The Relationship between Symptom Severity and Low Vitamin D Levels in Patients with Schizophrenia

Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Objective: To investigate the relationship between vitamin D levels and the incidence of skin SCC for the first time in Iran. Methods and Study Design: In this case-control study, 126 subjects were enrolled (63 in each group) out of referents to Razi Skin Hospital in Tehran in 2014. The risk factors for cancer gathered by self-reported questionnaires and blood samples were obtained to measure the level of 25-hydroxyvitamin D. Multivariate logistic regression was used to neutralize the effect of confounding factors. Results: Cases of SCC were more likely to be in men, older than 49 years and working in an outdoor environment, and with longtime exposure to sunlight and a personal history of skin cancers. Family history of skin cancer and of cigarette smoking were not significantly related to SCC. In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P < 0.001). Mean level of 25-hydroxyvitamin D was 40.99 ng/mL in the SCC group and 26.34 ng/mL in the control group (P < 0.05). In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk. In the adjusted model, vitamin D did not independently predict the likelihood of SCC. Conclusion: Vitamin D level and SCC risk are directly related, although not in an independent fashion. Indeed, this relation is severely confounded by exposure to sunlight, which was evidenced by an increased vitamin D level in the people working outside and the higher prevalence of SCC in the same population.

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Causal analysis shows evidence of atopic dermatitis leading to an increase in vitamin D levels

10.1101/2020.04.22.20075077 ◽

2020 ◽

Author(s):

Daniel R Drodge ◽

Ashley Budu-Aggrey ◽

Lavinia Paternoster

Keyword(s):

Vitamin D ◽

Atopic Dermatitis ◽

Serum Vitamin ◽

Strong Relationship ◽

Reverse Direction ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Standard Deviations ◽

The Relationship ◽

Gwa Studies

AbstractAtopic dermatitis (AD) patients have been observed to have lower vitamin D levels. Previous studies have found little evidence that vitamin D levels causally influence the risk of AD, but the reverse direction has not yet been investigated.Here we used Mendelian Randomization to assess the causal relationship between AD and serum vitamin D levels, using genetic data from the most recent GWA studies of vitamin D and AD.There was little evidence for vitamin D levels causally influencing AD risk (odds per standard deviations increase in log-transformed vitamin D levels =1.233, 95% CI 0.927 to 1.639, P-value =0.150). However, genetic liability for AD raises serum vitamin D levels by 0.043 (95% CI 0.017 to 0.069) standard deviations per doubling of odds of disease (P-value =0.001). The AD-associated filaggrin (FLG) mutation R501X appears to show a particularly strong relationship with vitamin D. However, the relationship between AD and vitamin D holds when R501X is omitted (0.018, 95% CI 0.004 to 0.031, P-value =0.008).We found evidence that AD is causally associated with an increase in serum vitamin D levels. Whilst the AD-associated FLG gene has a particularly strong relationship with vitamin D, other AD SNPs show a consistent direction of effect, suggesting that AD more generally influences serum vitamin D levels.

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The relationship between serum vitamin D levels and bone mineral density in community-dwelling elderly

European Geriatric Medicine ◽

10.1016/j.eurger.2012.07.200 ◽

2012 ◽

Vol 3 ◽

pp. S92

Author(s):

H. Yildiz ◽

T. Atli ◽

M. Varli ◽

S. Aras ◽

A. Yalcin ◽

...

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Bone Mineral ◽

Serum Vitamin ◽

Community Dwelling ◽

Mineral Density ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Relationship

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The relationship between erectile dysfunction severity, mean platelet volume and vitamin D levels

The Aging Male ◽

10.1080/13685538.2018.1459544 ◽

2018 ◽

Vol 23 (3) ◽

pp. 173-178 ◽

Cited By ~ 10

Author(s):

Mehmet Gokhan Culha ◽

Hasan Anil Atalay ◽

Halil Lutfi Canat ◽

Ilter Alkan ◽

Sait Ozbir ◽

...

Keyword(s):

Vitamin D ◽

Erectile Dysfunction ◽

Mean Platelet Volume ◽

Platelet Volume ◽

Vitamin D Levels ◽

The Relationship

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P52 The relationship of vitamin D levels with disease activity in systemic lupus erythematosus

10.1136/lupus-2020-eurolupus.99 ◽

2020 ◽

Author(s):

Lambros Athanassiou ◽

Ifigenia Kostoglou ◽

Pavlos Tsakiridis ◽

Aikaterini Tzanavari ◽

Eirini Devetzi ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Disease Activity ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Vitamin D Levels ◽

Relationship Of ◽

The Relationship

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Suppression of Parathyroid Hormone as a Proxy for Optimal Vitamin D Status: Further Analysis of Two Parallel Studies in Opposite Latitudes

Nutrients ◽

10.3390/nu12040942 ◽

2020 ◽

Vol 12 (4) ◽

pp. 942 ◽

Cited By ~ 1

Author(s):

Marcela M. Mendes ◽

Kathryn H. Hart ◽

Susan A. Lanham-New ◽

Patrícia B. Botelho

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Total Sample ◽

Vitamin D Insufficiency ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Low Latitude ◽

Vitamin D Levels ◽

Cubic Model ◽

The Relationship

Optimal vitamin D status has commonly been defined as the level of 25-hydroxyvitamin D (25(OH)D) at which parathyroid hormone (PTH) concentrations would be maximally suppressed, represented by an observed minimum plateau. Previous findings indicate a large variation in this plateau, with values ranging from <30 nmol/L up to 100 nmol/L. This disparity in values might be explained by differences in study design and methodology, ethnicity, age, gender and latitude. This study aimed to investigate the concentration of 25(OH)D at which PTH concentrations were suppressed in Brazilian women living in opposite latitudes (high vs. low: i.e., UK and Brazil), during wintertime. Using data from the D-SOL study (Interaction between Vitamin D Supplementation and Sunlight Exposure in Women Living in Opposite Latitudes), the association between 25(OH)D status and PTH levels were examined in 135 Brazilian women (56 living in England and 79 living in Brazil, aged 20–59 years old). Mean PTH concentrations for Brazilian women with vitamin D deficiency (<25 nmol/L) were significantly higher compared to those with vitamin D insufficiency (25–49.9 nmol/L) (p < 0.01), vitamin D adequacy (50–74.9 nmol/L) (p < 0.01) and those with optimal vitamin D status (>75 nmol/L) (p < 0.001). Regression modelling was used to investigate the relationship between serum 25(OH)D and PTH for the sample as a whole and for each group separately. A cubic model was statistically significant for the total sample (p < 0.001), whereas a linear model presented the best fit for Brazilian women living in England (p = 0.04) and there were no statistically significant models fitted for Brazilian women living in Brazil. The cubic model suggests that 25(OH)D concentrations above 70–80 nmol/L are optimal to suppress the parathyroid gland in Brazilian women. These findings contribute to a better understanding of the relationship between 25(OH)D and PTH in populations living in a low latitude location and are of great relevance for discussions regarding the estimation of optimal cut-offs for vitamin D levels in the Brazilian population as well as for other low latitude locations.

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