-4658.2009.07069.x ◽

2009 ◽

Vol 276 (13) ◽

pp. 3470-3480 ◽

Cited By ~ 19

Author(s):

Dong Hoon Shin ◽

Shan Hua Li ◽

Seung-Won Yang ◽

Byung Lan Lee ◽

Myung Kyu Lee ◽

...

Keyword(s):

Nuclear Factor Kappab ◽

Nuclear Factor ◽

Moderate Hypoxia ◽

Hypoxia inducible factor‐1 promotes liver fibrosis in nonalcoholic fatty liver disease by activating PTEN/p65 signaling pathway

Journal of Cellular Biochemistry ◽

10.1002/jcb.28734 ◽

2019 ◽

Vol 120 (9) ◽

pp. 14735-14744 ◽

Cited By ~ 8

Author(s):

Jie Han ◽

Yaping He ◽

Hui Zhao ◽

Xiaowei Xu

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Signaling Pathway ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver ◽

Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells

Investigational New Drugs ◽

10.1007/s10637-010-9462-y ◽

2010 ◽

Vol 29 (6) ◽

pp. 1177-1187 ◽

Cited By ~ 15

Author(s):

Qinjie Weng ◽

Jun Zhang ◽

Ji Cao ◽

Qing Xia ◽

Duoduo Wang ◽

...

Keyword(s):

Signaling Pathway ◽

Hepatoma Cells ◽

Human Hepatoma ◽

Human Hepatoma Cells ◽

Oxide Derivative

High glucose concentrations attenuate hypoxia-inducible factor-1α expression and signaling in non-tumor cells

Experimental Cell Research ◽

10.1016/j.yexcr.2010.02.019 ◽

2010 ◽

Vol 316 (7) ◽

pp. 1179-1189 ◽

Cited By ~ 23

Author(s):

Nathalie Dehne ◽

Gudrun Hintereder ◽

Bernhard Brüne

Keyword(s):

Tumor Cells ◽

High Glucose ◽

Hypoxia Inducible Factor 1Α