Correction: miRNA Repertoires of Demosponges Stylissa carteri and Xestospongia testudinaria

Abstract Endosymbiont fungi from marine sponges are a rich source of medicinally active compounds. Indonesia has a huge number of marine sponges. This research was conducted to determine the antibacterial potential of endosymbiont fungi isolated from marine sponges collected from Kotok Kecil Island, Seribu Islands. The screening was conducted with two methods, the modified GIBEX and disc diffusion. Species of marine sponges were isolated, namely Petrosia sp., Stylissa carteri, Cinachyrella australiensis, Callyspongia sp., Petrosia nigrians, and Stylissa massa, and obtained 9 isolates of endosymbiont fungi. The GIBEX test against Escherichia coli and Streptococcus mutans showed that ethyl acetate extract had strongest antibacterial activity. Disc diffusion test of ethyl acetate extract, five isolates had antibacterial activity against S. mutans and four against E. coli. The isolate that showed the strongest antibacterial activity was from Petrosia sp. Which has an inhibition zone of 8.4 mm against E. coli and 7.45 mm against S. mutans. The main active compounds from the isolate of Petrosia sp. are butylhydroxytoluene and phthalic acid di-(2-propylpentyl) esters. Based on this study, we concluded that the endosymbiont fungi of marine sponges are potential to be developed for further development as source of antibacterial agents.

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AKTIVITAS ANTIMIKROBA DARI EKSTRAK DAN FRAKSI ORGANISME LAUT SPONS Stylissa carteri YANG DIKOLEKSI DARI PERAIRAN SELAT LEMBEH KOTA BITUNG

PHARMACON ◽

10.35799/pha.8.2019.29390 ◽

2019 ◽

Vol 8 (3) ◽

pp. 662

Author(s):

Cavieta C. A. Watupongoh ◽

Defny S. Wewengkang ◽

Henki Rotinsulu

Keyword(s):

Escherichia Coli ◽

Staphylococcus Aureus ◽

Antimicrobial Activity ◽

Candida Albicans ◽

Extraction Process ◽

Marine Biota ◽

Active Compounds ◽

Stylissa Carteri ◽

Agar Method ◽

Ethanol Extracts

ABSTRACTSponge is a multi-cell marine biota whose tissue and organ functions are very simple. Sponges have considerable potentially in producing active compounds that can be used in the pharmaceutical world. This study aimed to determine the presence of antimicrobial activity from extracts and fractions of the Stylissa carteri Sponge on against the microbes of Staphylococcus aureus, Escherichia coli, and Candida albicans. The extraction process was carried out by maceration using ethanol solvent, and fractionation was carried out using methanol, n-hexane and chloroform solvents. Antimicrobial activity was carried out by disk diffusion agar method. The results showed that the crude ethanol extracts and methanol fractions of the Stylissa carteri sponge actively inhibited the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans microbes. Keywords: Stylissa carteri, antimicrobial, Staphylococcus aureus, Escherichia coli, Candida albicans. ABSTRAKSpons merupakan biota laut multi sel yang fungsi jaringan dan organnya sangat sederhana. Spons memiliki potensi cukup besar dalam menghasilkan senyawa aktif yang dapat digunakan dalam dunia farmasi. Penelitian ini bertujuan untuk menentukan adanya Aktivitas Antimikroba dari ekstrak dan fraksi Spons Stylissa carteri terhadap mikroba Staphylococcus aureus, Escherichia coli, dan Candida albicans. Dilakukan proses ekstraksi dengan cara maserasi terhadap sampel menggunakan pelarut etanol, dan dilakukan fraksinasi menggunakan pelarut metanol, n-heksan dan kloroform. Aktivitas antimikroba dilakukan dengan metode difusi agar. Hasil penelitian menunjukkan bahwa ekstrak kasar dan fraksi metanol dari spons Stylissa carteri aktif menghambat pertumbuhan mikroba Staphylococcus aureus, Escherichia coli, dan Candida albicans. Kata Kunci : Stylissa carteri, antimikroba, Staphylococcus aureus, Escherichia coli, Candida albicans.

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A comparison of prokaryote communities inhabiting sponges, bacterial mats, sediment and seawater in Southeast Asian coral reefs

FEMS Microbiology Ecology ◽

10.1093/femsec/fiz169 ◽

2019 ◽

Cited By ~ 3

Author(s):

DFR Cleary ◽

ARM Polónia ◽

YM Huang ◽

S Putchakarn ◽

NCM Gomes ◽

...

Keyword(s):

Coral Reef ◽

Relative Abundance ◽

Host Species ◽

Sponge Species ◽

Reef Habitat ◽

Bacterial Mats ◽

Stylissa Carteri ◽

Seawater Samples ◽

Acanthella Cavernosa ◽

Coral Reef Habitat

Abstract In the present study, we used Illumina sequencing to explore the prokaryote communities of 17 demosponge species and how they compare with bacterial mat, sediment and seawater samples (all sampled from coral reef habitat in Taiwan and Thailand). The studied sponge species formed three clusters. OTU richness and evenness were by far highest in the sediment and bacterial mat biotopes. There were pronounced differences in OTU richness and evenness among clusters and also considerable variation among certain host species within clusters. Additionally, the relative abundance of some prokaryotic taxa also differed among clusters with Poribacteria, for example, being recorded in all sponge species, but with very low relative abundances in species of two of the three clusters. This sponge-associated phylum was, however, recorded at relatively high mean abundance in bacterial mat samples, which also housed relatively high abundances of actinobacterial and Chloroflexi members. Our results support the HMA status of the species Aaptos lobata, Hyrtios erectus, Pseudoceratina purpurea and Xestospongia testudinaria, which clustered together and LMA status of the species Acanthella cavernosa, Echinodictyum asperum, Jaspis splendens, Ptilocaulis spiculifer, Stylissa carteri and Suberites diversicolor, which also clustered together. Other species (Agelas cavernosa, Agelas nemoechinata, Acanthostylotella cornuta, Paratetilla sp., Hymeniacidon sp. and Haliclona cymaeformis) deviated somewhat from the typical HMA/LMA dichotomy and formed a strongly supported cluster.

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Novel polymorphic microsatellite markers developed for a common reef sponge, Stylissa carteri

Marine Biodiversity ◽

10.1007/s12526-013-0151-x ◽

2013 ◽

Vol 43 (3) ◽

pp. 237-241 ◽

Cited By ~ 6

Author(s):

Emily C. Giles ◽

Pablo Saenz-Agudelo ◽

Michael L. Berumen ◽

Timothy Ravasi

Keyword(s):

Microsatellite Markers ◽

Stylissa Carteri ◽

Polymorphic Microsatellite

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Carteramine A, an Inhibitor of Neutrophil Chemotaxis, from the Marine Sponge Stylissa carteri.

ChemInform ◽

10.1002/chin.200728186 ◽

2007 ◽

Vol 38 (28) ◽

Author(s):

Hirotsugu Kobayashi ◽

Koki Kitamura ◽

Koji Nagai ◽

Yoichi Nakao ◽

Nobuhiro Fusetani ◽

...

Keyword(s):

Marine Sponge ◽

Neutrophil Chemotaxis ◽

Stylissa Carteri

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Unprecedented Stylissazoles A-C from Stylissa carteri: Another Dimension for Marine Pyrrole-2-aminoimidazole Metabolite Diversity

Angewandte Chemie International Edition ◽

10.1002/anie.201000444 ◽

2010 ◽

Vol 49 (28) ◽

pp. 4775-4779 ◽

Cited By ~ 21

Author(s):

Kirti Patel ◽

Rémi Laville ◽

Marie-Thérèse Martin ◽

Supriya Tilvi ◽

Céline Moriou ◽

...

Keyword(s):

Stylissa Carteri ◽

Metabolite Diversity

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miRNA Repertoires of Demosponges Stylissa carteri and Xestospongia testudinaria

PLoS ONE ◽

10.1371/journal.pone.0149080 ◽

2016 ◽

Vol 11 (2) ◽

pp. e0149080 ◽

Cited By ~ 7

Author(s):

Yi Jin Liew ◽

Taewoo Ryu ◽

Manuel Aranda ◽

Timothy Ravasi

Keyword(s):

Stylissa Carteri

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Ethanol Extract of Stylissa carteri Induces Cell Death in Parental and Paclitaxel-Resistant Cervical Cancer Cells

International Journal of Integrated Health Sciences ◽

10.15850/ijihs.v6n2.1378 ◽

2018 ◽

Vol 6 (2) ◽

pp. 91-96

Author(s):

Isna Nisrina Hardani ◽

◽

Fachreza Aryo Damara ◽

Annisa Dewi Nugrahani ◽

Muhammad Hasan Bashari ◽

...

Keyword(s):

Cervical Cancer ◽

Cell Death ◽

Cancer Cells ◽

Ethanol Extract ◽

Cervical Cancer Cells ◽

Stylissa Carteri

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Review Jurnal: Potensi Spons Laut Sebagai Anti Kanker Payudara

Jurnal Mandala Pharmacon Indonesia ◽

10.35311/jmpi.v6i01.56 ◽

2020 ◽

Vol 6 (01) ◽

pp. 30-52

Author(s):

Adryan Fristiohady ◽

Lidya Agriningsih Haruna

Keyword(s):

World Health Organization ◽

World Health ◽

Geodia Cydonium ◽

Stylissa Carteri ◽

Health Organization ◽

Mcf 7

Angka kejadian dan kematian pada penderita kanker payudara terus mengalami peningkatan di setiap tahunnya. Prevalensi kejadian 8-9% wanita mengalami kanker payudara. Menurut data World Health Organization (WHO) tahun 2018 menyebutkan angka kejadian kanker payudara di Indonesia sebesar 42,1 per 100.000 penduduk dengan rata-rata angka kematian 17 per 100.000 penduduk. Kanker payudara adalah kanker invasif paling sering terjadi pada wanita di seluruh dunia dan penyebab kematian kanker tertinggi kedua, setelah kanker paru-paru. Kebanyakan wanita dengan kanker payudara akan menjalani beberapa jenis operasi. Pembedahan sering dikombinasikan dengan perawatan lain seperti terapi radiasi, kemoterapi, terapi hormon, dan/atau terapi yang ditargetkan. Studi tentang produk alami laut sebagai sumber kandidat obat masih jarang. Sumber daya laut telah menghasilkan sejumlah besar senyawa bioaktif baru. Spons mewakili salah satu sumber senyawa bioaktif laut yang paling menjanjikan terutama untuk bidang farmasi dalam pengobatan kanker payudara. Penulisan review jurnal ini menggunakan metode studi pustaka. Review jurnal ini membahas tentang beberapa spons laut dan aktivitas antikanker payudara. Dari hasil ulasan jurnal didapatkan bahwa beberapa spons laut dengan aktivitas antikanker payudara yaitu Monanchora viridis, Hyrtios erectus, Xestospongia, Psammaplysilla, Haliclona sp, Stylissa carteri, Aaptos sp, Callyspongia siphonella, Ancorina sp, Haliclona caerulea, Spongia pertusa Esper, Siphonochalina siphonella, Geodia cydonium, Manihinea lynbeazleyae, Theonella mirabilis, Spheciospongia vagabunda, Stryphuous ponderosus, dan Theonella sp, dengan berbagai macam aktivitas seperti antiproliferatif, proapoptotik, dan proinflamasi pada lini sel kanker payudara T11, SUM159PT, MCF-7, BT-474, MCF-7/adr, MDA MB 231, MDA MB 468, SKBR3, HCC-1954, T-47D, MCF7-Nanog, MCF-10A, dan SUM149.

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